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91. 发明授权

US07785792B2 Targeted modification of chromatin structure 有权
标题翻译：靶向修饰染色质结构
公开(公告)号：US07785792B2
公开(公告)日：2010-08-31
申请号：US12217953
申请日：2008-07-10
申请人： Alan P. Wolffe , Elizabeth J. Wolffe, legal representative , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
发明人： Alan P. Wolffe , Trevor Collingwood , Philip D. Gregory , Andrew Snowden , Fyodor Urnov
IPC分类号： C12Q1/68 , C12Q1/66 , C12Q1/34 , C12N15/00
CPC分类号： C12N15/1058 , C07K14/4702 , C07K2319/00 , C07K2319/02 , C07K2319/09 , C07K2319/24 , C07K2319/43 , C07K2319/71 , C07K2319/75 , C07K2319/81 , C12N15/102 , C12N15/1034 , C12N15/62 , C12N15/63 , C12N15/66 , C12N15/67 , C12Q1/6811 , G06F19/22 , G06F19/28
摘要： Methods and compositions for targeted modification of chromatin structure, within a region of interest in cellular chromatin, are provided. Such methods and compositions are useful for facilitating processes such as, for example, transcription and recombination, that require access of exogenous molecules to chromosomal DNA sequences.
摘要翻译：提供了在细胞染色质感兴趣的区域内靶向修饰染色质结构的方法和组合物。这些方法和组合物可用于促进需要外源分子进入染色体DNA序列的过程，例如转录和重组。

92. 发明授权

US07704721B2 Compositions and methods to prevent AAV vector aggregation 有权
标题翻译：防止AAV载体聚集的组成和方法
公开(公告)号：US07704721B2
公开(公告)日：2010-04-27
申请号：US11141996
申请日：2005-06-01
申请人： John Fraser Wright , Guang Qu
发明人： John Fraser Wright , Guang Qu
IPC分类号： C12N7/02
CPC分类号： C12N7/00 , C12N2750/14111 , C12N2750/14151
摘要： Compositions and methods are provided for preparation of concentrated stock solutions of AAV virions without aggregation. Formulations for AAV preparation and storage are high ionic strength solutions (e.g. μ˜500 mM) that are nonetheless isotonic with the intended target tissue. This combination of high ionic strength and modest osmolarity is achieved using salts of high valency, such as sodium citrate. AAV stock solutions up to 6.4×1013 vg/mL are possible using the formulations of the invention, with no aggregation being observed even after ten freeze-thaw cycles. The surfactant Pluronic® F68 may be added at 0.001% to prevent losses of virions to surfaces during handling. Virion preparations can also be treated with nucleases to eliminate small nucleic acid strands on virions surfaces that exacerbate aggregation.
摘要翻译：提供组合物和方法用于制备没有聚集的AAV病毒体的浓缩储备溶液。用于AAV制备和储存的制剂是与目的组织等渗的高离子强度溶液（例如μ〜500mM）。高离子强度和适度渗透压的这种组合使用高价盐，例如柠檬酸钠。使用本发明的制剂可达到6.4×1013vg / mL的AAV储备溶液，即使在十次冻融循环后也没有观察到聚集。表面活性剂Pluronic®F68可以以0.001％添加，以防止在处理过程中损伤表面的病毒粒子。病毒颗粒制剂也可用核酸酶处理，以消除加重聚集的病毒粒子表面上的小核酸链。

93. 发明授权

US07622256B2 Method for selecting compounds that modulate MIF-induced expression of ICAM-1 and/or VCAM-1 失效
标题翻译：选择调节MIF诱导的ICAM-1和/或VCAM-1表达的化合物的方法
公开(公告)号：US07622256B2
公开(公告)日：2009-11-24
申请号：US11807604
申请日：2007-05-29
申请人： Kirk W. Johnson , Sharmila Vijay , Matthew Gross , Federico C. A. Gaeta
发明人： Kirk W. Johnson , Sharmila Vijay , Matthew Gross , Federico C. A. Gaeta
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： A61K31/437
摘要： Methods of antagonizing MIF activity using ibudilast are described. Also described are methods of screening for MIF antagonists. These agents can be used for treating addictions, including drug and behavioral addictions, as well as for treating neuropathic pain.
摘要翻译：描述了使用异丁司特拮抗MIF活性的方法。还描述了筛选MIF拮抗剂的方法。这些药物可用于治疗成瘾症，包括药物和行为上瘾，以及治疗神经性疼痛。

94. 发明授权

US07534775B2 Methods and compositions for modulating cardiac contractility 有权
标题翻译：调节心脏收缩力的方法和组合物
公开(公告)号：US07534775B2
公开(公告)日：2009-05-19
申请号：US11101095
申请日：2005-04-07
申请人： H. Steve Zhang , Lei Zhang
发明人： H. Steve Zhang , Lei Zhang
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/4703 , A61K48/00
摘要： Methods and compositions are provided for modulating cardiac contractility by regulating transcription of the phsopholamban gene using engineered zinc finger proteins.
摘要翻译：提供的方法和组合物通过使用工程化锌指蛋白调节phhopholamban基因的转录来调节心脏收缩力。

95. 发明授权

US07534613B2 Methods of treating parkinson's disease using viral vectors 有权
标题翻译：使用病毒载体治疗帕金森病的方法
公开(公告)号：US07534613B2
公开(公告)日：2009-05-19
申请号：US11102521
申请日：2005-04-08
申请人： Krys Bankiewicz , Janet Cunningham
发明人： Krys Bankiewicz , Janet Cunningham
IPC分类号： C12N15/63 , C12N15/00 , A01N63/00 , A01N43/04 , A61K48/00
CPC分类号： A61K31/198 , A01N63/00 , A61K9/5184 , A61K35/761 , A61K38/45 , A61K38/51 , A61K45/06 , A61K47/6901 , A61K48/00 , A61K48/0025 , A61K48/0075 , A61K51/00 , A61K51/0402 , C12N7/00 , C12N15/63 , C12N15/86 , C12N2750/14142 , C12N2750/14143 , C12Y401/01028
摘要： Methods of delivering viral vectors, particularly recombinant AAV virions, to the CNS are provided. Also provided are methods of treating Parkinson's Disease.
摘要翻译：提供将病毒载体，特别是重组AAV病毒粒子递送至CNS的方法。还提供治疗帕金森病的方法。

96. 发明授权

US07491531B2 Randomized libraries of zinc finger proteins 有权
标题翻译：锌指蛋白的随机文库
公开(公告)号：US07491531B2
公开(公告)日：2009-02-17
申请号：US10337216
申请日：2003-01-06
申请人： Casey C. Case , Edward J. Rebar , Andrew Jamieson
发明人： Casey C. Case , Edward J. Rebar , Andrew Jamieson
IPC分类号： C12N15/11 , C12N15/63 , C12N15/79
CPC分类号： C12N15/1079
摘要： The present invention relates to methods of using libraries of randomized zinc finger proteins to identify genes associated with selected phenotypes.
摘要翻译：本发明涉及使用随机锌指蛋白的文库鉴定与选择的表型相关的基因的方法。

97. 发明授权

US07449566B2 Polynucleotide encoding novel HCV non-structural polypeptide 有权
标题翻译：编码新型HCV非结构多肽的多核苷酸
公开(公告)号：US07449566B2
公开(公告)日：2008-11-11
申请号：US11195009
申请日：2005-08-02
申请人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
发明人： Doris Coit , Angelica Medina-Selby , Mark Selby , Michael Houghton
IPC分类号： C07H21/04 , C12N15/00 , A61K39/29
CPC分类号： C07K14/005 , A61K39/00 , A61K47/593 , A61K47/62 , A61K2039/53 , A61K2039/57 , C12N2770/24222
摘要： Polypeptides comprising a mutant non-structural Hepatitis C virus useful in diagnostic and/or immunogenic compositions are disclosed, in which the mutant is an N-terminal mutation that functionally disrupts the catalytic domain of NS3. Polynucleotides encoding these polypeptides, host cells transformed with polynucleotides and methods of using the polypeptides and polynucleotides are also disclosed.
摘要翻译：公开了包含可用于诊断和/或免疫原性组合物的突变非结构性丙型肝炎病毒的多肽，其中所述突变体是功能性破坏NS3的催化结构域的N-末端突变。还公开了编码这些多肽的多核苷酸，用多核苷酸转化的宿主细胞和使用多肽和多核苷酸的方法。

98. 发明授权

US07316911B2 Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases 失效
标题翻译：使用纤维蛋白溶解性金属蛋白酶治疗留置导管闭塞的方法
公开(公告)号：US07316911B2
公开(公告)日：2008-01-08
申请号：US11249646
申请日：2005-10-13
申请人： Christopher F. Toombs
发明人： Christopher F. Toombs
IPC分类号： C12Q1/56
CPC分类号： A61L29/048 , A61K38/00 , A61K38/4886 , A61L29/16 , A61L2300/254 , A61L2300/42 , C12Q1/56 , G01N33/86 , Y10S514/822
摘要： A method is provided for the localized intravascular administration of a fibrinolytic metalloproteinase to a human subject in amounts that are both safe and effective to lyse an occluding fibrin-containing blood clot, while also avoiding the neutralizing effects of α2-macroglobulin in the circulating blood. A method is also provided for the treatment of a blood clot in, around or attached to an indwelling vascular access device. A method for restoring patency and function of an indwelling vascular access device is also provided.
摘要翻译：提供了一种方法，用于对人受试者进行局部血管内给予纤维蛋白溶解性金属蛋白酶，其用量是安全和有效地裂解含闭塞纤维蛋白的凝块，同时也避免了α2的中和作用 > - 巨球蛋白在循环血液中。还提供了一种用于治疗在血管入口装置内，周围或附着于血管通路装置的血块的方法。还提供了一种恢复血管通路装置的通畅和功能的方法。

99. 发明授权

US07303760B2 Method for treating multi-drug resistant tumors 有权
标题翻译：多药耐药肿瘤治疗方法
公开(公告)号：US07303760B2
公开(公告)日：2007-12-04
申请号：US10714085
申请日：2003-11-14
申请人： Samuel Zalipsky , Alberto Gabizon
发明人： Samuel Zalipsky , Alberto Gabizon
IPC分类号： A61K9/127 , C07F9/02 , C07F53/00 , C07F321/00
CPC分类号： A61K31/407 , A61K47/543 , A61K47/6911
摘要： Methods for administering mitomycin C to a multi-drug resistant cell and for reducing the toxicity of the compound are described. In the methods, mitoymic C is provided in the form of a prodrug conjugate, where the drug is linked to a hydrophobic moiety, such as a lipid, through a cleavable dithiobenzyl linkage. The dithiobenzyl linkage is susceptible to cleavage by mild thiolysis, resulting in release of mitomycin C in its original form. The linkage is stable under nonreducing conditions. The prodrug conjugate can be incorporated into liposomes for administration in vivo and release of mitomycin C in response to endogenous in vivo reducing conditions or in response to administration of an exogenous reducing agent.
摘要翻译：描述了向多药耐药细胞施用丝裂霉素C并降低化合物的毒性的方法。在该方法中，丝裂蛋白C以前体药物缀合物的形式提供，其中药物通过可裂解的二硫代苄基键连接到疏水部分，例如脂质。二硫代苄基键易受到轻度硫解的裂解，导致丝裂霉素C以其原始形式释放。在非还原条件下，连接是稳定的。可以将前体药物缀合物掺入用于体内施用的体内脂质体中，并响应内源性体内还原条件或响应外源性还原剂的施用而释放丝裂霉素C.

100. 发明授权

US07291588B2 Immunogenic detoxified mutant E. coli LT-A toxin 失效
标题翻译：免疫原性解毒突变大肠杆菌LT-A毒素
公开(公告)号：US07291588B2
公开(公告)日：2007-11-06
申请号：US10304496
申请日：2002-11-25
申请人： Mariagrazia Pizza , Marzia Monica Giuliani , Rino Rappuoli
发明人： Mariagrazia Pizza , Marzia Monica Giuliani , Rino Rappuoli
IPC分类号： A61K39/108 , A61K38/16 , C07K14/195
CPC分类号： C07K14/245 , A61K38/00 , A61K39/00
摘要： An immunogenic detoxified protein is provided which comprises the amino acid sequence of subunit A of an E. coli heat labile toxin (LT-A) or a fragment thereof in which at least amino acid Ala-72 of the A subunits mutated, preferably by substitution with Arg. The toxoid is useful as vaccine against an enterotoxigenic strain of E. coli and is produced by recombinant DNA means by site-directed mutagenesis. It is also an effective adjuvant.
摘要翻译：提供免疫原性解毒蛋白，其包含大肠杆菌热不稳定毒素（LT-A）的亚基A的氨基酸序列或其片段，其中至少A亚基的氨基酸Ala-72突变，优选通过取代与精神。类毒素可用作针对大肠杆菌肠毒素菌株的疫苗，并且通过重组DNA方法通过定点诱变产生。它也是一种有效的佐剂。

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