专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

91. 发明授权

US08071651B2 5-amino-4-hydroxy-7-(imidazo [1,2-A] pyridin-6-ylmethyl)-8-methyl-nonamide derivatives and related compounds as renin inhibitors for the treatment of hypertension 失效
标题翻译： 5-氨基-4-羟基-7-（咪唑并[1,2-A]吡啶-6-基甲基）-8-甲基 - 非酰胺衍生物和相关化合物作为治疗高血压的肾素抑制剂
公开(公告)号：US08071651B2
公开(公告)日：2011-12-06
申请号：US11992132
申请日：2006-09-14
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stefan Stutz , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Stjepan Jelakovic
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stefan Stutz , Aleksandar Stojanovic , Christiane Marti , Dirk Behnke , Stjepan Jelakovic
IPC分类号： A01N43/42 , A01N43/40 , A01N43/58 , A01N43/00 , A01N43/64 , A01N37/18 , A01N35/00 , A01N33/18 , A01N33/24 , C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00 , A61K31/16 , A61K31/12
CPC分类号： C07D405/12 , C07D471/04
摘要： Compounds of the general formula (I) or its salt or a compound in which one or more atoms are replaced by their stable, nonradio-active isotopes, in particular its pharmaceutically acceptable salt; in which X is —CH2—; R is a mono- to tetra-substituted, mono- or bicyclic, unsaturated heterocyclic radical having 1 to 4 nitrogen atoms, R2 is C1-6alkyl or C3-6cycloalkyl; R3 is independently of one another H, C1-6alkyl, C1-6alkoxycarbonyl or C1-6alkanoyl; R4 is C2-6alkenyl, C1-6alkyl, unsubstituted or substituted aryl-C1-6alkyl or C3-8cycloalkyl; R5 is -Lm-R6; L is C1-6alkylene which is optionally substituted by 1-4 halogen, or a linker: formula (II) n=0, 1 or 2; m=0 or 1; R6 is a radical composed of 2 cyclic systems selected from bicyclo[x.y.z]alkyl, spiro[o.p]alkyl, mono- or bioxabicyclo[x.y.z]alkyl or mono- or bioxaspiro[o.p]alkyl, all of which may be substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino, or if m=0: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino, or if m=1: is also saturated C3-8heterocyclyl which comprises 1-2 oxygen atoms, optionally substituted by 1-3 substituents selected from C1-6alkyl, C1-6alkoxy, cyano, halogen, C1-6-alkoxy-C1-6alkyl, hydroxy-C1-6alkyl or dialkylamino; have renin-inhibiting properties and can be used as medicines for the treatment of hypertension.
摘要翻译：通式（I）的化合物或其盐或其中一个或多个原子被其稳定的非放射性活性同位素替代的化合物，特别是其药学上可接受的盐; 其中X是-CH 2 - ; R是具有1至4个氮原子的单 - 四取代的单 - 或双环不饱和杂环基，R 2是C 1-6烷基或C 3-6环烷基; R 3彼此独立地为H，C 1-6烷基，C 1-6烷氧基羰基或C 1-6烷酰基; R 4是C 2-6烯基，C 1-6烷基，未取代或取代的芳基-C 1-6烷基或C 3-8环烷基; R5是-Lm-R6; L是任选被1-4个卤素取代的C 1-6亚烷基或连接基：式（II）n = 0,1或2; m = 0或1; R6是由选自双环[xyz]烷基，螺[op]烷基，单或生双环[xyz]烷基或单 - 或生物密封[op]烷基的2个环状体组成的基团，所有这些可以被1- 选自C 1-6烷基，C 1-6烷氧基，氰基，卤素，C 1-6烷氧基-C 1-6烷基，羟基-C 1-6烷基或二烷基氨基的3个取代基，或者如果m = 0：也是饱和的C 3-8杂环基，其包含1-2个氧原子被1-3个选自C 1-6烷基，C 1-6烷氧基，氰基，卤素，C 1-6烷氧基-C 1-6烷基，羟基-C 1-6烷基或二烷基氨基取代的取代基取代，或者如果m = 1：也是饱和的C 3-8杂环基其包含1-2个氧原子，任选被1-3个选自C 1-6烷基，C 1-6烷氧基，氰基，卤素，C 1-6 - 烷氧基-C 1-6烷基，羟基-C 1-6烷基或二烷基氨基的取代基取代; 具有肾素抑制性质，可用作治疗高血压的药物。

92. 发明授权

US08058307B2 Alcanoic acid amides substituted by saturated O-heterocycles 失效
标题翻译：饱和O-杂环取代的烷酸酰胺
公开(公告)号：US08058307B2
公开(公告)日：2011-11-15
申请号：US11992127
申请日：2006-09-14
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stefan Stutz , Aleksandar Stojanovic , Stjepan Jelakovic , Christiane Marti
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stefan Stutz , Aleksandar Stojanovic , Stjepan Jelakovic , Christiane Marti
IPC分类号： A61K31/38 , A61K31/355 , A61K31/35 , C07D335/06 , C07D311/00 , C07D315/00 , C07D215/00
CPC分类号： A61K31/335
摘要： Compounds of the general formula (formula I) in which the meanings of the substituents R1 to R6 are as indicated in claim 1, have renin-inhibiting properties and can be used as medicines.
摘要翻译：取代基R 1〜R 6的含义如权利要求1所示的通式（式I）的化合物具有肾素抑制性质，可用作药物。

93. 发明授权

US08008334B2 Bis-heterocyclic imidazolyl compounds 有权
标题翻译：双杂环咪唑基化合物
公开(公告)号：US08008334B2
公开(公告)日：2011-08-30
申请号：US12086193
申请日：2006-12-08
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Michael Quirmbach , Christiane Marti , Aleksandar Stojanovic , Stefan Stutz
IPC分类号： C07D235/02 , C07D403/00 , A01N43/52 , A61K31/415
CPC分类号： C07D471/04
摘要： The patent application relates to new heterocyclic compounds of the general formula (I) in which R, R1, R2, R3, R4 and n have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.
摘要翻译：该专利申请涉及通式（I）的新的杂环化合物，其中R，R 1，R 2，R 3，R 4和n具有在说明书中更详细阐述的定义，其制备方法和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。

94. 发明申请

US20110092492A1 IMIDAZO COMPOUNDS 失效
标题翻译：咪唑化合物
公开(公告)号：US20110092492A1
公开(公告)日：2011-04-21
申请号：US12975949
申请日：2010-12-22
申请人： Peter HEROLD , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
发明人： Peter HEROLD , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
IPC分类号： A61K31/542 , C07D498/04 , C07D513/04 , A61K31/5383 , A61P3/00 , A61P9/04 , A61P7/00 , A61P5/40
CPC分类号： C07D513/04 , C07D498/04
摘要： Heterocyclic compounds of the formula (I) and salts, preferably pharmaceutically acceptable salts thereof, are provided in which R, R1, R2, Q, m and n have the meanings explained in detail in the description. Also provided are a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：提供式（I）的杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，Q，m和n具有在说明书中详细解释的含义。还提供了它们制备和使用这些化合物作为药物的方法，特别是作为醛固酮合成酶抑制剂。

95. 发明授权

US07879847B2 Imidazo compounds 有权
标题翻译：咪唑化合物
公开(公告)号：US07879847B2
公开(公告)日：2011-02-01
申请号：US12226214
申请日：2007-04-12
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Aleksandar Stojanovic , Christiane Marti , Stjepan Jelakovic , Stefan Stutz
IPC分类号： C07D498/04 , A61K31/5365
CPC分类号： C07D513/04 , C07D498/04
摘要： The application relates to novel heterocyclic compounds of the general formula (I) and salts, preferably pharmaceutically acceptable salts, thereof in which R, R1, R2, Q, m and n have the meanings explained in detail in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译：本申请涉及通式（I）的新型杂环化合物和其盐，优选其药学上可接受的盐，其中R，R 1，R 2，Q，m和n具有在说明书中详细解释的含义，制备和使用这些化合物作为药物，特别是作为醛固酮合酶抑制剂。

96. 发明申请

US20100331322A1 SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS 失效
标题翻译：替代的哌啶作为RININ抑制剂
公开(公告)号：US20100331322A1
公开(公告)日：2010-12-30
申请号：US12865932
申请日：2009-02-06
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Stjepan Jelakovic , Dirk Behnke
IPC分类号： A61K31/538 , C07D413/12 , C07D413/14 , A61P9/00 , A61P9/10 , A61P9/12 , A61P27/06
CPC分类号： C07D413/12 , C07D413/14
摘要： The present invention relates to compounds of the general formula (I) and the salts thereof, preferably the pharmaceutically acceptable salts thereof; in which R has the meaning explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本发明涉及通式（I）的化合物及其盐，优选其药学上可接受的盐; 其中R具有说明书中解释的含义，其制备方法和这些化合物用作药物，特别是作为肾素抑制剂。

97. 发明申请

US20100267713A1 4,4-DISUBSTITUTED PIPERIDINES 审中-公开
标题翻译： 4,4-取代的哌啶
公开(公告)号：US20100267713A1
公开(公告)日：2010-10-21
申请号：US12740720
申请日：2008-10-31
申请人： Peter Herold , Stjepan Jelakovic , Robert Mah , Christiane Marti , Stefan Stutz , Vincenzo Tschinke
发明人： Peter Herold , Stjepan Jelakovic , Robert Mah , Christiane Marti , Stefan Stutz , Vincenzo Tschinke
IPC分类号： A61K31/538 , C07D265/36 , A61P9/12 , A61P9/10 , A61P27/06
CPC分类号： C07D413/14
摘要： The application relates to 4,4-disubstituted piperidines of the general formula (I) and their salts, preferably their pharmaceutically acceptable salts, in which R2, has the meanings explained in the description, a process for their preparation and the use of these compounds as medicines, especially as renin inhibitors.
摘要翻译：本申请涉及通式（I）的4,4-二取代哌啶及其盐，优选其药学上可接受的盐，其中R2具有说明书中所述的含义，其制备方法和这些化合物的用途作为药物，特别是作为肾素抑制剂。

98. 发明授权

US07767690B2 Amino alcohol derivatives and their use as renin inhibitor 失效
标题翻译：氨基醇衍生物及其作为肾素抑制剂的用途
公开(公告)号：US07767690B2
公开(公告)日：2010-08-03
申请号：US10587046
申请日：2005-01-21
申请人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
发明人： Peter Herold , Stefan Stutz , Aleksandar Stojanovic , Vincenzo Tschinke , Christiane Marti , Michael Quirmbach
IPC分类号： A61K31/435 , C07D221/04
CPC分类号： C07D215/38 , C07D401/06 , C07D401/12 , C07D405/12 , C07D471/08 , C07D471/10
摘要： The application relates to novel amino alcohols of the general formula (I) where R, R1, R2, R3, R4, R5 and R6 each have the definitions illustrated in detail in the description, to a process for their preparation and to the use of these compounds as medicines, in particular as renin inhibitors.
摘要翻译：本申请涉及通式（I）的新型氨基醇，其中R，R 1，R 2，R 3，R 4，R 5和R 6各自具有在说明书中详细说明的定义，其制备方法和使用这些化合物作为药物，特别是作为肾素抑制剂。

99. 发明申请

US20100029694A1 Heterocyclic compounds and their use as aldosterone synthase inhibitors 审中-公开
标题翻译：杂环化合物及其作为醛固酮合酶抑制剂的用途
公开(公告)号：US20100029694A1
公开(公告)日：2010-02-04
申请号：US12585584
申请日：2009-09-18
申请人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
发明人： Peter Herold , Robert Mah , Vincenzo Tschinke , Christoph Schumacher , Michael Quirmbach
IPC分类号： A61K31/517 , A61K31/437 , A61P5/40
CPC分类号： C07D471/04 , C07D417/04
摘要： Heterocyclic compounds of the general formula (I) in which R, R1, R2, W, X, Y, Z and n have the meanings defined in the description, a process for their preparation and the use of these compounds as medicaments, in particular as aldosterone synthase inhibitors.
摘要翻译： R 1，R 2，W，X，Y，Z和n具有本说明书中定义的含义的通式（I）的杂环化合物，其制备方法和这些化合物作为药物的用途，特别是作为醛固酮合酶抑制剂。

100. 发明申请

US20090325947A1 NITRATE ESTERS OF PIPERIDINES 审中-公开
标题翻译：硝酸酯系列
公开(公告)号：US20090325947A1
公开(公告)日：2009-12-31
申请号：US12310022
申请日：2007-08-07
申请人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Isabelle Lyothier , Christoph Schumacher , Christiane Marti , Nathalie Jotterand
发明人： Peter Herold , Robert Mah , Stefan Stutz , Vincenzo Tschinke , Isabelle Lyothier , Christoph Schumacher , Christiane Marti , Nathalie Jotterand
IPC分类号： A61K31/5377 , C07D211/06 , A61K31/445 , C07D413/02
CPC分类号： C07D413/04 , C07D211/52 , C07D401/04 , C07D405/04 , C07D405/12
摘要： The application relates to novel nitrate ester derivatives of substituted piperidines of the general formula (I), wherein R1, R2, R3, X, Y and Z0, and m, n, p and q have the meanings explained in more detail in the description, a process for their preparation and the use of these compounds as a curative agent in cardiovascular diseases, in particular in high blood pressure and vascular and organ damage accompanying high blood pressure.
摘要翻译：本申请涉及通式（I）的取代哌啶的新型硝酸酯衍生物，其中R1，R2，R3，X，Y和Z0以及m，n，p和q具有在说明书中更详细解释的含义，其制备方法以及这些化合物作为心血管疾病中的治疗剂的用途，特别是伴有高血压的高血压和血管和器官损伤。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式