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91. 发明专利

CA2074278A1 PROCESS AND MAGNETIC DEVICE FOR IMMUNOLOGICAL ANALYSIS OF A SOLID PHASE 未知
公开(公告)号：CA2074278A1
公开(公告)日：1993-01-23
申请号：CA2074278
申请日：1992-07-21
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： MATTE CLAUDE , MULLER ANNE
IPC分类号： B03C1/28 , G01N33/543 , G01N33/557 , G01N33/558
摘要： PASTEUR SANOFI DIAGNOSTICS Process and magnetic device for immunological analysis on a solid phase The present invention relates to a process for determining or detecting by immuno adherence a biological substance present in a sample, which consists in introducing the sample into a receptacle on whose walls there is a component which has a specific immunological affinity for the substance to be tested for, in adding magnetic particles on which there is a substance which has a specific immunological affinity for the substance to be tested for, in subjecting them to several successive magnetic actions in order to accelerate the deposition of the said particles onto the walls and to displace those which have not formed specific bonds with the substance to be tested for which adheres to the walls via the component with affinity which is fixed thereto, and in observing the particles deposited.

92. 发明专利

CA2067584A1 AGGLUTINANT COMPLEX AS BLOOD TYPING REAGENT 未知
公开(公告)号：CA2067584A1
公开(公告)日：1992-11-03
申请号：CA2067584
申请日：1992-04-29
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： PERNELLE MICHEL
IPC分类号： G01N33/531 , G01N33/53 , G01N33/80
摘要： The invention relates to an agglutinant complex which is useful for the investigation of the antigens present on erythrocytes, and which results from affinity couplings between nonagglutinant IgG type antibodies specific for the antigen to be identified, a protein capable of binding to at least two sites on the Fc part of antibodies and an anti- immunoglobulin antibody or its fragments.

93. 发明专利

CA2286344C PEPTIDES SYNTHETIQUES UTILISABLES DANS LES ESSAIS BIOLOGIQUES POUR LA DETECTION DES INFECTIONS DUES AUX VIRUS VIH 1 DU GROUPE O 未知
公开(公告)号：CA2286344C
公开(公告)日：2012-08-07
申请号：CA2286344
申请日：1998-04-06
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： CHENEBAUX DENIS MARIE BERNARD , DELAGNEAU JEAN-FRANCOIS HUBERT , GADELLE STEPHANE JEAN XAVIER , RIEUNIER FRANCOIS YVES
IPC分类号： C07K14/16 , G01N33/569 , A61K38/16 , A61K39/00 , A61P31/12 , A61P37/04 , C12N7/00
摘要： L'invention concerne des peptides synthétiques trouvant leur application dans les essais biologiques de détection des infections dues aux virus VIH-1 du groupe O, leur procédé de préparation, des compositions et des trousses contenant de tels peptides ainsi que les essais biologiques mettant en oeuvre de tels peptides.

94. 发明专利

FR2777907B1 未知
公开(公告)号：FR2777907B1
公开(公告)日：2002-08-30
申请号：FR9805329
申请日：1998-04-28
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： FRECHON DOMINIQUE THERESE MARI , LAURE FRANCOISE , THIERRY DOMINIQUE
IPC分类号： C12N15/09 , C07H21/00 , C07K14/245 , C12N1/21 , C12N9/08 , C12N15/31 , C12Q1/68 , C12Q1/689 , C12N5/10
摘要： Nucleic sequences of plasmid origin are isolated from bacteria of the enterohaemorrhagic Escherichia coli group (EHEC) and used for the identification of EHEC(s), especially those possessing the genes encoding the virulence factors enterohaemolysin and intimin, and more particularly the specific detection of serotype O157:H7, and in detection kits.

95. 发明专利

GR3035226T3 IMMUNOENZYMATIC CONJUGATE, PREPARATION METHOD THEREFOR AND USES THEREOF 未知
公开(公告)号：GR3035226T3
公开(公告)日：2001-04-30
申请号：GR20010400042
申请日：2001-01-11
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： CUCUROU CHRISTOPHE , COGNET GILLES , GADELLE STEPHANE , LE SAGER CARINE
IPC分类号： C12N9/08 , C12P21/08 , G01N33/535 , G01N33/58
摘要： PCT No. PCT/FR96/00113 Sec. 371 Date Nov. 22, 1996 Sec. 102(e) Date Nov. 22, 1996 PCT Filed Jan. 23, 1996 PCT Pub. No. WO96/23226 PCT Pub. Date Aug. 1, 1996Immunoenzymatic conjugate consisting of glycosylated labelling enzymes in copolymer form and substances having immunological activity. Method for the production of the conjugates according to the invention and use of the said conjugates in diagnostic kits.

96. 发明专利

AU726241B2 Process for bacteria identification and for determination of the sensitivity of bacteria to antibiotics and apparatus and measuring supports for carrying out this process 未知
公开(公告)号：AU726241B2
公开(公告)日：2000-11-02
申请号：AU5221596
申请日：1996-05-13
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： BAJARD JEAN
IPC分类号： C12M1/34 , C12Q1/18 , G01N35/02
摘要： A process for bacteria identification and for determining the sensitivity of bacteria to antibiotics, and a apparatus and measuring supports for carrying out this process. There is manually introduced, by means of a sampling and transfer tool, a given volume of bacterial colony into a primary receiver. This is automatically dispersed within a liquid to form a precalibrated inoculum in the primary receiver. There is automatically carried out total or partial transfer of this precalibrated inoculum between the primary receiver and one or more measuring supports, these transfers being carried out without the precalibrated inoculum being placed in contact with an element other than a sampling and transfer tool and/or the primary receiver and its final measuring support or supports and in such a way that the transferred quantities of bacteria correspond to the quantities required for the analyses to be carried out. The precalibrated inoculum is automatically distributed, optionally after having appropriately diluted it to end up with a definitive calibration in one or more compartments of the measuring supports containing mainly appropriate reagents. Measurements are taken on the content of the compartments during or at the end of one or more incubations undergone by the inoculum in the measuring supports, the measurements taken being registered by a computer and being processed in order to characterized the growth of the bacteria present in the inoculum, to identify them and/or to determine their sensitivity to various antibiotics.

97. 发明专利

BR9809078A 未知
公开(公告)号：BR9809078A
公开(公告)日：2000-08-01
申请号：BR9809078
申请日：1998-04-06
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： CHENEBAUX DENIS MARIE BERNARD , DELAGNEAU JEAN-FRANCOIS HUBERT , GADELLE STEPHANE JEAN XAVIER , RIEUNIER FRANCOIS YVES
IPC分类号： G01N33/569 , A61K38/16 , A61K39/00 , A61P31/12 , A61P37/04 , C07K14/16 , C12N7/00
摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): &Dgr;-Z-TrpGlyCys-Θ-CysTyrThrSer-&OHgr; (I) wherein &Dgr; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&Xgr;1-Ser-&Xgr;2-, -&Xgr;1-Gln-&Xgr;2-, or -&Xgr;1-Asn-&Xgr;2-, wherein -&Xgr;1 represents a peptide sequence of 0 to 9 amino acids and -&Xgr;2 represents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &OHgr;, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&Sgr;-Ψ wherein &Sgr; represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.

99. 发明专利

PL336115A1 SYNTHETIC PEPTIDES SUITABLE FOR USE IN BIOLOGICAL TESTS SERVING TO DETECT INFECTIONS CAUSED BY HIV-1 VIRUS OF 0 GROUP 未知
公开(公告)号：PL336115A1
公开(公告)日：2000-06-05
申请号：PL33611598
申请日：1998-04-06
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： CHENEBAUX DENIS MARIE BERNARD , DELAGNEAU JEAN-FRANCOIS HUBERT , GADELLE STEPHANE JEAN XAVIER , RIEUNIER FRANCOIS YVES
IPC分类号： A61K38/16 , G01N33/569 , A61K39/00 , A61P31/12 , A61P37/04 , C07K14/16 , C12N7/00
摘要： Synthetic peptides of the monomer type with 13 to 33 amino acids, in linear form or in a form cyclized by means of inter-cysteine disulphide bridges, have the general formula (I): &Dgr;-Z-TrpGlyCys-Θ-CysTyrThrSer-&OHgr; (I) wherein &Dgr; is a biotinyl radical, a biocytinyl radical, a hydrogen atom, an acetyl (CH3CO—) radical, an aliphatic chain which may contain one or two thiol, an aldehyde functional group, or an amine functional group, Z represents peptide sequence -&Xgr;1-Ser-&Xgr;2-, -&Xgr;1-Gln-&Xgr;2-, or -&Xgr;1-Asn-&Xgr;2-, wherein -&Xgr;1 represents a peptide sequence of 0 to 9 amino acids and -&Xgr;2 represents a peptide sequence of 0 to 5 amino acids, Θis -Arg Gly Arg Leu Ile-(SEQ ID NO: 15), -Arg Gly Arg Leu Val-(SEQ ID NO: 16), -Arg Gly Lys Leu Ile-(SEQ ID NO: 17), -Arg Gly Lys Leu Val-(SEQ ID NO: 18), -Lys Gly Arg Leu Ile-(SEQ ID NO: 19), or -Lys Gly Arg Leu Val-(SEQ ID NO: 20), &OHgr;, attached to the —CO— group of serine, is a hydroxyl (—OH) radical, an amino (—NH2) radical, an alkoxy radical having 1 to 6 carbon atoms, a peptide sequence of formula Val-&Sgr;-Ψ wherein &Sgr; represents a sequence of formula -(AA1)-Trp Asn-(AA2)-(AA3) wherein (AA1) represents an amino acid different from lysine, (AA2) represents an amino acid, and (AA3) is serine or a threonine residue, and Ψ, attached to the —CO— residue of the free AA3 amino acid, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms, and a peptide sequence of formula -Val-Ψ wherein Ψ, attached to the —CO— residue of valine, is OH, NH2, or an alkoxy radical having from 1 to 6 carbon atoms.

100. 发明专利

FR2764989B1 未知
公开(公告)号：FR2764989B1
公开(公告)日：1999-08-27
申请号：FR9707730
申请日：1997-06-20
申请人： PASTEUR SANOFI DIAGNOSTICS
发明人： BOUANANI MAJIDA , KAMAL NADIA , LARUE CATHERINE CHRISTIANE MAR , MANI JEAN CLAUDE , PAU BERNARD CHRISTIAN , SIOHAN ELISABETH
IPC分类号： G01N33/53 , C07K14/62 , C07K16/26 , C12N5/10 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/68 , G01N33/74 , C12N5/18

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