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91. 发明申请

WO2010033991A2 DETECTION OF HUMAN SOMATIC CELL REPROGRAMMING 审中-公开
标题翻译：人体细胞重编程序的检测
公开(公告)号：WO2010033991A2
公开(公告)日：2010-03-25
申请号：PCT/US2009/057849
申请日：2009-09-22
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , DALEY, George Q. , PARK, In-Hyun , SCHLAEGER, Thorsten M. , CHAN, Elayne , RATANASIRINTRAWOOT, Sutheera
发明人： DALEY, George Q. , PARK, In-Hyun , SCHLAEGER, Thorsten M. , CHAN, Elayne , RATANASIRINTRAWOOT, Sutheera
IPC分类号： C12N5/071 , C12N5/02 , C12Q1/68
CPC分类号： G01N33/6872 , C12Q1/6881 , C12Q2600/124 , C12Q2600/158 , G01N33/502 , G01N33/5023 , G01N33/5044 , G01N33/5047 , G01N33/5073 , G01N33/53 , G01N33/536 , G01N33/56966 , G01N33/577 , G01N33/58 , G01N33/582 , G01N33/6854 , G01N2333/705 , G01N2333/70596 , G01N2333/90 , G01N2500/10
摘要： The methods and kits described herein are based, in part, to the discovery of a phenotype representing a fully-reprogrammed iPS cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed iPS cells and further permits one of skill in the art to monitor the emergence of iPS cells during the reprogramming process. The methods/kits can also be performed using real time using live cell imaging. Also described herein are methods for screening candidate reprogramming agents by monitoring the emergence of fully-reprogrammed iPS cells in the presence and absence of such an agent.
摘要翻译：本文所述的方法和试剂盒部分基于发现代表完全重编程序的iPS细胞和几种重编程中间体的表型。本文描述的方法和试剂盒允许识别完全重编程的iPS细胞，并且进一步允许本领域技术人员在重编程过程期间监测iPS细胞的出现。该方法/试剂盒也可以使用活细胞成像实时进行。本文还描述了通过在存在和不存在这种试剂的情况下监测完全重编程序的iPS细胞的出现来筛选候选重编程剂的方法。

92. 发明申请

WO2009149239A1 METHODS OF MODULATING ANGIOGENESIS VIA TRPV4 审中-公开
标题翻译：通过TRPV4调节血管生成的方法
公开(公告)号：WO2009149239A1
公开(公告)日：2009-12-10
申请号：PCT/US2009/046219
申请日：2009-06-04
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , THODETI, Charles, K.
发明人： INGBER, Donald, E. , THODETI, Charles, K.
IPC分类号： A61K38/00 , A61K31/70
CPC分类号： C12N15/1138 , A61K31/70 , A61K31/713 , A61K45/06 , C07K16/2842 , C12N2310/14 , G01N33/5064
摘要： The present invention relates to methods of inhibiting capillary endothelial (CE) cell migration, the formation of CE networks and angiogenesis, and uses thereof for the purpose of treating angiogenesis-related diseases and disorders, particularly when the diseases or disorders are directly related aberrant angiogenesis. Inhibition is achieved by inhibiting TRPV4 activity, such as the levels of TRPV4 expression, calcium influx through TRPV4, and/or the intracellular signaling from TRPV4 via β1 integrin activation.
摘要翻译：本发明涉及抑制毛细血管内皮细胞迁移，CE网络形成和血管生成的方法及其用于治疗血管生成相关疾病和病症的用途，特别是当疾病或病症直接相关异常血管生成。通过抑制TRPV4活性，例如TRPV4表达的水平，通过TRPV4的钙流入和/或通过β1整联蛋白激活来自TRPV4的细胞内信号传导来实现抑制。

93. 发明申请

WO2009129524A2 HIGH-THROUGHPUT PLASMID DNA PREPARATION 审中-公开
标题翻译：高通量质粒DNA制备
公开(公告)号：WO2009129524A2
公开(公告)日：2009-10-22
申请号：PCT/US2009/041087
申请日：2009-04-20
申请人： THE GENERAL HOSPITAL CORPORATION , BOYCE, Frederick, M.
发明人： BOYCE, Frederick, M.
IPC分类号： C12N15/10 , C12N1/20 , C12Q1/68
CPC分类号： C12N15/1003
摘要： The present invention provides for compositions and methods of high-throughput plasmid DNA purification from E. coli bacteria. More specifically, an acidic, zwitterionic detergent solution provides for superior removal of contaminating endotoxins and improves transfectability of plasmid DNA.
摘要翻译：本发明提供了从E纯化高通量质粒DNA的组合物和方法。大肠杆菌细菌。更具体地说，酸性的两性离子洗涤剂溶液提供了优异的污染性内毒素去除并改善了质粒DNA的转染性。

94. 发明申请

WO2009088849A3 TREATMENT OR PREVENTION OF INFLAMMATION BY TARGETING CYCLIN D1 审中-公开
公开(公告)号：WO2009088849A3
公开(公告)日：2009-07-16
申请号：PCT/US2008/088523
申请日：2008-12-30
申请人： IMMUNE DISEASE INSTITUTE, INC. , PEER, Dan , SHIMAOKA, Motomu
发明人： PEER, Dan , SHIMAOKA, Motomu
IPC分类号： A61K48/00 , A61P29/00 , A61K39/395
摘要： In one aspect, the invention relates to the treatment and/or prevention of inflammation by inhibition of cyclin D1. In one embodiment, Th1-mediated inflammation is selectively inhibited or reduced by a method comprising administering an agent that inhibits cyclin D1. In another embodiment, an autoimmune disease or a disorder characterized by or involving a Th1 inflammatory response is treated or prevented in a subject by a method comprising administering to the subject an agent that inhibits cyclin D1.

95. 发明申请

WO2009052256A3 BOWEL PURGATIVE AND USES THEREOF 审中-公开
公开(公告)号：WO2009052256A3
公开(公告)日：2009-04-23
申请号：PCT/US2008/080116
申请日：2008-10-16
申请人： THOMAS JEFFERSON UNIVERSITY , KASTENBERG, David
发明人： KASTENBERG, David
IPC分类号： A61K9/08 , A61K47/10 , A61K47/12 , A61K47/34 , A61K9/00
摘要： The present invention is directed to a dry composition for admixture with water for oral administration to a mammal and methods of using the composition for cleansing the bowel of a mammal in need thereof.

96. 发明申请

WO2009052132A1 HUMAN AMNIOTIC FLUID DERIVED MESENCHYMAL STEM CELLS 审中-公开
标题翻译：人类乳液衍生的中胚层干细胞
公开(公告)号：WO2009052132A1
公开(公告)日：2009-04-23
申请号：PCT/US2008/079916
申请日：2008-10-15
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , FAUZA, Dario
发明人： FAUZA, Dario
IPC分类号： C12N5/08 , A01N1/02 , A61K35/50
CPC分类号： C12N5/0605 , A01N1/02 , A01N1/021 , A61K35/12 , A61K35/50 , C12N5/0668
摘要： The invention provide methods for isolating, expanding, and enriching human fetal mesenchymal stem cells (MSCs) from human amniotic fluid in the absence of non-human derived animal products, cryopreserving the human fetal MSC in the absence of non-human derived animal products for future uses, thawing the cryopreserved MSCs for therapeutic use and/or further cell expansion, expanding the thawed previously cryopreserved stem cells in the absence of non-human derived animal products, and differentiating the MSCs.
摘要翻译：本发明提供了在没有非人源性动物产品的情况下从人羊水中分离，扩增和富集人胎儿间充质干细胞（MSC）的方法，在不存在非人源性动物产物的情况下对人胎儿MSC进行冷冻保存未来的使用，解冻冷冻保存的MSC用于治疗用途和/或进一步的细胞扩增，在不存在非人源性动物产物的情况下扩展解冻的先前冷冻保存的干细胞，并分化MSC。

97. 发明申请

WO2009014863A3 ASC AND PYRIN-ASC PYROPTOSOMES AND USES THEREOF 审中-公开
公开(公告)号：WO2009014863A3
公开(公告)日：2009-01-29
申请号：PCT/US2008/068747
申请日：2008-06-30
申请人： THOMAS JEFFERSON UNIVERSITY , ALNEMRI, Emad S.
发明人： ALNEMRI, Emad S.
IPC分类号： G01N33/50
摘要： The present invention relates to the field of immune responses and to inflammation. Embodiments of the invention relate to methods of: (1) isolating and detecting inflammasomes associated with pyroptosis-ASC pyroptosomes; (2) diagnosing inflammation; (3) detecting pathogen; (4) screening for anti-inflammatory agents; and (5) treatment of auto-inflammatary diseases and disorder.

98. 发明申请

WO2009009655A1 STROMAL INTERACTING MOLECULE KNOCKOUT MOUSE AND USES THEREOF 审中-公开
标题翻译：结构相互作用分子锁定鼠标及其用途
公开(公告)号：WO2009009655A1
公开(公告)日：2009-01-15
申请号：PCT/US2008/069636
申请日：2008-07-10
申请人： IMMUNE DISEASE INSTITUTE, INC. , OH-HORA, Masatsugu , HOGAN, Patrick , FESKE, Stefan , RAO, Anjana
发明人： OH-HORA, Masatsugu , HOGAN, Patrick , FESKE, Stefan , RAO, Anjana
IPC分类号： A61K31/00
CPC分类号： C12N5/0636 , A01K67/0276 , A01K2217/075 , A01K2217/15 , A01K2217/206 , A01K2227/105 , A01K2267/0387 , C07K14/705 , C12N15/8509 , C12N2501/23 , C12N2501/24 , G01N33/566 , G01N33/574 , G01N33/6872 , G01N2333/5406 , G01N2333/55 , G01N2333/57 , G01N2500/10
摘要： This invention relates to knockout mice for the Ca 2+ sensor membrane protein STIM-1, STIM-2, or both, as well as cell lines from these knockout mice. Provided herein are various methods of use of isolated with knockout STIM-1 and/or STIM-2.
摘要翻译：本发明涉及Ca2 +感染膜蛋白STIM-1，STIM-2或两者的敲除小鼠，以及这些敲除小鼠的细胞系。本文提供了使用分离的敲除STIM-1和/或STIM-2的各种使用方法。

99. 发明申请

WO2009003110A3 METAP-2 INHIBITOR POLΫMERSOMES FOR THERAPEUTIC ADMINISTRATION 审中-公开
标题翻译： METAP-2抑制剂治疗的管理措施
公开(公告)号：WO2009003110A3
公开(公告)日：2008-12-31
申请号：PCT/US2008/068367
申请日：2008-06-26
申请人： CHILDREN'S MEDICAL CENTER CORPORATION , BENNY-RATSABY, Ofra
发明人： BENNY-RATSABY, Ofra
IPC分类号： A61K47/48 , A61P35/00
摘要： Described herein are MetAP-2 inhibitors and compositions and formulations thereof, and more particularly compositions and formulations of MetAP-2 inhibitors wherein the MetAP-2 inhibitor is associated with a block copolymer comprising a hydrophilic polymer moiety and a hydrophobic polymer moiety. The present invention also relates to compositions and formulations comprising MetAP-2 inhibitors for oral administration or administration via routes such as topical or ocular administration. The present invention also provides methods to treat conditions associated with or related to the over-expression or over-activity of MetAP-2 by administering the compositions and formulations comprising MetAP-2 inhibitors as disclosed herein.
摘要翻译：本文描述了MetAP-2抑制剂及其组合物和制剂，更具体地说是MetAP-2抑制剂的组合物和制剂，其中MetAP-2抑制剂与包含亲水聚合物部分的嵌段共聚物缔合并且疏水聚合物部分。本发明还涉及包含MetAP-2抑制剂的组合物和制剂，用于口服给药或通过诸如局部或眼部给药的途径给药。本发明还提供了通过施用如本文所公开的包含MetAP-2抑制剂的组合物和制剂来治疗与MetAP-2的过度表达或过度活性相关或与之相关的病症的方法。

100. 发明申请

WO2008157337A1 METHOD AND DEVICE FOR THE CONCENTRATION OF MULTIPLE MICROORGANISMS AND TOXINS FROM LARGE LIQUID TOXINS 审中-公开
标题翻译：用于浓缩大量液体毒素的多种微生物和毒素的方法和装置
公开(公告)号：WO2008157337A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/066894
申请日：2008-06-13
申请人： TRUSTEES OF TUFTS COLLEGE , HAEMONETICS CORPORATION , ZUKERMAN, Udi , TZIPORI, Saul , STACEY, Gary
发明人： ZUKERMAN, Udi , TZIPORI, Saul , STACEY, Gary
IPC分类号： B01D21/26
CPC分类号： B01D21/262 , B01D21/302 , B01D2221/10 , B03C3/15 , B03C5/02 , B03C2201/26 , B04B5/10 , G01N1/4077
摘要： A method for the simultaneous concentration of multiple toxins from large volumes of water. The method includes the steps of providing a disposable separation centrifuge bowl, the centrifuge bowl including a positively charged material at it's inner core. A large water sample contaminated with toxins from a group consisting of protozoa, bacteria, bacterial spores, and toxins is delivered to the centrifuge bowl. A centrifugal force is applied to the separation bowl. The water sample is concentrated to remove large particles of the toxins in the bowl due to the centrifugal forces. The concentrated water sample is passes through the positively charged inner core to capture any remaining concentrated targets by electrostatic forces and the concentrated targets are eluted.
摘要翻译：从大量水中同时浓缩多种毒素的方法。该方法包括提供一次性分离离心机碗的步骤，离心机碗在其内核处包含带正电荷的材料。从原生动物，细菌，细菌孢子和毒素组成的组中被毒素污染的大量水样品被输送到离心机碗中。离心力被施加到分离碗。由于离心力，将水样品浓缩以除去碗中的大量毒素。浓缩水样品通过带正电荷的内核，通过静电力捕获任何剩余的浓缩靶，并且浓缩的靶被洗脱。

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