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91. 发明专利

NZ540092A Cyanoguanidines and cyanoamidines as ErbB2 and EGFR inhibitors 未知
公开(公告)号：NZ540092A
公开(公告)日：2007-06-29
申请号：NZ54009203
申请日：2003-11-10
申请人： ARRAY BIOPHARMA INC
发明人： WALLACE ELI , TOPALOV GEORGE , ZHAO QIAN , LYSSIKATOS JOSEPH P
IPC分类号： A61P31/18 , A61P35/00 , C07D239/94 , C07D401/12 , C07D403/12 , C07D405/04 , C07D417/14 , A61K31/4706 , A61K31/517 , C07D215/42
摘要： Disclosed is a compound of formula (I) wherein: At least one of the positions 6 or 7 of the quinazoline ring must be substituted by a group A and the remaining positions are optionally substituted by up to three R2 groups; X is N, CH or a C-CN group; R1 is independently aryl or heteroaryl substituted by at least one R6 group and optionally substituted by up to three R5 groups where R5 and R6 are as described in the specification; R2 represents H, halogen, cyano, nitro, trifluoromethyl, difluoromethyl, trifluoromethoxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, optionally substituted as defined; and A is represented by formula (II) wherein: T represents alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, or heterocyclylalkyl optionally substituted as defined; L is N or a CR4 group where R4 is as defined in the specification; Q is selected from CR3R11R12 or NR11R12 where R3 is the same as R2 above and R11 and R12 are as defined; D represents H, trifluoromethyl, difluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl, heterocyclylalkyl, -SO2NR9R7, -C(O)R9, -OC(O)R9 or -C(O)NR7R9 optionally substituted as defined; and The remaining substituents are as defined in the specification. Compounds of the type discloser are EGFR and ErbB2 inhibitors useful in the treatment of hyperproliferative diseases.

92. 发明专利

BRPI0414111A 未知
公开(公告)号：BRPI0414111A
公开(公告)日：2006-10-31
申请号：BRPI0414111
申请日：2004-09-01
申请人： ARRAY BIOPHARMA INC
发明人： WALLACE ELI , HURLEY BRIAN , YANG HOON WOON , LYSSIKATOS JOSEPH , MARLOW ALLISON L , BLAKE JIM
IPC分类号： A61K31/42 , C07D20060101 , C07D261/20 , C07D471/04
摘要： Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

93. 发明专利

NO20061171L 未知
公开(公告)号：NO20061171L
公开(公告)日：2006-04-10
申请号：NO20061171
申请日：2006-03-13
申请人： ARRAY BIOPHARMA INC
发明人： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC分类号： C07D239/94 , A61K31/517 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , C07D498/10
摘要： This invention provides quinazoline analogs of Formula I: where A is bonded to at least one of the carbons at the 5, 6, 7 or 8 position of the bicyclic ring, and the ring is substituted by up to two independent R3 groups. The invention also includes methods of using compounds of Formula I as type I receptor tyrosine kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

94. 发明专利

IS8288A Hliðstæður qínazólíns sem tálmar týrósín kínasa vitaka 未知
公开(公告)号：IS8288A
公开(公告)日：2006-02-07
申请号：IS8288
申请日：2006-02-07
申请人： ARRAY BIOPHARMA INC
发明人： WALLACE ELI , TOPALOV GEORGE , LYSSIKATOS JOSEPH , BUCKMELTER ALEXANDRE , ZHAO QIAN
IPC分类号： C07D239/94 , C07D401/12 , C07D413/12 , C07D413/14 , C07D417/14 , C07D498/04 , C07D498/08 , A61K31/51 , A61K31/517 , A61K31/535 , C07D403/00 , C07D239/82

95. 发明专利

CA2546353A1 BICYCLIC INHIBITORS OF MEK AND METHODS OF USE THEREOF 未知
公开(公告)号：CA2546353A1
公开(公告)日：2005-06-09
申请号：CA2546353
申请日：2004-11-18
申请人： ARRAY BIOPHARMA INC
发明人： BLAKE JIM , WALLACE ELI , YANG HONG WOON
IPC分类号： A01N43/64 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/80 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
摘要： Disclosed are compounds of the Formula I and pharmaceutically acceptable salts and prodrugs thereof, wherein R 1 , R 2 , R 7 , R 8 and R 9 , W, X and Y are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

96. 发明专利

AU2004270699A1 Heterocyclic inhibitors of MEK and methods of use thereof 未知
公开(公告)号：AU2004270699A1
公开(公告)日：2005-03-17
申请号：AU2004270699
申请日：2004-09-01
申请人： ARRAY BIOPHARMA INC
发明人： YANG HOON WOON , WALLACE ELI , LYSSIKATOS JOSEPH , BLAKE JIM , HURLEY BRIAN , MARLOW ALLISON L
IPC分类号： A61K31/42 , C07D20060101 , C07D261/20 , C07D471/04
摘要： Disclosed are compounds of the Formula III and pharmaceutically acceptable salts and prodrugs thereof, wherein R1, R2, R7, R8, R9 R10, and W are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.

97. 发明专利

CY1112297T1 ΕΤΕΡΟΚΥΚΛΙΚΟΙ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΜΕΚ ΚΑΙ ΜΕΘΟΔΟΙ ΧΡΗΣΗΣ ΑΥΤΩΝ 未知
公开(公告)号：CY1112297T1
公开(公告)日：2015-12-09
申请号：CY121100105
申请日：2012-01-31
申请人： ARRAY BIOPHARMA INC
发明人： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC分类号： C07D237/24 , A61K31/501 , A61P35/00 , C07D213/80 , C07D213/82 , C07D213/85
摘要： ΑποκαλύπτονταιαναστολείςΜΕΚχρήσιμοιστηθεραπείαυπερπολλαπλασιαστικώνασθενειών, όπωςκαρκίνουκαιφλεγμονήςσεθηλαστικάκαιφλεγμονωδώνκαταστάσεων. Επίσηςαποκαλυπτόμενεςείναιμέθοδοιχρήσηςτέτοιωνενώσεωνστηθεραπείαυπερπολλαπλασιαστικώνασθενειώνσεθηλαστικάκαιφαρμακευτικέςσυνθέσειςπουπεριέχουντέτοιεςενώσεις.

98. 发明专利

CY1111155T1 ΕΤΕΡΟΚΥΚΛΙΚΟΙ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΜΕΚ 未知
公开(公告)号：CY1111155T1
公开(公告)日：2015-11-04
申请号：CY111100098
申请日：2011-01-31
申请人： ARRAY BIOPHARMA INC
发明人： MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM
IPC分类号： C07D213/80 , A01N33/02 , A01N43/42 , A01N43/54 , A01N43/58 , A01N43/60 , A01N43/64 , A01N43/90 , A61K20060101 , A61K31/40 , A61K31/415 , A61K31/416 , A61K31/4353 , A61K31/44 , A61K31/4439 , A61K31/4745 , A61K31/495 , A61K31/50 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/655 , A61P35/00 , C07D20060101 , C07D209/44 , C07D209/46 , C07D213/82 , C07D215/48 , C07D221/04 , C07D231/56 , C07D237/24 , C07D237/26 , C07D237/28 , C07D237/32 , C07D239/74 , C07D401/04 , C07D401/06 , C07D403/02 , C07D413/02 , C07D413/04 , C07D413/14 , C07D417/02 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/02 , C07D491/02 , C07D498/02
摘要： Αποκαλύπτονταιενώσειςτουτύπου (I) καιφαρμακευτικώςαποδεκτάάλατακαιπροφάρμακάτους, στονοποίοτα R1, R2, R7, R8 και R9, R10, R20, R21, και R22 είναιόπωςορίζεταιστηνπεριγραφή. ΤέτοιεςενώσειςείναιαναστολείςτηςΜΕΚκαιχρήσιμεςστηθεραπείαυπερπολλαπλασιαστικώννόσωνκαρκίνοςκαιφλεγμονή, σεθηλαστικάκαιφλεγμονώδειςπαθήσεις. Αποκαλύπτονταιεπίσηςμέθοδοιχρήσηςτέτοιωνενώσεωνστηθεραπείαυπερπολλαπλασιαστικώννόσωνσεθηλαστικάκαιφαρμακευτικέςσυνθέσειςπουπεριέχουντέτοιεςενώσεις.

99. 发明专利

PT1673339E INIBIDORES HETEROCÍCLICOS DE MEK E MÉTODOS PARA SUA UTILIZAÇÃO 未知
公开(公告)号：PT1673339E
公开(公告)日：2013-07-29
申请号：PT04783028
申请日：2004-09-01
申请人： ARRAY BIOPHARMA INC
发明人： MARLOW ALLISON L , WALLACE ELI , BLAKE JIM , LYSSIKATOS JOSEPH , HURLEY BRIAN , YANG HOON WOON
IPC分类号： A61K31/42 , A61K31/437 , C07D20060101 , C07D261/20 , C07D471/04

100. 发明专利

ES2405785T3 Inhibidores heterocíclicos de MEK y métodos de uso de los mismos 未知
公开(公告)号：ES2405785T3
公开(公告)日：2013-06-03
申请号：ES11003827
申请日：2006-05-17
申请人： ARRAY BIOPHARMA INC , ASTRAZENECA AB
发明人： STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , MARLOW ALLISON L , WALLACE ELI , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JIM , LEONARD JOHN , FIELDING MARK RICHARD
IPC分类号： C07D237/24 , A61K31/501 , A61P35/00 , C07D213/80 , C07D213/82 , C07D213/85
摘要： Composición farmacéutica que comprende un compuesto que tiene la fórmula V: **Fórmula** o una sal farmacéuticamente aceptable del mismo, en la que: R3 es HOCH2CH2O o (S)-MeCH(OH)CH2O; y R9 es H, CH3, F o Cl, siempre que cuando R9 es Cl, entonces R3 no puede ser HOCH2CH2O en combinación con un agente antitumoral o un inhibidor de la transducción de señales.

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