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91. 发明申请

WO2010027405A2 STABLE SOLID FORMULATIONS OF GC-C RECEPTOR AGONIST POLYPEPTIDES SUITABLE FOR ORAL ADMINISTRATION 审中-公开
标题翻译：适用于口腔管理的GC-C受体激动剂多肽的稳定配方
公开(公告)号：WO2010027405A2
公开(公告)日：2010-03-11
申请号：PCT/US2009/004685
申请日：2009-08-14
申请人： IRONWOOD PHARMACEUTICALS, INC. , FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
发明人： FRETZEN, Angelika , WITOWSKI, Steven , GROSSI, Alfredo , ZHAO, Hong
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , A61K9/1676 , A61K9/5078 , A61K31/085 , A61K31/235 , A61K31/355 , A61K45/06 , A61K2300/00
摘要： Solid, stable formulations of GC-C receptor agonist polypeptide suitable for oral administration are described herein as are methods for preparing such formulations. The GC-C receptor agonist polypeptide formulations described herein are stable and have a sufficient shelf life for manufacturing, storing and distributing the drug.
摘要翻译：本文描述了适用于口服给药的固体，稳定的GC-C受体激动剂多肽制剂，作为制备这些制剂的方法。本文所述的GC-C受体激动剂多肽制剂是稳定的并且具有用于制造，储存和分配药物的足够的保质期。

92. 发明申请

WO2009009716A1 POLYMERIC DRUG DELIVERY SYSTEMS CONTAINING AN AROMATIC ALLYLIC ACID 审中-公开
标题翻译：含有芳香多糖的聚合物药物递送系统
公开(公告)号：WO2009009716A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069743
申请日：2008-07-11
申请人： ENZON PHARMACEUTICALS, INC. , ZHAO, Hong
发明人： ZHAO, Hong
IPC分类号： C12N11/06
CPC分类号： A61K47/34 , A61K38/50 , A61K47/60
摘要： The present invention provides polymeric delivery systems including an aromatic allyllic acyl group. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供包括芳族烯丙基酰基的聚合物递送系统。还公开了制备聚合物递送系统的方法和使用其的治疗哺乳动物的方法。

93. 发明申请

WO2008098178A3 TREATMENT OF RESISTANT OR REFRACTORY CANCERS WITH MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN 审中-公开
标题翻译：用7-甲氧基-10-羟基喜树碱多臂共聚物处理抗性或耐药肿瘤
公开(公告)号：WO2008098178A3
公开(公告)日：2008-12-24
申请号：PCT/US2008053438
申请日：2008-02-08
申请人： ENZON PHARMACEUTICALS INC , ZHAO HONG , SAPRA PUJA
发明人： ZHAO HONG , SAPRA PUJA
IPC分类号： A61K31/33
CPC分类号： A61K47/552 , A61K47/55 , A61K47/60
摘要： A method of treating a resistant or refractory cancer in a mammal includes administering an effective amount of a compound of to the mammal. In preferred aspects, the cancer is resistant or refractory to CPT-1 1 or CPT therapy.
摘要翻译：治疗哺乳动物的抗性或难治性癌症的方法包括给哺乳动物施用有效量的化合物。在优选的方面，癌症对CPT-11或CPT疗法具有抗性或难治性。

94. 发明申请

WO2008034123A3 POLYMERIC CONJUGATES CONTAINING POSITIVELY-CHARGED MOIETIES 审中-公开
标题翻译：含有正电荷时间的聚合物共轭物
公开(公告)号：WO2008034123A3
公开(公告)日：2008-11-06
申请号：PCT/US2007078598
申请日：2007-09-15
申请人： ENZON PHARMACEUTICALS INC , ZHAO HONG , REDDY PRASANNA , HORAK IVAN , XIA JING
发明人： ZHAO HONG , REDDY PRASANNA , HORAK IVAN , XIA JING
IPC分类号： A61K31/21 , A61K31/33 , A61K31/704 , A61K31/765 , A61K38/02
CPC分类号： C12N15/87
摘要： The present invention provides polymeric conjugates containing positively charged moieties. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供含有带正电荷部分的聚合物缀合物。还公开了制备聚合物递送系统的方法以及使用该系统治疗哺乳动物的方法。

95. 发明申请

WO2008119015A3 SYNTHESIS OF THIOHYDANTOINS 审中-公开
标题翻译：合成巯基唐氏霉素
公开(公告)号：WO2008119015A3
公开(公告)日：2008-10-02
申请号：PCT/US2008/058429
申请日：2008-03-27
申请人： SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH , OUERFELLI, Ouathek , DILHAS, Anna , YANG, Guangbin , ZHAO, Hong
发明人： OUERFELLI, Ouathek , DILHAS, Anna , YANG, Guangbin , ZHAO, Hong
IPC分类号： C07D213/84 , C07D213/61 , C07D213/74 , C07D213/64 , C07C255/46 , C07C217/58 , C07C253/30 , C07D213/72 , C07C209/24
摘要： A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
摘要翻译：提供了已发现可用于治疗前列腺癌的抗雄激素A52的新型合成。 A52以及结构相关的类似物可以通过本发明的途径来制备。这种新的合成方案可用于制备千克规模量的纯A52。

96. 发明申请

WO2008034119A3 POLYALKYLENE OXIDES HAVING HINDERED ESTER-BASED BIODEGRADABLE LINKERS 审中-公开
标题翻译：聚烯烃氧化物具有基于酯的生物可降解接头
公开(公告)号：WO2008034119A3
公开(公告)日：2008-09-25
申请号：PCT/US2007078593
申请日：2007-09-15
申请人： ENZON PHARMACEUTICALS INC , ZHAO HONG
发明人： ZHAO HONG
IPC分类号： A61K39/395 , A61K31/70 , C07C271/10 , C12P21/06
CPC分类号： C08G65/329
摘要： The present invention provides polymeric delivery systems including hindered ester moieties. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.
摘要翻译：本发明提供了包括受阻酯部分的聚合物递送系统。还公开了制备聚合物递送系统的方法以及使用该系统治疗哺乳动物的方法。

97. 发明申请

WO2007079327A2 METHOD FOR TRANSFER OF USER IDENTITY BETWEEN CDMA WIRELESS COMMUNICATION DEVICES 审中-公开
标题翻译：用于在CDMA无线通信设备之间传送用户标识的方法
公开(公告)号：WO2007079327A2
公开(公告)日：2007-07-12
申请号：PCT/US2006061979
申请日：2006-12-13
申请人： MOTOROLA INC , THORSON DEAN E , ALBERTH WILLIAM P JR , ZHAO HONG
发明人： THORSON DEAN E , ALBERTH WILLIAM P JR , ZHAO HONG
IPC分类号： H04W8/26
CPC分类号： H04W8/265
摘要： A method is provided for transferring user identities between one CDMA wireless communication device (120) and another in a wireless CDMA communication system (100) having a network system controller (140). The network controller (140) receives an activation command from a wireless communication device (120), the activation command including identification information identifying the activating wireless communication device (404). Next, the network controller determines whether the activating wireless communication device is a transferred identity wireless communication device in response to the identification information (424). The network controller then activates the activating wireless communication device with a transferred identity (436) if the activating wireless communication device is determined to be a transferred identity wireless communication device (424).
摘要翻译：提供了一种用于在具有网络系统控制器（140）的无线CDMA通信系统（100）中在一个CDMA无线通信设备（120）与另一CDMA无线通信设备之间传送用户身份的方法。网络控制器（140）从无线通信设备（120）接收激活命令，激活命令包括标识激活无线通信设备（404）的标识信息。接下来，网络控制器响应于识别信息确定激活无线通信设备是否是被转移身份无线通信设备（424）。如果激活无线通信设备被确定为被转移的身份无线通信设备（424），则网络控制器激活具有被转移身份的激活无线通信设备（436）。

98. 发明申请

US20100175204A1 Open and Close Apparatus for a Shelter of a Boarding Bridge 有权
标题翻译：打开和关闭登机桥庇护所的设备
公开(公告)号：US20100175204A1
公开(公告)日：2010-07-15
申请号：US12668130
申请日：2007-06-11
申请人： Xue Gong Tang , Zhao Hong Zhang
发明人： Xue Gong Tang , Zhao Hong Zhang
IPC分类号： E01D15/10 , B64F1/30
CPC分类号： B64F1/305
摘要： An open and close apparatus for a shelter of a boarding bridge includes at least one extension arm means provided on the portal frame, each extension arm means comprising: an upper arm having one end pivotally coupled with a column of the portal frame; a lower arm having one end pivotally coupled with the other end of the upper arm and the other end pivotally coupled with an upper end of the flexible frame; a propeller controlled by a control system and including an extension rod and a main body for accommodating the extension rod, wherein one end of the extension rod is pivotally coupled with the lower arm, and one end of the main body is pivotally coupled with the upper arm; and overpressure protection means for buffering an acting force between the shelter and the aircraft shell, and the overpressure protection means is connected to the control system such that when the acting force exceeds a predetermined value, the control system controls the propeller to stop protruding and/or contracting the extension rod. The open and close apparatus in the present invention can perfectly seal with an entrance of an aircraft with a large profile curve variety and is simple in configuration, and can prevent the aircraft shell from distortion or damage when the aircraft shell squeezes or collides with the shelter.
摘要翻译：一种用于登机桥的遮蔽物的开闭设备包括设置在门架上的至少一个延伸臂装置，每个延伸臂装置包括：上臂，其一端可枢转地与门架的柱相连; 下臂，其一端与所述上臂的另一端枢转联接，另一端与所述柔性框架的上端枢转地联接; 由控制系统控制的螺旋桨，包括延伸杆和用于容纳延伸杆的主体，其中延伸杆的一端与下臂枢转地连接，并且主体的一端与上部臂; 以及用于缓冲所述防护罩和所述飞行器壳体之间的作用力的超压保护装置，并且所述超压保护装置连接到所述控制系统，使得当所述作用力超过预定值时，所述控制系统控制所述螺旋桨停止突出和/ 或收缩延长杆。本发明的开闭装置可以与具有大型曲线变化的飞机的入口完美地密封，并且构造简单，并且可以防止飞机外壳挤压或与防护罩碰撞时的飞机壳体变形或损坏。

99. 发明授权

US09207894B2 Print preview with page numbering for multiple pages per sheet 有权
标题翻译：打印预览页面编号，每页多页
公开(公告)号：US09207894B2
公开(公告)日：2015-12-08
申请号：US12234539
申请日：2008-09-19
申请人： David Waltman , Zhao-Hong Max Mai
发明人： David Waltman , Zhao-Hong Max Mai
IPC分类号： G06F15/00 , G06F3/12 , G06F17/21
CPC分类号： G06F3/1256 , G06F3/1205 , G06F3/1208 , G06F3/125 , G06F3/1284 , G06F17/212 , G06F17/217
摘要： A sheet preview system generates a print preview of a sheet that has a layout specifying a position and orientation for each page. To generate the print preview of the sheet, the sheet preview system displays a representation of the sheet that includes an image of each page of the sheet. The sheet preview system positions and orients the images in accordance with the layout of the sheet. The sheet preview system then displays in association with each displayed image of a page the page number of that page. The sheet preview system may orient the page number of the page in accordance with the orientation of the page.
摘要翻译：纸张预览系统生成纸张的打印预览，其具有指定每页的位置和方向的布局。要生成工作表的打印预览，工作表预览系统将显示包含工作表的每个页面的图像的工作表的表示。纸张预览系统根据纸张的布局定位和定向图像。然后，纸张预览系统与页面的每个显示的图像相关联地显示该页面的页码。纸张预览系统可以根据页面的方向来定向页面的页面编号。

100. 发明授权

US08582919B2 Altering the appearance of a digital image using a shape 有权
标题翻译：使用形状改变数字图像的外观
公开(公告)号：US08582919B2
公开(公告)日：2013-11-12
申请号：US11859868
申请日：2007-09-24
申请人： Larry T Hatfield , Scott H Douglas , Nicholas W Rohring , Matthew J Kotler , Steven P Geffner , David Wayne Waltman , Auston Warner Zahrt , Zhao-Hong Mai
发明人： Larry T Hatfield , Scott H Douglas , Nicholas W Rohring , Matthew J Kotler , Steven P Geffner , David Wayne Waltman , Auston Warner Zahrt , Zhao-Hong Mai
IPC分类号： G06K9/00
CPC分类号： G06T11/60
摘要： Technologies are described herein for altering the appearance of a digital image using a shape. A mask edit mode of operation is provided in which an application program displays a mask shape superimposed on a digital image. The application program also provides user interface controls for altering the size, position, and rotation of the digital image independently of the mask shape, and user interface controls for altering the size, position, and rotation of the mask shape independently of the digital image. When a cropping request is received, the portion of the digital image within the mask shape is mapped onto the mask shape, thereby creating a mask-cropped shape, and a normal editing mode is entered. In the normal editing mode a set of user interface controls is provided for modifying the size, position, and rotation of the mask-cropped shape.
摘要翻译：本文描述了用于使用形状改变数字图像的外观的技术。提供了一种掩模编辑操作模式，其中应用程序显示叠加在数字图像上的掩模形状。应用程序还提供用于不依赖于掩模形状改变数字图像的尺寸，位置和旋转的用户界面控制，以及用于独立于数字图像改变掩模形状的尺寸，位置和旋转的用户界面控制。当接收到裁剪请求时，将掩模形状内的数字图像的部分映射到掩模形状，从而创建掩模切割形状，并且进入正常编辑模式。在正常编辑模式中，提供了一组用户界面控件来修改掩模裁剪形状的大小，位置和旋转。

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