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1. 发明申请

WO2012032109A3 VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON METHAN IN EINEM PHOTOBIOREAKTOR 审中-公开
公开(公告)号：WO2012032109A3
公开(公告)日：2012-03-15
申请号：PCT/EP2011/065536
申请日：2011-09-08
申请人： UNIVERSITÄT LEIPZIG , SÄCHSISCHES INSTITUT FÜR ANGEWANDTE BIOTECHNOLOGIE AN DER UNIVERSITÄT LEIPZIG E.V. , KARLSRUHER INSTITUT FÜR TECHNOLOGIE , UNIVERSITÄT BREMEN , WILHELM, Christian , POSTEN, Clemens , RÄBIGER, Norbert
发明人： WILHELM, Christian , POSTEN, Clemens , RÄBIGER, Norbert
IPC分类号： C12M1/00 , C12M1/113 , C12M1/12 , C12M1/18 , C12P5/02 , C12N9/02 , C12R1/89
摘要： Die Erfindung betrifft ein Verfahren zur Herstellung von Methan durch Kultivierung von Algen und methanogenen Mikroorganismen und eine Vorrichtung zur Durchführung des Verfahrens. Das Wesen der Erfindung besteht in einem Photobioreaktor, der aus zwei Zonen bestehend aus Sonnenlicht und einem sauerstoffangereichertem und kohlendioxid-abgereichertem Gasgemisch direkt Methan erzeugt. Die Reaktion erfolgt in zwei Teilschritten, die in zwei verschiedene Bereiche verlagert sind. Im ersten aeroben Abschnitt erfolgt mit Hilfe der Photosynthese in Algenzellen die Synthese von Glykolat, das von den Zellen ausgeschieden wird. Die Algen bilden auf einem Trägermaterial einen Biofilm, der mit Hilfe eines kontinuierlichen bzw. semi-kontinuierlichen Flüssigkeitsstromes einerseits mit Nährstoffen versorgt wird und andererseits das ausgeschiedene Glykolat in die zweite Zone transferiert. Dieses Kompartiment ist durch eine sauerstoffundurchlässige Membran anaerob und enthält methanogene Bakterien. Diese setzen das eingeschleuste Glykolat direkt zu Methan um.

2. 发明公开

EP2614135A2 VERFAHREN UND VORRICHTUNG ZUR HERSTELLUNG VON METHAN IN EINEM PHOTOBIOREAKTOR 审中-公开
标题翻译：方法和装置甲烷在光生物反应器中生产
公开(公告)号：EP2614135A2
公开(公告)日：2013-07-17
申请号：EP11755317.2
申请日：2011-09-08
申请人： Universität Leipzig , Sächsisches Institut für Angewandte Biotechnologie an der Universität Leipzig e.V. , Karlsruher Institut für Technologie , Universität Bremen
发明人： WILHELM, Christian , POSTEN, Clemens , RÄBIGER, Norbert
IPC分类号： C12M1/00 , C12M1/113 , C12M1/12 , C12M1/18 , C12P5/02 , C12N9/02 , C12R1/89
CPC分类号： C12M21/02 , C12M21/04 , C12M23/34 , C12N9/0004 , C12N9/0006 , C12N9/16 , C12N9/88 , C12P5/023 , C12P7/42 , C12P39/00 , C12Y101/01026 , C12Y101/03015 , C12Y101/99014 , C12Y301/03018 , C12Y401/01039 , Y02E50/343
摘要： The invention relates to a method for producing methane by culturing algae and methanogenic microorganisms, and to a facility for carrying out the process. The essence of the invention is a photobioreactor which directly generates methane from two zones composed of sunlight and an oxygen-enriched and carbon-dioxide-depleted gas mixture. The reaction is carried out in two sub steps which take place in two different zones. In the first, aerobic part, glycolate is synthesized in algal cells by photosynthesis, and this glycolate is excreted by the cells. The algae form a biofilm on a support material, which biofilm is firstly supplied by nutrients with the aid of a continuous or semicontinuous stream of liquid and secondly transfers the excreted glycolate into the second zone. This compartment is anaerobic due to an oxygen-impermeable membrane and comprises methanogenic bacteria, which directly convert the introduced glycolate into methane.

3. 发明公开

US20230265522A1 MULTI-GENE EXPRESSION ASSAY FOR PROSTATE CARCINOMA 审中-公开
公开(公告)号：US20230265522A1
公开(公告)日：2023-08-24
申请号：US17920109
申请日：2021-04-19
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E. V. , UNIVERSITÄT LEIPZIG
发明人： Kristin Reiche , Conny Blumert , Friedemann Horn , Markus Kreuz , Dominik Otto , Catharina Bertram , Jörg Hackermüller , Manfred Wirth , Suzanne Füssel , Michael Fröhner
IPC分类号： C12Q1/6886 , G16B20/00 , G16B40/20
CPC分类号： C12Q1/6886 , G16B20/00 , G16B40/20 , C12Q2600/118 , C12Q2600/166
摘要： Prostate cancer is the most prevalent solid cancer among men in Western Countries. The clinical behavior of localized prostate cancer is highly variable. Hence, there is a high clinical need for precise biomarkers for identification of aggressive disease in addition to established clinical parameters. The present invention relates to a prognostic multi-gene expression score based on transcriptome-wide gene expression analysis providing a method for calculating a score (ProstaTrend score) that allows the prediction of death of disease (DoD) and/or biochemical recurrence (BCR), long-term prognosis and outcome of prostate cancer patients. The present invention is an independent predictor of prognosis and is suitable for the identification of high-risk patients among patients with a clinical classification of low or intermediate risk prior and after surgery, such as radical prostatectomy.

4. 发明申请

US20220026421A1 METHOD, SURFACE, PARTICLE AND KIT FOR THE DETECTION OF ANALYTES IN SAMPLES 有权
公开(公告)号：US20220026421A1
公开(公告)日：2022-01-27
申请号：US17297150
申请日：2019-11-18
申请人： TECHNISCHE UNIVERSITÄT DRESDEN , UNIVERSITÄT LEIPZIG
发明人： Gerhard RÖDEL , Kai OSTERMANN , Julia DÖRING , Christian DAHMANN , Tilo POMPE , David RETTKE , Steve MARTIN
IPC分类号： G01N33/53 , G01N33/543 , G01N33/545 , C07K14/37 , C12N9/10
摘要： The invention relates to a method, to a surface, to a particle, and to a kit for the detection of low molecular weight analytes such as crop protection agents in samples. In particular, the invention relates to a method for the detection of glyphosate through protein-functionalised surfaces and functionalised particles by means of reflection interference contrast microscopy (RICM).

5. 发明授权

US10774097B2 Boron compounds as inhibitors of lipoxygenase and the lipoxygenase pathway, and preparation and use thereof 有权
公开(公告)号：US10774097B2
公开(公告)日：2020-09-15
申请号：US15770477
申请日：2016-10-21
申请人： UNIVERSITÄT LEIPZIG
发明人： Evamarie Hey-Hawkins , Robert Kuhnert
IPC分类号： C07F5/02 , A61P25/28 , A61P37/08
摘要： The invention relates to chemical compound of the general structure [A-R3—X—R4] where A=[R1-R2] or [R1] R1=aryl, heteroaryl R2=alkyl, aryl, heteroaryl, carbonyl, thiocarbonyl, alkyl ester, alkyl thioester R3=O, S, NH X=closo- or nido-boron cluster R4= where Z=OH, SH, NH2 where R5 is selected from H, alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and R6 is selected from alkyl, aryl, heteroaryl, alkyl ether, alkyl thioether, alkylamine and where R3 and R4 are in meta or para positions to one another, to a process for preparation thereof and to the use thereof, especially in medicine, for example in the inhibition of lipoxygenase.

6. 发明授权

US09801977B2 Method for deriving melanocytes from the hair follicle outer root sheath and preparation for grafting 有权
公开(公告)号：US09801977B2
公开(公告)日：2017-10-31
申请号：US14354545
申请日：2012-10-29
申请人： Vuk Savkovic , Christina Dieckmann , Jan-Christoph Simon , Michaela Schulz-Siegmund , Michael Hacker
发明人： Vuk Savkovic , Christina Dieckmann , Jan-Christoph Simon , Michaela Schulz-Siegmund , Michael Hacker
IPC分类号： C12N5/071 , A61K35/36 , A61L27/38 , A61L27/60
CPC分类号： A61L27/3834 , A61L27/3895 , A61L27/60 , C12N5/0626 , C12N2500/02 , C12N2500/38 , C12N2501/33 , C12N2501/81 , C12N2506/03 , C12N2533/40
摘要： The present invention relates to the field of biology and medicine, and more specifically, to the field of stem-cell biology, involving producing or generating melanocytes from stem-cells and precursors derived from human hair root. Additionally, the present invention relates to the materials and method for producing autografts, homografts or allografts comprising melanocytes in general, as well as the materials and methods for producing autografts, homografts and allografts comprising melanocytes for the treatment of diseases related to depigmentation of the skin and for the treatment of scars.

7. 发明申请

US20170045533A1 METHOD AND MEANS FOR THE NON-INVASIVE DIAGNOSIS OF TYPE II DIABETES MELLITUS 审中-公开
标题翻译： II型糖尿病非侵入性诊断方法与手段
公开(公告)号：US20170045533A1
公开(公告)日：2017-02-16
申请号：US15101885
申请日：2014-12-05
申请人： UNIVERSITAT LEIPZIG , OHIO UNIVERSITY
发明人： Ralf HOFFMANN , Andrej FROLOV , Sandro SPILLER , Yichao LI , Lonnie R. WELCH
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N2440/38 , G01N2800/042
摘要： The invention relates to a method and means for the non-invasive diagnosis of type II diabetes mellitus. The glycation state is determined in at least one glycation position of selected plasma proteins.
摘要翻译：本发明涉及II型糖尿病非侵入性诊断的方法和手段。在选定的血浆蛋白质的至少一个糖基化位置上测定糖基化状态。

8. 发明申请

US20150036145A1 Twin-focus photothermal correlation spectroscopy method and device for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers 有权
标题翻译：双光光热相关光谱法和装置，用于表征液体和生物材料中的动力学过程，借助吸收标记
公开(公告)号：US20150036145A1
公开(公告)日：2015-02-05
申请号：US14232304
申请日：2012-07-12
申请人： Frank Cichos , Marco Braun , Markus Selmke , Romy Schachoff
发明人： Frank Cichos , Marco Braun , Markus Selmke , Romy Schachoff
IPC分类号： G01N21/31 , G01N33/487
CPC分类号： G01N21/31 , B82Y15/00 , G01N21/171 , G01N33/487 , G01N2021/1789
摘要： The invention relates to a method and a device for twin-focus photothermal correlation spectroscopy for the characterization of dynamical processes in liquids and biomaterials with the help of absorbing markers. Thereby non-fluorescent absorbing nano objects are heated by an intensity-modulated heating laser which leads to a refractive index gradient lens around the object. This refractive index gradient is detected by a detection laser with a focal volume that, depending on the position of the heated object relative to the focal plane of the detection beam, splits into two-sub-volumes forming a twin-focus comprising two sharply separated parts of a focal volume showing no spatial overlap.
摘要翻译：本发明涉及一种用于双焦点光热相关光谱法的方法和装置，用于借助于吸收标记物来表征液体和生物材料中的动力学过程。由此，非荧光吸收纳米物体被强度调制的加热激光器加热，该激光导致物体周围的折射率梯度透镜。该折射率梯度通过具有聚焦体积的检测激光器来检测，该焦点体积根据被加热物体相对于检测光束的焦平面的位置分裂为形成双焦点的双子体积，包括两个明显分离的没有空间重叠的焦点体积的部分。

9. 发明申请

US20130211061A1 Method and compositions for the identification of agents that have a potential effect against chronic inflammatory diseases 有权
标题翻译：用于鉴定对慢性炎性疾病具有潜在作用的药剂的方法和组合物
公开(公告)号：US20130211061A1
公开(公告)日：2013-08-15
申请号：US13813179
申请日：2011-07-29
申请人： Ulf Wagner , Manuela Rossol
发明人： Ulf Wagner , Manuela Rossol
IPC分类号： G01N33/50
CPC分类号： G01N33/5047 , C12N15/1138 , C12N2310/14 , C12N2310/531 , G01N33/566
摘要： The present invention is based on two important experimental observations: The first observation is that increased extracellular concentrations of ionized calcium are found in erosive arthritis and stimulate monocytic IL-1β release via the CaSR and GPRC6A. Simultaneous stimulation of monocytes with calcium ions and selected TLR ligands results in a 20-fold increased IL1β response compared to lipopolysaccharide (LPS) alone. During the crosstalk between GPCR and TLR signaling, phospholipase C is activated, which triggers calcium dependent potassium channels, resulting in potassium efflux, caspase-1 activation and IL-1β release. The amplification of IL1β secretion at sites of locally increased calcium ion concentrations aggravates rheumatoid arthritis. The second important observation is that both CaSR and GPRC6A, are highly expressed in the synovial membrane of patients with rheumatoid arthritis, but expression of GPRC6A, but not of CaSR, is lower in patients with osteoarthritis (s. FIG. 1). The latter is generally not accompanied by inflammation. Thus, expression of GPRC6A appears to be upregulated in chronic inflammatory situations. Based on these experimental observations the invention provides a method and compositions for the identification of agents that have a potential effect against chronic inflammatory conditions, in particular erosive arthritis and atherosclerosis.
摘要翻译：本发明基于两个重要的实验观察：第一个观察结果是在侵蚀性关节炎中发现电离钙的细胞外浓度增加，并通过CaSR和GPRC6A刺激单核细胞IL-1beta的释放。使用钙离子和选择的TLR配体同时刺激单核细胞导致与单独的脂多糖（LPS）相比，IL1beta反应增加20倍。在GPCR和TLR信号传导之间的串扰中，磷脂酶C被激活，其触发钙依赖性钾通道，导致钾流出，胱天蛋白酶-1激活和IL-1beta释放。局部增加钙离子浓度位点IL1beta分泌的扩增加重了类风湿性关节炎。第二个重要的观察结果是，CaSR和GPRC6A都在类风湿性关节炎患者的滑膜中高度表达，但骨关节炎患者GPRC6A的表达较低，而不是CaSR的表达较低（图1）。后者通常不伴有炎症。因此，GPRC6A的表达似乎在慢性炎症状态下上调。基于这些实验观察，本发明提供了用于鉴定对慢性炎性病症，特别是侵蚀性关节炎和动脉粥样硬化具有潜在作用的药剂的方法和组合物。

10. 发明授权

US10670576B2 Device and method for measuring impedance in organotypic tissues 审中-公开
公开(公告)号：US10670576B2
公开(公告)日：2020-06-02
申请号：US15408649
申请日：2017-01-18
申请人： Universität Leipzig
发明人： Andrea Robitzki , Andrée Rothermel , Heinz-Georg Jahnke , Ina Sternberger , Frank Striggow , Till Mack
IPC分类号： G01N33/483 , G01N27/04 , C12M1/42 , C12N13/00
摘要： The present invention refers to a device for measuring impedance in organotypic tissue comprising at least one recording chamber with a liquid permeable membrane supporting the organotypic tissue, at least one bottom electrode and at least one top electrode, wherein the liquid permeable membrane divides the recording chamber into a top chamber and a bottom chamber, wherein at least the bottom chamber contains culture medium for the organotypic tissue, and the bottom electrode(s) is/are located in the bottom chamber and the top electrode(s) is/are located in the top chamber, and wherein the organotypic tissue is located between the bottom electrode(s) and the top electrode(s). The present invention also refers to the use of the device according to the present invention for measuring impedance in organotypic tissue. Furthermore, the present invention relates to a method for analyzing the effect of test compounds on pathological and non-pathological organotypic tissue by measuring the impedance of the organotypic tissue, wherein the organotypic tissue is cultured in a culture medium during the time of the analysis and the impedance of the organotypic tissue is measured at least once before and at least once after treating the organotypic tissue with the test compound or the impedance of the organotypic tissue treated with the test compound is compared to a non-treated organotypic tissue, wherein the impedance is measured using at least one electrode at each of two opposing sides of the organotypic tissue, and the electrodes are contacted with the culture medium or the tissue during measuring the impedance.

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