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91. 发明申请

WO1996032963A1 INDUCTION AND ENHANCEMENT OF THE IMMUNE RESPONSE TO POLYSACCHARIDES WITH BACTERIAL LIPOPROTEINS 审中-公开
标题翻译：诱导和增强对细菌脂多糖的多糖的免疫应答
公开(公告)号：WO1996032963A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005226
申请日：1996-04-16
申请人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE , SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
发明人： HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE , SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , SNAPPER, Clifford, M. , MOND, James, J. , CAPIAU, Carine , HAUSER, Pierre , PRIEELS, Jean-Paul
IPC分类号： A61K39/385
CPC分类号： C07K14/285 , A61K39/385 , A61K2039/55516 , A61K2039/55594 , A61K2039/6068 , Y02A50/482
摘要： The present invention provides a method of inducing or enhancing an immune response to polysaccharides or other T cell-independent antigen by the coadministration of the antigen with bacterial lipoproteins (including covalent attachment of the antigen and lipoproteins). In a preferred embodiment, the lipoprotein of the invention is lipoprotein D.
摘要翻译：本发明提供了通过将抗原与细菌脂蛋白（包括抗原和脂蛋白的共价连接）共同施用来诱导或增强对多糖或其它与T细胞无关的抗原的免疫应答的方法。在优选的实施方案中，本发明的脂蛋白是脂蛋白D.

92. 发明申请

WO1994025600A1 RECOMBINANT ANTIGENS FROM MUMPS VIRUS AND THEIR USE IN VACCINES 审中-公开
标题翻译：巨噬细胞病毒的重组抗原及其在疫苗中的应用
公开(公告)号：WO1994025600A1
公开(公告)日：1994-11-10
申请号：PCT/EP1994001297
申请日：1994-04-26
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , BOLLEN, Alex , HOUARD, Sophie , NORRBY, Erling, Carl, Jacob , VARSANYI, Tamas, Mark
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： C12N15/45
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/033 , C12N2760/18722
摘要： The invention provides recombinant DNA encoding an antigen of mumps virus selected from the group comprising: (a) the full length fusion protein (F), complete with signal peptide(s) and membrane anchor domain (a) (designated herein as Fs+a+); the full length attachment protein or hemagglutinin-neuraminidase (HN); the full length nucleocapsid protein (NP); (b) the truncated fusion protein lacking the membrane anchor domain (herein designated Fs+a-); (c) a hybrid protein derived by fusion of the F, HN and/or NP proteins or portions thereof. Also within the scope of the invention are vectors comprising the DNA of the invention and a host such as a vaccinia virus, mammalian cell or bacterial cell transformed or transfected with the vector; and proteins expressed by the hosts.
摘要翻译：本发明提供编码腮腺炎病毒抗原的重组DNA，其选自以下组：（a）具有信号肽和膜锚定域（a）的全长融合蛋白（F）（本文称为Fs + a + ）; 全长附着蛋白或血凝素 - 神经氨酸酶（HN）; 全长核壳蛋白（NP）; （b）缺少膜锚定结构域的截短融合蛋白（本文称为Fs + a-）; （c）通过融合F，HN和/或NP蛋白或其部分衍生的杂合蛋白。在本发明的范围内也是包含本发明DNA和载体转化或转染的宿主例如痘苗病毒，哺乳动物细胞或细菌细胞的载体; 和由宿主表达的蛋白质。

93. 发明申请

WO1994014484A2 STORAGE DEVICES 审中-公开
标题翻译：存储设备
公开(公告)号：WO1994014484A2
公开(公告)日：1994-07-07
申请号：PCT/EP1993003665
申请日：1993-12-21
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , THILLY, Jacques
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： A61M05/00
CPC分类号： B01L9/543 , A61M5/008 , A61M2207/00
摘要： For storage of syringes, a support rack comprising a plurality of elongate fingers (2) connected together at one end by a spine member (1) is used. The fingers (2) define parallel support channels (5) open at one end, and the syringes are stored in the channels (5) with their lips or wings (4) resting on the elongate fingers (2). Also disclosed are support cradles, storage boxes, and lifting devices for handling the loaded racks. The support rack is better adapted than existing systems for cooperation with automated machinery since it can receive syringes into the channels by a horizontal translation movement, readily provided by a simple pushing device.
摘要翻译：为了存储注射器，使用支撑架，其包括通过脊部构件（1）在一端连接在一起的多个细长指状物（2）。手指（2）限定在一端开口的平行的支撑通道（5），并且注射器通过其嘴唇或翼（4）放置在细长指状物（2）上而储存在通道（5）中。还公开了用于处理装载的机架的支撑架，储物箱和提升装置。支撑架比现有的系统更适合与自动化机械配合使用，因为它可以通过简单推动装置容易提供的水平平移运动将注射器接收到通道中。

94. 发明申请

WO1992011366A1 CLONING AND EXPRESSION OF A PROTEIN ANTIGEN OF TOXOPLASMA GONDII 审中-公开
标题翻译：克隆和表达弓形虫GONDII蛋白抗原
公开(公告)号：WO1992011366A1
公开(公告)日：1992-07-09
申请号：PCT/EP1991002423
申请日：1991-12-16
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , INNOGENETICS S.A. , SAAVEDRA-DURAN, Rafael , HERION, Pascal
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , INNOGENETICS S.A.
IPC分类号： C12N15/30
CPC分类号： C07K14/45 , A61K39/00
摘要： A purified antigen of T. gondii having a molecular weight of 54-kDa (as determined by Western blotting) is provided which is reactive with antibodies raised against a recombinant protein obtained by expression of a defined T. gondii cDNA (Figure 2) in a host cell; also provided are immunogenic fragments of the 54-kDa antigen. Recombinant DNA encoding the 54-kDa antigen, host cells for expression of such DNA, a vaccine for treating or preventing toxoplasmosis infection in humans and animals, and test kits for detection of T. gondii antigen or antibody are also described.
摘要翻译：提供分子量为54-kDa（通过蛋白质印迹测定）的弓形体的纯化抗原，其与通过将定义的弓形虫cDNA（图2）表达获得的重组蛋白产生的抗体反应宿主细胞; 还提供了54-kDa抗原的免疫原性片段。还描述了编码54-kDa抗原的重组DNA，用于表达这种DNA的宿主细胞，用于治疗或预防人和动物弓形虫病感染的疫苗，以及用于检测弓形虫抗原或抗体的测试试剂盒。

95. 发明申请

WO1992001796A1 MYCOBACTERIAL EXPRESSION VECTOR 审中-公开
公开(公告)号：WO1992001796A1
公开(公告)日：1992-02-06
申请号：PCT/EP1991001332
申请日：1991-07-13
申请人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.) , JACOBS, Paul , HAESELEER, Françoise , MASSAER, Marc , BOLLEN, Alex
发明人： SMITHKLINE BEECHAM BIOLOGICALS (S.A.)
IPC分类号： C12N15/74
CPC分类号： C07K14/445 , A61K39/00 , C12N15/74
摘要： The invention provides a mycobacterial expression vector containing exogenous DNA encoding a protein of interest (e.g. an antigen) under the control of the promoter and ribosomal binding site for the 64 KD protein of Mycobacterium bovis BCG. Also provided are mycobacteria transformed with the mycobacterial expression vectors and vaccine compositions comprising the transformed mycobacteria.
摘要翻译：本发明提供了含有编码目标蛋白质的外源DNA（例如抗原）的分枝杆菌表达载体，其在启动子和牛分枝杆菌BCG的64KD蛋白的核糖体结合位点的控制下。还提供了用分枝杆菌表达载体和包含转化的分枝杆菌的疫苗组合物转化的分枝杆菌。

96. 发明申请

WO2002062378A2 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2002062378A2
公开(公告)日：2002-08-15
申请号：PCT/EP2002/001361
申请日：2002-02-08
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , BERTHET, Francois-Xavier, Jacques , DENOEL, PHilippe , NEYT, Cecile, Anne , POOLMAN, Jan , THONNARD, Joelle
发明人： BERTHET, Francois-Xavier, Jacques , DENOEL, PHilippe , NEYT, Cecile, Anne , POOLMAN, Jan , THONNARD, Joelle
IPC分类号： A61K39/00
CPC分类号： C07K14/285 , A61K2039/52 , C07K14/195 , C07K14/22 , C12N1/20 , Y02A50/484
摘要： The present invention relates to the field of novel, engineered Gram-negative bacterial strains that have improved outer-membrane vesicle shedding properties, and vaccine compositions comprising these bacteria or vesicles. The present invention provides a hyperbledding Gram-negative bacterium which has been genetically modified by either or both processes selected from a group of consisting of: down-regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein(s).
摘要翻译：本发明涉及具有改善的外膜囊泡脱落性质的遗传工程革兰氏阴性菌株，以及包含这些细菌或囊泡的疫苗组合物。本发明提供了通过选自以下组中的任一种或两种方法遗传修饰的双链体革兰氏阴性细菌：一种或多种tol基因的表达下调; 以及编码包含肽聚糖相关位点的蛋白质的一个或多个基因的突变以减弱所述蛋白质的肽聚糖结合活性。

97. 发明申请

WO2002034288A3 VACCINE FOR TREATING ALLERGY 审中-公开
公开(公告)号：WO2002034288A3
公开(公告)日：2002-05-02
申请号：PCT/EP2001/012392
申请日：2001-10-24
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , ACAMBIS RESEARCH LIMITED , VINALS Y DE BASSOLS, Carlota
发明人： VINALS Y DE BASSOLS, Carlota
IPC分类号： A61K39/00
摘要： The present invention relates to the provision of novel medicaments for the treatment, prevention or amelioration of allergic disease. In particular, the novel medicaments are epitopes or mimotopes derived from IgE. The novel regions presented may be the target for both passive and active immunoprophylaxis or immunotherapy. The invention further relates to methods for production of the medicaments, pharmaceutical compositions containing them and their use in medicine. Also forming an aspect of the present invention are ligands, especially monoclonal antibodies, which are capable of binding the IgE regions of the present invention, and their use in medicine as passive immunotherapy or immunoprophylaxis.

98. 发明申请

WO1998019702A1 ACELLULAR PERTUSSIS VACCINE WITH DIPHTHRIAE- AND TETANUS-TOXOIDS 审中-公开
标题翻译：具有DIPHTHRIAE-和TETANUS-TOXOIDS的细胞PERTUSSIS疫苗
公开(公告)号：WO1998019702A1
公开(公告)日：1998-05-14
申请号：PCT/EP1997006180
申请日：1997-11-04
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , FLORENT, Patrick , STEPHENNE, Jean , VANDECASSERIE, Christian
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： A61K39/10
CPC分类号： A61K39/08 , A61K39/0018 , A61K39/05 , A61K39/099 , A61K39/12 , A61K2039/70 , C12N2730/10134 , Y02A50/466
摘要： The invention provides a diphtheria, tetanus and pertussis vaccine comprising a low dose of each of diphtheria toxoid (D), tetanus toxoid (T), pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (69K). The vaccine maintains an ability to prevent pertussis while showing exceptionally low reactogenicity. Combination vaccines comprising additional antigens are also provided.
摘要翻译：本发明提供白喉，破伤风和百日咳疫苗，其包含低剂量的白喉类毒素（D），破伤风类毒素（T），百日咳毒素（PT），丝状血凝素（FHA）和促生长素（69K））。该疫苗保持预防百日咳的能力，同时显示极低的反应原性。还提供了包含另外的抗原的组合疫苗。

99. 发明申请

WO1998018819A1 PURIFICATION OF RESPIRATORY SYNCYTIAL VIRUS ANTIGENS 审中-公开
标题翻译：呼吸道同源性病毒抗原的纯化
公开(公告)号：WO1998018819A1
公开(公告)日：1998-05-07
申请号：PCT/EP1997006016
申请日：1997-10-27
申请人： SMITHKLINE BEECHAM BIOLOGICALS S.A. , BOLLEN, Alex , GHEYSEN, Dirk , HOUARD, Sophie , PRIEELS, Jean-Paul , SLAOUI, Moncef, Mohamed , VAN OPSTAL, Omar , ANDRE, Christophe, Jacques, Robert
发明人： SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： C07K14/135
CPC分类号： C07K14/005 , A61K39/00 , C12N2760/18522
摘要： The present invention relates to purification of respiratory syncytial virus (RSV) proteins and for use in vaccines.
摘要翻译：本发明涉及呼吸道合胞病毒（RSV）蛋白的纯化并用于疫苗。

100. 发明申请

WO1994019013A1 INFLUENZA VACCINE COMPOSITIONS CONTAINING 3-O-DEACYLATED MONOPHOSPHORYL LIPID A 审中-公开
标题翻译：含有3-O-脱乙基一羟基脂肪酸的流感疫苗组合物A
公开(公告)号：WO1994019013A1
公开(公告)日：1994-09-01
申请号：PCT/EP1994000448
申请日：1994-02-15
申请人： SMITHKLINE BEECHAM CORPORATION , SMITHKLINE BEECHAM BIOLOGICALS S.A. , DILLON, Susan , NISHIKAWA, Hirotoshi , MONTE, Paul, Dal , GYURICK, Robert, J. , GARCON-JOHNSON, Nathalie, Marie-Josephe, Claude
发明人： SMITHKLINE BEECHAM CORPORATION , SMITHKLINE BEECHAM BIOLOGICALS S.A.
IPC分类号： A61K39/145
CPC分类号： A61K39/39 , A61K9/127 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55505 , A61K2039/55555 , A61K2039/55572 , A61K2039/58 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： The present invention provides vaccine compositions capable of enhancing a protective response to a selected influenza antigen, said composition containing at least the antigen and 3D-MPL, and methods of enhancing an immune response to influenza using these compositions.
摘要翻译：本发明提供能够增强对所选择的流感抗原的保护性应答的疫苗组合物，所述组合物至少包含抗原和3D-MPL，以及使用这些组合物增强对流感的免疫应答的方法。

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