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91. 发明授权

US06319664B1 Low protein-binding polymer product produced using low HLB number non-ionic surfactant 有权
标题翻译：使用低HLB值非离子表面活性剂制备的低蛋白结合聚合物产物
公开(公告)号：US06319664B1
公开(公告)日：2001-11-20
申请号：US09507422
申请日：2000-02-18
申请人： Dana Craig Bookbinder , Edward John Fewkes, Jr. , James Arthur Griffin , Frances M. Smith , David L. Tennent
发明人： Dana Craig Bookbinder , Edward John Fewkes, Jr. , James Arthur Griffin , Frances M. Smith , David L. Tennent
IPC分类号： C12Q100
CPC分类号： C07H21/00 , B01L3/50 , B01L3/5082 , B01L2200/12 , B01L2300/16 , B05D7/02 , C07B2200/11 , C08J7/047 , C08J7/065 , C08J2471/00 , C09D5/00 , G01N33/54393
摘要： Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying to a hydrophobic polymer surface a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 and at least one hydrophilic element which can extend into an aqueous solution; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions. Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article. Molding uses shear condition that cause the surfactant to move to the surface of a polymer product formed by the molding such that a hydrophilic part of the surfactant extends from the surface to provide a surface having low binding for proteins.
摘要翻译：蛋白质结合水平小于约50-80ng / cm 2的疏水性聚合物表面通过以下方式实现：（1）将疏水性聚合物表面施用由HLB值少的溶剂和非离子表面活性剂组成的涂布溶液可以延伸至水溶液中的至少一种亲水性元素; 和（2）干燥表面以除去溶剂，从而使表面活性剂与疏水性聚合物直接接触。已经发现低HLB值和干燥步骤的组合产生低结合表面，其可以经受多次用水和/或蛋白质溶液洗涤。或者，低结合表面可以通过将非离子表面活性剂施加到与熔融聚合物接触的模具表面并将聚合物形成期望的形状，例如多孔板，移液管尖端等中来制备。此外，低粘合表面可以通过将HLB数小于或等于10的非可溶性非离子表面活性剂在模制制品之前加入到聚合物共混物中来制备。成型使用剪切条件，使得表面活性剂移动到通过模制形成的聚合物产品的表面，使得表面活性剂的亲水部分从表面延伸，以提供具有低蛋白质结合的表面。

92. 发明授权

US09878272B2 Porous inorganic membranes and method of manufacture 有权
公开(公告)号：US09878272B2
公开(公告)日：2018-01-30
申请号：US13115349
申请日：2011-05-25
申请人： Dana Craig Bookbinder , Gary S Calabrese , Yunfeng Gu , Jianguo Wang
发明人： Dana Craig Bookbinder , Gary S Calabrese , Yunfeng Gu , Jianguo Wang
IPC分类号： B01D29/05 , B01D67/00 , B01D71/02
CPC分类号： B01D29/05 , B01D67/0046 , B01D67/0058 , B01D67/0095 , B01D71/02 , B01D71/024 , B01D71/025 , B01D71/027 , B01D71/028 , B01D2325/04 , Y10T428/249981
摘要： A method is provided for making a porous inorganic membrane by using a mixture of an inorganic material, organic polymer particles and a solvent to form a slurry, the particles being non-spherical, distributing the slurry onto a surface, drying the slurry to remove the solvent and firing the dried slurry to produce the porous inorganic membrane. Examples of organic polymer particles include particles of acrylic. A substrate with a porous inorganic membrane disposed on the substrate is also provided, the inorganic membrane having an average thickness of from about 0.5 micron to about 30 microns, a porosity of from about 30% to about 65%, a median pore size (d50) of from about 0.01 micron to about 1 micron, and a value of (d90−d10)/d50 less than about 2, as measured by mercury porosimetry. An example of a substrate includes an inorganic porous support.

93. 发明授权

US09193625B2 Glass with surface and central regions under compression 有权
标题翻译：玻璃表面和中心区域受压缩
公开(公告)号：US09193625B2
公开(公告)日：2015-11-24
申请号：US13989585
申请日：2011-11-29
申请人： Dana Craig Bookbinder , Timothy Michael Gross
发明人： Dana Craig Bookbinder , Timothy Michael Gross
IPC分类号： C03C21/00 , B32B17/00 , B32B17/10 , C03C3/083 , C03B23/203
CPC分类号： C03C21/002 , B32B17/06 , B32B17/10045 , B32B17/10137 , C03B23/203 , C03C3/083 , Y10T428/131 , Y10T428/24992
摘要： A glass article having an engineered stress profile. The central or core region of the glass is in compression and the surface or outer region of the glass is either under neutral stress or in compression. The outer surface region and the core region are separated by an intermediate region that is under tension. A flaw that penetrates the outer region in compression will propagate in the underlying tensile intermediate layer, but will not penetrate though the compressive core region of the glass. The compressive core region prevents flaws from penetrating through the thickness of the glass.
摘要翻译：具有工程应力分布的玻璃制品。玻璃的中心或核心区域处于压缩状态，玻璃的表面或外部区域处于中性应力或压缩状态。外表面区域和芯区域被处于张力的中间区域分开。在压缩中穿透外部区域的缺陷将在下面的拉伸中间层中传播，但是不会穿过玻璃的压缩芯部区域。压缩芯区域防止瑕疵穿透玻璃的厚度。

94. 发明申请

US20150306847A1 Facilitated Processing for Controlling Bonding Between Sheet and Carrier 有权
标题翻译：用于控制片材和载体之间的粘合的便利处理
公开(公告)号：US20150306847A1
公开(公告)日：2015-10-29
申请号：US14651720
申请日：2013-12-13
申请人： Robert Alan BELLMAN , Dana Craig BOOKBINDER , Robert George MANLEY , Prantik MAZUMDER , CORNING INCORPORATED
发明人： Robert Alan Bellman , Dana Craig Bookbinder , Robert George Manley , Prantik Mazumder
IPC分类号： B32B17/06 , B32B3/04 , B32B7/12
CPC分类号： B32B17/06 , B32B3/04 , B32B7/12 , B32B2255/26 , B32B2457/206 , B32B2457/208 , C03C27/10 , C03C2218/328 , H01L51/0096 , Y02E10/549
摘要： A method of forming an article from a glass sheet (20) having a glass-sheet bonding surface (24) and a glass carrier (10) having a carrier bonding surface (14). At least one of the glass sheet and carrier bonding surfaces is coated with a surface modification layer (30), and then the glass sheet is connected with the carrier via the surface modification layer. From the perimeter of the glass sheet and the carrier while connected, there is removed a portion of the surface modification layer so as to expose a portion (19, 29) of the bonding surface on each of the glass sheet and the carrier. The glass sheet and carrier are then heated at a temperature ≧400° C. so as to bond the perimeter of the glass sheet (26) with the perimeter of the carrier (16).
摘要翻译：一种从具有玻璃板接合面（24）的玻璃板（20）和具有载体接合面（14）的玻璃载体（10）形成物品的方法。玻璃板和载体接合面中的至少一个涂覆有表面改性层（30），然后玻璃板经由表面改性层与载体连接。从连接的玻璃板和载体的周边起，除去一部分表面改性层，以便露出玻璃板和载体上的每一个上的接合表面的部分（19,29）。然后将玻璃板和载体在≥400℃的温度下加热，以便将玻璃板（26）的周边与载体（16）的周边粘合。

95. 发明授权

US08981025B2 Polymerizable catonic peptide monomers and polymers 有权
标题翻译：可聚合的共聚肽单体和聚合物
公开(公告)号：US08981025B2
公开(公告)日：2015-03-17
申请号：US13369689
申请日：2012-02-09
申请人： Dana Craig Bookbinder , Paul Ernest Gagnon, Jr. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
发明人： Dana Craig Bookbinder , Paul Ernest Gagnon, Jr. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
IPC分类号： C08F222/38 , C08G69/10 , C08F220/70 , C08F220/58
CPC分类号： C08F222/38 , C08F220/58 , C08F220/70 , C08G69/10
摘要： Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaan-Z1n1 wherein Z and Z1 are polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.
摘要翻译：本文公开了官能化的阳离子肽单体：选自赖氨酸或精氨酸或其衍生物的两个或更多个带正电荷的氨基酸的肽链，其被官能化，意味着它们与一个或多个聚合部分结合。官能化阳离子肽单体可以用式Z-Xanan-Z1n1描述，其中Z和Z 1是聚合部分，n 1是0或1的整数; Xaa各自独立地是氨基酸Lys或Arg，n是2至10的整数，并且其中Xaa的至少一个Xaa氨基酸是Lys，其中氨基酸序列的羧基末端被酰胺化。官能化阳离子肽单体可以组合并聚合以形成细胞培养物表面。

96. 发明授权

US08842957B2 Multimode optical fiber and system incorporating such 有权
标题翻译：多模光纤及其结合的系统
公开(公告)号：US08842957B2
公开(公告)日：2014-09-23
申请号：US13432553
申请日：2012-03-28
申请人： Scott Robertson Bickham , Dana Craig Bookbinder , Xin Chen , Ming-Jun Li , Pushkar Tandon
发明人： Scott Robertson Bickham , Dana Craig Bookbinder , Xin Chen , Ming-Jun Li , Pushkar Tandon
IPC分类号： G02B6/02 , G02B6/028
CPC分类号： G02B6/0288 , G02B6/0281
摘要： According to some embodiments, a multimode optical fiber comprises a graded index glass core with refractive index Δ1, a maximum refractive index delta Δ1MAX, and a core radius between 10 and 40 microns; and cladding region surrounding the core comprising refractive index Δ4, wherein the fiber exhibits an overfilled bandwidth at an operating wavelength in a 900 to 1250 nm wavelength range of greater than 2.5 GHz-km. According to some embodiments the fiber exhibits an overfilled bandwidth at a wavelength between 950 and 1100 nm which is greater than 4 GHz-km. According to some embodiments the fiber exhibits an overfilled bandwidth at a wavelength between 950 and 1100 nm which is greater than 10 GHz-km.
摘要翻译：根据一些实施例，多模光纤包括具有折射率＆Dgr; 1，最大折射率δ＆Dgr; 1MAX和10至40微米的芯半径的渐变折射率玻璃芯; 以及围绕包含折射率＆Dgr; 4的芯的包覆区域，其中在大于2.5GHz-km的900至1250nm波长范围内的光纤在工作波长处表现出过满的带宽。根据一些实施方案，光纤在950和1100nm之间的波长上表现出超过4GHz-km的过满的带宽。根据一些实施例，在大于10GHz-km的波长在950和1100nm之间的光纤表现出过满的带宽。

97. 发明申请

US20130322837A1 MULTIMODE OPTICAL FIBER AND SYSTEM COMPRISING SUCH FIBER 有权
标题翻译：多模光纤和包含这种光纤的系统
公开(公告)号：US20130322837A1
公开(公告)日：2013-12-05
申请号：US13553899
申请日：2012-07-20
申请人： Scott Robertson Bickham , Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
发明人： Scott Robertson Bickham , Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
IPC分类号： G02B6/028
CPC分类号： G02B6/0288 , G02B6/02023 , G02B6/0281 , G02B6/0365
摘要： One exemplary multimode optical fiber includes a graded index glass core having a diameter in the range of 41 microns to 80 microns, a graded index having an alpha less than 2.04 and a maximum relative refractive index in the range between 0.6% and 1.8%. The cladding includes a depressed-index annular portion. The fiber has an overfilled bandwidth greater than 2.5 GHz-km at at least one wavelength between 1200 nm and 1700 nm.
摘要翻译：一个示例性多模光纤包括直径在41微米至80微米范围内的分级折射率玻璃芯，具有α小于2.04的分级折射率和0.6％至1.8％范围内的最大相对折射率。包层包括凹陷折射率的环形部分。该纤维在1200nm至1700nm之间的至少一个波长处具有大于2.5GHz-km的过满的带宽。

98. 发明授权

US08538219B2 Large effective area optical fiber with low bend loss 有权
标题翻译：具有低弯曲损耗的大面积有效面积的光纤
公开(公告)号：US08538219B2
公开(公告)日：2013-09-17
申请号：US12915388
申请日：2010-10-29
申请人： Scott Robertson Bickham , Dana Craig Bookbinder , Ming-Jun Li , Snigdharaj Kumar Mishra , Pushkar Tandon
发明人： Scott Robertson Bickham , Dana Craig Bookbinder , Ming-Jun Li , Snigdharaj Kumar Mishra , Pushkar Tandon
IPC分类号： G02B6/02
CPC分类号： G02B6/03683 , G02B6/02019
摘要： An optical fiber includes a central glass core region comprising maximum refractive index delta percent Δ1, a first inner annular region surrounding said core comprising refractive index delta percent Δ2, a depressed annular region surrounding said inner annular region and comprising Δ3 and a third annular region surrounding the depressed annular region comprising refractive index delta percent Δ4; wherein Δ1MAX>Δ4>Δ2>Δ3. The difference between Δ4 and Δ2 is greater than 0.01% and profile volume, |V3| is at least 10%-μm2. The fibers exhibit an effective area at 1550 nm which is greater than 110 μm2.
摘要翻译：光纤包括中心玻璃芯区域，其包括最大折射率Δ百分比Δ1，围绕所述芯的第一内环形区域，包括折射率Δ百分比Δ2，环绕所述内环形区域的凹陷环形区域，包括Delta3和包围第三环形区域凹陷的环形区域包括折射率Δ百分比Δ4; 其中Delta1MAX> Delta4> Delta2> Delta3。 Delta4和Delta2之间的差值大于0.01％，曲线体积| V3 | 至少为10％-mum2。纤维在1550nm处表现出大于110mum2的有效面积。

99. 发明申请

US20130114935A1 BEND LOSS RESISTANT MULTI-MODE FIBER 有权
标题翻译：弯曲耐磨多模光纤
公开(公告)号：US20130114935A1
公开(公告)日：2013-05-09
申请号：US13289029
申请日：2011-11-04
申请人： Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
发明人： Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
IPC分类号： G02B6/028
CPC分类号： G02B6/0288 , G02B6/0281 , G02B6/03627
摘要： A graded index multimode optical fiber comprising: (a) a silica core doped with germania, and at least one co-dopant, comprising one of P2O5 or F or B2O3, the core extending to outermost core radius, r1 and having a dual alpha, α1; (b) a low index inner cladding surrounding the core and off-set from said core; (c) an outer cladding surrounding and in contact with the inner cladding, such that at least the region of the inner cladding off-set from said core has a lower refractive index than the outer cladding. The center germania concentration at the centerline, CGe1, is greater than or equal to 0, and an outermost germania concentration in the core CGe2, at r1 is greater than or equal to 0. The core has a center co-dopant concentration at the centerline, Cc-d1, greater than or equal to 0, and an outermost co-dopant concentration Cc-d2, at r1, wherein Cc-d2 is greater than or equal to 0.
摘要翻译：一种分级折射率多模光纤，包括：（a）掺杂有氧化锗的二氧化硅芯，以及包含P2O5或F或B2O3之一的至少一种共掺杂物，所述芯延伸到最外芯半径r1并具有双重α， alpha1; （b）围绕所述芯并偏离所述芯的低折射率内包层; （c）包围并与内包层接触的外包层，使得至少从所述芯偏离的内包层的区域具有比外包层更低的折射率。中心线CGe1处的中心锗浓度大于或等于0，核心CGe2中r1处的最外层氧化铈浓度大于或等于0.核心在中心线处具有中心共掺杂剂浓度，Cc-d1，大于或等于0，最外侧辅助掺杂浓度Cc-d2在r1处，其中Cc-d2大于或等于0。

100. 发明申请

US20130114934A1 GE-P CO-DOPED MULTIMODE OPTICAL FIBER 有权
标题翻译： GE-P共掺多模光纤
公开(公告)号：US20130114934A1
公开(公告)日：2013-05-09
申请号：US13289021
申请日：2011-11-04
申请人： Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
发明人： Dana Craig Bookbinder , Ming-Jun Li , Pushkar Tandon
IPC分类号： G02B6/028
CPC分类号： G02B6/0288 , G02B6/0281
摘要： According to at least one embodiment a graded index multimode fiber comprises: (i) a silica based core co-doped with GeO2 and 1 to 12 mole % P2O5; the core having a dual alpha, α1 and α2, where 1.8≦α1≦2.4 and 1.9≦α2≦2.4 at the wavelength (λ) range between 840 and 1100 nm; and (ii) a silica based cladding region surrounding the core, wherein the fiber has a numerical aperture NA and 0.185≦NA≦0.25 (more preferably 0.185≦NA≦0.23). Preferably, the silica based cladding region surrounding the core has refractive index lower than that of pure silica.
摘要翻译：根据至少一个实施方案，分级折射率多模光纤包括：（i）与GeO 2和1至12摩尔％的P 2 O 5共掺的二氧化硅基核; 核心具有双α，α1和α2，其中波长（λ）范围在840和1100nm之间的1.8 @α1@ 2.4和1.9 @α2@ 2.4; 和（ii）围绕芯的二氧化硅基包覆区，其中纤维具有数值孔径NA和0.185 @ NA @ 0.25（更优选0.185 @ NA @ 0.23）。优选地，围绕芯的二氧化硅基包覆区的折射率优于纯二氧化硅的折射率。

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