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91. 发明公开

EP2478019A1 MIT WIRKSTOFFHALTIGEN ÜBERZÜGEN BESCHICHTETE PELLETS 有权
标题翻译：与ACTIVE涂料含包覆的糖丸
公开(公告)号：EP2478019A1
公开(公告)日：2012-07-25
申请号：EP10755128.5
申请日：2010-09-13
申请人： BASF SE
发明人： KOLTER, Karl , DJURIC, Dejan , FISCHER, Stefan , KARL, Matthias
IPC分类号： C08F220/00 , C08F226/06 , C08F290/06 , C09D4/00 , C09D171/00 , C09D201/00 , A61K9/00 , A61K47/00
CPC分类号： A61K9/1676 , A61K9/1641 , C08F218/08 , C08F226/06 , C08F283/06 , C08L1/02 , C08L5/00 , C08L51/08 , C09D151/08 , C09D171/02
摘要： The invention relates to preparations of active substances of low solubility in water, made of carrier particles having coatings containing active substances, wherein the active substances of low solubility are embedded in coatings made of amphiphilic copolymers.

92. 发明公开

EP2477605A1 FESTE PHARMAZEUTISCHEN ZUBEREITUNGEN ENTHALTEND AMPHIPHILE COPOLYMERE AUF BASIS VON POLYETHERN IN KOMBINATION MIT TENSIDEN 审中-公开
标题翻译：固体药物制剂含两亲性共聚物基础上组合聚醚与表面活性剂
公开(公告)号：EP2477605A1
公开(公告)日：2012-07-25
申请号：EP10754472.8
申请日：2010-09-13
申请人： BASF SE
发明人： KOLTER, Karl , DJURIC, Dejan , FISCHER, Stefan
IPC分类号： A61K9/14 , A61K47/10 , A61K47/34 , A61K31/00
CPC分类号： A61K9/146 , A61K47/10 , A61K47/34
摘要： The invention relates to formulations comprising preparations of active substances of low solubility in water in a polymer matrix of polyether copolymers, wherein the polyether copolymers are obtained by radically initiated polymerization of a mixture of 30 to 80% by weight of N-vinyl lactam, 10 to 50% by weight of vinyl acetate, and 10 to 50% by weight of a polyether, and of at least one surfactant in which the active substance of low solubility in water is amorphously present in the polymer matrix.

93. 发明公开

EP2306987A1 VERFAHREN ZUM BESCHICHTEN VON TABLETTEN 有权
标题翻译：方法片剂包衣
公开(公告)号：EP2306987A1
公开(公告)日：2011-04-13
申请号：EP09772483.5
申请日：2009-07-01
申请人： BASF SE
发明人： KOLTER, Karl , ROTTMANN, Nils , ANGEL, Maximilian
IPC分类号： A61K9/28
CPC分类号： A61K9/284 , A61K9/2853
摘要： The present invention relates to a polymer composition for coating solid substrates (S) comprising: a) 0.5-90 wt.-% polyethylene glycol with a weight-averaged molecular weight in the range of 1,500 to 20,000 g/mol (Component A), b) 0.5-20 wt.-% of a water-soluble polyvinyl pyrolidone with a K value according to Fikentscher in the range of 12 to 90 (Component B), c) 0-95 wt.-% of a solvent (L), and d) 0-70 wt.-% of one or more non-polymeric auxiliaries (Component C).

94. 发明公开

EP2164462A2 PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN 有权
标题翻译： PHARMAZEUTISCHE FORMULIERUNGFÜRDIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN
公开(公告)号：EP2164462A2
公开(公告)日：2010-03-24
申请号：EP08760389.0
申请日：2008-06-03
申请人： BASF SE
发明人： KOLTER, Karl , SCHÖNHERR, Michael , GEBERT, Silke , MEYER-BÖHM, Kathrin , MASCHKE, Angelika
IPC分类号： A61K9/00 , A61K9/20 , A61K9/16
CPC分类号： A61K9/2018 , A61K9/0056 , A61K9/2027 , A61K9/2054
摘要： The invention relates to a pharmaceutical formulation in the form of agglomerates containing A) an adjuvant consisting of a) 60 - 97 % by weight of sugar or sugar alcohols, b) 1 - 25 % by weight of a disintegration agent c)1 - 15 % by weight of water insoluble, film-forming polymers d) 0 -15 % by weight of water soluble polymers, and e) 0 - 15 % by weight of additional conventional pharmaceutical adjuvants, the sum of the components a) to e) totalling 100 % by weight, and B) at least one active ingredient.
摘要翻译：本发明涉及附聚物形式的药物制剂，其含有A）佐剂，其包含a）60-97重量％的糖或糖醇，b）1-25重量％的崩解剂c）1-15 重量％的水不溶性成膜聚合物，d）0-15％重量的水溶性聚合物，和e）0-15％重量的另外的常规药物佐剂，组分a）-e）总量 100重量％，和B）至少一种活性成分。

95. 发明公开

EP2164461A1 PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON KAU- UND LUTSCH-TABLETTEN 有权
标题翻译：咀嚼和棒棒糖片剂
公开(公告)号：EP2164461A1
公开(公告)日：2010-03-24
申请号：EP08760353.6
申请日：2008-06-02
申请人： BASF SE
发明人： KOLTER, Karl , SCHÖNHERR, Michael , GEBERT, Silke , MEYER-BÖHM, Kathrin , MASCHKE, Angelika
IPC分类号： A61K9/00 , A61K9/20 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： The present invention relates to pharmaceutical formulations for the production of chewable tablets and lozenges, comprising agglomerates based on sugar or sugar alcohols and disintegrants and water-insoluble polymers in combination with a viscosity-increasing/gel-forming polymer. The invention further relates to the corresponding chewable tablets and lozenges.

96. 发明公开

EP2164460A1 PHARMAZEUTISCHE FORMULIERUNG FÜR DIE HERSTELLUNG VON SCHNELL ZERFALLENDEN TABLETTEN 有权
标题翻译：药物制剂FOR FAST崩解片剂的制造
公开(公告)号：EP2164460A1
公开(公告)日：2010-03-24
申请号：EP08760350.2
申请日：2008-06-02
申请人： BASF SE
发明人： KOLTER, Karl , SCHÖNHERR, Michael , GEBERT, Silke , MEYER-BÖHM, Kathrin , MASCHKE, Angelika
IPC分类号： A61K9/00 , A61K9/20 , A61K47/26
CPC分类号： A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2054
摘要： The invention relates to a pharmaceutical formulation in the form of compacts containing A) an agglomerated auxiliary agent fraction consisting of a1) 60 - 97 % by weight of sugar or sugar alcohols, a2) 1 - 25 % by weight of a disintegration agent selected from the group consisting of crospovidone, croscarmellose, sodium carboxymethyl starch and L-hydroxypropyl cellulose, a3) 1 - 15 % by weight of water insoluble film-forming polymers, a4) 0 - 15 % by weight of water-soluble polymers, and a5) 0 - 15 % by weight of additional conventional pharmaceutical adjuvants, the sum of the components a1) to a5) totalling 100 % by weight, B) at least one active ingredient, C) 0 to 10 % by weight, in relation to the total quantity and A) to D) of a lubricant or mould release agent, and D) optionally additional pharmaceutical auxiliary agents.
摘要翻译：在压坯包括a1的组成A）凝聚的赋形剂含量）为60〜97％（重量）的糖或糖醇的形式的药物制剂，A2）（重量）的崩解剂1-25％，选自交聚维酮中选出，联羧甲基纤维素，羧甲基淀粉钠和L-羟丙基纤维素，a3）的（重量）的水不溶性成膜聚合物的A4）（重量）的水溶性聚合物的和a5）0-15％0-15％1-15％（重量）的另外的药学惯用的赋形剂，总组分a1）至a5的）由100％是重量，B）至少一种活性成分，C）0至重量10％，基于A的总量）至D），的润滑剂或脱模剂，和D），如果合适的话，另外的药物赋形剂。

97. 发明公开

EP1924633A1 WÄSSRIGE POLYVINYLACETATDISPERSIONEN MIT HOHER SCHERSTABILITÄT 有权
标题翻译：水性聚乙烯高剪切稳定性
公开(公告)号：EP1924633A1
公开(公告)日：2008-05-28
申请号：EP06792970.3
申请日：2006-08-23
申请人： BASF SE
发明人： ANGEL, Maximilian , KOLTER, Karl
IPC分类号： C08J3/00
CPC分类号： C08J3/12 , A61K8/8147 , A61K9/284 , A61K9/5026 , A61K2800/56 , A61Q19/00 , C08F2/22 , C08F218/08 , C08F220/06 , C08J2333/00 , C09D131/04
摘要： The invention relates to an aqueous polymer dispersion which is produced by radically polymerising vinyl acetate in the presence of 0.05 - 5 wt.% acrylic acid or methacrylic acid or mixtures thereof, under the proviso that the total weight of monomers is 100 wt.%, and 0.001 - 1 wt.% of at least one ionic emulsifying agent.

99. 发明授权

EP3337458B1 VERWENDUNG VON WASSERLÖSLICHEN POLYMEREN AUF BASIS VON N-VINYLPYRROLIDON UND ACRYLSÄURE ALS PHARMAZEUTISCHE HILFSTOFFE 有权
公开(公告)号：EP3337458B1
公开(公告)日：2019-10-16
申请号：EP16751610.3
申请日：2016-08-17
申请人： BASF SE
发明人： SCHIFFTER, Heiko Alexander , ANGEL, Maximilian , KOLTER, Karl , GUTH, Felicitas
IPC分类号： A61K9/14 , A61K9/00 , A61K9/16 , A61K9/48 , A61K31/451 , A61K31/4515

100. 发明公开

EP3365421A1 FESTE LÖSUNGEN VON GERUCHS- UND GESCHMACKSSTOFFEN MIT VINYLLACTAMPOLYMEREN 有权
公开(公告)号：EP3365421A1
公开(公告)日：2018-08-29
申请号：EP16781432.6
申请日：2016-10-13
申请人： BASF SE
发明人： KOLTER, Karl , PELZER, Ralf , KARL, Matthias
IPC分类号： C11D3/50 , A23L27/00 , A61L9/01 , A61Q13/00 , A61K8/02 , A61K9/20 , C11D3/37 , A61K8/81
CPC分类号： C11B9/0015 , A23L27/2026 , A23L27/203 , A23L27/74 , A23V2002/00 , A61K8/0287 , A61K8/34 , A61K8/817 , A61K8/8182 , A61K47/10 , A61K47/32 , A61K47/34 , A61K47/46 , A61L9/01 , A61Q13/00 , C11B9/0034 , C11D3/00 , C11D3/3776 , C11D3/3788 , C11D3/505
摘要： Optically transparent, solid water-soluble formulations of odoriferous substances and flavoring agents, containing at least one synthetic odoriferous substance and flavoring agent; in said formulations, the odoriferous substances and flavoring agents are homogeneously embedded in a polyvinyl lactam-based polymer matrix.

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