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91. 发明授权

US08170636B2 Optical sensor confidence algorithm 有权
标题翻译：光学传感器置信算法
公开(公告)号：US08170636B2
公开(公告)日：2012-05-01
申请号：US11758188
申请日：2007-06-05
申请人： Can Cinbis
发明人： Can Cinbis
IPC分类号： A61B5/1455 , A61B6/00
CPC分类号： G01N21/15 , A61B5/0031 , A61B5/0086 , A61B5/1459 , A61N1/3706 , G01N21/49 , G01N2201/0642
摘要： An implantable medical device system including an optical sensor monitors for the presence of overgrowth on the sensor by sensing light scattered by a measurement volume, the sensed light corresponding to a first wavelength, and deriving an overgrowth metric in response to the sensed light. The overgrowth metric is correlated to the presence of overgrowth on the sensor and is compared to a predetermined threshold. The presence of overgrowth on or near the sensor is detected in response to the overgrowth metric crossing the threshold.
摘要翻译：包括光学传感器的可植入医疗装置系统通过感测由测量体积散射的光，对应于第一波长的感测光，以及响应于感测到的光而导出过度生长度量来监测传感器上是否存在过度生长。过度生长度量与传感器上过度生长的存在相关，并与预定阈值进行比较。响应于越过阈值的过度生长度量来检测在传感器上或附近存在过度生长。

92. 发明授权

US08038626B2 Implantable tissue perfusion sensing system and method 有权
标题翻译：植入式组织灌注感应系统及方法
公开(公告)号：US08038626B2
公开(公告)日：2011-10-18
申请号：US12039326
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B5/02
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device system for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, determines changes in perfusion in response to first changes in the plurality of light measurements in a direction indicative of a decrease in blood oxygenation and second changes in a direction indicative of a decrease in blood volume, and adjusts delivery of therapy by the device in response to the determined loss of perfusion.
摘要翻译：一种用于感测心脏事件的医疗装置系统，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源和检测发射光的检测器。处理器响应于由检测器检测到的发射光来确定多个光测量值，响应于多个光测量中指示血氧饱和度降低的方向和方向上的第二变化的方向响应于第一变化来确定灌注变化指示血容量的减少，并且响应于确定的灌注损失来调整装置的治疗递送。

93. 发明申请

US20110160557A1 TESTING COMMUNICATION DURING IMPLANTATION 有权
标题翻译：植入过程中的测试通讯
公开(公告)号：US20110160557A1
公开(公告)日：2011-06-30
申请号：US12732403
申请日：2010-03-26
申请人： Can Cinbis , H. Toby Markowitz
发明人： Can Cinbis , H. Toby Markowitz
IPC分类号： A61B5/04
CPC分类号： A61B5/0028 , A61B5/0031 , A61B2034/2053 , A61B2560/0271 , A61N1/37205 , A61N1/37217 , A61N1/37241 , A61N1/3756
摘要： A system and method are described for testing communication through a patient during implantation using telemetry coupling electrodes on a delivery catheter. In one example, at least two telemetry coupling electrodes may be placed on or within a delivery catheter to test conductive communication with external body electrodes during implantation. In some instances, the telemetry coupling electrodes of the delivery catheter may approximate the spacing of telemetry electrodes on an IMD. In this manner, testing conductively coupled communication with telemetry coupling electrodes of the catheter may be used to mimic the telemetry electrodes on the IMD and determine a target position and/or orientation of an electrode or electrodes of the IMD for successful conductive communication through the body.
摘要翻译：描述了一种用于在植入期间通过患者使用传送导管上的遥测耦合电极来测试通信的系统和方法。在一个示例中，至少两个遥测耦合电极可以放置在输送导管上或内部，以在植入期间测试与外部身体电极的导电连通。在一些情况下，输送导管的遥测耦合电极可以接近IMD上遥测电极的间距。以这种方式，测试与导管的遥测耦合电极的导电耦合通信可以用于模拟IMD上的遥测电极，并且确定IMD的电极或电极的目标位置和/或取向以通过身体成功地导电连通。

94. 发明授权

US07787947B2 Method and apparatus for using an optical hemodynamic sensor to identify an unstable arrhythmia 有权
标题翻译：使用光学血液动力学传感器来识别不稳定心律失常的方法和装置
公开(公告)号：US07787947B2
公开(公告)日：2010-08-31
申请号：US11394477
申请日：2006-03-31
申请人： Sourav Bhunia , Walter H. Olson , Can Cinbis
发明人： Sourav Bhunia , Walter H. Olson , Can Cinbis
IPC分类号： A61N1/00
CPC分类号： A61B5/14542 , A61B5/1459 , A61N1/3621 , A61N1/36557 , A61N1/3956
摘要： A medical device identifies a hemodynamically unstable arrhythmia based upon optical hemodynamic sensor signals. The optical hemodynamic sensor includes a light source for transmitting light corresponding to first and second wavelengths through a blood perfused tissue of a patient and a light detector for generating optical signals corresponding to an intensity of the detected light at the first and second wavelengths. At a low motion period for the patient, optical signals are obtained from the optical hemodynamic sensor and are analyzed to determine a baseline motion level for the patient. Subsequent signals obtained from the optical hemodynamic sensor are compared to the baseline motion levels, with only those signals corresponding to periods where motion does not exceed the baseline level of motion being further analyzed to determine if they are consistent with a hemodynamically unstable arrhythmia.
摘要翻译：医疗设备基于光学血液动力学传感器信号识别血液动力学不稳定的心律失常。光学血液动力学传感器包括用于通过患者的血液灌注组织透射与第一和第二波长相对应的光的光源，以及用于产生与第一和第二波长的检测光的强度对应的光信号的光检测器。在患者的低运动周期中，从光学血液动力学传感器获得光学信号，并且被分析以确定患者的基线运动水平。将从光学血液动力学传感器获得的后续信号与基线运动水平进行比较，只有那些对应于运动未超过基线运动水平的周期的信号进行进一步分析，以确定它们是否与血液动力学不稳定的心律失常一致。

95. 发明授权

US07682316B2 Implantable heart sound sensor with noise cancellation 有权
标题翻译：具有噪音消除的植入式心音传感器
公开(公告)号：US07682316B2
公开(公告)日：2010-03-23
申请号：US11781734
申请日：2007-07-23
申请人： David A. Anderson , Can Cinbis
发明人： David A. Anderson , Can Cinbis
IPC分类号： A61B5/02
CPC分类号： A61N1/36514 , A61B7/003 , A61B7/006 , A61B7/008 , A61B2562/0204 , A61N1/36578 , A61N1/3702
摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.
摘要翻译：植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。

96. 发明申请

US20080208067A1 IMPLANTABLE TISSUE PERFUSION SENSING SYSTEM AND METHOD 有权
标题翻译：可植入组织渗透感应系统及方法
公开(公告)号：US20080208067A1
公开(公告)日：2008-08-28
申请号：US12039281
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B5/02
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of electrodes sensing cardiac signals utilized to identify a cardiac event, a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, and generates a blood volume index in response to a light source of the plurality of light sources emitting light at an isobestic wavelength. The blood volume index is then utilized to verify the identifying of the cardiac event.
摘要翻译：一种用于感测心脏事件的医疗装置，其包括感测用于识别心脏事件的心脏信号的多个电极，能够发射多个波长的光的多个光源以及检测发射光的检测器。处理器响应于由检测器检测到的发射光来确定多个光测量，并且响应于以异常波长发射光的多个光源的光源产生血液体积指数。然后利用血容量指数来验证心脏事件的识别。

97. 发明申请

US20080208020A1 IMPLANTABLE TISSUE PERFUSION SENSING SYSTEM AND METHOD 有权
标题翻译：可植入组织渗透感应系统及方法
公开(公告)号：US20080208020A1
公开(公告)日：2008-08-28
申请号：US12039263
申请日：2008-02-28
申请人： Can Cinbis , James K. Carney
发明人： Can Cinbis , James K. Carney
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459 , A61B5/0059 , A61B5/024 , A61B5/046 , A61B5/0464 , A61B5/14542 , A61B5/7214 , A61N1/3925
摘要： A medical device for sensing cardiac events that includes a plurality of light sources capable of emitting light at a plurality of wavelengths, and a detector to detect the emitted light. A processor determines a plurality of light measurements in response to the emitted light detected by the detector, updates, for each of the plurality of wavelengths, a first normalization coefficient and a second normalization coefficient in response to the detected emitted light, and adjusts the determined plurality of light measurements in response to the first normalization coefficient and the second normalization coefficient.
摘要翻译：一种用于感测心脏事件的医疗装置，其包括能够发射多个波长的光的多个光源，以及检测器，用于检测发射的光。处理器响应于由检测器检测到的发射光来确定多个光测量，响应于检测到的发射光，针对多个波长中的每一个更新第一归一化系数和第二归一化系数，并且调整所确定的响应于第一归一化系数和第二归一化系数的多个光测量。

98. 发明申请

US20070238992A1 Implantable sensor 审中-公开
标题翻译：植入式传感器
公开(公告)号：US20070238992A1
公开(公告)日：2007-10-11
申请号：US11344667
申请日：2006-02-01
申请人： William Donofrio , Jeffrey Nycz , Can Cinbis , Matthew Morrison , Susan Drapeau , Qingshan (Sam) Ye
发明人： William Donofrio , Jeffrey Nycz , Can Cinbis , Matthew Morrison , Susan Drapeau , Qingshan (Sam) Ye
IPC分类号： A61B8/00
CPC分类号： A61B8/0875 , A61B5/076 , A61B5/4509 , A61B5/4528 , A61B5/6882 , A61B7/005 , A61B7/006 , A61B8/4472 , A61B8/56 , A61B8/565
摘要： An implantable sensor for detecting changes in tissue density is disclosed. The implantable sensor includes a transducer adapted for detecting indicators of tissue density. The implantable sensor includes memory for storing data corresponding to the tissue density indicators detected by the sensor. A telemetry circuit is configured for transmitting the tissue density data outside of the body.
摘要翻译：公开了一种用于检测组织密度变化的植入式传感器。可植入传感器包括适于检测组织密度指标的换能器。可植入传感器包括用于存储对应于由传感器检测的组织密度指示符的数据的存储器。遥测电路被配置用于将身体外的组织密度数据传输。

99. 发明申请

US20070156190A1 Subcutaneous ICD with motion artifact noise suppression 审中-公开
标题翻译：皮下ICD与运动伪影噪声抑制
公开(公告)号：US20070156190A1
公开(公告)日：2007-07-05
申请号：US11324076
申请日：2005-12-30
申请人： Can Cinbis
发明人： Can Cinbis
IPC分类号： A61N1/00
CPC分类号： A61N1/3925 , A61B5/0402 , A61B5/7207 , A61B5/721 , A61N1/3756
摘要： A subcutaneous implantable cardioverter defibrillator (SubQ ICD) includes a housing carrying electrodes for sensing ECG signals and delivering therapy. A sensor detects local motion in the area of the housing and produces a noise signal related to motion artifact noise contained in ECG signals derived from the electrode array. An adaptive noise cancellation circuit enhances ECG signals based on the local motion noise signal. A therapy delivery circuit delivers cardioversion and defibrillation pulses based upon the enhanced ECG signals.
摘要翻译：皮下植入式心律转复除颤器（SubQ ICD）包括承载电极的壳体，用于感测ECG信号并递送治疗。传感器检测壳体区域中的局部运动，并且产生与源自电极阵列的ECG信号中包含的运动伪影噪声相关的噪声信号。自适应噪声消除电路基于局部运动噪声信号来增强ECG信号。治疗递送电路基于增强的ECG信号提供心脏复律和除颤脉冲。

100. 发明授权

US5479926A Imaging system display processor 失效
标题翻译：成像系统显示处理器
公开(公告)号：US5479926A
公开(公告)日：1996-01-02
申请号：US401715
申请日：1995-03-10
申请人： Kutay Ustuner , Matthew I. Haller , Ting-Lan Ji , Pai-Chi Li , Can Cinbis
发明人： Kutay Ustuner , Matthew I. Haller , Ting-Lan Ji , Pai-Chi Li , Can Cinbis
IPC分类号： A61B8/00 , G01S7/52 , G01S15/89 , G06T1/00 , H03H17/02
CPC分类号： H03H17/0202 , G01S7/52026 , G01S7/52046 , G01S15/8995 , G01S7/5206 , G01S7/52071
摘要： A display processor for an ultrasonic imaging system includes a two-dimensional filter to generate a smoothed image signal I.sub.p from a high spatial resolution image signal I.sub.D. I.sub.p is optimized for high contrast resolution and good tissue differentiation, and I.sub.D is optimized for high detail resolution and the display of fine structural details. I.sub.p and I.sub.D are applied as addressing inputs to a look-up table that provides an output image signal I.sub.O that combines both detail resolution of I.sub.D and contrast resolution of I.sub.p. I.sub.O can display detail resolution as brightness and contrast resolution as color. I.sub.O can also be formed as a weighted combination or sum of I.sub.p and I.sub.D.
摘要翻译：用于超声成像系统的显示处理器包括二维滤波器，以从高空间分辨率图像信号ID生成平滑图像信号Ip。 Ip针对高对比度分辨率和良好的组织分化进行了优化，并针对高细节分辨率和精细结构细节的显示进行了优化。 Ip和ID被用作寻址表的寻址输入，该查询表提供输出图像信号IO，其结合ID的细节分辨率和Ip的对比度分辨率。 IO可以将亮度和对比度分辨率的细节分辨率显示为彩色。 IO也可以形成为Ip和ID的加权组合或总和。

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