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1. 发明申请

US20080311044A1 Methods of determining hair follicle inductive properties 有权
标题翻译：确定毛囊诱导性质的方法
公开(公告)号：US20080311044A1
公开(公告)日：2008-12-18
申请号：US11811744
申请日：2007-06-12
申请人： Ying Zheng , Satish Parimoo , Kurt Stricker Stenn
发明人： Ying Zheng , Satish Parimoo , Kurt Stricker Stenn
IPC分类号： A61K49/00 , A01K67/033
CPC分类号： A61K49/0006 , A01K67/0271 , A01K2227/105 , A01K2267/03 , G01N33/5082
摘要： The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into skin of a mammal and determining whether at least one hair follicle forms.
摘要翻译：本发明提供了一种用于确定组合物的头发诱导性质的方法，包括将包含解离的真皮细胞和表皮细胞的组合物注射到哺乳动物的皮肤中并确定是否形成至少一种毛囊。

2. 发明授权

US07985537B2 Methods for determining the hair follicle inductive properties of a composition 有权
标题翻译：用于确定组合物的毛囊诱导性质的方法
公开(公告)号：US07985537B2
公开(公告)日：2011-07-26
申请号：US11811744
申请日：2007-06-12
申请人： Ying Zheng , Satish Parimoo , Kurt Stricker Stenn
发明人： Ying Zheng , Satish Parimoo , Kurt Stricker Stenn
IPC分类号： C12Q1/00
CPC分类号： A61K49/0006 , A01K67/0271 , A01K2227/105 , A01K2267/03 , G01N33/5082
摘要： The present invention provides a method for determining hair inductive properties of a composition comprising injecting a composition comprising dissociated dermal cells and epidermal cells into skin of a mammal and determining whether at least one hair follicle forms.
摘要翻译：本发明提供了一种用于确定组合物的头发诱导性质的方法，包括将包含解离的真皮细胞和表皮细胞的组合物注射到哺乳动物的皮肤中并确定是否形成至少一种毛囊。

3. 发明申请

US20100291580A1 BIOMARKERS FOR TRICHOGENICITY 审中-公开
标题翻译：生物标志物的生物多样性
公开(公告)号：US20100291580A1
公开(公告)日：2010-11-18
申请号：US12808623
申请日：2008-12-18
申请人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
发明人： Satish Parimoo , Honghua Yang , Ying Homan , Wei Chen , Ying Zheng , Kurt Stenn
IPC分类号： C12Q1/68 , G01N33/566 , C12N15/79
CPC分类号： C12Q1/6881 , C12Q2600/178 , G01N33/6881 , G01N33/6893 , G01N2500/10
摘要： Biomarkers for identifying trichogenic cells have been identified. The biomarkers include microRNA as wells as mRNA and proteins. Certain biomarkers are upregulated in trichogenic cells compared to non-trichogenic cells; whereas, other biomarkers are down-regulated in trichogenic cells compared to non-trichogenic cells. The cells can be dermal cells, epidermal cells, or a combination thereof. Preferably the cells are mammalian, more preferably the cells are human. One embodiment provides a method for selecting trichogenic cells by assaying the cells for expression of one or more biomarkers for trichogenicity, and selecting the cells having increased expression of the one or more biomarkers relative to a control, wherein increased expression of the a biomarker in the cells is indicative of trichogenicity. Preferably, the one or more biomarkers are selected from the group consisting of hsa-miR-200c, hsa-miR-205, hsa-miR-200a*, hsa-miR-200a, hsa-miR-141, hsa-miR-182, DEPDC1, hFLEG1, ESM1, TOME-1, THBD and combinations thereof.
摘要翻译：已鉴定出用于鉴定发生细胞的生物标志物。生物标志物包括微RNA作为mRNA和蛋白质的孔。与非致毛细胞相比，某些生物标志物在致毛细胞中上调; 而与非致毛细胞相比，其他生物标志物在发育细胞中下调。细胞可以是真皮细胞，表皮细胞或其组合。优选地，细胞是哺乳动物，更优选细胞是人。一个实施方案提供了一种用于通过测定细胞用于表达一种或多种针刺性生物标志物的细胞并选择相对于对照而增加一种或多种生物标志物表达的细胞的方法，其中所述生物标志物在细胞表示毛发性。优选地，一种或多种生物标志物选自hsa-miR-200c，hsa-miR-205，hsa-miR-200a *，hsa-miR-200a，hsa-miR-141，hsa-miR-182 ，DEPDC1，hFLEG1，ESM1，TOME-1，THBD及其组合。

4. 发明申请

US20060062770A1 Organogenesis from dissociated cells 审中-公开
标题翻译：解离细胞的器官发生
公开(公告)号：US20060062770A1
公开(公告)日：2006-03-23
申请号：US11203804
申请日：2005-08-15
申请人： Ying Zheng , Xiaobing Du , Wei Wang , Marylene Boucher , Satish Parimoo , Kurt Stenn
发明人： Ying Zheng , Xiaobing Du , Wei Wang , Marylene Boucher , Satish Parimoo , Kurt Stenn
IPC分类号： A61K35/36
CPC分类号： A61K35/36 , A61K8/02 , A61K8/985 , A61K35/12 , A61Q7/00 , C12N5/0627
摘要： A method assay for rapidly and reproducibly generating hair follicles from dissociated epithelial and mesenchymal cells is disclosed. The method serves both as a tool for measuring the trichogenic (i.e., hair growth-inducing) property of cells and for studying the mechanisms dissociated cells employ to assemble an organ. In a method of this application dissociated cells, isolated from newborn mouse skin, are injected into adult mouse truncal skin, hair follicles develop. This process involves the aggregation of epithelial cells to form clusters which are sculpted by apoptosis to generate “infundibular cysts”. From the “infundibular cysts” hair germs form followed by follicular buds and then pegs which grow asymmetrically to differentiate into cycling mature pilosebaceous structures. Using various techniques, exposure of the “infundibular cysts” by puncturing, piercing, or scratching the skin and, in an approach, covering the exposed cysts with a wound dressing material produced egressing hair follicles.
摘要翻译：公开了一种用于从解离的上皮和间充质细胞中快速和可重复地产生毛囊的方法测定法。该方法既用于测量细胞的致毛体（即毛发生长诱导）性质和用于研究解离的细胞用于组装器官的机制。在这种方法中，从新生小鼠皮肤分离的解离的细胞被注射到成年小鼠的截肢皮肤中，形成毛囊。该过程涉及上皮细胞的聚集以形成通过凋亡而雕刻以产生“漏斗状囊肿”的簇。从“漏斗状囊肿”毛发细胞形式，然后是滤泡芽，然后是不对称生长的分离成循环成熟的皮脂状结构的栓。使用各种技术，通过穿刺，刺穿或刮伤皮肤暴露“漏斗状囊肿”，并且在使用产生流出毛囊的伤口敷料材料覆盖暴露的囊肿的方法中。

5. 发明申请

US20130149397A1 Modulation of Thymosin Beta-4 in Skin 有权
公开(公告)号：US20130149397A1
公开(公告)日：2013-06-13
申请号：US13324150
申请日：2011-12-13
申请人： Siming Chen , Qian Zheng , Satish Parimoo
发明人： Siming Chen , Qian Zheng , Satish Parimoo
IPC分类号： A61K8/97 , A61Q19/00 , A61K8/44 , A61Q19/08 , C12Q1/68 , A61K8/49
CPC分类号： A61K8/44 , A61K8/445 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/97 , A61K36/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C12Q1/68
摘要： Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.

6. 发明申请

US20130109691A1 Cosmetic Use of N-Heteroarybisamide Analogs and Related Compounds 有权
标题翻译： N-异构双相酰胺类似物和相关化合物的化妆品用途
公开(公告)号：US20130109691A1
公开(公告)日：2013-05-02
申请号：US13285458
申请日：2011-10-31
申请人： Satish Parimoo , Nancy T. Ilaya , John W. Lyga
发明人： Satish Parimoo , Nancy T. Ilaya , John W. Lyga
IPC分类号： A61K31/415 , A61K8/49 , A61Q19/08 , A61P17/02 , A61K31/5377 , A61Q19/00
CPC分类号： A61K8/494 , A61K8/49 , A61K9/0014 , A61K31/415 , A61K2800/10 , A61Q19/007 , A61Q19/08
摘要： Cosmetic and dermatological compositions comprising N-heteroarylbisamide analogs and methods of using such compositions to impart anti-aging benefits to the skin and/or improve skin conditions resulting from reduced collagen and hyaluronic acid production are disclosed. The N-heteroarylbisamides are believed to stimulate collagen and hyaluronic acid production and restore or maintain homeostasis for these compounds.
摘要翻译：公开了包含N-杂芳基双酰胺类似物的化妆品和皮肤病学组合物以及使用这些组合物赋予皮肤抗老化益处和/或改善由胶原蛋白和透明质酸产生减少引起的皮肤病症的方法。据信N-杂芳基双酰胺刺激胶原蛋白和透明质酸的产生并恢复或维持这些化合物的体内平衡。

7. 发明授权

US09044408B2 Cosmetic use of N-heteroarylbisamide analogs and related compounds 有权
标题翻译： N-杂芳基双酰胺类似物和相关化合物的化妆品用途
公开(公告)号：US09044408B2
公开(公告)日：2015-06-02
申请号：US13285458
申请日：2011-10-31
申请人： Satish Parimoo , Nancy T. Ilaya , John W. Lyga
发明人： Satish Parimoo , Nancy T. Ilaya , John W. Lyga
IPC分类号： A61K31/415 , A61Q19/08 , A61P17/02 , A61K8/49
CPC分类号： A61K8/494 , A61K8/49 , A61K9/0014 , A61K31/415 , A61K2800/10 , A61Q19/007 , A61Q19/08
摘要： Cosmetic and dermatological compositions comprising N-heteroarylbisamide analogs and methods of using such compositions to impart anti-aging benefits to the skin and/or improve skin conditions resulting from reduced collagen and hyaluronic acid production are disclosed. The N-heteroarylbisamides are believed to stimulate collagen and hyaluronic acid production and restore or maintain homeostasis for these compounds.
摘要翻译：公开了包含N-杂芳基双酰胺类似物的化妆品和皮肤病学组合物以及使用这些组合物赋予皮肤抗老化益处和/或改善由胶原蛋白和透明质酸产生减少引起的皮肤病症的方法。据信N-杂芳基双酰胺刺激胶原蛋白和透明质酸的产生并恢复或维持这些化合物的体内平衡。

8. 发明授权

US6045998A Technique for differential display 失效
标题翻译：差分显示技术
公开(公告)号：US6045998A
公开(公告)日：2000-04-04
申请号：US832021
申请日：1997-04-02
申请人： Nicholas Combates , Jose R. Pardinas , Satish Parimoo , Stephen M. Prouty , Kurt S. Stenn
发明人： Nicholas Combates , Jose R. Pardinas , Satish Parimoo , Stephen M. Prouty , Kurt S. Stenn
IPC分类号： C12N15/10 , C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6809 , C12N15/1096
摘要： The method of this invention relates to the use of improved anchor primers and a novel purification process to increase the efficiency and accuracy of the differential display technique.
摘要翻译：本发明的方法涉及使用改进的锚定引物和新的纯化方法来提高差示显示技术的效率和精度。

9. 发明授权

US08632827B2 Modulation of thymosin beta-4 in skin 有权
标题翻译：皮肤中胸腺素β-4的调节
公开(公告)号：US08632827B2
公开(公告)日：2014-01-21
申请号：US13324150
申请日：2011-12-13
申请人： Siming Chen , Qian Zheng , Satish Parimoo
发明人： Siming Chen , Qian Zheng , Satish Parimoo
IPC分类号： A01N65/00
CPC分类号： A61K8/44 , A61K8/445 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/97 , A61K36/00 , A61Q19/00 , A61Q19/02 , A61Q19/06 , A61Q19/08 , C12Q1/68
摘要： Methods for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin.
摘要翻译：提供了预防，改善或减少皮肤老化症状的方法，其使用刺激胸腺素β-4在皮肤中表达的活性剂，除类视黄醇以外。还提供了用于筛选刺激胸腺素β-4表达水平的物质的方法以及使用筛选方案鉴定的活性剂治疗皮肤的方法。

10. 发明授权

US08568797B2 Method for enhancing the growth and fullness of hair 有权
标题翻译：增加头发生长和丰满度的方法
公开(公告)号：US08568797B2
公开(公告)日：2013-10-29
申请号：US13231329
申请日：2011-09-13
申请人： Michele C. Duggan , Satish Parimoo , Cheng Hwang
发明人： Michele C. Duggan , Satish Parimoo , Cheng Hwang
IPC分类号： A61K36/00
CPC分类号： A61K8/49 , A61K8/342 , A61K8/97 , A61K31/045 , A61K31/426 , A61K36/185 , A61K38/06 , A61K45/06 , A61Q7/00 , A61K2300/00
摘要： New fibroblast growth factor receptor 1 (FGFR1) inhibitors have been identified which are useful for promoting the retention and/or growth of keratin fibers, such as hair of the scalp, hair of the face (moustache, beard, etc.), eyebrows, eyelashes, and the like. The FGFR1 inhibitors may be formulated in effective amounts in a variety of cosmetic and personal care products.
摘要翻译：已经鉴定了新的成纤维细胞生长因子受体1（FGFR1）抑制剂，其可用于促进角蛋白纤维的保留和/或生长，例如头皮毛发，面部毛发（胡子，胡须等），眉毛，睫毛等。 FGFR1抑制剂可以有效量配制在各种化妆品和个人护理产品中。

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