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    • 91. 发明授权
    • Process for preparing 2-isocephem derivatives
    • 制备2-异头孢烯衍生物的方法
    • US5688942A
    • 1997-11-18
    • US732446
    • 1996-11-06
    • Michio SasaokaDaisuke SuzukiDelsoo SuhYoshihisa Tokumaru
    • Michio SasaokaDaisuke SuzukiDelsoo SuhYoshihisa Tokumaru
    • C07D513/04A61K31/54A61P31/04C07D205/08C07D498/04C07D501/00C07D507/08
    • C07D205/08C07D501/00Y02P20/55
    • A process for preparing a 2-isocephem derivative characterized in that a thioacetic acid derivative which itself is basic or a mixture of a base and a thioacetic acid derivative is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-isocephem derivative represented by the general formula (2), and a process for preparing a 2-oxaisocephem derivative characterized in that a base is caused to act on a 2-azetidinyl-3,4-dihalogeno-2-butenoic acid compound represented by the general formula (1) in a water-containing organic solvent to obtain a 3-halomethyl-2-oxaisocephem derivative represented by the general formula (3) ##STR1## wherein R.sup.1 is a hydrogen atom, amino or protected amino, R.sup.2 is a hydrogen atom or lower alkoxyl, R.sup.1 and R.sup.2, when taken together, form a cyclic amino protecting group, R.sup.3 is a hydrogen atom or carboxylic acid protecting group, W is a leaving group, and X and Y are the same or different and are each a halogen atom ##STR2## wherein R.sup.1, R.sup.2, R.sup.3 and X are the same as above, ##STR3## wherein R.sup.1, R.sup.2, R.sup.3 and X are the same as above.
    • PCT No.PCT / JP96 / 00538 Sec。 371日期:1996年11月6日 102(e)日期1996年11月6日PCT 1996年3月6日PCT公布。 公开号WO96 / 28453 日期1996年9月19日制备2-异头孢烯衍生物的方法,其特征在于使本身为碱性的硫代乙酸衍生物或碱和硫代乙酸衍生物的混合物作用于2-氮杂环丁烷基-3,4- 由通式(1)表示的二卤代-2-丁烯酸化合物在含水有机溶剂中得到由通式(2)表示的3-卤代甲基-2-异头孢烯衍生物,以及制备2- 恶唑磺酸衍生物,其特征在于使碱在含水有机溶剂中作用于由通式(1)表示的2-氮杂环丁烷基-3,4-二卤代-2-丁烯酸化合物,得到3-卤代甲基 - 由通式(3)表示的2-氧代硫代衍生物无或被保护的氨基,R2是氢原子或低级烷氧基,R1和R2一起形成环状氨基保护基,R3是氢原子或羧酸保护基 组,W是离职小组,X和Y是sam e或不同,各自为卤素原子,其中R1,R2,R3和X与上述相同,其中R1,R2,R3和X与上述相同。
    • 92. 发明授权
    • Negative impedance driving apparatus having temperature compensation
circuit
    • 具有温度补偿电路的负阻抗驱动装置
    • US4980920A
    • 1990-12-25
    • US421256
    • 1989-10-13
    • Masao NoroDaisuke Suzuki
    • Masao NoroDaisuke Suzuki
    • H03F1/30H03F1/38H03F1/56H03F3/181H04R3/00
    • H03F1/56H03F3/181H04R3/002H04R3/007H03F2200/03H03F2200/369
    • A driving apparatus for negative-impedance driving a speaker as a load, comprises a detection element, a positive feedback circuit, a temperature compensation circuit, a sensor element, a control circuit, and an input f characteristic control circuit. The resistor as the detection element connected in series with the load detects a current flowing through the load. The feedback circuit feeds back a detection output of the detection element to an input side of the driving apparatus. The temperature compensation circuit controls the negative-impedance driving state to compensate for an increase in load impedance upon an increase in temperature of the load. The sensor element detects that a temperature of the load reaches a predetermined value. The control circuit stops temperature compensation of the temperature compensation circuit or decreases a degree of temperature compensation in accordance with an output from the sensor element. The input f characteristic control circuit controls frequency characteristic of an input signal in accordance with an output from the control circuit.
    • 扬声器用作负载负阻抗驱动装置,包括检测元件,正反馈电路,温度补偿电路,传感器元件,控制电路和输入f特性控制电路。 作为与负载串联连接的检测元件的电阻检测流过负载的电流。 反馈电路将检测元件的检测输出反馈到驱动装置的输入侧。 温度补偿电路控制负阻抗驱动状态,以补偿负载温度升高时负载阻抗的增加。 传感器元件检测到负载的温度达到预定值。 控制电路停止温度补偿电路的温度补偿或者根据传感器元件的输出来降低温度补偿的程度。 输入f特性控制电路根据控制电路的输出控制输入信号的频率特性。
    • 97. 发明授权
    • Oil-in-water emulsion composition and method for producing the same
    • 水包油乳液组合物及其制备方法
    • US09345651B2
    • 2016-05-24
    • US13981170
    • 2012-01-24
    • Tomomi KuromiyaDaisuke SuzukiMasayoshi Miyamoto
    • Tomomi KuromiyaDaisuke SuzukiMasayoshi Miyamoto
    • A61K8/44A61K8/06A61Q19/02
    • A61K8/44A61K8/062A61K2800/21A61Q19/02
    • Disclosed is an oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester and a method for producing the same. An oil-in-water type emulsion composition containing a physiologically acceptable salt of a tranexamate ester can be obtained by preparing an oil phase including: A) a physiologically acceptable salt of a tranexamate ester; B) an amphiphilic substance; C) an oily substance; and D) water, a water-soluble organic solvent or a mixture thereof wherein the weight ratio of the ingredients A:B is in the range of 1:0.5 to 1:2.5, the weight ratio of the ingredients A:C is in the range of 1:1 to 1:5.0, and the weight ratio of the ingredients A:D is 1:0.2 to 1:5.0, and adding the oil phase to a water phase including E) water, a water-soluble organic solvent or a mixture thereof.
    • 本发明公开了一种含有氨基甲酸酯酯的生理学上可接受的盐的水包油型乳剂组合物及其制造方法。 含有氨甲酯酯的生理学上可接受的盐的水包油型乳剂组合物可以通过制备油相得到,该油相包括:A)氨基甲酸酯的生理学上可接受的盐; B)两亲物质; C)油性物质; 和D)水,水溶性有机溶剂或其混合物,其中成分A:B的重量比在1:0.5至1:2.5的范围内,成分A:C的重量比在 范围为1:1至1:5.0,成分A:D的重量比为1:0.2至1:5.0,并将油相加入到包含E)水,水溶性有机溶剂或 它们的混合物。
    • 98. 发明授权
    • Sunscreen products in which excessive whiteness due to titanium dioxide and zinc oxide is visually masked upon skin application
    • 防晒产品,其中由于二氧化钛和氧化锌引起的过度白度在皮肤应用时被视觉遮蔽
    • US09186305B1
    • 2015-11-17
    • US14280983
    • 2014-05-19
    • Daisuke Suzuki
    • Daisuke Suzuki
    • A61K8/11A61K8/06A61K8/29A61K8/27A61Q17/04
    • A61K8/11A61K8/064A61K8/27A61K8/29A61K2800/20A61K2800/56A61K2800/63A61K2800/651A61Q17/04
    • Sunscreen products that do not require the use of organic, ultraviolet-absorbing agents are provided. Effective protection of the skin from ultraviolet light is attained by increasing the amounts of titanium dioxide and zinc oxide. To mask the excessive whiteness that would otherwise result from the oxides, the sunscreen products contain multilayer-type encapsulations containing pigments. Before use, the pigments are enveloped in capsules that muffle the pigments' color. When the sunscreen product is applied to the skin, the capsules break and the pigments are released to counter the excessive whiteness due to titanium dioxide and zinc oxide. Sunscreen product precursors, from which these sunscreen products can be generated by stirring, are also provided. A sunscreen product package contains the sunscreen product precursor and a stirring ball. A method of ultraviolet protection is provided by shaking the sunscreen product package and applying the sunscreen product thus generated to the skin.
    • 提供了不需要使用有机紫外线吸收剂的防晒产品。 通过增加二氧化钛和氧化锌的量可以有效地保护皮肤免受紫外线的影响。 为了掩盖否则由氧化物引起的过度白度,防晒产品含有含有颜料的多层型包封物。 在使用前,颜料被包裹在胶囊中,以消除颜料的颜色。 当防晒产品施用于皮肤时,胶囊破裂并释放颜料以抵消由于二氧化钛和氧化锌引起的过度白度。 还提供了通过搅拌可以产生这些防晒产品的防晒产品前体。 防晒产品包装包含防晒产品前体和搅拌球。 通过摇动防晒产品包装并将由此产生的防晒产品应用于皮肤来提供紫外线防护的方法。
    • 99. 发明授权
    • Image processing device and method
    • 图像处理装置及方法
    • US09153015B2
    • 2015-10-06
    • US14002144
    • 2012-01-31
    • Yoshitaka ToyodaDaisuke SuzukiKoichi YamashitaTakashi ItoNarihiro Matoba
    • Yoshitaka ToyodaDaisuke SuzukiKoichi YamashitaTakashi ItoNarihiro Matoba
    • G06T5/20H04N5/21G06T5/00
    • G06T5/20G06T5/002G06T5/008G06T2207/20182H04N5/21
    • For each pixel in an image (Din), a contrast correlation value (CT) is detected for peripheral areas centered around the pixel to be corrected (1), a contrast enhancement coefficient (Ken) is determined in accordance with the contrast correlation value (CT) (2), and in accordance with the enhancement coefficient (Ken), local contrast is enhanced for each pixel and an intermediate image (D3) is generated (3). When performing noise reduction (5) by smoothing the intermediate image (D3) in the time direction, the degree of noise reduction is controlled in accordance with a noise reduction coefficient (Knr) that is large where the enhancement coefficient (Ken) is large. With respect to a low-contrast image such as one captured under fog, haze or other poor weather conditions, the contrast in areas having reduced contrast is appropriately improved, and the noise that is enhanced in conjunction with contrast improvement is reduced, enabling a high quality image to be obtained.
    • 对于图像(Din)中的每个像素,以围绕待校正像素(1)为中心的周边区域检测对比度相关值(CT),根据对比度相关值( CT)(2),并且根据增强系数(Ken),对于每个像素增强局部对比度,并且生成中间图像(D3)(3)。 当通过在时间方向上平滑中间图像(D3)来执行降噪(5)时,根据增强系数(Ken)大的噪声降低系数(Knr)来控制噪声降低的程度。 对于诸如在雾,雾或其他差的天气条件下捕获的低对比度图像,适当地改善了对比度降低的区域中的对比度,并且降低了与对比度改善相结合的噪声,使得能够高 要获得质量图像。