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91. 发明授权

US06762176B1 2-aminopyridine derivatives, their use as medicines and pharmaceutical compositions containing them 失效
标题翻译： 2-氨基吡啶衍生物，它们作为药物和含有它们的药物组合物的用途
公开(公告)号：US06762176B1
公开(公告)日：2004-07-13
申请号：US09743043
申请日：2001-03-08
申请人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
发明人： Pierre-Etienne Chabrier de Lassauniere , Serge Auvin , Jerry Harnett , Dominique Pons , Gérard Ulibarri , Dennis Bigg
IPC分类号： A61K3133
CPC分类号： C07K14/70575 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0325 , A01K2267/0368 , A01K2267/0381 , A61K2039/505 , C07D213/73 , C07D401/04 , C07D405/12 , C07K16/2875 , C07K16/2878 , C12N15/8509
摘要： The invention concerns novel 2-aminopyridine derivatives having an activity inhibiting NO-synthase enzymes producing nitrogen monoxide NO and/or trapping reactive forms of oxygen, the methods for preparing them, pharmaceutical compositions containing them and their therapeutic uses, particularly their use as NO-synthase inhibitors and for trapping reactive forms of oxygen whether selectively or not.
摘要翻译：本发明涉及具有抑制产生一氧化氮NO和/或捕获反应性形式的氧的NO合成酶的活性的新型2-氨基吡啶衍生物，其制备方法，含有它们的药物组合物及其治疗用途，特别是其作为NO- 合成酶抑制剂和用于捕获反应性形式的氧，无论是否有选择性。

92. 发明授权

US06740356B2 Process for the production of a bituminous sealing sheet 有权
标题翻译：生产沥青密封片的方法
公开(公告)号：US06740356B2
公开(公告)日：2004-05-25
申请号：US09983785
申请日：2001-10-25
申请人： Pierre Etienne Bindschedler , Hervé Fellmann , Rémi Perrin
发明人： Pierre Etienne Bindschedler , Hervé Fellmann , Rémi Perrin
IPC分类号： B05D136
CPC分类号： D06N5/00 , E04D5/10 , E04D5/12 , Y10T428/24488 , Y10T428/24612
摘要： A process and an installation for the production of a bituminous sealing sheet, comprises a strip impregnated and/or coated with a given bitumen and having a zone in the shape or a band or a portion of a band of a different bitumen from the first bitumen. A strip (2) is produced which is impregnated and/or coated except for at least one zone in the form of a strip or a strip portion (4) on at least one of its surfaces (2′, 2″), having a thinner thickness of bitumen (3, 3′) or no application of bitumen (3, 3′), to be used at the at least one strip or strip portion (4), over a controlled thickness, a different bitumen (5) from that initially applied and finally, after cooling and solidification of the eventually added bitumen (5), processing the resulting sheet or sealed membrane (11) 5 in the desired form, the processing operations being carried out by continuous movement of the strip (2) in an installation (6) or suitable coating line comprising at least two coating stations (7, 7′, 8).
摘要翻译：用于生产沥青密封片的方法和装置包括浸渍和/或涂覆给定沥青的条带，并且具有与第一沥青不同的沥青的形状或带或部分带的区域。制造条带（2），其被浸渍和/或涂覆，除了在其至少一个表面（2'，2“）上的带状或带状部分（4）形式的至少一个区域，其具有要在所述至少一个带状或带状部分（4）上使用的较薄的沥青（3,3'）或不应用沥青（3,3'），在受控的厚度上，不同的沥青（5）从最初施加的，最后，在最终添加的沥青（5）的冷却和固化之后，以所需形式处理所得到的片材或密封膜（11）5，处理操作通过条带（2）的连续移动）在包括至少两个涂布站（7,7'，8）的安装（6）或合适的涂层生产线中。

93. 发明授权

US06607778B2 Solid delivery systems for aroma ingredients 失效
标题翻译：用于芳香成分的固体输送系统
公开(公告)号：US06607778B2
公开(公告)日：2003-08-19
申请号：US09847906
申请日：2001-05-03
申请人： Jerry Richard Mutka , Robert Clark McIver , Christine Ann Palmer , Daniel Benczedi , Pierre-Etienne Bouquerand , Antoine Firmenich
发明人： Jerry Richard Mutka , Robert Clark McIver , Christine Ann Palmer , Daniel Benczedi , Pierre-Etienne Bouquerand , Antoine Firmenich
IPC分类号： A23L1221
CPC分类号： A61Q11/00 , A23L27/70 , A23P10/30 , A61K8/0283 , A61K8/498 , A61K8/60 , A61K8/73 , A61K8/732 , A61K9/1617 , A61K9/1623 , A61K9/1652 , A61K2800/56
摘要： The present invention relates to novel solid systems for the delivery of aroma chemicals and flavoring ingredients, including an extrusion formed matrix containing an effective amount of certain specific hydrophilic aroma materials. These systems are useful for flavoring consumer products. An extrusion of solid Furaneol® compound and derivatives that have a content of up to 40% by weight of Furaneol® compound are disclosed.
摘要翻译：本发明涉及用于递送芳香化学品和调味成分的新型固体系统，包括含有有效量的某些特定的亲水性芳香物质的挤出成形基质。这些系统可用于调味消费品。公开了固体Furaneol化合物的挤出和具有高达40重量％的呋喃醇化合物的含量的衍生物。

94. 发明授权

US6155321A Machine for laying a thermoweldable covering strip 失效
标题翻译：用于铺设热熔覆盖带的机器
公开(公告)号：US6155321A
公开(公告)日：2000-12-05
申请号：US118858
申请日：1998-07-20
申请人： Pierre Etienne Bindschedler , Denis Cartier
发明人： Pierre Etienne Bindschedler , Denis Cartier
IPC分类号： E01C23/03 , F23D14/62 , B32B31/00
CPC分类号： F23D14/62 , E01C23/03 , Y10T156/1715 , Y10T156/1788
摘要： A machine for laying a thermoweldable strip covering includes a movable support chassis provided with a support for a strip of rolled-up covering and for the unrolling and application of this strip, and at least one unit for the production of hot air, prolonged by an ejection nozzle provided with an outlet opening in the form of a transverse slot and whose outlet flow is directed toward the thermoweldable undersurface of the covering strip immediately prior to its application onto the support to be covered.
摘要翻译：一种用于铺设可热焊接的带材覆盖物的机器包括：可移动的支撑底盘，其设置有用于卷起的覆盖物带的支撑件，并用于该条带的展开和应用;以及至少一个用于产生热空气的单元，喷嘴设置有横向槽的形式的出口开口，并且其出口流在其被施加到待覆盖的支撑件之前立即指向覆盖带的可热焊接的下表面。

95. 发明申请

US20140255578A1 GRANULES COMPRISING AN ACTIVE SUBSTANCE 有权
标题翻译：包含活性物质的颗粒
公开(公告)号：US20140255578A1
公开(公告)日：2014-09-11
申请号：US14352631
申请日：2012-10-18
申请人： Pascal Beaussoubre , Pierre-Etienne Bouquerand , François Meyer , Nathalie Thiebaut , Kenneth Wong
发明人： Pascal Beaussoubre , Pierre-Etienne Bouquerand , François Meyer , Nathalie Thiebaut , Kenneth Wong
IPC分类号： A23L1/222 , A23L1/221 , C11B9/00
CPC分类号： A23L27/201 , A23L27/11 , A23L27/13 , A61K8/0225 , A61K8/0241 , A61K8/25 , A61K8/73 , A61K2800/412 , A61K2800/56 , A61K2800/84 , A61Q13/00 , B01J2/04 , C11B9/00 , C11D3/222 , C11D3/505 , C11D11/02
摘要： The present invention relates to granules comprising an active substance, obtained by spray-drying an emulsion comprising said active substance, solid particles, water and a water-soluble biopolymer having a molecular weight below 100 KDa. The invention further relates to a process for obtaining such granules and to products containing them.
摘要翻译：本发明涉及包含通过喷雾干燥包含所述活性物质，固体颗粒，水和分子量低于100KDa的水溶性生物聚合物的乳液获得的活性物质的颗粒。本发明还涉及获得这种颗粒和含有它们的产品的方法。

96. 发明授权

US08642591B2 Composition containing amidine derivatives or carboxamide derivatives and steroids, as a medicament 失效
标题翻译：含有脒衍生物或羧酰胺衍生物和类固醇作为药物的组合物
公开(公告)号：US08642591B2
公开(公告)日：2014-02-04
申请号：US12282131
申请日：2007-03-06
申请人： Bernadette Pignol , Serge Auvin , Dennis Bigg , Pierre-Etienne Chabrier de Lassauniere
发明人： Bernadette Pignol , Serge Auvin , Dennis Bigg , Pierre-Etienne Chabrier de Lassauniere
IPC分类号： A61K31/54 , A61K31/56 , A01N45/00
CPC分类号： A61K31/341 , A61K31/5415 , A61K31/573 , A61K31/58 , A61K31/585 , A61K2300/00
摘要： The present invention relates to a composition containing at least one amidine derivative or carboxamide derivative of general formula (I) or (A) in combination with at least one compound chosen from steroids, corticoids or corticosteroids, wherein said composition is suitable for the preparation of a medicament.
摘要翻译：本发明涉及包含至少一种通式（I）或（A）的脒衍生物或羧酰胺衍生物与至少一种选自类固醇，皮质激素或皮质类固醇的化合物组合的组合物，其中所述组合物适用于制备药物。

97. 发明授权

US08468039B2 Method for handling large amounts of standard data 有权
标题翻译：处理大量标准数据的方法
公开(公告)号：US08468039B2
公开(公告)日：2013-06-18
申请号：US11599381
申请日：2006-11-15
申请人： Cédric Dourthe , Thierry Dufresne , Pierre Etienne Melet , Gilles Chaumont
发明人： Cédric Dourthe , Thierry Dufresne , Pierre Etienne Melet , Gilles Chaumont
IPC分类号： G06Q10/00
CPC分类号： G06F17/30489 , G06Q50/14
摘要： A method for handling large amounts of standard data contained in one or more databases conforming to a standard data model is described. When large amounts of standard data are needed to answer requests of end-users of a software application, the method assumes that a significantly reduced amount of metadata useable by the software application are first built out of the large amounts of standard data. The metadata are stored in an intermediate database of metadata and delivered to the software application through a metadata engine in lieu of the large amounts of standard data. The invention allows software application to consider much larger amounts of standard data to better answer end-user requests in an acceptable elapsed time.
摘要翻译：描述了一种处理包含在符合标准数据模型的一个或多个数据库中的大量标准数据的方法。当需要大量标准数据来回答软件应用程序的最终用户的请求时，该方法假设由大量的标准数据首先构建出由软件应用程序可用的大量减少的元数据。元数据存储在元数据的中间数据库中，并通过元数据引擎代替大量的标准数据传送到软件应用程序。本发明允许软件应用考虑更大量的标准数据，以在可接受的经过时间内更好地回答最终用户请求。

98. 发明授权

US08288560B2 Derivatives of heterocycles with 5 members, their preparation and their use as medicaments 有权
标题翻译：具有5个成员的杂环衍生物，其制备及其作为药物的用途
公开(公告)号：US08288560B2
公开(公告)日：2012-10-16
申请号：US13053092
申请日：2011-03-21
申请人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
发明人： Pierre-Etienne Chabrier De Lassauniere , Jeremiah Harnett , Dennis Bigg , Anne-Marie Liberatore , Jacques Pommier , Jacques Lannoy , Christophe Thurieau
IPC分类号： C07D277/28
CPC分类号： C07D277/28 , A61K31/417 , A61K31/4178 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/427 , A61K31/454 , A61K31/496 , C07D233/64 , C07D261/04 , C07D263/32 , C07D277/24 , C07D403/04 , C07D403/06 , C07D405/06 , C07D409/06 , C07D413/06 , C07D417/04 , C07D417/06
摘要： The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, R1 and R2 are notably independently hydrogen, alkyl or cycloalkyl and Ω is —NR46R47 or —OR48, R46 and R47 are notably independently hydrogen, alkyl, cycloalkyl or —(CH2)k—COOR51, R51 is notably alkyl or haloalkyl and R48 is notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.
摘要翻译：本发明涉及噻唑，恶唑，咪唑，异恶唑和其中Het为噻唑，恶唑，咪唑，异恶唑或异恶唑啉的通式（I）的异恶唑啉衍生物，n为0至6的整数，A特别选自各种任选取代的芳基，B特别是氢，烷基或苯基，R 1和R 2特别独立地是氢，烷基或环烷基，和OHgr; 是-NR46R47或-OR48，R46和R47独特地是氢，烷基，环烷基或 - （CH2）k-COOR51，R51尤其是烷基或卤代烷基，R48特别是氢或烷基。这些化合物具有有利的药理学性质，其允许其用于治疗学，特别是用于治疗神经变性疾病或疼痛。

99. 发明授权

US08280870B2 Search engine and associated method 有权
标题翻译：搜索引擎及相关方法
公开(公告)号：US08280870B2
公开(公告)日：2012-10-02
申请号：US12713149
申请日：2010-02-25
申请人： Pierre-Etienne Melet , Thierry Dufresne , Cëdric Dourthe , Marc Patoureaux
发明人： Pierre-Etienne Melet , Thierry Dufresne , Cëdric Dourthe , Marc Patoureaux
IPC分类号： G06F17/30 , G06Q99/00
CPC分类号： G06Q50/14 , G06Q10/00 , G06Q10/04
摘要： A method of searching for a entity amongst a plurality of entities, wherein all the entities are linked by at least one criterion in common and have a plurality of data formats, wherein each entity comprises a set of data which can be searched by means of criteria entered by a user; and wherein each entity has a data format; and further wherein a specific one of the data formats defines a standard record format; the method comprising the steps of: determining the data format of an entity; if the data format of the entity does not match the standard record format, passing the entity to a pre-processing engine; if the data format of the entity does match the standard record format, passing standard record format data of the entity to a main processing engine; in the pre-processing engine comparing the entity data format to the standard record format and applying a conversion to the entity set of data; converting the entity set of data to the standard record format based on the conversion to form a converted set of data; passing the converted set of data to the main processing engine; in the main processing engine receiving the standard record format entity set of data and the converted set of data; and producing a set of results combining the converted set of data and the standard record format data for selection by a user of a preferred entity.
摘要翻译：一种在多个实体中搜索实体的方法，其中所有实体通过至少一个共同标准链接并具有多个数据格式，其中每个实体包括可以通过标准搜索的一组数据由用户输入; 并且其中每个实体具有数据格式; 并且其中特定的数据格式定义了标准记录格式; 该方法包括以下步骤：确定实体的数据格式; 如果实体的数据格式与标准记录格式不符，则将实体传递给预处理引擎; 如果实体的数据格式符合标准记录格式，则将实体的标准记录格式数据传递给主处理引擎; 在预处理引擎中将实体数据格式与标准记录格式进行比较，并将转换应用于实体数据集; 基于转换将实体数据集合转换为标准记录格式以形成转换的数据集; 将转换的数据集传递给主处理引擎; 在主处理引擎中接收标准记录格式实体数据集和转换后的数据集; 并且产生一组结合转换的数据集合和标准记录格式数据的结果，以供优选实体的用户选择。

100. 发明授权

US08227014B2 Large glassy beads 有权
标题翻译：大玻璃珠
公开(公告)号：US08227014B2
公开(公告)日：2012-07-24
申请号：US11484450
申请日：2006-07-10
申请人： Pierre-Etienne Bouquerand
发明人： Pierre-Etienne Bouquerand
IPC分类号： A23L1/22
CPC分类号： A23G3/0021 , A23G3/38 , A23G3/42 , A23G3/50 , A23G3/54 , A23G4/10 , A23G4/20 , A23L27/72 , A23P10/30 , A23V2002/00 , A23V2200/224 , A23V2250/502 , A23V2250/1862
摘要： The present invention relates to a particulate composition in the form of a large spherical glassy bead having a cross-sectional diameter greater than 5 mm. The bead comprises an encapsulating carrier composition essentially made of fibrous materials, which are both sugarless and non-cariogenic and an encapsulant, such as a flavor material.
摘要翻译：本发明涉及具有大于5mm的横截面直径的大球形玻璃珠形式的颗粒组合物。珠包含基本由纤维材料制成的包封载体组合物，其既不含糖又不致龋齿，且为密封剂，如风味物质。

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