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91. 发明授权

US4113826A Fluid flow control valves 失效
标题翻译：流体流量控制阀
公开(公告)号：US4113826A
公开(公告)日：1978-09-12
申请号：US761900
申请日：1977-01-24
申请人： Alan Philip Jones
发明人： Alan Philip Jones
IPC分类号： F16K1/00 , B29C35/00 , B29C43/00 , B29C45/00 , B29C45/14 , B29C55/00 , B29C65/70 , F16K27/02 , B29F1/00
CPC分类号： F16K27/0272 , B29C45/14622
摘要： A method of forming an injection moulded lining on a valve body comprises the step of defining a cavity having a main portion which when filled with lining material forms the desired lining, and an extension portion continuous with an edge of the main portion. Lining material is injected into the extension portion until the cavity is filled. Any sprues produced by the injection are on the tab formed by the material in the extension portion and not on the lining proper. Thus, there is no danger of damaging the lining as sprues are removed, and they do not cause local stress in the lining.
摘要翻译：在阀体上形成注射成型衬垫的方法包括以下步骤：确定具有主要部分的空腔，当填充衬里材料形成期望的衬里时，以及与主要部分的边缘连续的延伸部分。衬里材料被注入到延伸部分中，直到空腔被填充。由注射产生的任何浇道都在由延伸部分中的材料形成的接片上，而不是在衬里上。因此，除去浇口不会损坏衬里，并且不会在衬里中引起局部应力。

92. 发明授权

US1220835A Box-strap. 失效
标题翻译： BOX-STRAP。
公开(公告)号：US1220835A
公开(公告)日：1917-03-27
申请号：US12175816
申请日：1916-09-23
申请人： FORBES PHILIP JONES
发明人： FORBES PHILIP JONES
CPC分类号： B65D9/22

93. 发明申请

US20130158003A1 HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF 有权
公开(公告)号：US20130158003A1
公开(公告)日：2013-06-20
申请号：US13700051
申请日：2011-05-26
申请人： John Emmerson Campbell , Michael Charles Hewitt , Philip Jones , Linghong Xie
发明人： John Emmerson Campbell , Michael Charles Hewitt , Philip Jones , Linghong Xie
IPC分类号： C07D403/06 , C07D409/06 , C07D405/14 , C07D409/14 , C07D498/04 , C07D417/06 , C07D413/06 , C07D487/04 , C07D471/14 , C07D471/04 , C07D401/14
CPC分类号： C07D498/06 , A61K31/4164 , A61K31/4178 , A61K31/4709 , A61K31/498 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/5383 , C07D233/58 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/06 , C07D417/06 , C07D471/04 , C07D471/06 , C07D471/14 , C07D487/04 , C07D491/056 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

94. 发明申请

US20130048783A1 LANDING GEAR ATTACHMENT 有权
标题翻译：接地齿轮附件
公开(公告)号：US20130048783A1
公开(公告)日：2013-02-28
申请号：US13569528
申请日：2012-08-08
申请人： Andrija Ekmedzic , Mario Straccia , Philip Jones
发明人： Andrija Ekmedzic , Mario Straccia , Philip Jones
IPC分类号： B64C25/10
CPC分类号： B64C25/04
摘要： A landing gear attachment apparatus (100) hasa landing gear side bearing retention arrangement (104) connected to an aircraft side attachment apparatus (102), held together by a series of fuse pins. The interaction between a fuse pin carrier and a trunnion block varies the amount of load required to separate the landing gear from the fuselage depending on the direction of the load.
摘要翻译：起落架附接装置（100）具有连接到飞行器侧连接装置（102）的起落架侧轴承保持装置（104），其通过一系列熔丝销保持在一起。保险丝销托架和耳轴座之间的相互作用根据负载方向改变将起落架与机身分离所需的负载量。

95. 发明授权

US08188084B2 Pyridinone and pyridazinone derivatives as inhibitors of poly (ADP-ribose) polymerase (PARP) 有权
标题翻译：作为聚（ADP-核糖）聚合酶（PARP）抑制剂的吡啶酮和哒嗪酮衍生物
公开(公告)号：US08188084B2
公开(公告)日：2012-05-29
申请号：US12227513
申请日：2007-05-25
申请人： Philip Jones , Olaf Kinzel , Giovanna Pescatore , Laura Llauger Bufi , Carsten Schultz-Fademrecht , Federica Ferrigno
发明人： Philip Jones , Olaf Kinzel , Giovanna Pescatore , Laura Llauger Bufi , Carsten Schultz-Fademrecht , Federica Ferrigno
IPC分类号： C07D401/12 , A61P35/00 , A61P9/10 , A61P29/00
CPC分类号： C07D471/04 , A61K31/435 , A61K31/495 , C07D237/14 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/10 , C07D471/10 , C07D487/04 , C07D491/10
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性病症，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

96. 发明授权

US08126451B2 Synchronous CDMA communication system 有权
标题翻译：同步CDMA通信系统
公开(公告)号：US08126451B2
公开(公告)日：2012-02-28
申请号：US12016663
申请日：2008-01-18
申请人： Carlo Luschi , Steve Allpress , Philip Jones
发明人： Carlo Luschi , Steve Allpress , Philip Jones
IPC分类号： H04W4/00
CPC分类号： H04B17/345 , H04B1/7115 , H04B17/27 , H04B17/318 , H04B17/336 , H04L25/0212 , H04L25/0224 , H04L25/03019
摘要： Methods are described of processing signals received over a wireless communication channel by a receiver in a wireless cellular network. A method includes receiving a sequence of signal samples. The received sequence of samples can be used to estimate at least one channel coefficient for at least one transmission path. An estimate of an orthogonality factor can be generated based on said at least one channel coefficient. An estimate of the disturbance can be generated based on said at least one estimated channel coefficient. An estimate of input signal power can be generated using the received sequence. An estimate of cell geometry can be generated using the estimated orthogonality factor, estimated disturbance, and estimated input signal power. The estimate of cell geometry can be used in processing received data samples. Related methods of processing digital samples are described. Related receivers are also described.
摘要翻译：描述了处理由无线蜂窝网络中的接收机在无线通信信道上接收的信号的方法。一种方法包括接收信号样本序列。所接收的样本序列可以用于估计至少一个传输路径的至少一个信道系数。可以基于所述至少一个信道系数来生成正交因子的估计。可以基于所述至少一个估计的信道系数来产生扰动的估计。可以使用接收到的序列来生成输入信号功率的估计。可以使用估计的正交因子，估计的干扰和估计的输入信号功率来生成小区几何的估计。单元几何的估计可用于处理接收的数据样本。描述处理数字样本的相关方法。还描述了相关接收机。

97. 发明授权

US08080573B2 Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors 有权
标题翻译：杂环取代的酰胺和硫酰胺衍生物作为组蛋白脱乙酰酶（hdac）抑制剂
公开(公告)号：US08080573B2
公开(公告)日：2011-12-20
申请号：US12084269
申请日：2006-10-26
申请人： Philip Jones , Jesus Maria Ontoria Ontoria
发明人： Philip Jones , Jesus Maria Ontoria Ontoria
IPC分类号： A61K31/4164 , C07D233/54
CPC分类号： C07D403/12 , C07D233/64 , C07D409/14
摘要： The present invention related to compounds of formula (I): or a pharmaceutically acceptable salt, stereoisomer or tautomer thereof. Compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. Compounds of the present invention are useful for treating or preventing neurodegenerative diseases, schizophrenia and stroke among other diseases.
摘要翻译：本发明涉及式（I）化合物：或其药学上可接受的盐，立体异构体或互变异构体。本发明化合物是组蛋白脱乙酰酶（HDAC）的抑制剂，可用于治疗包括癌症在内的细胞增殖性疾病。本发明的化合物可用于治疗或预防神经变性疾病，精神分裂症和中风等疾病。

98. 发明授权

US08071623B2 Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors 有权
标题翻译：酰胺取代的吲唑作为聚（ADP-核糖）聚合酶（PARP）抑制剂
公开(公告)号：US08071623B2
公开(公告)日：2011-12-06
申请号：US12006993
申请日：2008-01-08
申请人： Philip Jones , Jesus Maria Ontoria Ontoria , Rita Scarpelli , Carsten Schultz-Fademrecht
发明人： Philip Jones , Jesus Maria Ontoria Ontoria , Rita Scarpelli , Carsten Schultz-Fademrecht
IPC分类号： A61K31/445 , C07D231/56
CPC分类号： C07D401/10 , A61K31/4439
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts, stereoisomers or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- and/or radiosensitizers for cancer treatment.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，立体异构体或互变异构体，其是聚（ADP-核糖）聚合酶（PARP）的抑制剂，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血性疾病，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤或皮肤衰老以及UV诱导的皮肤损伤，以及用作癌症治疗的化学和/或放射增敏剂。

99. 发明申请

US20110183989A1 SATURATED BICYCLIC HETEROCYCLIC DERIVATIVES AS SMO ANTAGONISTS 有权
标题翻译：饱和双环杂环衍生物作为SMO拮抗剂
公开(公告)号：US20110183989A1
公开(公告)日：2011-07-28
申请号：US13060718
申请日：2009-08-28
申请人： Danila Branca , Federica Ferrigno , Jose Ignacio Martin Hernando , Philip Jones , Olaf Kinzel , Savina Malancona , Ester Muraglia , Maria Cecilia Palumbi , Giovanna Pescatore , Rita Scarpelli
发明人： Danila Branca , Federica Ferrigno , Jose Ignacio Martin Hernando , Philip Jones , Olaf Kinzel , Savina Malancona , Ester Muraglia , Maria Cecilia Palumbi , Giovanna Pescatore , Rita Scarpelli
IPC分类号： A61K31/4985 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula I: and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of the Sonic Hedgehog pathway, in particular Smoantagonists. Thus the compounds of this invention are useful for the treatment of diseases associated with abnormal hedgehog pathway activation, including cancer, for example basal cell carcinoma, medulloblastoma, prostate, pancreatic, breast, colon, bone and small cell lung cancers, and cancers of the upper GI tract.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐或互变异构体，其是Sonic Hedgehog途径的抑制剂，特别是Smoantagonists。因此，本发明的化合物可用于治疗与异常hedgehog途径活化相关的疾病，包括癌症，例如基底细胞癌，成神经管细胞瘤，前列腺，胰腺癌，乳腺癌，结肠癌，骨细胞和小细胞肺癌，以及癌症上胃肠道

100. 发明申请

US20110053911A1 TRICYCLIC DERIVATIVES AS INHIBITORS OF POLY(ADP-RIBOSE) POLYMERASE (PARP) 失效
标题翻译：作为聚（ADP-RIBOSE）聚合酶（PARP）的抑制剂的三聚衍生物
公开(公告)号：US20110053911A1
公开(公告)日：2011-03-03
申请号：US12922270
申请日：2009-03-13
申请人： Raffaele Ingenito , Philip Jones , Laura Llauger Bufi , Jesus Maria Ontoria Ontoria , Rita Scarpelli
发明人： Raffaele Ingenito , Philip Jones , Laura Llauger Bufi , Jesus Maria Ontoria Ontoria , Rita Scarpelli
IPC分类号： A61K31/55 , C07D471/16 , C07D487/06 , A61K31/4375 , A61K31/551 , A61K31/438 , A61P35/00 , A61P9/10 , A61P29/00 , A61P3/10 , A61P9/00 , A61P27/02 , A61P17/00
CPC分类号： C07D471/06 , C07D471/16
摘要： The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly(ADP-ribose)polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischaemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes mellitus, neurodegenerative diseases, retroviral infections, retinal damage, skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment.
摘要翻译：本发明涉及作为聚（ADP-核糖）聚合酶（PARP）的抑制剂的式（I）化合物及其药学上可接受的盐或互变异构体，因此可用于治疗癌症，炎性疾病，再灌注损伤，缺血状况，中风，肾衰竭，心血管疾病，心血管疾病以外的血管疾病，糖尿病，神经变性疾病，逆转录病毒感染，视网膜损伤，皮肤衰老和紫外线诱发的皮肤损伤，以及用于癌症治疗的化学或放射增敏剂。

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