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91. 发明申请

US20110199854A1 FLASH TANKS 审中-公开
标题翻译：洗衣机
公开(公告)号：US20110199854A1
公开(公告)日：2011-08-18
申请号：US12999533
申请日：2009-06-17
申请人： Christopher Gordon Coleman , Jie Wu
发明人： Christopher Gordon Coleman , Jie Wu
IPC分类号： B01F15/02 , B01F15/06
CPC分类号： C01F7/064
摘要： A method and an apparatus for supplying a slurry at high temperature and pressure, such as a process slurry from Bayer process digestion units, to a tank is disclosed. The process and the apparatus at least substantially eliminates bottom settling of solid particulate material and side wall scale by supplying the process slurry from Bayer process digestion units with a swirling motion into flash tanks.
摘要翻译：公开了一种用于在高温和高压下供应浆料的方法和装置，例如从拜耳工艺消化单元的工艺浆料到罐。所述方法和装置至少基本上消除了固体颗粒材料和侧壁垢的底部沉降，其通过将来自拜耳过程消化单元的处理浆料以旋转运动提供到闪蒸罐中。

92. 发明申请

US20110190315A1 INDOLINE SCAFFOLD SHP-2 INHIBITORS AND CANCER TREATMENT METHOD 有权
标题翻译： INDOLINE SCAFFLE SHP-2抑制剂和癌症治疗方法
公开(公告)号：US20110190315A1
公开(公告)日：2011-08-04
申请号：US13055113
申请日：2009-07-21
申请人： Jie Wu , Nicholas J. Lawrence , Said M. Sebti
发明人： Jie Wu , Nicholas J. Lawrence , Said M. Sebti
IPC分类号： A61K31/496 , C07D403/12 , C12N5/071 , C12N5/09 , A61P35/00 , A61P35/02
CPC分类号： C07D405/06 , C07D209/08 , C07D215/36
摘要： The subject invention concerns methods and compounds for inhibiting Shp2. In one embodiment, a compound of the invention has a chemical structure as shown in formula I or II: wherein X, Y, and Z are independently N or S; R1 is cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; —COOH; —C(R3)3, wherein R3 can independently be any of —H or halogen; or —OR4, wherein R4 can be any of H, alkyl, or heteroalkyl; R2 is alkyl, alkylcarbonyl, heteroalkylcarbonyl, aryl, arylcarbonyl, heterocycloalkylcarbonyl, cycloalkylcarbonyl, or —C(O)NR6R7, any of which can be optionally substituted with one or more of halogen; alkyl; heteroalkyl; carbonyl; —OR4, wherein R4 can be —H, alkyl, or heteroalkyl; —OH; —C(R3)3, wherein R3 can independently be any of —H or halogen; aryl, which can be substituted with one or more of halogen or —OR4; heterocycloalkyl; or —C(O)OR5, wherein R5 can be —H or alkyl; R6 and R7 are independently —H, alkyl, heteroalkyl, aryl, or heteroaryl; and R′ is H or alkyl; or a pharmaceutically acceptable salt or hydrate thereof.
摘要翻译：本发明涉及抑制Shp2的方法和化合物。在一个实施方案中，本发明的化合物具有如式I或II所示的化学结构：其中X，Y和Z独立地为N或S; R 1是环烷基，杂环烷基，芳基或杂芳基，其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; -COOH; -C（R 3）3，其中R 3可以独立地为-H或卤素; 或-OR 4，其中R 4可以是H，烷基或杂烷基中的任何一个; R 2是烷基，烷基羰基，杂烷基羰基，芳基，芳基羰基，杂环烷基羰基，环烷基羰基或-C（O）NR 6 R 7，其中任何一个可以任选被一个或多个卤素取代; 烷基; 杂烷基; 羰; -OR4，其中R4可以是-H，烷基或杂烷基; -哦; -C（R 3）3，其中R 3可以独立地为-H或卤素; 芳基，其可被一个或多个卤素或-OR 4取代; 杂环烷基; 或-C（O）OR 5，其中R 5可以是-H或烷基; R6和R7独立地是-H，烷基，杂烷基，芳基或杂芳基; 和R'是H或烷基; 或其药学上可接受的盐或水合物。

93. 发明授权

US07957495B2 Method and device for suppressing narrowband interference 有权
标题翻译：用于抑制窄带干扰的方法和装置
公开(公告)号：US07957495B2
公开(公告)日：2011-06-07
申请号：US11817553
申请日：2006-02-24
申请人： Jie Wu , Jinlin Zhang , Shijie Yang
发明人： Jie Wu , Jinlin Zhang , Shijie Yang
IPC分类号： H03D1/04 , H03D1/06 , H03K5/01 , H03K6/04 , H04B1/10 , H04L1/00 , H04L25/08
CPC分类号： H04B1/1036 , H04B1/7102
摘要： The method obtains an interference detection result by detecting sampled digital signals in real time in a transform domain, then maps the interference detection result into an interference suppression pulse function on the basis of a unit noise pulse function, and carries out interference suppression filtering in the transform domain according to the interference suppression pulse function. The present invention is capable of detecting narrowband interference such as monotone, frequency modulation, and phase modulation interferences in a receive channel adaptively in real-time, and suppressing the interference adaptively according to the quantity, energy and bandwidth of the interference, so as to reduce the influence of the interference. Therefore, the present invention may enhance robustness of the communication system against interference. Moreover, the present invention does not need multiple notch devices, costs low and may be implemented simply and reliably.
摘要翻译：该方法通过在变换域中实时检测采样数字信号，获得干扰检测结果，然后基于单位噪声脉冲函数将干扰检测结果映射到干扰抑制脉冲功能，并在干扰抑制滤波中进行干扰抑制滤波根据干扰抑制脉冲函数变换域。本发明能够实时地自适应地检测接收信道中的单调，调频和相位调制干扰等窄带干扰，并根据干扰的数量，能量和带宽自适应地抑制干扰，从而减少干扰的影响。因此，本发明可以提高通信系统的抗干扰性。此外，本发明不需要多个切口装置，成本低廉并且可以简单可靠地实现。

94. 发明授权

US07879913B2 Iptakalim hydrochloride for decreasing nicotine use 有权
标题翻译：盐酸伊曲他滨用于减少尼古丁的使用
公开(公告)号：US07879913B2
公开(公告)日：2011-02-01
申请号：US11168156
申请日：2005-06-28
申请人： Jie Wu
发明人： Jie Wu
IPC分类号： A01N33/02 , A01N33/18 , A01N33/24 , A61K31/13 , A61K31/04
CPC分类号： A61K31/13
摘要： A method for decreasing nicotine and other substance use in humans is disclosed. Iptakalim hydrochloride (IPT) is a novel nicotine acetylcholine receptor (nAChR) blocker. According to the disclosed method, IPT is used to block human α4β2-nAChR function. Specifically, IPT exhibits a selective blockade of α4 subunit-containing human nAChR subtypes. According to the disclosed method, IPT is thus used to block the major nicotine targets in the brain, the α4β2-nAChRs natively expressed in midbrain (VTA) DA system, the brain reward center, and in turn to reduce the nicotine-induced reward signals, namely dopamine level increase in nucleus accumbens. Therefore, IPT is capable of servicing as a nAChR antagonist agent and thus is a novel treatment for decreasing nicotine dependence in humans.
摘要翻译：公开了一种减少人体中尼古丁和其他物质使用的方法。盐酸依普卡林（IPT）是一种新型的尼古丁乙酰胆碱受体（nAChR）阻滞剂。根据所公开的方法，IPT用于阻断人α4和bgr2-nAChR功能。具体来说，IPT表现出对含有α4亚基的人类nAChR亚型的选择性阻断。根据所公开的方法，IPT因此用于阻断大脑中的主要尼古丁靶标，在中脑（VTA）DA系统中本征表达的α4和bGR2-nAChRs，脑回报中心，从而减少尼古丁诱导奖励信号，即伏隔核多巴胺水平升高。因此，IPT能够作为nAChR拮抗剂进行维护，因此是降低人类尼古丁依赖性的新型治疗方法。

95. 发明申请

US20100141470A1 SYSTEMS, METHODS, AND COMPUTER PROGRAM PRODUCTS FOR REFRESHING DATA 有权
标题翻译：用于刷新数据的系统，方法和计算机程序产品
公开(公告)号：US20100141470A1
公开(公告)日：2010-06-10
申请号：US12464793
申请日：2009-05-12
申请人： Douglas Neal Rowitch , Zoltan Biacs , Ravikumar Varma Dandu , Donovan Gerard Trisko , Jie Wu , John Gerard Delucchi , Grant Alexander Marshall , Ashok Bhatia
发明人： Douglas Neal Rowitch , Zoltan Biacs , Ravikumar Varma Dandu , Donovan Gerard Trisko , Jie Wu , John Gerard Delucchi , Grant Alexander Marshall , Ashok Bhatia
IPC分类号： G08B5/22
CPC分类号： G01S19/258 , G01S19/05 , H04L47/12
摘要： A method performs an update for a first device that consumes information with a known expiration time. The first device operates within a network that accommodates other devices also consuming the information. The method includes setting a time for the first device to refresh the information, the time to refresh being based on a pseudorandom time offset. The method also includes sending a refresh request to a resource for the data during the set time.
摘要翻译：方法执行消耗具有已知到期时间的信息的第一设备的更新。第一个设备在网络中运行，以适应其他也会消耗信息的设备。该方法包括基于伪随机时间偏移来设置第一设备刷新信息的时间，刷新的时间。该方法还包括在设定的时间内向数据的资源发送刷新请求。

96. 发明申请

US20080171096A1 Method for Decreasing Nicotine and Other Substance Use in Humans 审中-公开
公开(公告)号：US20080171096A1
公开(公告)日：2008-07-17
申请号：US12013224
申请日：2008-01-11
申请人： Jie Wu
发明人： Jie Wu
IPC分类号： A61K31/435 , A61K36/00 , A61P25/18
CPC分类号： A61K36/185
摘要： A method for decreasing nicotine and other substance use in humans is disclosed. Tetrahydroberberine (THB) and its analogs, l-Tetrahydropalmatine (l-THP) and l-Stepholidine (l-SPD), are present in and can be isolated from several plants in the Magnoliidae superorder. According to the disclosed method, THB and its analogs are used to block nicotine-induced DA release, and modulate heterologous or homoeric expression of human nicotinic acetylcholine receptors (nAChR) in humans. Specifically, THB exhibits bi-directory modulation of α4β2-nAChR-mediated currents induced by nicotine. THB also shows predominant inhibition on homologously expressed α7-nAChR function. Thus, according to the disclosed method, THB is used to simultaneous blockade midbrain DA system function, the brain reward center, and neuronal α4β2- and α7-nAChR function, the major nicotine targets in the brain. Therefore, THB and its analogs serve as a novel class of natural compounds to decrease nicotine dependence in humans. Furthermore other substances, such as alcohol, cocaine, and opiates, also operate by triggering the brain reward center, resulting in a cycle of substance or alcohol abuse. THB and its analogs can be used to decrease use of substances such as alcohol, cocaine, and opiates. Finally, because THB and its analogs are DA antagonists, THB and its analogs can also be used as a treatment for Parkinson's Disease, Alzheimer's Disease and Schizophrenia.

97. 发明申请

US20060293393A1 Iptakalim hydrochloride for decreasing nicotine use 有权
标题翻译：盐酸伊曲他滨用于减少尼古丁的使用
公开(公告)号：US20060293393A1
公开(公告)日：2006-12-28
申请号：US11168156
申请日：2005-06-28
申请人： Jie Wu
发明人： Jie Wu
IPC分类号： A61K31/13
CPC分类号： A61K31/13
摘要： A method for decreasing nicotine and other substance use in humans is disclosed. Iptakalim hydrochloride (IPT) is a novel nicotine acetylcholine receptor (nAChR) blocker. According to the disclosed method, IPT is used to block human α4β2-nAChR function. Specifically, IPT exhibits a selective blockade of α4 subunit-containing human nAChR subtypes. According to the disclosed method, IPT is thus used to block the major nicotine targets in the brain, the α4β2-nAChRs natively expressed in midbrain (VTA) DA system, the brain reward center, and in turn to reduce the nicotine-induced reward signals, namely dopamine level increase in nucleus accumbens. Therefore, IPT is capable of servicing as a nAChR antagonist agent and thus is a novel treatment for decreasing nicotine dependence in humans.
摘要翻译：公开了一种减少人体中尼古丁和其他物质使用的方法。盐酸依普卡林（IPT）是一种新型的尼古丁乙酰胆碱受体（nAChR）阻滞剂。根据所公开的方法，IPT用于阻断人α4β2-nAChR功能。具体来说，IPT表现出对含有α4亚基的人类nAChR亚型的选择性阻断。根据所公开的方法，IPT因此被用于阻断大脑中的主要尼古丁靶标，中脑（VTA）DA系统中本征表达的α4β2-nAChRs，脑回报中心，进而减少尼古丁诱导的奖励信号，即伏隔核多巴胺水平升高。因此，IPT能够作为nAChR拮抗剂进行维护，因此是降低人类尼古丁依赖性的新型治疗方法。

98. 发明公开

US20230158092A1 Supplement Compositions 审中-公开
公开(公告)号：US20230158092A1
公开(公告)日：2023-05-25
申请号：US17990699
申请日：2022-11-20
申请人： Ming Jie WU
发明人： Ming Jie WU
IPC分类号： A61K36/428 , A61K36/75 , A61K36/758 , A61K36/062 , A61K36/288 , A61K36/539 , A61K36/537 , A61K36/9066 , A61K36/90 , A61K36/79 , A61K36/233 , A61K36/074 , A61K36/258 , A61K35/586 , A23L33/105
CPC分类号： A61K36/428 , A61K36/75 , A61K36/758 , A61K36/062 , A61K36/288 , A61K36/539 , A61K36/537 , A61K36/9066 , A61K36/90 , A61K36/79 , A61K36/233 , A61K36/074 , A61K36/258 , A61K35/586 , A23L33/105
摘要： The invention provides unique compositions containing mixtures of extracts from medicinal plants and animal parts, as well as related uses for improving health and treating diseases. The inventive compositions provide a wide range of health benefits in the human body in comparison to effects from individual components contained therein.

99. 外观设计

USD984726S1 Cigarette filter 有权
公开(公告)号：USD984726S1
公开(公告)日：2023-04-25
申请号：US29883486
申请日：2023-01-30
申请人： Jie Wu , Qing He
设计人： Jie Wu , Qing He

100. 发明申请

US20170059431A1 BRAKE MEASURING GAUGE AND METHOD 审中-公开
标题翻译：制动测量仪和方法
公开(公告)号：US20170059431A1
公开(公告)日：2017-03-02
申请号：US14843859
申请日：2015-09-02
申请人： CHENG-JIE WU
发明人： CHENG-JIE WU
IPC分类号： G01L5/28
CPC分类号： B60T7/102 , B60T11/046 , F16D2125/60 , F16D2125/64 , G01B5/00 , G01B5/0028
摘要： A brake measuring gauge and method are disclosed. The measuring gauge comprises two measuring rods and a horizontal rule. Each of the two measuring rod has at least a connecting rod formed at an end of the measuring rod to engage with a nut. The horizontal ruler has a central hole formed at a central portion of a surface thereof, and two through holes are formed at relative positions on two ends of the horizontal ruler, and two scales are separately formed at a lateral side of the horizontal ruler. By using the measuring gauge to measure and calculate the dimensions of components of the brake rotor, the user can obtain precise sizes of the adapter bases for different types of the calipers or the brake discs.
摘要翻译：公开了一种制动测量计和方法。测量计包括两个测量棒和一个水平规则。两个测量杆中的每一个具有形成在测量杆的端部处的至少一个连杆，以与螺母啮合。水平尺具有形成在其表面的中心部分的中心孔，并且在水平尺的两端的相对位置处形成两个通孔，并且在水平尺的横向侧分开形成两个标尺。通过使用测量计来测量和计算制动转子部件的尺寸，用户可以获得不同类型的卡钳或制动盘的适配器底座的精确尺寸。

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