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91. 发明授权

US08177837B2 Percutaneously deployed vascular valves 有权
标题翻译：经皮部署血管瓣膜
公开(公告)号：US08177837B2
公开(公告)日：2012-05-15
申请号：US13008629
申请日：2011-01-18
申请人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
发明人： Brian C. Case , Charles W. Agnew , Jacob A. Flagle
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/068 , A61F2002/8483 , A61F2210/0076 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0034 , A61F2230/0095
摘要： Described are percutaneous vascular valves free of attached support structures and deployment systems and methods for providing attachment of the valves within a vascular vessel.
摘要翻译：描述的是没有附接的支撑结构的经皮血管瓣和用于在血管容器内提供阀附件的展开系统和方法。

92. 发明授权

US08157810B2 Prosthesis adapted for placement under external imaging 有权
标题翻译：假体适应放置在外部成像
公开(公告)号：US08157810B2
公开(公告)日：2012-04-17
申请号：US10787307
申请日：2004-02-26
申请人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
发明人： Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Ray Leonard, II
IPC分类号： A61F11/00
CPC分类号： A61F2/2475 , A61B90/39 , A61F2/2418 , A61F2230/0026 , A61F2230/0095 , A61F2250/0098
摘要： A expandable prosthesis having an imageable structure comprising one or more elements visually distinguishable by an external (e.g., radiographic or ultrasonic) imaging system, the structure being located about a first axis that corresponds to a structural feature of the prosthesis that is configured to perform a specific function particular to that axis. The imageable structure is configured to assist in the rotational orientation of the prosthesis during placement within the implantation site. In one embodiment, the prosthesis comprises a venous valve that includes imageable elements or structure, such as a pair of radiopaque markers, that defines the orifice of the valve structure such that the orifice can be oriented with a particular anatomical feature under imaging, such as to align the orifice with the long axis of the vessel. In another embodiment, the imageable structure is configured to permit an aperture located about a stent graft to be oriented with a anatomical feature of the vessel, such as a branch vessel opening. The invention includes a method for using imageable structure to confirm that the orientation of the prosthesis within a delivery apparatus is consistent the desired delivery approach to be used.
摘要翻译：一种具有可成像结构的可扩张假体，其包括可由外部（例如，射线照相或超声）成像系统在视觉上区分的一个或多个元件，所述结构围绕与假体的结构特征对应的第一轴定位，所述第一轴构造成执行特定于该轴的特定功能。可成像结构构造成在放置在植入部位期间有助于假体的旋转取向。在一个实施例中，假体包括静脉瓣，其包括可成像元件或结构，例如一对不透射线的标记，其限定瓣膜结构的孔，使得孔可以在成像下具有特定解剖特征，例如以将孔与容器的长轴对准。在另一个实施例中，可成像结构被配置为允许围绕支架移植物定位的孔与容器的解剖特征（例如分支血管开口）定向。本发明包括一种使用可成像结构来确认假体在输送装置内的取向与所要使用的输送方法一致的方法。

93. 发明授权

US07833267B2 Methods and systems for modifying vascular valves 有权
标题翻译：改变血管瓣膜的方法和系统
公开(公告)号：US07833267B2
公开(公告)日：2010-11-16
申请号：US12257720
申请日：2008-10-24
申请人： Jacob A. Flagle , Brian C. Case
发明人： Jacob A. Flagle , Brian C. Case
IPC分类号： A61F2/24
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/064 , A61B17/122 , A61B18/1492 , A61B2017/00783 , A61F2/06 , A61F2/2475 , Y10S623/904
摘要： Described are methods and systems for modifying vascular valves in order to reduce retrograde blood flow through the valves. Preferred methods include connecting vascular valve leaflets with at least one remodelable material, such that the valve leaflets become fused by the ingrowth of the patient's native tissue. Preferred remodelable materials include collagenous extracellular matrix material, such as small intestine submucosa.
摘要翻译：描述了用于修改血管瓣膜以减少通过瓣膜的逆行血流量的方法和系统。优选的方法包括将血管瓣叶与至少一种可重塑材料连接，使得瓣膜小叶通过患者的天然组织的向内生长而变得熔化。优选的可重塑材料包括胶原细胞外基质材料，例如小肠粘膜下层。

94. 发明申请

US20100174361A1 PROSTHETIC VALVE WITH SEMI-RIGID AND FLEXIBLE LEAFLETS 审中-公开
标题翻译：具有半刚性和柔性叶片的前置阀
公开(公告)号：US20100174361A1
公开(公告)日：2010-07-08
申请号：US12723840
申请日：2010-03-15
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

95. 发明申请

US20100063577A1 METHOD OF IMPLANTING A PROSTHETIC VALVE 审中-公开
标题翻译：植入预制阀的方法
公开(公告)号：US20100063577A1
公开(公告)日：2010-03-11
申请号：US12621214
申请日：2009-11-18
申请人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
发明人： Brian C. Case , Thomas A. Osborne , Jacob A. Flagle , Fred T. Parker
IPC分类号： A61F2/06 , A61F2/82
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2230/0067 , A61F2230/0078 , A61F2230/008 , A61F2250/0063
摘要： Methods of implanting a prosthetic valve in a body vessel are provided. A first expandable frame member is delivered to and deployed at a point of treatment in a body vessel. A second expandable frame member is delivered to the point of treatment. The second expandable frame member has an attached graft member that forms a valve adapted to permit fluid flow through the body vessel in a first direction and to substantially prevent fluid flow through the body vessel in a second, opposite direction. After deployment of the first expandable frame member, the second expandable frame member is deployed at the point of treatment such that the second frame member is positioned radially inward of the first frame member within said body vessel to form a prosthetic valve.
摘要翻译：提供了将人造瓣植入人体容器中的方法。第一可膨胀框架构件被输送到身体容器中并在其处处被部署。第二可膨胀框架构件被输送到处理点。第二可膨胀框架构件具有附接的移植构件，其形成适于允许流体沿第一方向流过身体容器的阀，并且基本上防止流体沿第二相反方向流过身体容器。在展开第一可膨胀框架构件之后，第二可膨胀框架构件在处理点处展开，使得第二框架构件位于所述主体容器内的第一框架构件的径向内侧以形成人造瓣膜。

96. 发明申请

US20100057201A1 PROSTHETIC VALVE WITH VESSEL ENGAGING MEMBER 审中-公开
标题翻译：具有船舶参与成员的前置阀
公开(公告)号：US20100057201A1
公开(公告)日：2010-03-04
申请号：US12616518
申请日：2009-11-11
申请人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa
发明人： Jacob A. Flagle , Brian C. Case , Andrew K. Hoffa
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2220/0033 , A61F2220/005 , A61F2230/0078
摘要： Medical devices for implantation in a body vessel are provided. Each medical device comprises a main body, a valve, and a vessel engaging member. The vessel engaging member is disposed on an outer surface of the main body. Kits including a plurality of vessel engaging members for use with one or more valve members are also provided. The vessel engaging members have varying radial dimensions, allowing assembly of medical devices having varying radial dimensions. Methods of treating a patient using medical devices according to the invention are also provided.
摘要翻译：提供用于植入体内的医疗装置。每个医疗装置包括主体，阀和容器接合构件。容器接合构件设置在主体的外表面上。还提供了包括与一个或多个阀构件一起使用的多个容器接合构件的套件。容器接合构件具有变化的径向尺寸，允许组装具有变化径向尺寸的医疗装置。还提供了使用根据本发明的医疗装置治疗患者的方法。

97. 发明授权

US07628803B2 Implantable vascular device 有权
公开(公告)号：US07628803B2
公开(公告)日：2009-12-08
申请号：US10642372
申请日：2003-08-15
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.

98. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

99. 发明申请

US20090216311A1 INTRALUMINAL SUPPORT FRAME 有权
标题翻译：内部支持框架
公开(公告)号：US20090216311A1
公开(公告)日：2009-08-27
申请号：US12463394
申请日：2009-05-09
申请人： Jacob Flagle , Brian C. Case
发明人： Jacob Flagle , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/2418 , A61F2/2475 , A61F2/915 , A61F2002/075 , A61F2002/825 , A61F2002/91533 , A61F2002/91575 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054
摘要： Intraluminal support frames for placement within a body vessel are provided. The support frames include a plurality of ring structures and first and second sets of connector segments. Connector segments of the first set join adjacent pairs of ring structures while connector segments of the second set join at least three ring structures. Medical devices are also provided that include a support frame and an additional component, such as a graft member or valve member
摘要翻译：提供用于放置在体内容器内的管腔内支架。支撑框架包括多个环形结构以及第一和第二组连接器段。第一组的连接器段连接相邻的环形结构对，而第二组的连接器段连接至少三个环结构。还提供医疗装置，其包括支撑框架和附加构件，例如移植构件或阀构件

100. 发明授权

US07563277B2 Removable covering for implantable frame projections 有权
标题翻译：用于可植入框架突起的可移除覆盖物
公开(公告)号：US07563277B2
公开(公告)日：2009-07-21
申请号：US11583395
申请日：2006-10-19
申请人： Brian C. Case , Charles W. Agnew
发明人： Brian C. Case , Charles W. Agnew
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/06 , A61F2/2418 , A61F2/848 , A61F2220/0016 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device can include a frame with one or more projections each having at least one edge extending from the surface of the frame, and a biocompatible, water-soluble removable material coated over at least a portion of the at least one edge. The projections can be barbs positioned to engage the interior wall of a body vessel or to attach a material, such as a valve leaflet or graft, to the frame. The removable material can be dissolved within a body vessel upon implantation, thereby exposing the at least one edge. Methods of making an implantable medical device and methods of treating a subject are also disclosed.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置可以包括具有一个或多个突起的框架，每个突起具有从框架的表面延伸的至少一个边缘以及涂覆在至少一个边缘的至少一部分上的生物相容性的水溶性可移除材料。突起可以是定位成接合身体容器的内壁的倒钩或者将诸如瓣膜小叶或移植物的材料附接到框架。可移植材料可以在植入时溶解在体内容器中，从而暴露至少一个边缘。还公开了制造可植入医疗装置的方法和治疗受试者的方法。

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