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91. 发明授权

US09617560B2 Simian (gorilla) adenovirus or adenoviral vectors and methods of use 有权
公开(公告)号：US09617560B2
公开(公告)日：2017-04-11
申请号：US14349470
申请日：2012-10-05
申请人： GenVec, Inc.
发明人： Douglas E. Brough , Jason G. D. Gall , Duncan McVey
IPC分类号： C12N15/86 , C07K14/005 , C12N7/00
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/10322 , C12N2710/10333 , C12N2710/10343 , C12N2760/18034 , C12N2760/18522 , C12N2840/60
摘要： The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.

92. 发明授权

US09586998B2 Methods of propagating monkey adenoviral vectors 有权
标题翻译：繁殖猴腺病毒载体的方法
公开(公告)号：US09586998B2
公开(公告)日：2017-03-07
申请号：US14817910
申请日：2015-08-04
申请人： GenVec, Inc.
发明人： Jason Gall , Douglas Brough , Christoph Kahl , Duncan McVey
IPC分类号： C07K14/005 , C12N15/86 , C12N7/00
CPC分类号： C07K14/005 , C12N7/00 , C12N15/86 , C12N2710/10322 , C12N2710/10332 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides methods for propagating a monkey adenovirus in a cell, including a human cell, comprising one or more gene products isolated from a human adenovirus. Also provided are methods for propagating wherein the monkey adenovirus comprises a nucleic acid sequence encoding a human adenovirus gene product. The invention further provides a monkey adenovirus, including a replication-deficient monkey adenovirus, obtained by such propagation methods.
摘要翻译：本发明提供了在细胞中繁殖猴腺病毒的方法，包括人细胞，其包含从人腺病毒分离的一种或多种基因产物。还提供了用于繁殖的方法，其中猴腺病毒包含编码人腺病毒基因产物的核酸序列。本发明还提供了通过这种繁殖方法获得的猴腺病毒，其包括复制缺陷型猴腺病毒。

93. 发明授权

US09233153B2 Affenadenovirus (gorilla) or adenoviral vectors and methods of use 有权
标题翻译：腺病毒（大猩猩）或腺病毒载体及使用方法
公开(公告)号：US09233153B2
公开(公告)日：2016-01-12
申请号：US14349421
申请日：2012-10-05
申请人： GenVec, Inc.
发明人： Jason G. D. Gall , Duncan McVey , Douglas E. Brough
IPC分类号： C07K14/005 , C12N15/86 , A61K39/155
CPC分类号： C12N15/86 , A61K39/155 , A61K48/00 , C07K14/005 , C12N7/00 , C12N2710/10043 , C12N2710/10322 , C12N2710/10333 , C12N2710/10343
摘要： The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pIX protein, DNA polymerase protein, penton protein, hexon protein, and/or fiber protein.
摘要翻译：本发明提供了一种腺病毒或腺病毒载体，其特征在于包含一个或多个特定的核酸序列或一个或多个特定的氨基酸序列或其部分，涉及例如腺病毒pIX蛋白，DNA聚合酶蛋白，penton蛋白，六邻体蛋白质和/或纤维蛋白质。

94. 发明申请

US20150297699A1 MALARIA ANTIGENS AND METHODS OF USE 有权
标题翻译： MALARIA抗原和使用方法
公开(公告)号：US20150297699A1
公开(公告)日：2015-10-22
申请号：US14441988
申请日：2013-11-12
申请人： GENVEC, INC.
发明人： Ping Chen , Duncan McVey , Douglas Brough , Joseph Bruder
IPC分类号： A61K39/015
CPC分类号： A61K39/015 , A61K2039/5256 , A61K2039/53 , Y02A50/412
摘要： The invention is directed to a composition comprising one or more polypeptides or one or more nucleic acid sequences that can induce a protective immune response against Plasmodium species that infect humans. The invention also is directed to a method of using such compositions to induce a protective immune response against a Plasmodium parasite in a mammal.
摘要翻译：本发明涉及包含一种或多种多肽或一种或多种可诱导针对感染人的疟原虫物种的保护性免疫应答的核酸序列的组合物。本发明还涉及使用这样的组合物来诱导针对哺乳动物的疟原虫寄生虫的保护性免疫应答的方法。

95. 发明申请

US20150167018A1 MODIFIED SEROTYPE 28 ADENOVIRAL VECTORS 有权
标题翻译：改性SEROTYPE 28 ADENOVIRAL VECTORS
公开(公告)号：US20150167018A1
公开(公告)日：2015-06-18
申请号：US14403651
申请日：2013-05-28
申请人： GenVec, Inc.
发明人： Lisa Wei , Douglas E. Brough , C. Richter King
IPC分类号： C12N15/86 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/0008 , C12N2710/10021 , C12N2710/10043 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2710/16634 , C12N2810/6018
摘要： The invention provides a replication-deficient serotype 28 adenoviral vector characterized by comprising a portion of a serotype 45 adenoviral hexon protein and/or a portion of a serotype 45 fiber protein in place of the endogenous serotype 28 hexon and/or fiber protein.
摘要翻译：本发明提供了一种复制缺陷型血清型28腺病毒载体，其特征在于包含部分血清型45腺病毒六邻体蛋白和/或血清型45纤维蛋白的一部分代替内源性血清型28六邻体和/或纤维蛋白。

96. 发明申请

US20040166091A1 Materials and methods for treating disorders of the ear 审中-公开
标题翻译：用于治疗耳朵疾病的材料和方法
公开(公告)号：US20040166091A1
公开(公告)日：2004-08-26
申请号：US10373249
申请日：2003-02-24
申请人： GenVec, Inc.
发明人： Douglas E. Brough
IPC分类号： A61K048/00 , C12N015/861
CPC分类号： A61K38/17 , A61K38/00 , A61K48/005 , A61P27/00 , C07K14/4702 , C12N7/00 , C12N15/86 , C12N2501/60 , C12N2710/10343
摘要： The invention is directed to a method of changing the sensory perception of an animal. The method comprises administering an expression vector comprising a nucleic acid sequence encoding an atonal-associated factor, which is expressed to produce the atonal-associated factor resulting in generation of hair cells that allow perception of stimuli in the inner ear. Also provided is a method of generating a hair cell in differentiated sensory epithelia in vivo. The method comprises contacting differentiated sensory epithelial cells with an adenoviral vector (a) deficient in one or more replication-essential gene functions of the E1 region and E4 region, (b) comprising a spacer in the E4 region, and (c) comprising a nucleic acid sequence encoding an atonal-associated factor. The nucleic acid sequence is expressed to produce the atonal-associated factor such that a hair cell is generated. An adenoviral vector encoding an atonal-associated factor also is provided.
摘要翻译：本发明涉及一种改变动物的感觉知觉的方法。所述方法包括施用包含编码无关联因子的核酸序列的表达载体，所述核酸序列被表达以产生导致产生能够感知内耳中的刺激的毛细胞的无关性因子。还提供了一种在体内在分化感觉上皮细胞中产生毛细胞的方法。该方法包括使分化的感觉上皮细胞与E1区和E4区的一个或多个复制必需基因功能缺陷的腺病毒载体（a）接触，（b）在E4区中包含间隔基，和（c）包含编码无关联因子的核酸序列。表达核酸序列以产生无创因子，从而产生毛细胞。还提供了编码无关联因子的腺病毒载体。

97. 发明申请

US20030175245A1 Replication deficient adenoviral TNF vector 审中-公开
公开(公告)号：US20030175245A1
公开(公告)日：2003-09-18
申请号：US10424638
申请日：2003-04-25
申请人： GenVec, Inc.
发明人： Douglas E. Brough , C. Richter King , Imre Kovesdi , Jasper J. Schaible
IPC分类号： A61K048/00 , C12N007/00 , C12N015/861
CPC分类号： C12N15/86 , A61K38/191 , A61K48/00 , C12N2710/10343 , C12N2810/40
摘要： An adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a radiation inducible promoter operably linked to the nucleic acid sequence coding for TNF. This invention also provides an adenoviral vector comprising (a) an adenoviral genome deficient in the E4 region of the adenoviral genome, (b) a nucleic acid sequence coding for TNF, and (c) a spacer element of at least 15 base pairs in the E4 region of the adenoviral genome. A method of producing an adenoviral vector and a method of treating a tumor or cancer in a host comprising administering an anti-cancer or anti-tumor effective amount of the adenoviral vector of the present invention also is provided.

98. 发明申请

US20030099619A1 Method and composition for targeting an adenoviral vector 审中-公开
标题翻译：用于靶向腺病毒载体的方法和组合物
公开(公告)号：US20030099619A1
公开(公告)日：2003-05-29
申请号：US10304160
申请日：2002-11-25
申请人： GenVec, Inc.
发明人： Thomas J. Wickham , Imre Kovesdi , Petrus W. Roelvink , David Einfeld , Douglas E. Brough , Alena Lizonova
IPC分类号： A61K048/00 , C12Q001/70 , C12N015/861 , C07K014/705 , C07K014/075
CPC分类号： C12N15/86 , A61K48/00 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/80 , C12N2830/008
摘要： The invention provides adenoviral coat proteins comprising various non-native ligands. Further, the present invention provides an adenoviral vector that elicits less reticulo-endothelial system (RES) clearance in a host animal than a corresponding wild-type adenovirus. Also provided by the invention is a system comprising a cell having a non-native cell-surface receptor and a virus having a non-native ligand, wherein the non-native ligand of the virus binds the non-native cell-surface receptor of the cell. Using this system, a virus can be propagated. Further provided by the invention is a method of controlled gene expression utilizing selectively replication competence, a method of assaying for gene function, a method of isolating a nucleic acid, and a method of identifying functionally related coding sequences. Additionally, the invention provides a cell-surface receptor, which facilitates internalization.
摘要翻译：本发明提供了包含各种非天然配体的腺病毒外壳蛋白。此外，本发明提供了一种腺病毒载体，其在宿主动物中比相应的野生型腺病毒引起较少的网状内皮系统（RES）清除。本发明还提供了一种包含具有非天然细胞表面受体的细胞和具有非天然配体的病毒的系统的系统，其中所述病毒的非天然配体结合所述非天然细胞表面受体的非天然细胞表面受体细胞。使用该系统可以传播病毒。本发明进一步提供了利用选择性复制能力的受控基因表达的方法，基因功能测定方法，分离核酸的方法和识别功能相关编码序列的方法。另外，本发明提供了促进内化的细胞表面受体。

99. 发明申请

US20030086904A1 Therapeutic regimen for treating cancer 有权
标题翻译：治疗癌症的治疗方案
公开(公告)号：US20030086904A1
公开(公告)日：2003-05-08
申请号：US10151633
申请日：2002-05-17
申请人： GenVec, Inc.
发明人： Henrik S. Rasmussen , Karen W. Chu
IPC分类号： A61K048/00 , C12N007/00 , C12N015/861
CPC分类号： A61K35/761 , A61K38/191 , C12N2710/10332 , C12N2710/10341 , A61K2300/00
摘要： The invention provides a method for treating cancer in a human comprising administering to the human a dose of a pharmaceutical composition comprising (i) a pharmaceutically acceptable carrier and (ii) an adenoviral vector comprising a nucleic acid sequence encoding TNF-null operably linked to a promoter, wherein the dose comprises about 1null107 to about 4null1012 particle units (pu) of replication-deficient adenoviral vector, at least once in a therapeutic period comprising up to 10 weeks, whereby the cancer in human is treated. The invention further provides a method of treating a human for multiple tumors, wherein the method comprises contacting a first tumor with a dose of the pharmaceutical composition at least once in a therapeutic period comprising up to about 10 weeks, whereby the human is treated for the first tumor and one or more additional tumors.
摘要翻译：本发明提供了一种治疗人类癌症的方法，包括向人施用剂量的药物组合物，其包含（i）药学上可接受的载体和（ii）腺病毒载体，其包含编码与α-α可操作地连接的TNF-α的核酸序列启动子，其中所述剂量包含约1×10 7至约4×10 12个复制缺陷型腺病毒载体的颗粒单位（pu），在至多10周的治疗期内至少一次，由此治疗人类的癌症。本发明进一步提供了治疗多种肿瘤的方法，其中所述方法包括使第一肿瘤与一定剂量的药物组合物在至多约10周的治疗期内至少接触一次，由此将该人治疗为第一肿瘤和一个或多个另外的肿瘤。

100. 发明申请

US20030054553A1 Adenovector complementing cells 有权
标题翻译： Adenovector补体细胞
公开(公告)号：US20030054553A1
公开(公告)日：2003-03-20
申请号：US09910828
申请日：2001-07-23
申请人： GenVec, Inc.
发明人： Douglas E. Brough , Jason G.D. Gall , Imre Kovesdi
IPC分类号： C12N015/861 , C12N007/00 , C12N005/08
CPC分类号： C12N15/86 , C12N7/00 , C12N2710/10343 , C12N2710/10352
摘要： The invention provides cells, particularly NCI-H460 cells and Calu-1 cells, for the propagation of replication-deficient adenoviral vectors. The cells are lung carcinomas with either a wild-type p53 gene or a heterozygous K-ras mutation. The cells comprise at least one adenoviral nucleic acid sequence, which upon expression produces a gene product that complements for at least one essential gene function of one or more regions of an adenoviral genome so as to propagate a replication-deficient adenoviral vector comprising an adenoviral genome deficient in the at least one essential gene function of the one or more regions when present in the cell.
摘要翻译：本发明提供用于增殖复制缺陷型腺病毒载体的细胞，特别是NCI-H460细胞和Calu-1细胞。细胞是具有野生型p53基因或杂合K-ras突变的肺癌。细胞包含至少一种腺病毒核酸序列，其在表达时产生补充腺病毒基因组的一个或多个区域的至少一个必需基因功能的基因产物，以便繁殖包含腺病毒基因组的复制缺陷型腺病毒载体当存在于细胞中时，一个或多个区域的至少一个必需基因功能缺陷。

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