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    • 91. 发明申请
    • System and method for calculating taxes and multi-currency pricing
    • 计算税收和多币种定价的制度和方法
    • US20070043636A1
    • 2007-02-22
    • US11519380
    • 2006-09-11
    • Robert Foster
    • Robert Foster
    • G06Q40/00
    • G06Q40/02G06Q40/12G06Q40/123
    • A method and a system for determining taxes attributable to a financial transaction create a tax rate table, link an entity of the financial transaction to the tax rate table through a product rule, and calculate taxes based on the tax rate table according to one component of the financial transaction. The tax rate tables can be linked by a default product rule, which is a defined by a global variable. Alternatively, specific product rules can be used to link specific entities, such as tax jurisdiction records, or legal entity records. In one application, the method and the system calculate revenue tax, cost tax, input tax, and profits for each transaction. The method and the system may further include multi-currency support analysis for a financial transaction so that a financial transaction can be analyzed under a common currency, even though the financial transaction is conducted using one or more currencies in one or more jurisdictions.
    • 一种确定金融交易税收的方法和系统,创建税率表,通过产品规则将金融交易实体与税率表相连,并根据税率表按照 金融交易。 税率表可以由默认产品规则链接,该规则由全局变量定义。 或者,可以使用特定的产品规则来链接特定实体,例如税务管辖权记录或法定实体记录。 在一个应用中,方法和系统计算每笔交易的收入税,成本税,进项税和利润。 该方法和系统可以进一步包括金融交易的多货币支持分析,使得可以以共同货币分析金融交易,即使在一个或多个辖区内使用一种或多种货币进行金融交易。
    • 93. 发明申请
    • Cyclosporine analogue mixtures and their use as immunomodulating agents
    • 环孢霉素类似物混合物及其作为免疫调节剂的用途
    • US20050192214A1
    • 2005-09-01
    • US11118830
    • 2005-04-28
    • Selvaraj NaickerRandall YatscoffRobert Foster
    • Selvaraj NaickerRandall YatscoffRobert Foster
    • A61K38/00A61K9/00A61K9/107A61K9/48A61K38/13A61P19/02A61P37/06C07K7/00C07K7/52C07K7/64
    • C07K7/645A61K9/0095A61K9/1075A61K9/4858A61K38/00A61K38/13B82Y5/00C07K7/64Y10S530/806
    • The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine A. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives. Embodiments of the present invention are directed toward cis and trans-isomers of cyclosporin A analogs referred to as ISATX247, and derivatives thereof. Mixtures of ISATX247 isomers exhibit a combination of enhanced potency and reduced toxicity over the naturally occurring and presently known cyclosporins. ISATX247 isomers and alkylated, arylated, and deuterated derivatives are synthesized by stereoselective pathways where the particular conditions of a reaction determine the degree of siereoselectivity. The ratio of isomers in a mixture may range from about 10 to 90 percent by weight of the (E)-isomer to about 90 to 10 percent by weight of the (Z)-isomer, based on the total weight of the mixture.
    • 本发明涉及结构类似于环孢霉素A的环孢菌素类似物的异构体混合物。该混合物具有比单个异构体和天然存在的和其它目前已知的环孢菌素和环孢菌素衍生物更强的功效和降低的毒性。 本发明的实施方案涉及被称为ISA 247的环孢菌素A类似物及其衍生物的顺式和反式异构体。 ISA 247异构体的混合物显示了与天然存在的和目前已知的环孢菌素相比增强的效力和降低的毒性的组合。 通过立体选择性途径合成烷基化,芳基化和氘代衍生物,其中反应的特定条件决定了Silectoslectivity的程度。 基于混合物的总重量,混合物中异构体的比例可以为(E) - 异构体的约10至90重量%至(Z) - 异构体的约90至10重量%。