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1. 发明授权

US09422541B2 Apparatus for the extracorporeal treatment of blood 有权
标题翻译：用于体外治疗血液的装置
公开(公告)号：US09422541B2
公开(公告)日：2016-08-23
申请号：US14314387
申请日：2014-06-25
申请人： University of Limerick
发明人： Jakki Cooney , Todd Fumio Kagawa , Edmond Magner
IPC分类号： A61M1/36 , C12N9/52 , C12N11/14 , A61L33/00 , A61M1/34
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体置换的泵（6）以及连接到体外血液回路并被配置为接收来自电路的血液或血浆，治疗血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性，并能够不可逆地裂解，其中处理的血液或血浆中的人C5a的丰度比未经处理的血液或血浆中的少。该装置可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

2. 发明申请

US20090117092A1 COLLAGENOLYTIC ACTIVE ENZYME CONTAINING COMPOSITIONS, AND THEIR USE IN THE DENTAL FIELD 有权
标题翻译：包含组合物的胶原酶活性酶及其在牙齿领域的应用
公开(公告)号：US20090117092A1
公开(公告)日：2009-05-07
申请号：US12132315
申请日：2008-06-03
申请人： Oliver Kappler , Ingo R. Haeberlein
发明人： Oliver Kappler , Ingo R. Haeberlein
IPC分类号： A61K38/48 , A61P43/00
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.
摘要翻译：本发明涉及一种组合物，其包含至少一种在酸性pH下具有酶活性的胶原分解活性酶，用于无花果酶龋齿去除。此外，本发明涉及生产该胶原分解活性酶的方法，其包含组合物和去除龋齿的方法。本发明还涉及包含用于制备用于牙科应用的治疗剂的组合物的胶原分解活性酶的用途。

3. 发明授权

EP2886142B1 An apparatus for the extracorporeal treatment of blood 有权
标题翻译：装置用于血液体外处理
公开(公告)号：EP2886142B1
公开(公告)日：2016-05-25
申请号：EP14198204.1
申请日：2014-12-16
申请人： University of Limerick
发明人： Cooney, Jakki , Kagawa, Todd Fumio , Magner, Edmond
IPC分类号： A61M1/36 , C12N11/06 , A61L33/00 , A61M1/34 , C12N9/52 , C12N11/14
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111

4. 发明公开

US20240000926A1 PURIFICATION PROCESSES FOR POLYSACCHARIDES AND POLYPEPTIDE CONJUGATES THEREOF 审中-公开
公开(公告)号：US20240000926A1
公开(公告)日：2024-01-04
申请号：US18447146
申请日：2023-08-09
申请人： Vaxcyte, Inc.
发明人： Christopher R. BEHRENS , Paresh AGARWAL , Lu YIN , Peter T. DAVEY , Angie A. SEDRA
IPC分类号： A61K39/385 , C07K14/315 , C07K14/34 , C12N9/52 , A61K39/09 , A61P37/04 , C12P19/04 , C12P19/14 , A61K47/61 , A61K47/64
CPC分类号： A61K39/385 , C07K14/315 , C07K14/34 , C12N9/52 , C12Y304/2111 , A61K39/092 , A61P37/04 , C12P19/04 , C12P19/14 , A61K47/61 , A61K47/646 , A61K2039/6087
摘要： The present disclosure provides a process for purifying high-molecular weight bacterial polysaccharides (e.g., cell wall polysaccharides), and polypeptide-polysaccharide conjugates thereof, suitable for use in immunogenic compositions.

5. 发明申请

US20050265932A1 Collagenolytic active enzyme containing compositions, and their use in the dental field 审中-公开
标题翻译：含有胶原分解活性酶的组合物及其在牙科领域中的应用
公开(公告)号：US20050265932A1
公开(公告)日：2005-12-01
申请号：US11128553
申请日：2005-05-13
申请人： Oliver Kappler , Ingo Haeberlein
发明人： Oliver Kappler , Ingo Haeberlein
IPC分类号： A61K47/12 , A61K6/00 , A61K38/48 , A61P1/02 , A61P43/00 , C12N9/52 , C12N9/54 , A61K7/28
CPC分类号： A61K38/488 , A61K38/482 , C12N9/52 , C12N9/54 , C12Y304/2111 , A61K6/0029 , C08L3/00 , C08L39/06 , C08L1/28 , A61K2300/00
摘要： The invention relates to a composition comprising at least one collagenolytic active enzyme with enzymatic activity at acidic pH for drilless enzymatic caries removal. Furthermore, the present invention relates to a process of producing this collagenolytic active enzyme comprising composition and to processes of removing caries. The invention also relates to the use of collagenolytic active enzyme comprising compositions for producing a treatment agent for dental applications.
摘要翻译：本发明涉及一种组合物，其包含至少一种在酸性pH下具有酶活性的胶原分解活性酶，用于无花果酶龋齿去除。此外，本发明涉及生产该胶原分解活性酶的方法，其包含组合物和去除龋齿的方法。本发明还涉及包含用于制备用于牙科应用的治疗剂的组合物的胶原分解活性酶的用途。

6. 发明授权

US06270775B1 Streptococcal C5a peptidase vaccine 有权
标题翻译：链球菌C5a肽酶疫苗
公开(公告)号：US06270775B1
公开(公告)日：2001-08-07
申请号：US09206800
申请日：1998-12-07
申请人： Paul Patrick Cleary
发明人： Paul Patrick Cleary
IPC分类号： A61K3909
CPC分类号： C12N9/52 , A61K39/00 , A61K39/092 , C12Y304/2111
摘要： Novel vaccines for use against &bgr;-hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against &bgr;-hemolytic Streptococcus colonization or infection by administering such a vaccine.
摘要翻译：公开了用于抗β-溶血性链球菌定居或感染的新型疫苗。疫苗含有免疫原性量的链球菌C5a肽酶，或其片段或突变体。还公开了通过施用这样的疫苗来保护易感染的哺乳动物免受β-溶血性链球菌定植或感染的方法。

7. 发明申请

WO1997026008A1 STREPTOCOCCAL C5a PEPTIDASE VACCINE 审中-公开
公开(公告)号：WO1997026008A1
公开(公告)日：1997-07-24
申请号：PCT/US1997001056
申请日：1997-01-21
申请人： REGENTS OF THE UNIVERSITY OF MINNESOTA , CLEARY, Paul, P.
发明人： REGENTS OF THE UNIVERSITY OF MINNESOTA
IPC分类号： A61K39/09
CPC分类号： C12N9/52 , A61K39/00 , A61K39/092 , C12Y304/2111
摘要： Novel vaccines for use against beta -hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of streptococcal C5a peptidase, or a fragment or mutant thereof. Also disclosed is a method of protecting a susceptible mammal against beta -hemolytic Streptococcus colonization or infection by administering such a vaccine.
摘要翻译：公开了用于抗β-溶血性链球菌定居或感染的新型疫苗。疫苗含有免疫原性量的链球菌C5a肽酶，或其片段或突变体。还公开了通过施用这样的疫苗来保护易感染哺乳动物免受β-溶血性链球菌定植或感染的方法。

8. 发明公开

US20230293658A1 GROUP A STREP IMMUNOGENIC COMPOSITIONS WITH POLYSACCHARIDE-PROTEIN CONJUGATES 审中-公开
公开(公告)号：US20230293658A1
公开(公告)日：2023-09-21
申请号：US17820554
申请日：2022-08-17
申请人： Vaxcyte, Inc.
发明人： Jeffery C. FAIRMAN , Neeraj KAPOOR , Peter T. DAVEY , Angie A. SEDRA
IPC分类号： A61K39/09 , A61K38/48 , A61K39/112 , A61K39/116 , A61P31/04
CPC分类号： A61K39/092 , A61K38/482 , A61K39/0283 , A61K39/116 , A61P31/04 , C12Y304/2111 , A61K2039/6087
摘要： The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects.

9. 发明申请

US20160354534A1 APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD 审中-公开
标题翻译：用于血液提取物治疗的装置
公开(公告)号：US20160354534A1
公开(公告)日：2016-12-08
申请号：US15242775
申请日：2016-08-22
申请人： University of Limerick
发明人： Jakki Cooney , Todd Fumio Kagawa , Edmond Magner
IPC分类号： A61M1/36 , C12N9/52 , A61M1/34 , C12N11/14
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises a protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体置换的泵（6）以及连接到体外血液回路并被配置为接收来自电路的血液或血浆，治疗血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性，并能够不可逆地切割，其中处理的血液或血浆中的人C5a的丰度比未经处理的血液或血浆中的少。该装置可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

10. 发明申请

US20150166978A1 APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD 有权
标题翻译：用于血液提取物治疗的装置
公开(公告)号：US20150166978A1
公开(公告)日：2015-06-18
申请号：US14314387
申请日：2014-06-25
申请人： University of Limerick
发明人： Jakki Cooney , Todd Fumio Kagawa , Edmond Magner
IPC分类号： C12N11/14 , A61L33/00 , C12N9/52
CPC分类号： A61M1/3687 , A61L33/0047 , A61M1/3496 , A61M1/3689 , C12N9/52 , C12N11/14 , C12Y304/2111
摘要： An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
摘要翻译：一种用于血液体外处理的装置，包括体外血液回路（2），构造成在体外血液回路内提供流体置换的泵（6）以及连接到体外血液回路并被配置为接收来自电路的血液或血浆，治疗血液或血浆。反应室包含固定在载体上的蛋白酶，其中蛋白酶对血液或血浆中存在的人C5a具有特异性，并能够不可逆地裂解，其中处理的血液或血浆中的人C5a的丰度比未经处理的血液或血浆中的少。该装置可用于体外治疗患有炎症状况的患者的血液，特别是自身免疫疾病和败血症。

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