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91. 发明申请

US20170269083A1 Sample Collection and Analysis 审中-公开
公开(公告)号：US20170269083A1
公开(公告)日：2017-09-21
申请号：US15609919
申请日：2017-05-31
申请人： IDEXX Laboratories, Inc.
发明人： Matthew Howard Myles
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N1/30 , G01N33/569 , G01N33/56911 , G01N33/5695 , G01N2469/10 , Y10S436/811
摘要： Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.

92. 发明申请

US20160187348A1 Methods for Detecting Renal Disease 审中-公开
标题翻译：检测肾脏疾病的方法
公开(公告)号：US20160187348A1
公开(公告)日：2016-06-30
申请号：US15061327
申请日：2016-03-04
申请人： IDEXX Laboratories, Inc.
发明人： Mahalakshmi Yerramilli , Murthy VSN Yerramilli
IPC分类号： G01N33/68 , G01N33/70
摘要： The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (GFR), in an animal. GFR can be useful in the diagnosis and treatment of kidney disease or dysfunction. In various aspects, the disclosure is directed to the use of free symmetrical dimethylarginine (SDMA) and creatinine in blood samples from animals, in particular cats and dogs, to determine glomerular filtration rate and kidney disease.
摘要翻译：本公开涉及用于肾病的确定，诊断，进展和预后以及与肾脏疾病相关的死亡的方法和装置。本公开包括用于确定动物的肾功能，特别是估计肾小球滤过率（GFR）的方法。 GFR可用于诊断和治疗肾脏疾病或功能障碍。在各方面，本公开涉及在来自动物，特别是猫和狗的血液样品中使用游离对称的二甲基精氨酸（SDMA）和肌酐来测定肾小球滤过率和肾脏疾病。

93. 发明申请

US20160130353A1 Canine Anti-CD20 Antibodies 审中-公开
标题翻译：犬抗CD20抗体
公开(公告)号：US20160130353A1
公开(公告)日：2016-05-12
申请号：US14986624
申请日：2016-01-01
申请人： IDEXX Laboratories, Inc.
发明人： Melissa Beall
IPC分类号： C07K16/28 , C07K14/705
CPC分类号： C07K16/2887 , A61K39/39541 , A61K39/39558 , C07K14/70596 , C07K16/3061 , C07K2317/33 , C12N5/163 , G01N33/5052 , G01N33/564
摘要： The invention provides canine CD20 specific antibodies, methods of making the antibodies and methods of use of the antibodies.
摘要翻译：本发明提供犬CD20特异性抗体，制备抗体的方法和抗体的使用方法。

94. 发明授权

US08945945B1 Sample collection and analysis 有权
公开(公告)号：US08945945B1
公开(公告)日：2015-02-03
申请号：US14538381
申请日：2014-11-11
申请人： IDEXX Laboratories, Inc.
发明人： Matthew Howard Myles
IPC分类号： G01N33/543
CPC分类号： G01N33/56983 , G01N1/30 , G01N33/569 , G01N33/56911 , G01N33/5695 , G01N2469/10 , Y10S436/811
摘要： Management of the health status of an animal colony using a plurality of blood collection cards and the analysis of dried blood from members of the colony that has been collected on the cards. Members of the colony may be removed from the colony as a result of the analysis.

95. 发明申请

US20140170684A1 Methods, Devices, Kits and Compositions for Detecting Roundworm 有权
标题翻译：检测蛔虫的方法，装置，试剂盒和组合物
公开(公告)号：US20140170684A1
公开(公告)日：2014-06-19
申请号：US14045077
申请日：2013-10-03
申请人： IDEXX LABORATORIES, INC. , DIVERGENCE, INC.
发明人： David Allen Elsemore , Laurie A. Flynn , Jinming Geng , Michael Crawford
IPC分类号： G01N33/543
CPC分类号： G01N33/543 , C07K14/4354 , C07K16/18 , C12Q1/6888 , G01N33/5308
摘要： Methods, devices, kits and compositions for detecting the presence or absence of roundworm in a fecal sample are disclosed herein. The methods, devices, kits and compositions of the present invention may be used to confirm the presence or absence of roundworm in a fecal sample from a mammal that may also be infected with one or more of hookworm, whipworm, and heartworm. Confirmation of the presence or absence of roundworm in the mammal may be made, for example, for the purpose of selecting an optimal course of treating the mammal and/or for the purpose of determining whether the mammal has been rid of the infection after treatment has been initiated.
摘要翻译：本文公开了用于检测粪便样品中蛔虫存在或不存在的方法，装置，试剂盒和组合物。本发明的方法，装置，试剂盒和组合物可以用于确认来自哺乳动物的粪便样品中是否存在蛔虫，所述蛔虫样品也可能被钩虫，鞭虫和心丝虫中的一种或多种感染。可以确认哺乳动物中蛔虫的存在或不存在，例如，为了选择治疗哺乳动物和/或为了确定哺乳动物是否已经在治疗后已经除去感染的目的的最佳方法已经启动

96. 发明申请

US20130186475A1 FLUID PRESSURE CONTROL DEVICE FOR AN ANALYZER 有权
标题翻译：用于分析仪的流体压力控制装置
公开(公告)号：US20130186475A1
公开(公告)日：2013-07-25
申请号：US13744458
申请日：2013-01-18
申请人： IDEXX Laboratories Inc.
发明人： Bernhard Heitz , Kevin Kirspel
IPC分类号： G01N27/416
CPC分类号： G01N27/4163 , G01N33/0006 , G01N33/4925 , Y10T137/0396 , Y10T137/7793
摘要： A fluid pressure control device, including a pressurized fluid inlet, a first valve in fluid communication with the pressurized fluid inlet and controlling the flow of fluid from the pressurized fluid inlet, a first pressure measurement device detecting a fluid pressure downstream of the first valve, and a controller electrically coupled to the first valve. The first pressure measurement device causes the controller to operate the first valve such that a fluid downstream of the first valve is maintained at a substantially constant pressure.
摘要翻译：一种流体压力控制装置，包括加压流体入口，与加压流体入口流体连通并控制来自加压流体入口的流体流动的第一阀，检测第一阀下游的流体压力的第一压力测量装置，以及电耦合到所述第一阀的控制器。第一压力测量装置使得控制器操作第一阀，使得第一阀下游的流体保持在基本恒定的压力。

97. 发明申请

US20020148728A1 Immunoassays in capillary tubes 审中-公开
标题翻译：毛细血管中的免疫测定
公开(公告)号：US20020148728A1
公开(公告)日：2002-10-17
申请号：US10034424
申请日：2001-12-28
申请人： IDEXX Laboratories, Inc.
发明人： Amit Kumar , Larry Sheldon Jang , Danton Kai-Yu Leung , Richard Michele Rocco , Mark Charles Platshon
IPC分类号： G01F001/64 , C12M001/34
CPC分类号： G01N21/03 , G01N21/6428 , G01N33/54366 , G01N33/552 , G01N33/94 , G01N35/00 , G01N2021/0346 , G01N2021/6482
摘要： A fluorescent immunoassay employing the interior surface of a capillary tube is provided. Devices to permit immunoassays using one or more capillary tubes, an apparatus for use with the devices, and a process for screening for analyte in a sample using the devices and apparatus are also provided. Samples suspected of containing analyte are added to a disposable self-contained sample tray containing one or more sample wells, mixed with a reagent, drawn into one or more spaced-apart capillary tubes held within a disposable cartridge connected to an analytical apparatus, reacted with a binding member on the surface of the capillary tube, washed to stop the reaction, and dried by the apparatus. The capillary tube is then exposed to a signal generation device to create a fluorescence signal that is detected using a signal detector. The apparatus determines the presence of the analyte and optionally determines the amount of analyte present in the sample, and presents the results to the operator.
摘要翻译：提供采用毛细管内表面的荧光免疫测定法。还提供了使用一个或多个毛细管进行免疫测定的装置，用于装置的装置以及使用装置和装置筛选样品中的分析物的方法。怀疑含有分析物的样品被加入到一次性独立的样品盘中，该样品盘含有一个或多个样品孔，与试剂混合，被抽吸到一个或多个间隔开的毛细管中，所述毛细管保持在与分析装置连接的一次性盒中，与在毛细管表面上的结合构件，洗涤以停止反应，并通过该装置干燥。然后将毛细管暴露于信号产生装置以产生使用信号检测器检测的荧光信号。该装置确定分析物的存在并且任选地确定样品中存在的分析物的量，并将结果呈现给操作者。

98. 发明公开

US20230184636A1 Devices and Methods for Particle Solution Preparation 审中-公开
公开(公告)号：US20230184636A1
公开(公告)日：2023-06-15
申请号：US18078528
申请日：2022-12-09
申请人： IDEXX Laboratories, Inc.
发明人： Arvind Dev , Julie Rollins , Richard Holt , Michael A. Schrameyer , Richard Lemieux , Nicholas Gustafson , Andrey Asanov
IPC分类号： G01N1/28 , G01N1/10 , G01N1/08
CPC分类号： G01N1/2806 , G01N1/10 , G01N1/08 , G01N2001/185
摘要： A method for preparing an aliquot of solution comprising a plurality of particles is disclosed. The method includes agitating the solution with a baffle at a predetermined mixing speed to suspend the plurality of particles in the solution, wherein the baffle positioned at least partially within a vessel containing the solution, and wherein the vessel is engaged with a vessel receptacle configured to hold the vessel. The method also includes withdrawing, during the agitating, the aliquot of solution from the vessel with a pipette, such that an end of a pipette tip is positioned within the vessel.

99. 发明公开

US20230181421A1 Devices and Methods for Particle Solution Testing 审中-公开
公开(公告)号：US20230181421A1
公开(公告)日：2023-06-15
申请号：US18078519
申请日：2022-12-09
申请人： IDEXX Laboratories, Inc.
发明人： Jason Cyr , Kevin Chamberland , Stephan Hersey , Arvind Dev , Julie Rollins , Andrey Asanov
IPC分类号： A61J1/20 , A61M5/178 , A61M5/19
CPC分类号： A61J1/2096 , A61M5/1782 , A61M5/19 , A61J2205/10
摘要： A method for withdrawing a solution comprising a plurality of particles from a vial is disclosed. The method includes agitating the vial at a first predetermined mixing speed to suspend the plurality of particles in the solution. The method also includes withdrawing, during the agitating, a first volume of the solution from the vial with a pipette, such that an end of a pipette tip is positioned at a first predetermined depth within the vial.

100. 发明授权

US11441997B2 Quality control for point-of-care diagnostic systems 有权
公开(公告)号：US11441997B2
公开(公告)日：2022-09-13
申请号：US16368929
申请日：2019-03-29
申请人： IDEXX Laboratories, Inc.
发明人： Jeremy Hammond , Timothy Butcher , Jui Ming Lin , James Russell
IPC分类号： G01N15/14 , G16H50/20 , G16H40/40
摘要： The present disclosure relates to quality control for point-of-care medical diagnostic systems. In various embodiments, the system includes an on-board storage containing a synthetic quality control material, a plurality of sub-systems having a plurality of operating parameters and including a material analyzer, a database storing quality control results that include results of the material analyzer analyzing the synthetic quality control material over time, one or more processors, and at least one memory storing instructions which, when executed by the one or more processors, cause the system to, automatically without user intervention: generate a control chart based on the quality control results, determine that a parameter of the plurality of operating parameters is out-of-tolerance based on the control chart, and adjust at least one of the plurality of sub-systems without user intervention to bring the out-of-tolerance parameter to within tolerance.

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