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91. 发明专利

BR112012003283B1 sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico, composição farmacêutica, kit para uso em um método de internalização fotoquímica e uso de um sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico 未知
公开(公告)号：BR112012003283B1
公开(公告)日：2020-06-16
申请号：BR112012003283
申请日：2010-08-16
申请人： PCI BIOTECH AS
发明人： ANDERS HOGSET , JO KLAVENESS
IPC分类号： A61K9/00 , A61K41/00 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/87
摘要： sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico, composição farmacêutica, kit para uso em um método de internalização fotoquímica e uso de um sal farmaceuticamente aceitável de um agente fotossensibilizante anfifílico a invenção refere-se aos sais farmaceuticamente aceitáveis de agentes fotossensibilizantes anfifílicos que possuem uma solubilidade em água de pelo menos 0,5 mg/ml e ao seu uso em métodos de internalização fotoquímica. tais sais podem ser formados a partir de uma base farmaceuticamente aceitável, por exemplo, uma amina orgânica tal como um amino álcool, ou a partir de um ácido farmaceuticamente aceitável, por exemplo, um ácido sulfônico ou um derivado de ácido sulfônico. devido à sua maior solubilidade em água, tais sais são particularmente adequados para utilização na preparação de preparações farmacêuticas parenterais, por exemplo, para utilização como soluções para injeção ou infusão.

92. 发明专利

AU2014314149B2 Compound and method for vaccination and immunisation 未知
公开(公告)号：AU2014314149B2
公开(公告)日：2019-12-19
申请号：AU2014314149
申请日：2014-08-28
申请人： PCI BIOTECH AS
发明人： HOGSET ANDERS , JOHANSEN PAL
IPC分类号： A61K39/00 , A61K31/409 , A61K31/437 , A61K31/7115 , A61K35/14 , A61K39/12 , A61K41/00 , A61P35/00 , C12N5/0784
摘要： The present invention relates to a method of vaccination or immunisation involving the use of a photosensitizing agent, an antigenic molecule, e.g. a vaccine component, and an agent which enhances the effect of photochemical internalization (PCI)-mediated vaccination wherein the agent is a ligand for a Toll-like receptor (TLR) as defined herein, and irradiation with light of a wavelength effective to activate the photosensitizing agent. The invention also relates to antigenic, e.g. vaccine compositions, useful in such a method. The invention also provides a method of generating antigen presenting cells which may be used to generate an immune response, e.g. for vaccination, which involves using the same components as above to introduce antigenic molecules, e.g. vaccine components, into cells to achieve antigen presentation, and to antigenic compositions useful in such a method. The invention also provides use of cells generated in vitro by such methods for administration to a patient in vivo to elicit an immune response, e.g. to achieve vaccination. A method of internalising an antigenic molecule into a cell is also provided.

93. 发明专利

SG11201903057XA TREATMENT OF CHOLANGIOCARCINOMA WITH TPCS-2A INDUCED PHOTOCHEMICAL INTERNALISATION OF GEMCITABINE 未知
公开(公告)号：SG11201903057XA
公开(公告)日：2019-05-30
申请号：SG11201903057X
申请日：2017-10-13
申请人： PCI BIOTECH AS
发明人： HØGSET ANDERS , WALDAY PER EDVARD , SELBO PÅL KRISTIAN , EIVINDVIK KRISTIN , FINNESAND LENA
IPC分类号： A61K31/409 , A61K31/7068 , A61K33/24 , A61K41/00 , A61P35/00
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 19 April 2018 (19.04.2018) WIP0 1 PCT omit n OH 10 0 0111 INIM Ell MIME 011 (10) International Publication Number WO 2018/069536 Al (51) International Patent Classification: A61K 31/409 (2006.01) A61K 41/00 (2006.01) A61K 31/7068 (2006.01) A61P 35/00 (2006.01) A61K 33/24 (2006.01) (21) International Application Number: Published: — with international search report (Art. 21(3)) PCT/EP2017/076257 (22) International Filing Date: 13 October 2017 (13.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1617526.7 14 October 2016 (14.10.2016) GB 1704719.2 24 March 2017 (24.03.2017) GB (71) Applicant: PCI BIOTECH AS [NO/NO]; Ullern- chausseen 64, 0379 Oslo (NO). (72) Inventors: HOGSET, Anders; Rognerudveien 55, N-0681 Oslo (NO). WALDAY, Per Edvard; Drammensveien 104D, N-0273 Oslo (NO). SELBO, Pal Kristian; Anne Manes vei 9, N-0373 Oslo (NO). EIVINDVIK, Kristin; Lilleruts vei 41, N-1364 Fornebu (NO). FINNESAND, Lena; Solligrenda 22, N-0491 Oslo (NO). = (74) Agent: JONES, Elizabeth Louise; Dehns, St Bride's House, 10 Salisbury Square, London Greater London EC4Y 8JD (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, 1-1 MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). co (54) Title: TREATMENT OF CHOLANGIOCARCINOMA WITH TPCS-2A INDUCED PHOTOCHEMICAL INTERNALISATION OF GEMCITABINE \" (57) : The present invention provides TPCS2 a , gemcitabine and optionally another cytotoxic agent, preferably cisplatin, for C use in a method of treating a cholangiocarcinoma in a human patient comprising a photochemical internalization method. Related kits for performing the invention are also provided.

94. 发明专利

GB201804276D0 Method 未知
公开(公告)号：GB201804276D0
公开(公告)日：2018-05-02
申请号：GB201804276
申请日：2018-03-16
申请人： PCI BIOTECH AS

95. 发明专利

GB201704288D0 Method 未知
公开(公告)号：GB201704288D0
公开(公告)日：2017-05-03
申请号：GB201704288
申请日：2017-03-17
申请人： PCI BIOTECH AS

96. 发明专利

LT2464384T FOTOSENSITIZUOJANČIO AGENTO DRUSKA, SKIRTA NAUDOTI FOTOCHEMINEI INTERNALIZACIJAI 未知
公开(公告)号：LT2464384T
公开(公告)日：2017-04-10
申请号：LT10747249
申请日：2010-08-16
申请人： PCI BIOTECH AS
发明人： KLAVENESS JO , HOGSET ANDERS
IPC分类号： A61K41/00 , A61K9/00 , A61K38/14 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/87

97. 发明专利

DK2464384T3 SALT AF ET FOTOSENSIBILISERENDE STOF TIL ANVENDELSE I FOTOKEMISK INTERNALISERING 未知
公开(公告)号：DK2464384T3
公开(公告)日：2017-01-23
申请号：DK10747249
申请日：2010-08-16
申请人： PCI BIOTECH AS
发明人： KLAVENESS JO , HOGSET ANDERS
IPC分类号： A61K41/00 , A61K9/00 , A61K38/14 , A61K48/00 , A61P35/00 , A61P43/00 , C12N15/87

98. 发明专利

GB201604572D0 Method 未知
公开(公告)号：GB201604572D0
公开(公告)日：2016-05-04
申请号：GB201604572
申请日：2016-03-17
申请人： PCI BIOTECH AS

100. 发明专利

GB2517707A Antigen delivery device and method 未知
公开(公告)号：GB2517707A
公开(公告)日：2015-03-04
申请号：GB201315288
申请日：2013-08-28
申请人： PCI BIOTECH AS
发明人： GSET ANDERS H , WALDAY PER EDVARD , EIVINDVIK KRISTIN
IPC分类号： A61N5/06
摘要： A device 1 for activating light-induced rupture of endocytic vesicles in target cells of a patent so as to effect delivery of an administered antigen to cytosol in the target cells, the device 1 being adapted to be worn by a patient over a region of the patients skin where an antigen and a photosensitising agent have been or are to be administered, wherein the device comprises: a rear surface that is configured to be worn against the patients skin, a retaining part e.g. strap 3a,b,c, for retaining the device 1 in place over the region of the patients skin during an activation cycle. A light source 13 arranged to illuminate the region of the patients skin from the rear surface of the device, a control system to control the operation of the light source after initiation of the activation cycle, and a power supply to power the light source and the control system. Wherein, the control system is configured to vary the output of the light source 13 with respect to time in accordance with a pre-configured output sequence, wherein the output sequence includes an initial stage where the output of the light source 13 is set to be zero or generally below that which could deliver a light dose that can activate light-induced rupture of endocytic vesicles to allow time for the antigen and photosensitising agent to reach the target cells, and a later stage where the output of the light source is set to deliver a light does which can activate the light-induced rupture of the endocytic vesicles for effecting the delivery of the administered antigen to the cytosol of the targeted cells.

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