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1. 发明申请

WO2004017042A3 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 审中-公开
标题翻译：表面功能化的方法和试剂
公开(公告)号：WO2004017042A3
公开(公告)日：2004-12-09
申请号：PCT/US0325927
申请日：2003-08-18
申请人： ZYOMYX INC , CICERO RONALD , FORMAN JONATHAN , KERNEN PETER , LU HONGBO , QUINCY DAVID , SCHWEISER STEFAN , WAGNER PETER
发明人： CICERO RONALD , FORMAN JONATHAN , KERNEN PETER , LU HONGBO , QUINCY DAVID , SCHWEISER STEFAN , WAGNER PETER
IPC分类号： G01N33/547 , C12M1/00 , C12N15/09 , G01N20060101 , G01N33/543 , G01N37/00
CPC分类号： G01N33/54353 , B82Y30/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The arrays are particularly useful for high throughput drug screening and clinical diagnostics applications.
摘要翻译：公开了用于制造亲和试剂阵列的试剂和方法。还公开了使用亲和剂阵列的方法。阵列对于高通量药物筛选和临床诊断应用特别有用。

2. 发明申请

WO2004081983A2 SUBSTRATE PROCESSING APPARATUS AND METHOD FOR THE CONTROLLED FORMATION OF LAYERS INCUDING SELF-ASSEMBLED MONOLYAERS 审中-公开
标题翻译：基质处理装置和控制形成自发组合单体的层的方法
公开(公告)号：WO2004081983A2
公开(公告)日：2004-09-23
申请号：PCT/US2004006851
申请日：2004-03-03
申请人： ZYOMYX INC , HASSELBLATT MARKUS , WAGNER PETER , KERNEN PETER , ZAUGG FRANK , DE LA SALLE OLIVIER
发明人： HASSELBLATT MARKUS , WAGNER PETER , KERNEN PETER , ZAUGG FRANK , DE LA SALLE OLIVIER
IPC分类号： B01L9/00 , C40B60/14 , G01N1/34 , H01L21/00 , H01L51/00 , H01L51/40 , H01L
CPC分类号： B82Y30/00 , B01J2219/00281 , B01J2219/00353 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01L9/52 , B01L2300/0803 , B01L2300/0822 , B82Y40/00 , C40B60/14 , G01N1/405 , H01L21/67028 , H01L21/67034 , H01L21/67057 , H01L51/0002
摘要： Substrate processing methods and apparatuses are disclosed. One embodiment of the invention is directed to a substrate processing apparatus for processing an analytical substrate. The apparatus includes a substrate holder for holding a substrate and a processing chamber including an opening for receiving the substrate holder and the substrate. A fluid inlet and a fluid outlet are in the processing chamber. A washing device adapted to supply a wash liquid to the substrate while the substrate is in the processing chamber. A liquid removal device adapted to dry the substrate when the substrate is being withdrawn from the processing chamber.
摘要翻译：公开了基板处理方法和装置。本发明的一个实施例涉及用于处理分析基板的基板处理装置。该装置包括用于保持基板的基板保持件和包括用于接收基板保持件和基板的开口的处理室。流体入口和流体出口在处理室中。一种洗涤装置，适于在衬底处于处理室的同时向衬底提供洗涤液体。一种液体去除装置，适于在衬底从处理室中取出时干燥衬底。

3. 发明申请

WO2009076235A3 CELL ASSAY KIT AND METHOD 审中-公开
公开(公告)号：WO2009076235A3
公开(公告)日：2009-10-15
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/49 , G01N33/543 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

4. 发明申请

WO2009076235A2 CELL ASSAY KIT AND METHOD 审中-公开
标题翻译：细胞测定试剂盒和方法
公开(公告)号：WO2009076235A2
公开(公告)日：2009-06-18
申请号：PCT/US2008085737
申请日：2008-12-05
申请人： ZYOMYX INC , ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： C12Q1/06 , C12M1/00 , G01N33/53 , G01N33/569
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下通过细长收集室被拉伸，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

5. 发明专利

SI2229591T1 Oprema za analizo celic in postopek 未知
公开(公告)号：SI2229591T1
公开(公告)日：2012-12-31
申请号：SI200830720
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , MCMANUS-MUNOZ SILVIA , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/00

6. 发明专利

ZA201004600B CELL ASSAY KIT AND METHOD 未知
公开(公告)号：ZA201004600B
公开(公告)日：2011-06-29
申请号：ZA201004600
申请日：2010-06-30
申请人： ZYOMYX INC
发明人： RUIZ-TAYLOR LAURENCE , KERNEN PETER , TOBIAS RENEE , ZAUGG FRANK , WAGNER PETER
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

7. 发明专利

PL2229591T3 Sposób oraz zestaw do oznaczania komórek 未知
公开(公告)号：PL2229591T3
公开(公告)日：2012-12-31
申请号：PL08860287
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , MCMANUS-MUNOZ SILVIA , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/49 , G01N33/543 , G01N33/569

8. 发明专利

CA2496141A1 METHODS AND REAGENTS FOR SURFACE FUNCTIONALIZATION 未知
公开(公告)号：CA2496141A1
公开(公告)日：2004-02-26
申请号：CA2496141
申请日：2003-08-18
申请人： ZYOMYX INC
发明人： FORMAN JONATHAN , CICERO RONALD , KERNEN PETER , LU HONGBO , QUINCY DAVID , WAGNER PETER , SCHWEISER STEFAN
IPC分类号： G01N33/547 , C12M1/00 , C12N15/09 , G01N20060101 , G01N33/543 , G01N37/00
摘要： Reagents and method for making arrays of affinity agents are disclosed. Methods of using the arrays of affinity agents also are disclosed. The array s are particularly useful for high throughput drug screening and clinical diagnostics applications.

9. 发明专利

ES2389437T3 Estuche y método de ensayo de células 未知
公开(公告)号：ES2389437T3
公开(公告)日：2012-10-26
申请号：ES08860287
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , MCMANUS-MUNOZ SILVIA , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： G01N33/543 , G01N33/49 , G01N33/569
摘要： Un método para ensayar una muestra de células por la presencia de al menos una concentración umbral decélulas de un tipo determinado, que comprende:(a) hacer reaccionar una muestra de células que contiene células del tipo de células determinado con partículascapaces de unión específica a las células y que son eficaces, cuando se unen a las células, para aumentar ladensidad o susceptibilidad magnética de las células, permitiendo que se separen células ligadas a partículas ypartículas libres de células no ligadas a partículas en la muestra basado en su mayor velocidad de migración por unmedio seleccionado bajo la influencia de una fuerza gravitatoria o centrífuga aplicada o de campo magnético,(b) hacer que las células unidas a partículas y las partículas en la muestra de células migren por una cámara derecogida alargada con dimensiones de ancho y profundidad entre 10 - 500 micrómetros y que contiene el medioseleccionado y que tiene a lo largo de su longitud, una pluralidad de regiones de recogida de células, sometiendo lamuestra a una fuerza gravitatoria o centrífuga seleccionada o de campo magnético durante un periodo de tiemposuficiente para causar sustancialmente que todas las células unidas a partículas y las partículas llenencompletamente regiones de recogida de células sucesivas en la cámara de recogida e(c) inspeccionar la cámara para determinar si al menos una región de recogida seleccionada se llena parcialmente ocompletamente, como demuestra que la muestra de células contenga al menos una concentración umbral de célulasdel tipo de células determinado

10. 发明专利

CA2708256A1 CELL ASSAY KIT AND METHOD 未知
公开(公告)号：CA2708256A1
公开(公告)日：2009-06-18
申请号：CA2708256
申请日：2008-12-05
申请人： ZYOMYX INC
发明人： ZAUGG FRANK , TOBIAS RENEE , KERNEN PETER , RUIZ-TAYLOR LAURENCE , WAGNER PETER
IPC分类号： C12Q1/06 , C12M1/00 , G01N33/49 , G01N33/53 , G01N33/543 , G01N33/569
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell- collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.

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