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1. 发明公开

EP1784643A2 HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID 审中-公开
标题翻译：齐酶免疫试验口服液
公开(公告)号：EP1784643A2
公开(公告)日：2007-05-16
申请号：EP05795380.4
申请日：2005-08-26
申请人： Lin-Zhi International, Inc.
发明人： LIN, Marie , CHIA, Tom
IPC分类号： G01N33/535 , G01N33/536 , G01N33/542 , G01N33/94 , C07K16/44
CPC分类号： G01N33/94 , G01N33/581 , G01N2333/904
摘要： The present invention discloses homogeneous enzyme immunoassay systems, methods and kits useful for the qualitatively and quantitatively determination of analytes in oral fluid samples. The system involves a competitive enzyme immunoassay employing a conjugate comprising glucose-6-phosphate dehydrogenase (G6PDH) and an analyte. The methods and kits are particularly useful in the detection of recent drug use and for fast determination of analytes using auto-analyzers.

2. 发明公开

EP1784643A4 HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID 审中-公开
标题翻译：齐酶免疫试验口服液
公开(公告)号：EP1784643A4
公开(公告)日：2008-10-08
申请号：EP05795380
申请日：2005-08-26
申请人： LIN ZHI INTERNATIONAL INC
发明人： LIN MARIE , CHIA TOM
IPC分类号： G01N33/535 , C07K16/44 , G01N33/536 , G01N33/542 , G01N33/94
CPC分类号： G01N33/94 , G01N33/581 , G01N2333/904
摘要： HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID ABSTRACT OF THE DISCLOSURE The present invention discloses homogeneous enzyme immunoassay systems, methods and kits useful for the qualitatively and quantitatively determination of analytes in oral fluid samples. The system involves a competitive enzyme immunoassay employing a conjugate comprising glucose-6-phosphate dehydrogenase (G6PDH) and an analyte. The methods and kits are particularly useful in the detection of recent drug use and for fast determination of analytes using auto-analyzers.

3. 发明授权

US07560239B2 Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes 有权
标题翻译：用于同时检测多种分析物的均匀酶免疫测定
公开(公告)号：US07560239B2
公开(公告)日：2009-07-14
申请号：US10163018
申请日：2002-06-04
申请人： Marie Lin , Tom Chia , Chiu Chin Chang
发明人： Marie Lin , Tom Chia , Chiu Chin Chang
IPC分类号： G01N33/00
CPC分类号： G01N33/946 , G01N33/581 , G01N33/948 , G01N33/9486
摘要： Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly the plurality of analytes are structurally unrelated or significantly different, particularly to whether one or more of such analytes is present in a sample in a concentration that is above a predetermined minimum or cutoff value, and particularly for such analytes with different cutoffs. The methods and kits are particularly useful for-screening for the presence of a plurality of drugs (licit and/or illicit), performance-enhancing substances, and other chemicals, and involve a competitive enzyme immunoassay employing one or more conjugates of G6PDH with a plurality of the analytes.
摘要翻译：提供了用于同时检测多种分析物的方法和试剂盒，即确定样品中是否存在多种分析物中的一种或多种，特别是多种分析物在结构上不相关或显着不同，特别是关于一种或多种更多的这样的分析物以高于预定最小值或截止值的浓度存在于样品中，特别是对于具有不同截止值的这种分析物。这些方法和试剂盒对于筛选多种药物（合法和/或非法），性能增强物质和其它化学物质的存在特别有用，并且涉及使用一种或多种G6PDH缀合物的竞争性酶免疫测定法多个分析物。

4. 发明申请

US20030224373A1 Homogeneous enzyme immunoassay for simultaneous detection of multiple analytes 有权
公开(公告)号：US20030224373A1
公开(公告)日：2003-12-04
申请号：US10163018
申请日：2002-06-04
申请人： Lin-Zhi International Inc.
发明人： Marie Lin , Tom Chia , Chiu Chin Chang
IPC分类号： C12Q001/68 , G01N033/53 , G01N033/554 , G01N033/569
CPC分类号： G01N33/946 , G01N33/581 , G01N33/948 , G01N33/9486
摘要： Methods and kits are provided for the simultaneous detection of multiple analytes, i.e. to the determination of whether one or more of a plurality of analytes is present in a sample, particularly the plurality of analytes are structurally unrelated or significantly different, particularly to whether one or more of such analytes is present in a sample in a concentration that is above a predetermined minimum or cutoff value, and particularly for such analytes with different cutoffs. The methods and kits are particularly useful for-screening for the presence of a plurality of drugs (licit and/or illicit), performance-enhancing substances, and other chemicals, and involve a competitive enzyme immunoassay employing one or more conjugates of G6PDH with a plurality of the analytes.

5. 发明申请

US20060046273A1 Homogeneous enzyme immunoassay for oral fluid 审中-公开
标题翻译：口服液均匀酶免疫测定
公开(公告)号：US20060046273A1
公开(公告)日：2006-03-02
申请号：US10927823
申请日：2004-08-27
申请人： Cheng-I Lin , Marie Lin , Tom Chia
发明人： Cheng-I Lin , Marie Lin , Tom Chia
IPC分类号： G01N33/542 , G01N33/53
CPC分类号： G01N33/94 , G01N33/581 , G01N2333/904
摘要： The present invention discloses homogeneous enzyme immunoassay systems, methods and kits useful for the qualitatively and quantitatively determination of analytes in oral fluid samples. The system involves a competitive enzyme immunoassay employing a conjugate comprising glucose-6-phosphate dehydrogenase (G6PDH) and an analyte. The methods and kits are particularly useful in the detection of recent drug use and for fast determination of analytes using auto-analyzers.
摘要翻译：本发明公开了用于定性和定量测定口腔液样品中分析物的均相酶免疫测定系统，方法和试剂盒。该系统涉及使用包含葡萄糖-6-磷酸脱氢酶（G6PDH）和分析物的缀合物的竞争性酶免疫测定。该方法和试剂盒特别适用于检测最近的药物使用和使用自动分析仪快速测定分析物。

6. 发明申请

WO2006026601A3 HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID 审中-公开
公开(公告)号：WO2006026601A3
公开(公告)日：2006-03-09
申请号：PCT/US2005/030794
申请日：2005-08-26
申请人： LIN-ZHI INTERNATIONAL, INC. , LIN, Marie , CHIA, Tom
发明人： LIN, Marie , CHIA, Tom
IPC分类号： G01N33/535 , G01N33/536 , G01N33/542 , G01N33/94 , C07K16/44
摘要： The present invention discloses homogeneous enzyme immunoassay systems, methods and kits useful for the qualitatively and quantitatively determination of analytes in oral fluid samples. The system involves a competitive enzyme immunoassay employing a conjugate comprising glucose-6-phosphate dehydrogenase (G6PDH) and an analyte. The methods and kits are particularly useful in the detection of recent drug use and for fast determination of analytes using auto-analyzers.

7. 发明申请

WO2006026601A2 HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID 审中-公开
标题翻译：口服液体均质免疫免疫
公开(公告)号：WO2006026601A2
公开(公告)日：2006-03-09
申请号：PCT/US2005030794
申请日：2005-08-26
申请人： LIN ZHI INTERNATIONAL INC , LIN MARIE , CHIA TOM
发明人： LIN MARIE , CHIA TOM , LIN CHENG-I
IPC分类号： G01N33/542 , G01N33/53
CPC分类号： G01N33/94 , G01N33/581 , G01N2333/904
摘要： HOMOGENEOUS ENZYME IMMUNOASSAY FOR ORAL FLUID ABSTRACT OF THE DISCLOSURE The present invention discloses homogeneous enzyme immunoassay systems, methods and kits useful for the qualitatively and quantitatively determination of analytes in oral fluid samples. The system involves a competitive enzyme immunoassay employing a conjugate comprising glucose-6-phosphate dehydrogenase (G6PDH) and an analyte. The methods and kits are particularly useful in the detection of recent drug use and for fast determination of analytes using auto-analyzers.
摘要翻译：用于口腔液体的均质酶免疫学摘要本发明公开了用于定性和定量测定口腔液样品中分析物的均相酶免疫测定系统，方法和试剂盒。该系统涉及使用包含葡萄糖-6-磷酸脱氢酶（G6PDH）和分析物的缀合物的竞争性酶免疫测定。该方法和试剂盒特别适用于检测最近的药物使用和使用自动分析仪快速测定分析物。

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