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    • 8. 发明申请
    • CANNABINOID LIQUID FORMULATIONS FOR MUCOSAL AMDINISTRATION
    • 用于胶原蛋白激酶的CANNABINOID液体制剂
    • WO2004016246A1
    • 2004-02-26
    • PCT/GB2003/003574
    • 2003-08-14
    • GW PHARMA LIMITEDWHITTLE, Brian, Anthony
    • WHITTLE, Brian, Anthony
    • A61K9/12
    • A61K9/006
    • The invention relates to pharmaceutical formulations, and more particularly to formulations containing cannabinoids for administration via a pump action spray. In particular, the invention relates to pharmaceutical formulations, for use in administration of lipophilic medicaments comprising one or more cannabinoids via mucosal surfaces, comprising: at least one lipophilic medicament which comprises one or more cannabinoids, a solvent and a co-solvent, wherein the total amount of solvent and co-solvent present in the formulation is greater than 55 % wt/wt of the formulation, the formulation is absent of a self emulsifying agent and/or a fluorinated propellant, and the cannabinoid(s) is/are present in the formulation in an amount greater than 10 mg/ml.
    • 本发明涉及药物制剂,更具体地涉及含有通过泵作用喷雾给药的大麻素的制剂。 特别地,本发明涉及用于通过粘膜表面施用包含一种或多种大麻素的亲脂性药物的药物制剂,其包含:至少一种亲脂性药物,其包含一种或多种大麻素,溶剂和共溶剂,其中 制剂中存在的溶剂和共溶剂的总量大于制剂的55重量%/重量,制剂不含自乳化剂和/或氟化推进剂,并且大麻素存在 在制剂中的量大于10mg / ml。