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91. 发明专利

AU2003278807A8 KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy 未知
公开(公告)号：AU2003278807A8
公开(公告)日：2004-08-13
申请号：AU2003278807
申请日：2003-09-11
申请人： BRACCO INT B V , DYAX CORP
发明人： SATO AARON K , SEXTON DANIEL J , DRANSFIELD DANIEL T , LADNER ROBERT C , ARBOGAST CHRISTOPHE , BUSSAT PHILIPPE , FAN HONG , KHURANA SUDHA , LINDER KAREN E , MARINELLI EDMUND R , NANJAPPAN PALANIAPPA , NUNN ADRIAN , PILLAI RADHAKRISHNA , POCHON SIBYLLE , RAMALINGAM KONDAREDDIAR , SHRIVASTAVA AJAY , SONG BO , SWENSON ROLF E , WRONSKI MATHEW A VON
IPC分类号： A61K38/00 , A61K48/00 , A61K49/22 , A61K51/08 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/71 , C12Q1/00
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD

92. 发明专利

PL3365685T3 TEST IMMUNOLOGICZNY DO WYKRYWANIA ROZSZCZEPIONEGO WIELKOCZĄSTECZKOWEGO KININOGENU 未知
公开(公告)号：PL3365685T3
公开(公告)日：2021-08-02
申请号：PL16791171
申请日：2016-10-19
申请人： DYAX CORP
发明人： SEXTON DANIEL J , FAUCETTE RYAN , COSIC JANJA
IPC分类号： G01N33/68 , G01N33/86

93. 发明专利

AU2018253476B2 Plasma kallikrein binding proteins 未知
公开(公告)号：AU2018253476B2
公开(公告)日：2020-05-14
申请号：AU2018253476
申请日：2018-10-23
申请人： DYAX CORP
发明人： SEXTON DANIEL J
IPC分类号： C07K16/18 , A61K39/395 , A61P1/00 , A61P9/00 , A61P11/00 , A61P19/02 , A61P25/04 , A61P29/00 , C07K16/40
摘要： PLASMA KALLIKREIN BINDING PROTEINS Plasma kallikrein binding proteins and methods of using such proteins are described.

94. 发明专利

HK1255423A1 一種XIIA因子的單細胞克隆抗體抑制劑未知
公开(公告)号：HK1255423A1
公开(公告)日：2019-08-16
申请号：HK18114586
申请日：2018-11-15
申请人： DYAX CORP
发明人： MASON SHAUNA , KENNISTON JON A , NIXON ANDREW , SEXTON DANIEL J , COMEAU STEPHEN R , ADELMAN BURT
IPC分类号： C07K20060101

95. 发明专利

CO2019002607A2 Biomarcadores de metabolitos para enfermedades asociadas con el sistema de activación por contacto 未知
公开(公告)号：CO2019002607A2
公开(公告)日：2019-03-29
申请号：CO2019002607
申请日：2019-03-21
申请人： DYAX CORP
发明人： SEXTON DANIEL J , FAUCETTE RYAN , VISWANATHAN MALINI , GAUR TRIPTI
IPC分类号： G01N33/68
摘要： En la presente se proporcionan los métodos y kits para analizar una muestra biológica obtenida de un sujeto que tenga, se sospeche de tener, o que esté en riesgo de una enfermedad asociada con el sistema de activación por contacto.

96. 发明专利

SI2521568T1 Proteini, ki vežejo plazemski kalikrein 未知
公开(公告)号：SI2521568T1
公开(公告)日：2019-01-31
申请号：SI201131564
申请日：2011-01-06
申请人： DYAX CORP
发明人： SEXTON DANIEL J , VISWANATHAN MALINI
IPC分类号： A61K39/00 , C07K16/00

97. 发明专利

AU2018260845A1 Evaluation and treatment of bradykinin-mediated disorders 未知
公开(公告)号：AU2018260845A1
公开(公告)日：2018-11-22
申请号：AU2018260845
申请日：2018-11-07
申请人： DYAX CORP
发明人： SEXTON DANIEL J , FAUCETTE RYAN , KENNISTON JON A , CONLEY GREG , NIXON ANDREW , TENHOOR CHRISTOPHER , ADELMAN BURT , CHYUNG YUNG
IPC分类号： C07K16/40
摘要： EVALUATION AND TREATMENT OF BRADYKININ-MEDIATED DISORDERS The present disclosure provides methods for determining a value of cleaved kininogen, intact kininogen, or both, in a sample, the method comprising contacting a sample containing intact and cleaved kininogen with a detection reagent under conditions allowing for interaction between the detection agent and the intact and cleaved kininogen, wherein the detection agent specifically binds cleaved kininogen as compared to intact kininogen, or specifically binds intact kininogen as compared to cleaved kininogen; measuring the level of cleaved kininogen and the level of intact kininogen in the sample based on their interaction with the detection reagent; and determining a value of the cleaved kininogen, the value of the intact kininogen, or both, in the sample based on the amounts of the cleaved kininogen and intact kininogen. The present disclosure also provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.

98. 发明专利

CO2018007216A2 Ensayo de cuantificacion de peptido para diferenciar quininogeno de alto peso molecular (hmwk) de longitud completa y hmwk escindido 未知
公开(公告)号：CO2018007216A2
公开(公告)日：2018-09-20
申请号：CO2018007216
申请日：2016-12-15
申请人： DYAX CORP
发明人： FAUCETTE RYAN , WU JIANG , ZHANG GUODONG , SZEWC MARK , SEXTON DANIEL J , MUSTAFA GUL M
IPC分类号： C07K14/81 , G01N33/68
摘要： Acá se divulgan métodos para diferenciar quininógeno de alto peso molecular (HMWK) de longitud completa y HMWK escindido en una muestra. Dichos métodos pueden comprender tratar una muestra biológica con una proteasa para generar una pluralidad de péptidos digeridos, y medir uno o más péptidos originales, los cuales son indicadores de HMWK escindido y/o de HMWK de longitud completa.

99. 发明专利

CO2018001599A2 Un inhibidor de anticuerpo monoclonal de factor xiia 未知
公开(公告)号：CO2018001599A2
公开(公告)日：2018-05-10
申请号：CO2018001599
申请日：2018-02-19
申请人： DYAX CORP
发明人： ADELMAN BURT , NIXON ANDREW , MASON SHAUNA , KENNISTON JON A , SEXTON DANIEL J , COMEAU STEPHEN R
IPC分类号： C07K16/36
摘要： Acá se divulgan anticuerpos anti-Factor XIIa y método para usar los mismos para el tratamiento de enfermedades asociadas con Factor XII, incluyendo enfermedades asociadas con activación de sistema de contacto, señalización de precalicreína de plasma (por ejemplo, angioedema hereditario), y enfermedades oculares.

100. 发明专利

CA2995457A1 EVACUATED BLOOD COLLECTION TUBES CONTAINING PROTEASE INHIBITORS FOR THE ASSESSMENT OF CONTACT SYSTEM ACTIVATION 未知
公开(公告)号：CA2995457A1
公开(公告)日：2017-02-16
申请号：CA2995457
申请日：2016-08-12
申请人： DYAX CORP
发明人： SEXTON DANIEL J , FAUCETTE RYAN
IPC分类号： A61B5/154 , A61B5/15
摘要： Disclosed herein are evacuated blood collection tubes comprising protease inhibitor cocktails in liquid form and uses thereof for assessing features associated with the contact system in a subject, including the endogenous level of contact system activation, the endogenous level of a drug that targets a component of contact system during treatment, and/or the immunogenicity of such a drug.

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