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    • 92. 发明申请
    • RADIO FREQUENCY RECEIVER
    • 无线电频率接收机
    • US20130135048A1
    • 2013-05-30
    • US13488902
    • 2012-06-05
    • Seok-bong HYUNBong Hyuk ParkYun Ho ChoiJae Ho Jung
    • Seok-bong HYUNBong Hyuk ParkYun Ho ChoiJae Ho Jung
    • H03F3/45H03F3/16
    • H03F3/45179H03F3/72H03F2200/294H03F2203/45302H03F2203/45394H03F2203/7236
    • A radio frequency receiver of the present invention removes out-of-band jamming signals and interference signals without SAW filters. The radio frequency receiver includes: a low noise amplifier amplifying a signal received through an antenna; a second order intermodulation cancellation unit removing second order intermodulation caused by an out-of-band jamming or interference signal included in the signal output from the low noise amplifier; a passive mixer unit converting a frequency of the signal output from the second order intermodulation cancellation unit; and a low pass filter unit removing an out-of-band jamming or interference signal included in the signal output from the passive mixer unit and delivering the signal with the out-of-band jamming or interference signal removed therefrom to a transimpedance amplifier.
    • 本发明的射频接收机在没有SAW滤波器的情况下去除带外干扰信号和干扰信号。 射频接收机包括:放大通过天线接收的信号的低噪声放大器; 二阶互调消除单元去除由低噪声放大器输出的信号中包含的带外干扰或干扰信号引起的二阶互调; 无源混频器单元,转换从二阶互调消除单元输出的信号的频率; 以及低通滤波器单元,去除从无源混频器单元输出的信号中包含的带外干扰或干扰信号,并且将从其去除的带外干扰或干扰信号的信号传送到跨阻抗放大器。
    • 93. 发明申请
    • TRICARBONYL TECHNETIUM-99m OR RHENIUM-188 LABELED CYCLIC RGD DERIVATIVES, A PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES AS AN ACTIVE INGREDIENT FOR USE IN THE DIAGNOSIS OR TREATMENT OF ANGIOGENESIS-RELATED DISEASES
    • 三溴联苯技术-99m或RHENIUM-188标记循环RGD衍生物及其制备方法,以及含有衍生物作为活性成分的药物组合物用于诊断或治疗血管发生相关性疾病
    • US20130064766A1
    • 2013-03-14
    • US13699511
    • 2011-05-24
    • Byung Chul LeeSang Eun KimJi Sun KimByung Seok MoonJae Ho Jung
    • Byung Chul LeeSang Eun KimJi Sun KimByung Seok MoonJae Ho Jung
    • A61K51/08C07K1/13A61P9/00C07K7/64
    • A61K51/088A61K51/082C07D273/06C07D498/06C07D498/16C07K7/64G01N33/574G01N33/60
    • The present invention relates to tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives, a preparation method thereof, and a pharmaceutical composition containing the derivative as an active ingredient for use in the diagnosis or treatment (radiotherapy) of angiogenesis-related diseases. The tricarbonyl technetium-99m or rhenium-188 labeled cyclic RGD derivatives of the present invention has a high subnanomolar affinity to integrin αvβ3 (also called as a vitronectin receptor) that is activated in an angiogenic action induced by a tumor, reflects a high tumor image of the tricatvonyl technetium-99m labeled cyclic RGD derivative after initial intake in an animal in which cancer cells are transplanted, and acts exclusively upon cancer cells having selectively activated integrin αvβ3 because of a substantially low intake into the liver and intestines, compared to existing known radioactive isotope labeled cyclic RGD derivatives. These results show that the rhenium-188 labeled derivative, a therapeutic nuclide using the same precursor as used in the technetium-99m labeling, effectively inhibits the growth of a tumor and demonstrates therapeutic efficacy when administered via tail vein injection to an animal model bearing tumor, compared to a case where only saline has been injected, thereby making it useful as a medicine for the diagnosis or treatment of angiogenesis-related diseases.
    • 本发明涉及三羰基锝-99m或铼-188标记的环状RGD衍生物,其制备方法和含有该衍生物作为血管生成相关疾病的诊断或治疗(放射治疗)的有效成分的药物组合物。 本发明的三羰基锝-99m或铼-188标记的环状RGD衍生物在由肿瘤诱导的血管生成作用中被激活的整联蛋白αv&bgr 3(也称为玻连蛋白受体)具有高亚纳摩尔亲和力,反映了高 在移植了癌细胞的动物中,首先摄入三氯乙酰锝-99m标记的环状RGD衍生物的肿瘤图像,并且完全作用于具有选择性活化整联蛋白αv&bgr3的癌细胞,因为进入肝脏和肠的摄入量很低, 与现有已知的放射性同位素标记的环状RGD衍生物相比。 这些结果表明,使用与锝-99m标记中使用的相同前体的治疗性核素的铼-188标记的衍生物有效地抑制肿瘤的生长,并且当通过尾静脉注射施用于携带肿瘤的动物模型时显示出治疗功效 ,与仅注射盐水的情况相比,可以用作诊断或治疗血管发生相关疾病的药物。
    • 96. 发明申请
    • VARIABLE GAIN AMPLIFIER WITH FIXED BANDWIDTH
    • 具有固定带宽的可变增益放大器
    • US20120126895A1
    • 2012-05-24
    • US13296626
    • 2011-11-15
    • Seunghyun JANGJae Ho JUNG
    • Seunghyun JANGJae Ho JUNG
    • H03G3/30
    • H03G1/0088
    • Provided is a variable gain amplifier. The variable gain amplifier includes an operational amplifier, a variable feedback impedance unit, a variable compensation impedance unit, and a variable current source. The variable feedback impedance unit is connected between an inverting input terminal and output terminal of the operational amplifier, and has a feedback impedance value which varies for gain control. The variable compensation impedance unit is connected to the inverting input terminal, and has a compensation impedance value which varies in response to change of the feedback impedance value for maintaining a constant feedback factor. The variable current source is connected to the inverting input terminal, and supplies an output current, which varies in response to change of the compensation impedance value, to the variable compensation impedance unit.
    • 提供了可变增益放大器。 可变增益放大器包括运算放大器,可变反馈阻抗单元,可变补偿阻抗单元和可变电流源。 可变反馈阻抗单元连接在运算放大器的反相输入端子和输出端子之间,并具有增益控制变化的反馈阻抗值。 可变补偿阻抗单元连接到反相输入端,并且具有响应于用于维持恒定反馈因子的反馈阻抗值的变化而变化的补偿阻抗值。 可变电流源连接到反相输入端,并将响应于补偿阻抗值的变化而变化的输出电流提供给可变补偿阻抗单元。
    • 98. 发明申请
    • APPARATUS AND METHOD FOR REDUCING PEAK TO AVERAGE POWER RATION IN ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING SYSTEM
    • 在正交频分复用系统中降低平均功率的峰值的装置和方法
    • US20100135421A1
    • 2010-06-03
    • US12517925
    • 2007-11-28
    • Jae-Ho JungKwang Chun LeeSung Bin Im
    • Jae-Ho JungKwang Chun LeeSung Bin Im
    • H04L27/28
    • H04L27/2623
    • An apparatus for reducing PAPR (Peack to Average Power Ratio) in an OFDM (Orthogonal Frequency Division Multiplexing) system includes: an IFFT (Inverse Fast Fourier Transform) unit for performing an IFFT on an input data stream modulated using a specific constellation to generate time-domain signals; a time-domain clipping unit for performing a time-domain clipping on the time-domain signals at a clipping level determined by characteristics of the time-domain signals; an FFT (Fast Fourier Transform) unit for performing an FFT on the clipped time-domain signals to generate frequency-domain signals; and a frequency-domain clipping unit for performing a frequency-domain clipping on the frequency-domain signals. The time-domain clipping reduces in the OFDM system, and the frequency-domain clipping reduces distortions generated by the time-domain clipping.
    • 一种用于减少OFDM(正交频分复用)系统中的PAPR(Peack to Average Power Ratio)的装置,包括:用于对使用特定星座调制的输入数据流执行IFFT的IFFT(快速傅里叶逆变换)单元,以产生时间 域信号 时域剪辑单元,用于以由所述时域信号的特性确定的限幅电平对所述时域信号执行时域限幅; FFT(Fast Fourier Transform,快速傅里叶变换)单元,用于对所述经限幅的时域信号执行FFT以产生频域信号; 以及用于对频域信号执行频域限幅的频域限幅单元。 OFDM系统中的时域削波减少,频域削波减少了由时域削波产生的失真。