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1. 发明申请

WO2011141711A1 METHODS FOR SELECTING METHYLATION MARKERS 审中-公开
标题翻译：选择甲基标记的方法
公开(公告)号：WO2011141711A1
公开(公告)日：2011-11-17
申请号：PCT/GB2011/000733
申请日：2011-05-12
申请人： ABERYSTWYTH UNIVERSITY , MEADE, Andrew Paul , WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez
发明人： MEADE, Andrew Paul , WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez
IPC分类号： C12Q1/68
CPC分类号： G06F19/18 , C12Q1/6809 , C12Q1/6895 , C12Q2600/154 , C12Q2600/158 , G06F19/24 , C12Q2537/165 , C12Q2523/125
摘要： The present invention relates to a method of identifying sets of DNA loci for identifying atypical growth conditions and for identifying the identity or source of cells of interest. The method can include identifying a plurality of sets of DNA loci that may identify a plurality of atypical growth conditions in cells of different origin and/or genotype. There is also provided sets of DNA loci and uses thereof.
摘要翻译：本发明涉及一种识别DNA基因座的集合以识别非典型生长条件并鉴定感兴趣的细胞的身份或来源的方法。该方法可以包括识别多个可以鉴定不同来源和/或基因型的细胞中的非典型生长条件的DNA基因座组。还提供了一组DNA位点及其用途。

2. 发明授权

US08890089B2 Faecal markers 有权
标题翻译：粪便标记
公开(公告)号：US08890089B2
公开(公告)日：2014-11-18
申请号：US13255288
申请日：2010-03-09
申请人： Michael Lee , Michael Theodorou , Helen Ougham , Howard Thomas
发明人： Michael Lee , Michael Theodorou , Helen Ougham , Howard Thomas
IPC分类号： G01N21/64 , G01N33/12 , C09B61/00
CPC分类号： C09B61/00 , G01N33/12
摘要： Described are methods for analyzing an animal carcass, meat obtained therefrom, or product produced by or obtained from an animal for the presence or absence of faecal matter. The methods comprise analyzing an animal carcass, meat obtained therefrom, or product produced by or obtained from the animal for the presence or absence of a detectable marker, the presence of the detectable marker being indicative of the presence of faecal matter and the absence of the detectable marker being indicative of the absence of faecal matter, wherein the animal carcass, meat obtained therefrom, or product produced by or obtained from the animal has been obtained from an animal fed a composition comprising a supplement of the detectable marker and/or a precursor thereof. Also described are compositions for feeding to an animal and for use in the methods.
摘要翻译：描述了用于分析动物屠体，从其获得的肉，或由动物产生或获得的用于粪便物质的存在或不存在的产品的方法。所述方法包括分析动物屠体，从其获得的肉，或由动物产生或获自动物的产物，以检测标记的存在或不存在，可检测标记物是否存在指示粪便物质的存在和不存在可检测标记指示不存在粪便物质，其中动物尸体，由其获得的肉或由动物产生或从动物获得的产品已经从喂食包含可检测标记物和/或前体的补充物的组合物的动物获得其中。还描述了用于喂养动物并用于该方法的组合物。

3. 发明公开

EP2320750A1 BIOLOGICAL MATERIALS AND USES THEREOF 审中-公开
标题翻译：生物材料及其用途
公开(公告)号：EP2320750A1
公开(公告)日：2011-05-18
申请号：EP09766133.4
申请日：2009-06-19
申请人： Aberystwyth University , Compton Developments Limited
发明人： ALI, Ahmed , NEWBOLD, Charles James , HART, Kenton
IPC分类号： A23K1/16 , A23K1/18 , A23L1/30 , A61K36/185
CPC分类号： A61K36/185 , A23K20/105 , A23K50/10 , A23K50/20 , Y02P60/56
摘要： There is provided the use of a sandalwood extract or a sandalwood analogue as an additive to animal foodstuff for the reduction of methane production, reduction of bacterial mediated protein breakdown and reduces bacterial growth in the stomach. There are also provided food products and methods of making food products incorporating sandalwood extracts or sandalwood analogues.

4. 发明授权

US11311029B2 Prebiotic composition 有权
公开(公告)号：US11311029B2
公开(公告)日：2022-04-26
申请号：US15037917
申请日：2014-11-19
申请人： ABERYSTWYTH UNIVERSITY
发明人： Andrew John Lee , Joseph Gallagher , Steven Anthony Fish , Stephen Michael Morris
IPC分类号： A23K10/30 , A23K10/18 , A23K10/37 , A23L33/22 , A23L33/135
摘要： A composition comprising branched fructan molecules derived from a fructan extract of perennial high sugar grass (HSG) selected from the group consisting of AberMagic cultivar, AberDart cultivar, and S48 (Lolium spp), and obtained by enzymic endo-hydrolase hydrolysis, wherein said branched fructan molecules have a molecular weight of between 0.3 to 3 kDa, and wherein at least 50% of the branched fructan molecules present in the composition have a molecular weight of between 0.48 and 1.9 kDa is provided. Also provided are feed or food supplement comprising such a composition, a method of producing a composition comprising branched fructan molecules, and a method of making a feed or foodstuff.

5. 发明授权

US09050831B2 Ink curing apparatus with lamp housing and movable locking member 有权
标题翻译：具有灯壳和可动锁定构件的油墨固化装置
公开(公告)号：US09050831B2
公开(公告)日：2015-06-09
申请号：US14352558
申请日：2013-06-28
申请人： GEW (EC) LIMITED
发明人： Malcolm Rae , James Hicks
IPC分类号： B41J2/01 , B41J11/00 , F21V19/00 , F26B3/28 , F21V19/04 , B41F23/04 , F21V21/14 , C09D11/101 , H01R13/639
CPC分类号： B41J11/0015 , B41F23/0409 , B41F23/0453 , B41J11/002 , C09D11/101 , F21V19/008 , F21V19/04 , F21V21/14 , F26B3/28 , H01R13/639
摘要： A lamp housing (1) for an ink curing apparatus comprising at least one locking member (18) configured to lock a lamp (3) into the housing (1) wherein the locking member (18) is movable between an open position allowing removal of the lamp (3) and a closed position restricting vertical movement of the lamp (3).
摘要翻译：一种用于油墨固化装置的灯壳体（1），包括至少一个构造成将灯（3）锁定到壳体（1）中的锁定构件（18），其中锁定构件（18）可在允许移除灯（3）和限制灯（3）的垂直运动的关闭位置。

6. 发明申请

WO2016097759A1 ANTHELMINTIC COMPOUNDS 审中-公开
标题翻译： ANTHELMINTIC化合物
公开(公告)号：WO2016097759A1
公开(公告)日：2016-06-23
申请号：PCT/GB2015/054078
申请日：2015-12-18
申请人： ABERYSTWYTH UNIVERSITY
发明人： HOFFMANN, Karl Francis , NASH, Robert James , PEAK, Emily
IPC分类号： A61K31/00 , A61K31/122 , A61K31/4184 , A61K31/4985 , A61P33/10
CPC分类号： A61K31/00 , A61K31/122 , A61K31/4184 , A61K31/4985 , A61K2300/00
摘要： The present invention relates to compounds, in particular derivatives of the diterpenoids sempervirol and 7‐keto‐sempervirol, and their use in therapy, including in pharmaceutical compositions and combinations, especially in the treatment and/or prophylaxis of the tropical diseases schistosomiasis and/or fascioliasis, for example in humans or in non‐human land mammals such as sheep, cattle, other ruminants, or goats.
摘要翻译：本发明涉及化合物，特别是二萜类化合物sempervirol和7-酮基半胱氨酸的衍生物及其在治疗中的用途，包括药物组合物和组合，特别是治疗和/或预防热带病血吸虫病和/或 fascioliasis，例如在人类或非人类陆地哺乳动物如绵羊，牛，其他反刍动物或山羊中。

7. 发明申请

WO2015075440A1 PREBIOTIC COMPOSITION 审中-公开
标题翻译：预制组合物
公开(公告)号：WO2015075440A1
公开(公告)日：2015-05-28
申请号：PCT/GB2014/053414
申请日：2014-11-19
申请人： ABERYSTWYTH UNIVERSITY
发明人： LEE, Andrew John , GALLAGHER, Joseph , FISH, Steven Anthony , MORRIS, Stephen Michael
IPC分类号： A23L1/30 , A23L1/308 , A23K1/00 , A23K1/14
CPC分类号： A23K10/30 , A23K10/18 , A23K10/37 , A23L33/135 , A23L33/22 , A23V2002/00 , A23V2200/00 , A23Y2220/49 , A23Y2220/67 , A23Y2220/73 , A23Y2300/55 , Y02P60/877 , A23V2250/5046
摘要： A composition comprising branched fructan molecules, wherein said branched fructan molecules have; a molecular weight of between about 0.3 to about 3kDa;and/ora fructan chain length of about 2 to about 15 fructose units and/or an elution time of 7 to 22 minutes when on a Dionex HPAEC-PAD column. The invention also embraces a feed or food supplement comprising such compositions, a method of producing a composition comprising branched fructan molecules, and a method of making a feed or foodstuff.
摘要翻译：一种包含支链果聚糖分子的组合物，其中所述支链果聚糖分子具有：约0.3至约3kDa的分子量;和/或约2至约15个果糖单元的果聚糖链长度和/或在Dionex HPAEC-PAD柱上的洗脱时间为7至22分钟。本发明还包括含有这种组合物的饲料或食品补充剂，制备包含支链果聚糖分子的组合物的方法，以及制备饲料或食品的方法。

8. 发明申请

WO2014041372A1 LIPASES, POLYNUCLEOTIDES ENCODING THEM AND THEIR USES 审中-公开
标题翻译：利益，多核苷酸编码它们及其用途
公开(公告)号：WO2014041372A1
公开(公告)日：2014-03-20
申请号：PCT/GB2013/052414
申请日：2013-09-16
申请人： ABERYSTWYTH UNIVERSITY
发明人： PRIVÉ, Florence , NEWBOLD, Charles Jamie , HUWS, Sharon , SCOLLEN, Nigel
IPC分类号： C12N9/20 , C12N9/18 , C07K16/12 , C12P7/64 , G01N33/48 , G01N33/50 , A61K38/46 , C12P41/00 , C07K14/405
CPC分类号： C12N9/20 , A61K38/465 , A61K39/3955 , C07K16/40 , C07K2317/21 , C07K2317/76 , C12N9/18 , C12P7/64 , C12Y301/01003 , Y02E50/13
摘要： A lipase comprising a polypeptide or peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1-19 and the polynucleotides encoding the lipases is disclosed. The lipases and nucleic acid sequences encoding these lipases can be used in the preparation of polymers, in formulations which may comprise detergents, as catalysts, in the preparation of bioplastics, as part of diagnostic kits, in the preparation of biofuels and for the prevention and/or treatment of a disease.
摘要翻译：公开了含有包含选自SEQ ID NO：1-19的氨基酸序列和编码脂肪酶的多核苷酸的多肽或肽的脂肪酶。编码这些脂肪酶的脂肪酶和核酸序列可用于制备聚合物，在制剂中可以包含洗涤剂，催化剂，生物塑料的制备，作为诊断试剂盒的一部分，用于生物燃料的制备和预防和 /或治疗疾病。

9. 发明申请

WO2011157995A1 METHOD FOR PRODUCING A STRESS TOLERANT PLANT OR PRECURSOR THEREOF 审中-公开
标题翻译：用于生产耐应变材料或其前体的方法
公开(公告)号：WO2011157995A1
公开(公告)日：2011-12-22
申请号：PCT/GB2011/000904
申请日：2011-06-14
申请人： ABERYSTWYTH UNIVERSITY , WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez , TRICKER, Penelope , HADLEY, Paul
发明人： WILKINSON, Michael James , LOPEZ, Carlos Marcelino Rodriguez , TRICKER, Penelope , HADLEY, Paul
IPC分类号： A01H1/04
CPC分类号： A01H3/00 , A01H1/04
摘要： Provided are methods for the production of a stress tolerant plant or precursor thereof. The methods comprise (i) subjecting one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation; and (ii) generating offspring from said one or more parental plants. The offspring show enhanced tolerance relative to the one or more parental plants to one or more stress conditions selected from unfavourable conditions relating to relative humidity, water availability, periodic drought, nutrients, sunlight, wind, temperature, pH, exogenous chemicals, chemical toxins such as salt, herbivory, prophylactic chemicals, fertilizers, pathogen attack such as bacterial, fungal, or virus infection and pest infestation. Also provided are plants, or precursor thereof, produced by the methods and assays for identifying a plant, or precursor thereof, produced by the methods.
摘要翻译：提供了用于生产胁迫耐受植物或其前体的方法。所述方法包括（i）使一种或多种亲本植物经受一种或多种胁迫条件，所述胁迫条件选自与相对湿度，水可利用性，周期性干旱，营养物，阳光，风，温度，pH，外源化学物质，化学毒素如盐，食草，预防化学品，化肥，细菌，真菌或病毒感染和虫害等病原体攻击; 和（ii）从所述一个或多个亲本植物产生后代。后代显示相对于一个或多个亲本植物对一种或多种胁迫条件的增强的耐受性，所述胁迫条件选自与相对湿度，水可用性，周期性干旱，营养物，阳光，风，温度，pH，外源性化学物质，化学毒素等有关的不利条件作为盐，食草，预防化学物质，肥料，病原体攻击如细菌，真菌或病毒感染和害虫侵袭。还提供了通过用于鉴定通过该方法产生的植物或其前体的方法和测定法产生的植物或其前体。

10. 发明申请

WO2011033290A2 DUAL-FLUORESCENCE ASSAY 审中-公开
标题翻译：双色荧光测定
公开(公告)号：WO2011033290A2
公开(公告)日：2011-03-24
申请号：PCT/GB2010/051527
申请日：2010-09-13
申请人： ABERYSTWYTH UNIVERSITY , PEAK, Emily , HOFFMANN, Karl Francis
发明人： PEAK, Emily , HOFFMANN, Karl Francis
IPC分类号： G01N33/569
CPC分类号： G01N33/5308 , G01N33/5085 , G01N2021/6441 , G01N2333/43526
摘要： A two colour fluorescent assay and a kit are described that permit the determination of live and dead parasitic or non-parasitic worms, for example helminths. The assay permits screening for the effect of one or more agents or an event on the viability of a parasitic or non-parasitic worm, In one example, the assay comprises (a) providing a sample comprising one or more parasitic or non-parasitic worms; (b) contacting the parasitic or non-parasitic worms with a concentration of fluorescein diacetate sufficient to yield detectable green fluorescence in any live parasitic or non-parasitic worms present in the sample and a concentration of propidium iodide sufficient to yield detectable red fluorescence in any dead parasitic or non-parasitic worms present in the sample; and (c) detecting the red and green fluorescence of the parasitic or non-parasitic worms. The assay further comprises contacting the parasitic or non-parasitic worms with one or more test agents, or subjecting the parasitic or non-parasitic worms to an event. The assay allows for a rapid and objective score of parasitic or non-parasitic worm death and survival and enables the performance of high- throughput screens for the identification of potential agents against diseases such as schistosomiasis. Also described are methods and kits for discriminatory analysis of parasitic or non-parasitic worm phenotype and/or metabolics using FTIR analysis.
摘要翻译：描述了双色荧光测定和试剂盒，其允许测定活的和死的寄生虫或非寄生虫，例如蠕虫。该测定允许筛选一种或多种试剂或事件对寄生虫或非寄生虫的活力的影响。在一个实例中，测定包括（a）提供包含一种或多种寄生虫或非寄生虫的样品 ; （b）将寄生虫或非寄生虫与一种浓度的荧光素二乙酸酯接触，足以在样品中存在的任何活的寄生虫或非寄生虫中产生可检测的绿色荧光，以及足以产生任何可检测的红色荧光的碘化丙啶浓度存在于样品中的死寄生虫或非寄生虫; 和（c）检测寄生虫或非寄生虫的红色和绿色荧光。该测定还包括将寄生虫或非寄生虫与一种或多种测试试剂接触，或将寄生虫或非寄生虫蠕虫接触事件。该测定允许寄生虫或非寄生虫蠕虫死亡和存活的快速客观评分，并且能够实现高通量筛选用于鉴定针对诸如血吸虫病的疾病的潜在药剂。还描述了使用FTIR分析对寄生虫或非寄生虫表型和/或代谢物进行鉴别分析的方法和试剂盒。

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