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1. 发明申请

WO2004080321A1 SYSTEM AND METHODS FOR LASER TREATMENT OF OCULAR TISSUE 审中-公开
标题翻译：用于激光治疗眼组织的系统和方法
公开(公告)号：WO2004080321A1
公开(公告)日：2004-09-23
申请号：PCT/US2004/006709
申请日：2004-03-04
申请人： THE RESEARCH FOUNDATION OF CUNY , THE NEW YORK EYE AND EAR INFIRMARY , ALFANO, Robert, R. , GAYEN, Tapan, K. , MCCORMICK, Steven, A. , ROSEN, Richard , KATZ, Alvin , SAVAGE, Howard, E.
发明人： ALFANO, Robert, R. , GAYEN, Tapan, K. , MCCORMICK, Steven, A. , ROSEN, Richard , KATZ, Alvin , SAVAGE, Howard, E.
IPC分类号： A61B18/20
CPC分类号： A61F9/00821 , A61F9/008 , A61F2009/00863 , A61F2009/00865 , A61F2009/00872
摘要： A system and method for exposing ocular tissue to a beam of electromagnetic radiation tuned to an NIR wavelength between about 1380 nm and about 1600 nm in the water absorption band. The laser energy is absorbed by the water, which in turn, transfers the energy to collagen molecules. The helical collagen molecules partially denature and then re-nature to form a weld across the region of the tissues to be joined. In a preferred embodiment, the electromagnetic radiation originates from a laser. The lasers may be Cr 4+ doped crystals, Erbium fibers, and alloys of semiconductor laser diodes.
摘要翻译：一种将眼组织暴露于吸水带中调谐到约1380nm至约1600nm之间的NIR波长的电磁辐射束的系统和方法。激光能量被水吸收，这又将能量转移到胶原分子。螺旋胶原分子部分变性，然后重新自然，以在待连接的组织的区域上形成焊缝。在优选实施例中，电磁辐射源于激光。激光器可以是Cr + 4+掺杂晶体，铒光纤和半导体激光二极管的合金。

2. 发明公开

EP1668158A2 RNA DETECTION AND QUANTITATION 有权
标题翻译： RNA检测和定量
公开(公告)号：EP1668158A2
公开(公告)日：2006-06-14
申请号：EP04780049.5
申请日：2004-08-05
申请人： The Research Foundation of Cuny
发明人： HUANG, Zhen
IPC分类号： C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C12Q1/6813 , C12Q2521/301 , C12Q2525/131 , C12Q2533/101
摘要： The present invention is directed to a highly sensitive method for direct detection of at least one specific RNA in a sample. The presence of a specific RNA provides a positive indicator of a pathogenic agent, contaminant, and/or normal or abnormal genes in the sample. Applications for which the method of the invention is particularly well suited include point-of-care disease diagnosis, detection of microbial contamination in food and/or water supplies, and pathogen detection in biodefense.

3. 发明申请

US20210088699A1 PLASMONIC PHASE MODULATOR AND METHOD OF MODULATING AN SPP WAVE 有权
公开(公告)号：US20210088699A1
公开(公告)日：2021-03-25
申请号：US15948475
申请日：2018-04-09
申请人： Ngwe Thawdar , Michael Medley , The Research Foundation for The State University New York , The Research Foundation of CUNY
发明人： Josep Jornet , Prateek Kumar Singh , Gregory Aizin , Ngwe Thawdar , Michael Medley
IPC分类号： G02B5/00 , G02F1/025 , G02F1/035 , G02B6/122
摘要： A plasmonic phase modulator is provided. The modulator has a conductive layer, and a dielectric layer disposed on the conductive layer. A plasmonic layer is disposed on the dielectric layer. A plasmonic layer is disposed on the dielectric layer. The plasmonic layer is conductive to surface plasmon polariton (SPP) waves. The plasmonic layer may be, for example, a graphene sheet. A voltage signal source is operatively connected between the conductive layer and the plasmonic layer for modulating a propagation speed of an SPP wave propagating on the plasmonic layer.

4. 发明授权

US6006001A Fiberoptic assembly useful in optical spectroscopy 失效
标题翻译：光纤组件可用于光谱学
公开(公告)号：US6006001A
公开(公告)日：1999-12-21
申请号：US982332
申请日：1997-12-02
申请人： Robert R. Alfano , Stavros G. Demos , Gang Zhang
发明人： Robert R. Alfano , Stavros G. Demos , Gang Zhang
IPC分类号： A61B5/00 , G02B6/04 , G02B6/24
CPC分类号： G02B6/241 , A61B5/0059 , G02B6/04
摘要： A fiberoptic assembly for optical spectroscopic analysis of a sample. In a preferred embodiment, the assembly is well-suited for use inside the working channel of an endoscope and comprises a tubular outer jacket and a tubular inner jacket, the inner jacket being coaxial with and positioned inside the outer jacket. The open front end of the inner jacket is spaced rearwardly a short distance relative to the open front end of the outer jacket. The outer jacket has an outer diameter of approximately 2.2 mm. The assembly also includes a plug made of fused silica. The plug has a front cylindrical portion of comparatively large cross-sectional diameter and a rear cylindrical portion of comparatively small cross-sectional diameter. The front portion is mounted within the outer jacket by a friction-fit and extends longitudinally from the open front end thereof to the open front end of the inner jacket. The rear portion of the plug is mounted within the inner jacket by a friction-fit and extends rearwardly from its open front end for a short distance. A narrow-band filter in the form of a dielectric-coating is formed on the rear end of the rear portion of the plug. The assembly also includes an illumination fiber centered within the inner jacket and spaced rearwardly a short distance from the narrow-band filter. The output end of the illumination filter is shaped to collimate light emergent therefrom. The assembly additionally comprises a plurality of light collection fibers, which fibers are disposed within the outer tubular jacket and are spaced about the outside of the inner tubular jacket.
摘要翻译：用于光谱分析样品的光纤组件。在优选实施例中，该组件非常适合于在内窥镜的工作通道内部使用，并且包括管状外护套和管状内护套，内护套与外护套同轴并位于外护套内。内护套的开放前端相对于外护套的敞开前端向后隔开一短距离。外护套的外径约为2.2mm。组件还包括由熔融石英制成的塞子。插头具有比较大的横截面直径的前圆柱形部分和相对较小横截面直径的后圆柱形部分。前部通过摩擦配合安装在外护套内，并从其敞开的前端纵向延伸到内护套的敞开的前端。插头的后部通过摩擦配合安装在内护套内，并从其敞开的前端向后延伸短距离。在插头后部的后端形成电介质涂层形式的窄带滤波器。该组件还包括以内护套为中心并与窄带过滤器相隔一定距离的照明纤维。照明滤光器的输出端被成形为使从其出射的光准直。组件还包括多个聚光纤维，该纤维布置在外部管状护套内并且围绕内部管状护套的外部间隔开。

5. 发明授权

US6151522A Method and system for examining biological materials using low power CW excitation raman spectroscopy 失效
公开(公告)号：US6151522A
公开(公告)日：2000-11-21
申请号：US270383
申请日：1999-03-16
申请人： Robert R. Alfano , Wubao Wang
发明人： Robert R. Alfano , Wubao Wang
IPC分类号： A61B5/00 , G01J3/44 , G01N21/65 , A61B6/00
CPC分类号： A61B5/0075 , A61B5/0084 , A61B5/4312 , G01J3/44 , G01N21/65 , A61B5/0086
摘要： A method and system for examining biological materials using low-power cw excitation Raman spectroscopy. In accordance with the teachings of the invention, a low-power continuous wave (cw) pump laser beam and a low-power cw Stokes (or anti-Stokes) probe laser beam simultaneously illuminate a biological material and traverse the biological material in collinearity. The pump beam, whose frequency is varied, is used to induce Raman emission from the biological material. The intensity of the probe beam, whose frequency is kept constant, is monitored as it leaves the biological material. When the difference between the pump and probe excitation frequencies is equal to a Raman vibrational mode frequency of the biological material, the weak probe signal becomes amplified by one or more orders of magnitude (typically up to about 10.sup.4 -10.sup.6) due to the Raman emission from the pump beam. In this manner, by monitoring the intensity of the probe beam emitted from the biological material as the pump beam is varied in frequency, one can obtain an excitation Raman spectrum for the biological material tested. The present invention may be applied to in the in vivo and/or in vitro diagnosis of diabetes, heart disease, hepatitis, cancers and other diseases by measuring the characteristic excitation Raman lines of blood glucose, cholesterol, serum glutamic oxalacetic transaminase (SGOT)/serum glutamic pyruvic tansaminase (SGPT), tissues and other corresponding Raman-active body constituents, respectively. For example, it may also be used to diagnose diseases associated with the concentration of Raman-active constituents in urine, lymph and saliva It may be used to identify cancer in the breast, cervix, uterus, ovaries and the like by measuring the fingerprint excitation Raman spectra of these tissues. It may also be used to reveal the growing of tumors or cancers by measuring the levels of nitric oxide in tissue.

6. 发明授权

US10996379B2 Plasmonic phase modulator and method of modulating an SPP wave 有权
公开(公告)号：US10996379B2
公开(公告)日：2021-05-04
申请号：US15948475
申请日：2018-04-09
申请人： The Research Foundation for The State University of New York , The Research Foundation of CUNY , Ngwe Thawdar , Michael Medley
发明人： Josep Jornet , Prateek Kumar Singh , Gregory Aizin , Ngwe Thawdar , Michael Medley
IPC分类号： G02B5/00 , G02B6/122 , G02B6/12
摘要： A plasmonic phase modulator is provided. The modulator has a conductive layer, and a dielectric layer disposed on the conductive layer. A plasmonic layer is disposed on the dielectric layer. A plasmonic layer is disposed on the dielectric layer. The plasmonic layer is conductive to surface plasmon polariton (SPP) waves. The plasmonic layer may be, for example, a graphene sheet. A voltage signal source is operatively connected between the conductive layer and the plasmonic layer for modulating a propagation speed of an SPP wave propagating on the plasmonic layer.

7. 发明授权

US08965217B2 Superimposing optical transmission modes 有权
标题翻译：叠加光传输模式
公开(公告)号：US08965217B2
公开(公告)日：2015-02-24
申请号：US13803872
申请日：2013-03-14
申请人： Corning Incorporated
发明人： Daniel A. Nolan , Giovanni Milione , Robert R. Alfano
IPC分类号： H04B10/12 , H04B10/2569 , H04B10/2581 , H04J14/04 , H04B10/079
CPC分类号： H04B10/2569 , H04B10/0795 , H04B10/0799 , H04B10/2581 , H04J14/04
摘要： A method of superimposing N optical transmission modes for collective transmission along a multimode optical fiber is provided where each of the N optical signals comprises N distinct superimposed transmission modes (M1, M2, . . . ) and a portion of each of the N propagating optical signals is sampled at a receiving end of the data transmission network. N2−1 distinct measurement conditions are derived from a transmission matrix T and a special unitary matrix group SU(N) corresponding to the superimposed transmission modes (M1, M2, . . . ) at the receiving end of the data transmission network and N2−1 measurements are extracted from the sampled signals. The extracted N2−1 measurements are used to solve a matrix equation corresponding to the generated SU(N) matrices and the output matrix transposed and used to generating principal state launch conditions from the eigenvectors of the transposed output matrix to form a principal state in each of the N optical signals.
摘要翻译：提供了一种叠加用于沿着多模光纤的集体传输的N个光传输模式的方法，其中每个N个光信号包括N个不同的叠加传输模式（M1，M2 ...）和N个传播光纤在数据传输网络的接收端采样信号。 N2-1不同的测量条件从传输矩阵T和对应于在数据传输网络接收端的叠加传输模式（M1，M2 ...）的特殊酉矩阵组SU（N）导出，N2- 从采样信号中提取1个测量值。提取的N2-1测量用于求解与生成的SU（N）矩阵相对应的矩阵方程和转置的输出矩阵，并用于从转置的输出矩阵的特征向量产生主状态发射条件，以在每个状态中形成主状态的N个光信号。

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