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1. 发明申请

US20050252781A1 Method for packing electrochemically-deposited elements 审中-公开
标题翻译：电化学沉积元件的包装方法
公开(公告)号：US20050252781A1
公开(公告)日：2005-11-17
申请号：US10499155
申请日：2002-12-17
申请人： Yuval Golan , Brenda Laster , Gad Shani , Moshe Faraggi , Roberto Tulman
发明人： Yuval Golan , Brenda Laster , Gad Shani , Moshe Faraggi , Roberto Tulman
IPC分类号： A61N5/10 , G21G4/06 , C25D5/02
CPC分类号： A61N5/1027 , A61N2005/1024 , G21G4/06
摘要： A method for densely packaging an element inside a casing, such that the element-containing casing is suitable for use in the preparation of a radiation source, comprising providing a solution containing ions of said element, positioning a working electrode and at least one counter electrode in contact with said solution, connecting said working electrode and said at least one counter electrode to the negative and positive poles of a power source, respectively, passing an electrical current between said electrodes to electrochemically deposit said element on said working electrode in a geometrical form corresponding to the form of the interior of the casing and concurrently or sequentially loading said casing with said element.
摘要翻译：一种用于将元件密集地包装在壳体内的方法，使得含元素的壳体适用于制备辐射源，包括提供包含所述元件的离子的溶液，定位工作电极和至少一个对电极与所述溶液接触，分别将所述工作电极和所述至少一个对电极连接到电源的负极和正极，使电极在所述电极之间通过电学方式将所述元件以几何形式电沉积在所述工作电极上对应于壳体内部的形式，同时或顺序地将所述壳体装载到所述元件上。

2. 发明申请

US20050112058A1 Auger effect-based cancer therapy method 审中-公开
标题翻译：基于俄歇效应的癌症治疗方法
公开(公告)号：US20050112058A1
公开(公告)日：2005-05-26
申请号：US10902277
申请日：2004-07-30
申请人： Brenda Laster , Gad Shani , Moshe Faraggi , Yuval Golan
发明人： Brenda Laster , Gad Shani , Moshe Faraggi , Yuval Golan
IPC分类号： A61K31/409 , A61K41/00 , A61K51/00 , A61K31/555
CPC分类号： A61K31/409 , A61K41/00 , A61N2005/1024
摘要： A method for the treatment of a tumor, comprising administering to a subject a therapeutically effective amount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligand substituted with charged chemical groups, wherein said complex is capable of bringing said heavy element into close proximity to the nuclear DNA of cells in said tumors, and irradiating said tumor with photons above the K or L shell adsorption edge of said heavy element to elicit the emission of densely ionizing Auger electrons at the level of DNA.
摘要翻译：一种治疗肿瘤的方法，包括向受试者施用治疗有效量的重元素复合物与被带电化学基团取代的多齿，含吡咯的大环配体，其中所述复合物能够使所述重元素远离所述肿瘤中的细胞的核DNA，并且用所述重元素的K或L壳吸附边缘上的光子照射所述肿瘤，以在DNA水平引发密集电离的俄歇电子的发射。

3. 发明申请

US20070248534A1 Auger effect-based cancer therapy method 审中-公开
标题翻译：基于俄歇效应的癌症治疗方法
公开(公告)号：US20070248534A1
公开(公告)日：2007-10-25
申请号：US11649795
申请日：2007-01-05
申请人： Brenda Laster , Gad Shani , Moshe Faraggi , Yuval Golan
发明人： Brenda Laster , Gad Shani , Moshe Faraggi , Yuval Golan
IPC分类号： A61K51/12 , A61K103/30
CPC分类号： A61K31/409 , A61K41/00 , A61N2005/1024
摘要： A method for the treatment of a tumor, comprising administering to a subject a therapeutically effective amount of a complex of a heavy element with a polydentate, pyrrole-containing macrocyclic ligand substituted with charged chemical groups, wherein said complex is capable of bringing said heavy element into close proximity to the nuclear DNA of cells in said tumors, and irradiating said tumor with photons above the K or L shell adsorption edge of said heavy element to elicit the emission of densely ionizing Auger electrons at the level of DNA.
摘要翻译：一种治疗肿瘤的方法，包括向受试者施用治疗有效量的重元素复合物与被带电化学基团取代的多齿，含吡咯的大环配体，其中所述复合物能够使所述重元素远离所述肿瘤中的细胞的核DNA，并且用所述重元素的K或L壳吸附边缘上的光子照射所述肿瘤，以在DNA水平引发密集电离的俄歇电子的发射。

4. 发明授权

US4535246A Fast neutron radiography system 失效
标题翻译：快中子射线照相系统
公开(公告)号：US4535246A
公开(公告)日：1985-08-13
申请号：US405776
申请日：1982-08-06
申请人： Gad Shani
发明人： Gad Shani
IPC分类号： G01T3/06 , G01T3/00
CPC分类号： G01T3/06
摘要： A system for gamma-ray interference-free fast-neutron radiography is provd. The system comprises a radiation detector adapted to distinguish between neutron and gamma radiation, an imaging device transducing object-point related signals generated by the object-modified neutron and gamma radiation in the radiation detector. The system also includes a pulse-shaped discrimination and gating device for passing only neutron-induced image-producing pulses so as to filter out the gamma-ray induced, interfering signals.
摘要翻译：提供了一种无伽马射线干涉快中子射线照相系统。该系统包括适于区分中子和伽马辐射的辐射检测器，成像装置在辐射检测器中传导由物体修饰的中子产生的与物体相关的信号和伽马辐射。该系统还包括用于仅通过中子诱导的图像产生脉冲的脉冲形状鉴别和门控装置，以便滤除伽马射线引起的干扰信号。

5. 发明申请

US20090246126A1 Thulium-based capsule and devices for use in high dose rate brachytherapy 审中-公开
标题翻译： ium胶囊和用于高剂量率近距离放射治疗的装置
公开(公告)号：US20090246126A1
公开(公告)日：2009-10-01
申请号：US12385216
申请日：2009-04-01
申请人： Gad Shani
发明人： Gad Shani
IPC分类号： A61K51/12 , A61K51/00
CPC分类号： A61N5/1001 , A61N2005/1019
摘要： A capsule for high dose rate brachytherapy, wherein the capsule comprises within its interior space thulium-170, and further comprises at least one layer of a radiation emission modifying metal (e.g., gold), wherein said layer is provided either internally within the capsule or on the outer surface thereof.
摘要翻译：一种用于高剂量率近程放射治疗的胶囊，其中所述胶囊在其内部空间ium -701中包括至少一层辐射发射修饰金属（例如，金），其中所述层在胶囊内部或在其外表面上。

6. 发明申请

US20100099940A1 Thulium-containing low dose rate brachytherapy seed 审中-公开
标题翻译：含containing低剂量率近距离放射治疗种子
公开(公告)号：US20100099940A1
公开(公告)日：2010-04-22
申请号：US12585307
申请日：2009-09-10
申请人： Gad Shani , Amal Ayoub
发明人： Gad Shani , Amal Ayoub
IPC分类号： A61M36/12
CPC分类号： A61N5/1027 , A61N2005/1024
摘要： A low dose rate brachytherapy seed having activity in the range between 0.5 and 10 millicurie, preferably less than 3 millicurie, comprising thulium-170 placed within a casing and at least one layer of a radiation emission modifying metal, said layer being provided either internally within the casing or on the outer surface thereof. The radiation emission modifying metal is preferably gold.
摘要翻译：具有在0.5至10毫微米（优选小于3毫微米）范围内的活性的低剂量率近程放射治疗种子，其包含置于壳体内的ium -17和至少一层辐射发射修饰金属，所述层内部壳体或其外表面上。辐射发射改性金属优选为金。

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