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91. 发明申请

WO2006047671A3 4-AMINOTETRACYCLINES AND METHODS OF USE THEREOF 审中-公开
标题翻译： 4-AMINETETRACYCLINES及其使用方法
公开(公告)号：WO2006047671A3
公开(公告)日：2006-08-10
申请号：PCT/US2005038733
申请日：2005-10-25
申请人： PARATEK PHARM INNC , BERNIAC JOEL , BHATIA BEENA , GRIER MARK , NELSON MARK L , PAN JINGWEN
发明人： BERNIAC JOEL , BHATIA BEENA , GRIER MARK , NELSON MARK L , PAN JINGWEN
IPC分类号： C07C237/26 , A61K31/65 , A61P25/28 , A61P31/04 , A61P31/12 , C07C239/18
CPC分类号： C07C237/26 , C07C251/46 , C07C2603/46 , C07D221/18
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分涉及新的取代的四环素化合物应答状态，例如细菌感染和肿瘤，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。

92. 发明申请

WO2006047671A2 4-AMINOTETRACYCLINES AND METHODS OF USE THEREOF 审中-公开
标题翻译： 4-氨基葡萄糖和其使用方法
公开(公告)号：WO2006047671A2
公开(公告)日：2006-05-04
申请号：PCT/US2005/038733
申请日：2005-10-25
申请人： PARATEK PHARMACEUTICALS, INC. , BERNIAC, Joel , BHATIA, Beena , GRIER, Mark , NELSON, Mark, L. , PAN, Jingwen
发明人： BERNIAC, Joel , BHATIA, Beena , GRIER, Mark , NELSON, Mark, L. , PAN, Jingwen
IPC分类号： C07C239/18 , A61K31/65 , A61P25/28 , A61P31/04 , A61P31/12
CPC分类号： C07C237/26 , C07C251/46 , C07C2603/46 , C07D221/18
摘要： The present invention pertains, at least in part, to novel substituted tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression.
摘要翻译：本发明至少部分地涉及新的取代的四环素化合物反应状态，例如细菌感染和赘生物，以及四环素化合物的其它已知应用，例如阻断四环素外排和调节基因表达。

93. 发明申请

WO2005121284A2 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：WO2005121284A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019214
申请日：2005-06-02
申请人： POLAR MOLECULAR CORPORATION , NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
发明人： NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
IPC分类号： C10L1/18
CPC分类号： C10L1/14 , C10L1/143 , C10L1/1805 , C10L1/1852 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L10/04
摘要： Disclosed is an ether containing motor fuel additive composition which synergistically interacts with the ether additive to reduce fuel intake system deposit formation and/or combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含醚的运动燃料添加剂组合物，其与醚添加剂协同相互作用以减少燃料进入系统沉积物形成和/或燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

94. 发明申请

WO2005121283A2 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：WO2005121283A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019213
申请日：2005-06-02
申请人： POLAR MOLECULAR CORPORATION , NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
发明人： NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
IPC分类号： C10L1/18
CPC分类号： C10L1/143 , C10L1/1805 , C10L1/1852 , C10L1/1985 , C10L1/201 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L1/306 , C10L10/04
摘要： Disclosed is a leaded motor fuel additive composition which synergistically interacts with the alkyl lead additive to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含铅马达燃料添加剂组合物，其与烷基铅添加剂协同地相互作用以减少燃料进料系统沉积物形成和燃烧室沉积物形成，由此减少发动机ORI并保持期望的发动机性能。

95. 发明申请

WO2005121282A2 MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：电动燃油添加剂组合物
公开(公告)号：WO2005121282A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/019212
申请日：2005-06-02
申请人： POLAR MOLECULAR CORPORATION , NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
发明人： NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, Richard, A. , PRAKASH, Chandra , CHAPELET, Gilbert
IPC分类号： C10L1/18
CPC分类号： C10L10/10 , C10L1/143 , C10L1/1805 , C10L1/1824 , C10L1/1852 , C10L1/1985 , C10L1/221 , C10L1/2383 , C10L1/2387 , C10L1/305 , C10L10/04
摘要： Disclosed is a MMT containing motor fuel additive composition which synergistically combines the octane enhancing capabilities of MMT with the benefits of a special additive package to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby reducing engine ORI and maintaining desired engine performance.
摘要翻译：公开了一种含有MMT的运动燃料添加剂组合物，其协同地将MMT的辛烷值增强能力与特殊添加剂包装的优点相结合，以减少燃料进料系统沉积物形成和燃烧室沉积物形成，从而减少发动机ORI并保持期望的发动机性能。

96. 发明申请

WO2005118753A2 DIESEL MOTOR FUEL ADDITIVE COMPOSITION 审中-公开
标题翻译：柴油机燃油添加剂组合物
公开(公告)号：WO2005118753A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/019427
申请日：2005-06-02
申请人： POLAR MOLECULAR CORPORATION , NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, A. Richard , PRAKASH, Chandra , CHAPELET, Gilbert
发明人： NELSON, Otis, L., Jr. , NELSON, Mark, L. , NELSON, A. Richard , PRAKASH, Chandra , CHAPELET, Gilbert
IPC分类号： C10L1/18
CPC分类号： C10L1/238 , C10L1/2383 , C10L1/2387 , C10L10/02 , C10L10/12
摘要： Disclosed is a diesel fuel additive composition which accelerates combustion phenomenon, reduces ignition delay, and improves Cetane number, thereby lowering particulate emissions, and improving fuel economy in diesel engines.
摘要翻译：公开了一种加速燃烧现象，减少点火延迟并提高十六烷值，从而降低颗粒物排放并提高柴油机燃油经济性的柴油燃料添加剂组合物。

97. 发明申请

WO2004062674A2 SUBSTITUTED POLYAMINES AS INHIBITORS OF BACTERIAL EFFLUX PUMPS 审中-公开
标题翻译：作为细菌泡沫泵的抑制剂的替代聚酰胺
公开(公告)号：WO2004062674A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000331
申请日：2004-01-07
申请人： PARATEK PHARMACEUTICALS, INC. , NELSON, Mark, L. , ALEKSHUN, Michael, N.
发明人： NELSON, Mark, L. , ALEKSHUN, Michael, N.
IPC分类号： A61K31/7036
CPC分类号： A61K31/70 , A61K31/00 , A61K31/132 , A61K31/133 , A61K31/7036 , Y02A50/401 , Y02A50/406 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483 , A61K2300/00
摘要： Disclosed are methods of treating bacterial infections including those caused by multidrug resistant bacteria using polyamine efflux pump inhibiting compounds, including for example N -benzylated polyazaalkanes, N -benzylated polyaminoalkanes, or mixed N -benzylated poly(aza/amino)alkanes, optionally in combination with other drugs such as antibiotics, as well as pharmaceutical compositions thereof.
摘要翻译：公开的是使用多胺外排泵抑制化合物治疗细菌感染的方法，包括由多重耐药细菌引起的细菌感染的方法，包括例如N-苄基化的多烷基烷烃，N-苄基化聚氨基烷烃或混合的N-苄基化聚（氮杂/氨基）烷烃，任选地组合与其他药物如抗生素，以及其药物组合物。

98. 发明申请

WO1991013949A1 MOTOR FUEL ADDITIVE COMPOSITION AND METHOD FOR PREPARATION THEREOF 审中-公开
标题翻译：电动燃料添加剂组合物及其制备方法
公开(公告)号：WO1991013949A1
公开(公告)日：1991-09-19
申请号：PCT/US1991001332
申请日：1991-03-05
申请人： POLAR MOLECULAR CORPORATION , NELSON, Alfred, Richard , NELSON, Mark, L. , NELSON, Otis, L., Jr.
发明人： POLAR MOLECULAR CORPORATION
IPC分类号： C10L01/02
CPC分类号： C10L1/14 , C10L1/143 , C10L1/1608 , C10L1/1616 , C10L1/1641 , C10L1/18 , C10L1/182 , C10L1/1824 , C10L1/1852 , C10L1/1857 , C10L1/19 , C10L1/198 , C10L1/1985 , C10L1/2383 , C10L1/2387 , C10L1/306 , C10L10/04
摘要： A motor fuel additive composition comprises a mixture of:(a) from 5-50 weight percent, based upon the total weight of the additive, of a detergent component selected from the group consisting of (i) at least one nonionic compound having a molecular weight in the range of 200-1500, (ii) a reaction product of a substituted hydrocarbon and an amino compound, and (iii) a polybutylamine or polyisobutylamine; and (b) a fuel conditioner component comprising (i) from 2-50 weight percent, based upon the total weight of the additive, of a polar oxygenated hydrocarbon compound and (ii) from 2-50 weight percent, based upon the total weight of the additive, of an oxygenated compatibilizing agent. The fuel conditioner component may additionally comprise a hydrophilic separant, an aromatic hydrocarbon, or mixtures thereof. The additive may also additionally comprise a carrier oil or fluidizer. The additive is prepared by mixing together the detergent and fuel conditioner components, and is advantageous in that the detergent and fuel conditioner components synergistically interact to reduce both fuel intake system deposit formation and combustion chamber deposit formation, thereby inhibiting engine ORI.
摘要翻译：机动车燃料添加剂组合物包含以下混合物：（a）基于添加剂总重量的5-50重量％的洗涤剂组分，所述洗涤剂组分选自（i）至少一种具有分子重量在200-1500范围内，（ii）取代烃和氨基化合物的反应产物，和（iii）聚丁胺或聚异丁胺; 和（b）燃料调节剂组分，其包含（i）2-50重量％，基于添加剂的总重量，极性含氧烃化合物和（ii）2-50重量％，基于总重量的氧化相容剂的添加剂。燃料调节剂组分可另外包含亲水性分离剂，芳族烃或其混合物。添加剂还可另外包含载体油或流化剂。添加剂通过将洗涤剂和燃料调节剂组分混合在一起制备，并且有利的是，洗涤剂和燃料调节剂组分协同地相互作用以减少燃料进入系统沉积物形成和燃烧室沉积物形成，从而抑制发动机ORI。

99. 发明申请

WO2022093692A1 METHOD FOR PRODUCING PHENOL 审中-公开
公开(公告)号：WO2022093692A1
公开(公告)日：2022-05-05
申请号：PCT/US2021/056457
申请日：2021-10-25
申请人： SABIC GLOBAL TECHNOLOGIES B.V. , NOVYE TECHNOLOGY , NELSON, Mark Erik
发明人： SOKOLOV, Andrey Yurevich , SOKOLOV, Alexey Andreevich
IPC分类号： C07C37/74 , C07C39/04 , C07C45/82 , C07C49/08
摘要： A method of separating phenol can include: separating a first portion of acetone from a product stream in an evaporator unit, wherein the first portion of the acetone includes recycle acetone and bypass acetone; recycling the recycle acetone; withdrawing a bottom fraction from the evaporator unit; neutralizing the bottom fraction to form a distillation feed stream that is directed to a distillation column; separating the distillation feed stream into a bottom stream and an overhead stream, the bottom stream including a crude phenol fraction; passing the overhead stream through a condenser to produce a distillate as a crude acetone fraction, and wherein a reflux ratio of the distillation column is less than or equal to 0.40, with the reflux ratio a ratio of a weight of a reflux to distillate weight; and directing the bypass acetone around the distillation column.

100. 发明申请

WO2021178393A1 METHOD AND SYSTEM FOR OXIDIZING CUMENE AND HYDROCARBONS 审中-公开
公开(公告)号：WO2021178393A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/020445
申请日：2021-03-02
申请人： SABIC GLOBAL TECHNOLOGIES B.V. , NELSON, Mark Erik
发明人： DYKMAN, Arkady Samuilovich , ZINENKOV, Andrey Vladimirovich
IPC分类号： C07C407/00 , C07C409/10
摘要： A method for oxidizing a hydrocarbon includes feeding an oxidant to a top portion of a reactor; reacting the hydrocarbon with the oxidant in the reactor to obtain a reaction product stream, the reaction product stream exiting a reactor outlet at a bottom portion of the reactor; and recycling a portion of the reaction product stream to the top portion of the reactor; and introducing the oxidant into an oxidation liquid comprising the portion of the reaction product stream recycled to the top portion of the reactor to form a reaction media stream entering a reactor inlet at the top portion of the reactor. A pressure of the reactor outlet exceeds a pressure of the reactor inlet by at least 5%. The reaction media stream moves vertically downwards in the reactor.

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