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1. 发明申请

US20070167843A1 METHOD AND APPARATUS FOR DETECTING RESPIRATORY DISTURBANCES 有权
标题翻译：用于检测呼吸障碍的方法和装置
公开(公告)号：US20070167843A1
公开(公告)日：2007-07-19
申请号：US11565092
申请日：2006-11-30
申请人： Yong Cho , Steven Lu , Luc Mongeon , Scott Davie , Todd Sheldon , Mark Erickson , H. Markowitz
发明人： Yong Cho , Steven Lu , Luc Mongeon , Scott Davie , Todd Sheldon , Mark Erickson , H. Markowitz
IPC分类号： A61B5/02 , A61B5/08
CPC分类号： A61B5/0809 , A61B5/0205 , A61B5/0215 , A61B5/0402 , A61B5/1459 , A61B5/4818 , G06F19/00
摘要： A system and method for monitoring respiration including sensing a signal that varies with respiration, deriving a respiration parameter, applying criteria for detecting a respiration disturbance and determining one or more respiratory disturbance metrics. The system preferably includes an implantable sensor with an associated implantable medical device such that chronic respiration monitoring is possible. The implantable medical device may execute methods for detecting and measuring respiratory disturbances or may store data to be transferred to an external device for detecting and measuring respiratory disturbances. Respiratory disturbance detection may trigger a responsive action such as physiological data storage, a change in therapy delivery, or a clinician warning. Assessment of cardiac function may be made based on metrics of respiratory disturbances or a measure of circulatory delay time following detection of a respiratory disturbance.
摘要翻译：一种用于监测呼吸的系统和方法，包括感测随呼吸变化的信号，导出呼吸参数，应用用于检测呼吸障碍的标准和确定一个或多个呼吸障碍度量。该系统优选地包括具有相关联的可植入医疗装置的可植入传感器，使得可以进行慢性呼吸监测。可植入医疗装置可以执行用于检测和测量呼吸障碍的方法，或者可以将要传送到外部设备的数据存储以检测和测量呼吸障碍。呼吸道干扰检测可能会触发响应动作，如生理数据存储，治疗传递的变化或临床医生的警告。心脏功能的评估可以基于呼吸紊乱的度量或检测到呼吸障碍之后的循环延迟时间的量度进行。

2. 发明申请

US20050119711A1 Apparatus and method for monitoring for disordered breathing 有权
标题翻译：用于监测无序呼吸的装置和方法
公开(公告)号：US20050119711A1
公开(公告)日：2005-06-02
申请号：US10419404
申请日：2003-04-21
申请人： Yong Cho , Abed Lawabni , Todd Sheldon , H. Markowitz , Sameh Sowelam , Raylene Pitschneider
发明人： Yong Cho , Abed Lawabni , Todd Sheldon , H. Markowitz , Sameh Sowelam , Raylene Pitschneider
IPC分类号： A61B5/0205 , A61B5/08 , A61N1/18
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/0809 , A61B5/0816 , G06F19/00
摘要： The present invention relates to a device and method for monitoring for sleep disordered breathing or other types of disordered breathing such as Cheyne-Stokes breathing. More specifically, a device and method for detecting disordered breathing is provided that monitors a physiological parameter, which becomes cyclical due to apnea-hyperpnea (or arousal) alternation and provides the basis for the determination of a number of breathing disorder metrics.
摘要翻译：本发明涉及一种用于监测睡眠呼吸紊乱或其他类型无序呼吸（例如Cheyne-Stokes呼吸）的装置和方法。更具体地，提供了一种用于检测无序呼吸的装置和方法，其监测由于呼吸暂停呼吸（或唤醒）交替而变得周期性的生理参数，并且提供了确定多个呼吸障碍度量的基础。

3. 发明申请

US20050251218A1 Implantable medical device with circulation delay measurement and therapy control 有权
标题翻译：具有循环延迟测量和治疗控制的植入式医疗设备
公开(公告)号：US20050251218A1
公开(公告)日：2005-11-10
申请号：US10945639
申请日：2004-09-21
申请人： H. Markowitz , Pooja Mehta , Chad Giese , Mark Erickson , Yong Cho , Marina Jovanovic , Sameh Sowelam
发明人： H. Markowitz , Pooja Mehta , Chad Giese , Mark Erickson , Yong Cho , Marina Jovanovic , Sameh Sowelam
IPC分类号： A61N1/18 , A61N1/20 , A61N1/22 , A61N1/34 , A61N1/36 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3601 , A61N1/36557 , A61N1/3962
摘要： Oxygen saturation data is monitored during a predefined window to obtain a measurement of circulation delay. The measured circulation delay is used as a basis for determining therapies, including overdrive pacing. In some embodiments, circulation delay is used to identify patients that will benefit from overdrive pacing as a therapy for sleep disordered breathing.
摘要翻译：在预定窗口期间监测氧饱和度数据，以获得循环延迟的测量。测量的循环延迟被用作确定治疗的基础，包括超速起搏。在一些实施例中，循环延迟用于识别将受益于过度起搏起搏作为睡眠无序呼吸治疗的患者。

4. 发明申请

US20070213778A1 ALGORITHM FOR THE AUTOMATIC DETERMINATION OF OPTIMAL AV AND VV INTERVALS 有权
标题翻译：用于自动确定最佳AV和VV间隔的算法
公开(公告)号：US20070213778A1
公开(公告)日：2007-09-13
申请号：US11751250
申请日：2007-05-21
申请人： John Burnes , Yong Cho , David Igel , Luc Mongeon , John Rueter , Harry Stone , Jody Zilinski
发明人： John Burnes , Yong Cho , David Igel , Luc Mongeon , John Rueter , Harry Stone , Jody Zilinski
IPC分类号： A61N1/05
CPC分类号： A61N1/3627 , A61N1/36521 , A61N1/3682 , A61N1/3684
摘要： Methods and devices for determining optimal Atrial to Ventricular (AV) pacing intervals and Ventricular to Ventricular (VV) delay intervals in order to optimize cardiac output. Impedance, preferably sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change.
摘要翻译：用于确定最佳心房与心室（AV）起搏间隔和心室间室（VV）延迟间隔的方法和装置，以优化心输出量。在选择的心脏周期时间内，跨心脏测量阻抗，优选亚阈值阻抗，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。

5. 发明申请

US20060271117A1 Algorithm for the automatic determination of optimal pacing intervals 失效
标题翻译：自动确定最佳起搏间隔的算法
公开(公告)号：US20060271117A1
公开(公告)日：2006-11-30
申请号：US11135921
申请日：2005-05-24
申请人： John Burnes , David Igel , John Rueter , Yong Cho , Luc Mongeon , Harold Stone , Jodi Zilinski
发明人： John Burnes , David Igel , John Rueter , Yong Cho , Luc Mongeon , Harold Stone , Jodi Zilinski
IPC分类号： A61N1/362
CPC分类号： A61N1/36521
摘要： Impedance, e.g. sub-threshold impedance, is measured across the heart at selected cardiac cycle times as a measure of chamber expansion or contraction. One embodiment measures impedance over a long AV interval to obtain the minimum impedance, indicative of maximum ventricular expansion, in order to set the AV interval. Another embodiment measures impedance change over a cycle and varies the AV pace interval in a binary search to converge on the AV interval causing maximum impedance change indicative of maximum ventricular output. Another method varies the right ventricle to left ventricle (VV) interval to converge on an impedance maximum indicative of minimum cardiac volume at end systole. Another embodiment varies the VV interval to maximize impedance change. Other methods vary the AA interval to maximize impedance change over the entire cardiac cycle or during the atrial cycle.
摘要翻译：阻抗，例如亚阈值阻抗是在选定心脏周期时间内心脏测量的，作为腔室扩张或收缩的量度。为了设定AV间隔，一个实施例测量长AV间隔上的阻抗以获得指示最大心室扩张的最小阻抗。另一个实施例测量一个周期的阻抗变化，并且改变二进制搜索中的AV步速间隔以收敛于AV间隔，从而引起指示最大心室输出的最大阻抗变化。另一种方法将右心室改变为左心室（VV）间隔，以收敛于指示最终心脏收缩最小心脏容积的阻抗最大值。另一实施例改变VV间隔以最大化阻抗变化。其他方法改变AA间隔以最大化整个心动周期或心房周期期间的阻抗变化。

6. 发明申请

US20050148897A1 Implantable medical device with sleep disordered breathing monitoring 有权
标题翻译：可植入医疗器械，带有睡眠呼吸障碍监测
公开(公告)号：US20050148897A1
公开(公告)日：2005-07-07
申请号：US10746814
申请日：2003-12-24
申请人： Yong Cho , Eduardo Warman , Todd Sheldon
发明人： Yong Cho , Eduardo Warman , Todd Sheldon
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/08 , A61B5/083 , A61B5/087 , A61B5/11 , A61B5/113 , A61B7/00 , A61N1/36 , A61N1/365
CPC分类号： A61N1/3601 , A61B5/0031 , A61B5/01 , A61B5/0205 , A61B5/0215 , A61B5/022 , A61B5/0245 , A61B5/0456 , A61B5/0464 , A61B5/0476 , A61B5/0809 , A61B5/0816 , A61B5/0833 , A61B5/0836 , A61B5/087 , A61B5/0878 , A61B5/1116 , A61B5/1118 , A61B5/1135 , A61B5/4818 , A61B7/003 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device (IMD) includes a sensor for monitoring parameters indicative of sleep disordered breathing. The IMD also includes a position sensor that indicates the relative position and/or activity level of the patient. The position sensor data is used in one or more ways in conjunction with the SDB sensing. The position data is used to confirm that such sensed data is likely indicative of SDB or to select the appropriate criteria for comparison.
摘要翻译：可植入医疗装置（IMD）包括用于监测指示睡眠呼吸紊乱的参数的传感器。 IMD还包括指示患者的相对位置和/或活动水平的位置传感器。位置传感器数据以一种或多种方式与SDB感测结合使用。位置数据用于确认这样的感测数据可能表示SDB或选择适当的比较标准。

7. 发明申请

US20050090871A1 Implantable medical device and method for delivering therapy for sleep-disordered breathing 有权
标题翻译：植入式医疗装置和方法，用于为睡眠呼吸障碍提供治疗
公开(公告)号：US20050090871A1
公开(公告)日：2005-04-28
申请号：US10693375
申请日：2003-10-24
申请人： Yong Cho , H. Markowitz
发明人： Yong Cho , H. Markowitz
IPC分类号： A61B5/08 , A61N1/36 , A61N1/362 , A61N1/365
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device delivers augmentation therapy to intervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.
摘要翻译：可植入的医疗装置提供增强疗法以介入睡眠呼吸障碍的模式。增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。

8. 发明申请

US20050203579A1 Real-time optimization of right to left ventricular timing sequence in bi-ventircular pacing of heart failure patients 有权
标题翻译：心力衰竭患者双向心脏起搏的左心室正时序列的实时优化
公开(公告)号：US20050203579A1
公开(公告)日：2005-09-15
申请号：US10799260
申请日：2004-03-12
申请人： Sameh Sowelam , Todd Sheldon , Yong Cho
发明人： Sameh Sowelam , Todd Sheldon , Yong Cho
IPC分类号： A61B5/103 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/18 , A61N1/20 , A61N1/22
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36521 , A61N1/3684
摘要： A system and automated method for assessing ventricular synchrony in ambulatory patients is provided including at least one mechanical sensor (e.g., accelerometer, tensiometric sensor, force transducer, and the like) operatively coupled to a first myocardial location in order to measure a wall motion signal of a first chamber, and a second mechanical sensor operatively coupled to a second myocardial location in order to measure a wall motion signal of a second chamber. The wall motion signals are processed in order to identify the time at which a fiducial (e.g., an inflection point, a threshold crossing, a maximum amplitude, etc.) occurs for each respective signal. The temporal separation between the fiducial points on each respective signal is measured as a metric of ventricular synchrony and can be optionally utilized to adjust pacing therapy timing to improve synchrony.
摘要翻译：提供了一种用于评估移动患者的心室同步的系统和自动化方法，其包括至少一个可操作地耦合到第一心肌位置的机械传感器（例如，加速度计，张力传感器，力换能器等），以便测量壁运动信号以及可操作地耦合到第二心肌位置的第二机械传感器，以便测量第二腔室的壁运动信号。对墙壁运动信号进行处理，以便识别针对每个相应信号发生基准（例如，拐点，阈值交叉，最大振幅等）的时间。每个相应信号上的基准点之间的时间间隔被测量为心室同步的度量，并且可以可选地用于调整起搏治疗定时以改善同步。

9. 发明授权

US08793223B1 Online data consistency checking in a network storage system with optional committal of remedial changes 有权
标题翻译：网络存储系统中的在线数据一致性检查，可选择进行补救更改
公开(公告)号：US08793223B1
公开(公告)日：2014-07-29
申请号：US12368158
申请日：2009-02-09
申请人： Yong Cho , Maya Palem , Vignesh Sukumar , John K. Edwards , David Grunwald , Andy Kahn
发明人： Yong Cho , Maya Palem , Vignesh Sukumar , John K. Edwards , David Grunwald , Andy Kahn
IPC分类号： G06F17/30
CPC分类号： G06F11/1076 , G06F17/3007 , H04L67/1097
摘要： A network storage server includes a tool for detecting and fixing errors while the network storage server remains online (available for servicing client requests), which includes enabling a user to approve or disapprove remedial changes before the changes are committed. The technique bypasses the usual consistency point process for new or modified data blocks representing potential remedial changes. At a consistency point, dirty data blocks representing the potential remedial changes are written to a change log file residing outside the volume. The modified data blocks are written in sequential order to logical blocks of the change log file. In response to a user input indicating that a potential change should be committed, the corresponding modified data blocks are read from the change log file in the order in which they were written to the change log file, and they are written to persistent storage in that order.
摘要翻译：网络存储服务器包括用于在网络存储服务器保持联机（可用于服务客户端请求）的情况下检测和修复错误的工具，其中包括使用户在更改发生之前批准或不批准补救更改。该技术绕过代表潜在补救变化的新的或修改的数据块的通常一致性点过程。在一致性点上，将表示潜在补救措施更改的脏数据块写入驻留在卷外的更改日志文件。经修改的数据块按顺序写入变更日志文件的逻辑块。响应于指示应该提交潜在变化的用户输入，从更改日志文件中读取相应的修改后的数据块，并将它们写入到更改日志文件中，并将它们写入永久存储器订购。

10. 发明授权

US07438829B2 Thick film getter paste compositions for use in moisture control 失效
标题翻译：用于湿度控制的厚膜吸气剂糊组合物
公开(公告)号：US07438829B2
公开(公告)日：2008-10-21
申请号：US10712670
申请日：2003-11-13
申请人： Yong Cho , Terri Cardellino , James Daniel Tremel
发明人： Yong Cho , Terri Cardellino , James Daniel Tremel
IPC分类号： H01J1/56 , H01J35/20 , H01J7/18 , C03C8/02 , C03C8/16
CPC分类号： B01J20/183 , B01D53/261 , H01L51/5259
摘要： The invention is directed to a screen-printable getter composition comprising: (a) glass frit; dispersed in (b) organic medium. The invention is further directed to a screen-printable thick film getter composition comprising: (a) glass frit; and (b) desiccant material; dispersed in (c) organic medium.The present invention further relates to a getter composition utilizing low-softening temperature glasses comprising, based on weight %, 1-50% SiO2, 0-80% B2O3, 0-90% Bi2O3, 0-90% PbO, 0-90% P2O5, 0-60% Li2O, 0-30% Al2O3, 0-10% K2O, 0-10% Na2O, and 0-30% MO where M is selected from Ba, Sr, Ca, Zn, Cu, Mg and mixtures thereof. The glasses described herein may contain several other oxide constituents that can substitute glass network-forming elements or modify glass structure.
摘要翻译：本发明涉及一种可丝网印刷的吸气剂组合物，其包括：（a）玻璃料; 分散在（b）有机介质中。本发明还涉及一种可丝网印刷的厚膜吸气剂组合物，其包含：（a）玻璃料; 和（b）干燥剂材料; 分散在（c）有机介质中。本发明还涉及一种使用低软化温度玻璃的吸气剂组合物，其基于重量百分比为1-50％SiO 2，0-80％B 2 O 0〜90％的Bi 2 O 3，0〜90％的PbO，0〜90％的P 2

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