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91. 发明专利

CL2011002222A1 Metodo para preparar una proteina biologica condicionalmente activa; metodo para preparar un modificador condicionalmente activo de respuesta biologica. 未知
公开(公告)号：CL2011002222A1
公开(公告)日：2012-03-23
申请号：CL2011002222
申请日：2011-09-08
申请人： BIOATLA LLC
发明人： SHORT JAY M , CHANG HWAI WEN , FREY GERHARD , FROST GREGORY
IPC分类号： A61K38/17 , A61K38/095 , C12Q1/68
摘要： Método para preparar una proteína biológica condicionalmente activa; proteína biológica; composición farmacéutica que comprende dicha proteína; método para preparar un modificador condicionalmente activo de respuesta biológica.

92. 发明专利

SG177687A1 SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION HOSTS 未知
公开(公告)号：SG177687A1
公开(公告)日：2012-02-28
申请号：SG2012003356
申请日：2010-07-16
申请人： BIOATLA LLC
发明人： SHORT JAY MILTON
摘要： The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!™) allows for simultaneous evolution of protein performance and expression optimization.

93. 发明专利

CA2804746A1 NOVEL METHODS OF PROTEIN EVOLUTION 未知
公开(公告)号：CA2804746A1
公开(公告)日：2012-01-19
申请号：CA2804746
申请日：2011-03-04
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： G01N33/68 , C07K1/00 , G06F19/16
摘要： The present invention is relevant to proteins and novel methods of protein evolution. The present invention further relates to methods of identifying and mapping mutant polypeptides formed from, or based upon, a template polypeptide.

94. 发明专利

CA2823044C EXPRESS HUMANIZATION OF ANTIBODIES 未知
公开(公告)号：CA2823044C
公开(公告)日：2022-08-16
申请号：CA2823044
申请日：2011-12-28
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： C12N15/09 , C07K16/18 , C12N15/10 , C12N15/12 , C12N15/63 , C12P21/08
摘要： The disclosure provides a method for generation of humanized full length antibodies in mammalian cells. A library of humanized variants is provided with high, validated human framework diversity without requiring back-mutations to retain original affinity. Synthetic CDR encoding fragment libraries derived from a template antibody are ligated to human framework region encoding fragments from a human framework pool limited only to germline sequences from a functionally expressed antibodies. The vector comprises a nucleic acid sequence encoding HC framework region 4. No CDR grafting or phage display is required.

95. 发明专利

RU2764074C2 УСЛОВНО АКТИВНЫЕ ХИМЕРНЫЕ АНТИГЕННЫЕ РЕЦЕПТОРЫ ДЛЯ МОДИФИЦИРОВАННЫХ Т-КЛЕТОК 未知
公开(公告)号：RU2764074C2
公开(公告)日：2022-01-13
申请号：RU2017109966
申请日：2015-08-27
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： C40B10/00 , A61K35/17 , A61K39/44 , A61P35/00 , C07K14/705 , C07K16/46 , C07K19/00 , C12N5/10 , C12N15/13 , C12N15/63 , C40B30/04
摘要： Изобретениеотноситсяк областибиохимии, вчастностик химерномуантигенномурецепторудлясвязыванияс тирозинкиназнымрецепторомфакторароста. Раскрытывекторэкспрессии, генно-инженернаяцитотоксическаяклетка, фармацевтическаякомпозиция. Такжераскрытспособполученияхимерногоантигенногорецептора, способлечениярака. Изобретениепозволяетэффективнолечитьзаболевание, ассоциированноес тирозинкиназнымрецепторомфакторароста. 6 н. и 17 з.п. ф-лы, 6 ил., 3 табл., 7 пр.

96. 发明专利

AU2021202064A1 Mirac Proteins 未知
公开(公告)号：AU2021202064A1
公开(公告)日：2021-04-29
申请号：AU2021202064
申请日：2021-04-01
申请人： BIOATLA LLC
发明人： SHORT JAY M , CHANG HWAI WEN , FREY GERHARD , FROST GREGORY
IPC分类号： C12Q1/68 , A61K38/17 , C07K14/00 , C12P21/00
摘要： MIRAC PROTEINS Abstract This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.

97. 发明专利

ES2819865T3 Proteínas dirigidas a ortólogos 未知
公开(公告)号：ES2819865T3
公开(公告)日：2021-04-19
申请号：ES18196116
申请日：2015-01-07
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： G01N33/543 , G01N33/573 , G01N33/68
摘要： Un método para identificar un anticuerpo mutante interespecies a partir de un anticuerpo plantilla de una especie, en donde el anticuerpo plantilla muestra una actividad en una primera diana de la especie y el anticuerpo plantilla tiene seis regiones determinantes de complementariedad que comprenden n residuos de aminoácidos, el método comprende las etapas de: i. generar una biblioteca de n conjuntos independientes de anticuerpos mutantes a partir del anticuerpo plantilla, cada conjunto comprende anticuerpos mutantes que tienen un número X de residuos de aminoácidos predeterminados diferentes en una única posición predeterminada de una de las seis regiones determinantes de complementariedad; en donde cada conjunto de anticuerpos mutantes difiere en la única posición predeterminada; y el número de anticuerpos mutantes diferentes generados es equivalente a n x X; ii. seleccionar los anticuerpos mutantes que muestran la actividad en un ortólogo de la primera diana en otra especie; y iii. tamizar los anticuerpos mutantes seleccionados para detectar un anticuerpo mutante interespecies que muestra la actividad en la primera diana.

98. 发明专利

AU2019203813B2 Simultaneous, Integrated Selection and Evolution of Antibody/Protein Performance and Expression in Production Hosts 未知
公开(公告)号：AU2019203813B2
公开(公告)日：2021-03-11
申请号：AU2019203813
申请日：2019-05-31
申请人： BIOATLA LLC
发明人： SHORT JAY MILTON
IPC分类号： C12P21/06 , C40B30/04
摘要： SIMULTANEOUS, INTEGRATED SELECTION AND EVOLUTION OF ANTIBODY/PROTEIN PERFORMANCE AND EXPRESSION IN PRODUCTION The present disclosure provides methods of integrating therapeutic protein and antibody generation and/or selection, evolution and expression in a eukaryotic host for manufacturing in a single system. Therapeutic proteins, including antibodies, are generated, optimized and manufactured in the same eukaryotic host system. The disclosed system of Comprehensive Integrated Antibody Optimization (CIAO!TM) allows for simultaneous evolution of protein performance and expression optimization.

99. 发明专利

AU2017207263B2 Diagnostics using conditionally active antibodies 未知
公开(公告)号：AU2017207263B2
公开(公告)日：2021-01-07
申请号：AU2017207263
申请日：2017-01-10
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： G01N33/574 , G01N33/536 , G01N33/543
摘要： A method of detecting tumor cells in a sample from a subject. In the method, a sample is encapsulated to produce capsules with the sample encapsulated therein. The capsules are incubated under cell culture conditions suitable for supporting cell activity and growth of the tumor cells and the encapsulated sample is contacted with a conditionally active antibody that has a higher binding affinity to a cell surface protein on one or more tumor cells under a first value of the condition in a tumor microenvironment, in comparison with the binding affinity of the conditionally active antibody to the same cell surface protein under a second value of the condition.

100. 发明专利

AU2019203048B2 Express humanization of antibodies 未知
公开(公告)号：AU2019203048B2
公开(公告)日：2020-10-22
申请号：AU2019203048
申请日：2019-04-30
申请人： BIOATLA LLC
发明人： SHORT JAY M
IPC分类号： C07K16/18 , C12N15/09 , C12N15/10 , C12N15/12 , C12N15/63 , C12P21/08
摘要： EXPRESS HUMANIZATION OF ANTIBODIES Abstract The disclosure provides a method for generation of humanized full length antibodies in mammalian cells. A library of humanized variants is provided with high, validated human framework diversity without requiring back-mutations to retain original affinity. Synthetic CDR encoding fragment libraries derived from a template antibody are ligated to human framework region encoding fragments from a human framework pool limited only to germline sequences from a functionally expressed antibodies. The vector comprises a nucleic acid sequence encoding HC framework region 4. No CDR grafting or phage display is required.

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