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1. 发明申请

WO1991009864A1 DRUG FOR TREATING OR PREVENTING ISCHEMIC DISEASES OF HEART OR BRAIN 审中-公开
标题翻译：用于治疗或预防心脏或脑疾病的药物
公开(公告)号：WO1991009864A1
公开(公告)日：1991-07-11
申请号：PCT/JP1990000001
申请日：1990-01-04
申请人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD.
发明人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD. , KOGI, Kentaro , ABIRU, Toichi , YAMAGUCHI, Toyofumi
IPC分类号： C07H19/167
CPC分类号： C07H19/16
摘要： This invention relates to a drug for treating or preventing ischemic diseases of a heart or brain comprising as the active ingredient 2-alkynyladenosine represented by general formula (I), wherein n represents an integer of 2 to 15.
摘要翻译：本发明涉及用于治疗或预防心脏或脑部缺血性疾病的药物，其包含作为通式（I）表示的活性成分2-炔基腺苷，其中n表示2〜15的整数。

2. 发明申请

WO1990015812A1 INTERMEDIATE FOR 2-ALKYNYLADENOSINE SYNTHESIS, PRODUCTION OF SAID INTERMEDIATE, PRODUCTION OF 2-ALKYNYLADENOSINE FROM SAID INTERMEDIATE, AND STABLE 2-ALKYNYLADENOSINE DERIVATIVE 审中-公开
标题翻译：中间体2-烷基亚氨基腺嘌呤合成，生产中间体，从酸中间体生产2-烷基亚氨基腺嘌呤和稳定的2-烷基亚氨基衍生物
公开(公告)号：WO1990015812A1
公开(公告)日：1990-12-27
申请号：PCT/JP1990000807
申请日：1990-06-20
申请人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD. , YAMAGUCHI, Toyofumi , MIYASHITA, Takanori , SAKATA, Shinji , ABIRU, Toichi , MATSUDA, Akira , UEDA, Tohru , KOGI, Kentaro
发明人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD.
IPC分类号： C07H19/16
CPC分类号： C07H19/16 , Y02P20/55
摘要： A new compound of formula (I), wherein A represents a living group, which is useful as an intermediate for the synthesis of 2-alkynyladenosine; production of said compound; production of 2-alkynyladenosine (IV), wherein A=NH2 from said compound; 2-alkynyladenosine derivative of formula (V), wherein A=NHR4; and preservation of 2-alkynyladenosine in the form of said derivative. In the above formula, R1 to R4 represent each hydrogen or a protective group, and n is an integer of 1 to 15, provided that the case where all of R1 to R4 are hydrogen atoms is excluded.

3. 发明申请

WO1990005526A1 AGENT FOR TREATMENT AND PROPHYLAXIS OF ISCHEMIC DISEASE OF HEART OR BRAIN 审中-公开
标题翻译：治疗和预防心脑血管疾病的药物
公开(公告)号：WO1990005526A1
公开(公告)日：1990-05-31
申请号：PCT/JP1989001158
申请日：1989-11-15
申请人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD. , KOGI, Kentaro , ABIRU, Toichi , YAMAGUCHI, Toyofumi
发明人： YAMASA SHOYU KABUSHIKI KAISHA , TOA EIYO LTD.
IPC分类号： A61K31/70
CPC分类号： A61K31/70 , C07H19/16
摘要： The invention relates to an agent for treatment and prophylaxis of ischemic diseases of the heart or brain which contains as an active ingredient 2-alkynyladenosine represented by general formula (I), wherein n represents an integer of 2 to 15.
摘要翻译：本发明涉及一种用于治疗和预防心脏或脑的缺血性疾病的药剂，其包含作为通式（I）表示的活性成分2-炔基腺苷，其中n表示2〜15的整数。

4. 发明申请

WO1990010080A1 PRODUCTION OF NUCLEOSIDE 审中-公开
标题翻译：生产核苷
公开(公告)号：WO1990010080A1
公开(公告)日：1990-09-07
申请号：PCT/JP1990000240
申请日：1990-02-27
申请人： YAMASA SHOYU KABUSHIKI KAISHA , YAMAUCHI, Hiroshi , UTSUGI, Hideki , MIDORIKAWA, Yuichiro
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： C12P19/38
CPC分类号： C12N9/12 , C12P19/38 , C12R1/07 , Y10S435/832
摘要： This invention relates to a method of producing a nucleoside by reacting a base donor, a sugar residue donor, and a phosphate donor with one another in the presence of an enzymatic preparation containing a nucleoside phosphorylase to thereby form an N-glycoside linkage between a base portion of the base donor and a sugar residue portion of the sugar residue donor, characterized in that said enzymatic preparation containing a nucleoside phosphorylase is one based on the cells of at least one microorganism selected from among those belonging to thermophilic bacteria of the genus Bacillus and having a high nucleoside phosphorylase activity per unit weight of the cell.

5. 发明申请

WO1991010432A1 ATARACTIC 审中-公开
标题翻译：镇静剂
公开(公告)号：WO1991010432A1
公开(公告)日：1991-07-25
申请号：PCT/JP1991000015
申请日：1991-01-11
申请人： YAMASA SHOYU KABUSHIKI KAISHA , IMAIZUMI, Masahiro , SAKATA, Shinji
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： A61K31/505
CPC分类号： C07D239/553 , A61K31/505
摘要： An ataractic containing as the active ingredient 1-amino-5-halogenouracil of general formula (I) or a pharmaceutically acceptable salt thereof. In the said formula X represents halogen.

6. 发明申请

WO1992019638A1 1-'beta'-D-ARABINOFURANOSYL-(E)-5-(2-HALOGENOVINYL)-URACIL DERIVATIVE 审中-公开
标题翻译：（β-D-阿拉伯呋喃糖基-L-（E）-5-（2-吗啉代乙烯基） - 脲类衍生物
公开(公告)号：WO1992019638A1
公开(公告)日：1992-11-12
申请号：PCT/JP1992000527
申请日：1992-04-23
申请人： YAMASA SHOYU KABUSHIKI KAISHA , SAKATA, Shinji , MACHIDA, Haruhiko , IJICHI, Katsushi , KANO, Fumitaka
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： C07H19/09
CPC分类号： C07H19/06
摘要： A novel derivative of 1-β-D-arabinofuranosyl-(E)-5-(2-halogenovinyl)uracil represented by general formula (I), which can remain in the blood at a high concentration for long when orally administered; an antiviral drug containing the same as an active ingredient; and a method of treating viral infections by administering a safe and effective dose of the same to a patient with a viral infection, wherein X represents halogen and R1 to R3 may be the same or different from one another and each represents hydrogen, lower alkyl or aralkyl, provided that the case where all of R?1, R2 and R3¿ are hydrogen atoms at the same time is excluded.

7. 发明申请

WO1991006555A1 NUCLEOSIDE DERIVATIVE 审中-公开
标题翻译：核苷衍生物
公开(公告)号：WO1991006555A1
公开(公告)日：1991-05-16
申请号：PCT/JP1990001371
申请日：1990-10-25
申请人： UEDA, Sumiko +hm , UEDA, Nozomi +hm , UEDA, Hiromi +hm , UEDA, Masato +hm , YAMASA SHOYU KABUSHIKI KAISHA , MATSUDA, Akira , WATAYA, Yusuke , ISHII, Akira
发明人： UEDA, Sumiko +hm , UEDA, Nozomi +hm , UEDA, Hiromi +hm , UEDA, Masato +hm , YAMASA SHOYU KABUSHIKI KAISHA , UEDA, Tohru +di
IPC分类号： C07H19/16
CPC分类号： A61K31/70 , C07H19/16 , C07H19/23 , C07H23/00 , Y02A50/409
摘要： Nucleoside derivatives having a potent antiprotozoan activity and a reduced adverse effect and being effective in treating diseases caused by protozoan, such as 2'- and/or 5'-acylated, aralkylated or silylated 3'-deoxyinosine; allopurinol 3'-deoxyriboside; 2'- and/or 5'-acylated, aralkylated or silylated allopurinol 3'-deoxyriboside; and 2'-, 3'-, and/or 5'-acylated, aralkylated or silylated allopurinol riboside.

8. 发明申请

WO1991006005A1 METHOD OF ASSAYING D-VANILLYLMANDELIC ACID, AND REAGENT AND KIT THEREFOR 审中-公开
标题翻译： D-吡喃甘油酸的测定方法及其试剂和试剂盒
公开(公告)号：WO1991006005A1
公开(公告)日：1991-05-02
申请号：PCT/JP1990001344
申请日：1990-10-18
申请人： YAMASA SHOYU KABUSHIKI KAISHA , KURODA, Manami , SUGI, Masato
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： G01N33/53
CPC分类号： A61K31/40 , A61K31/445 , A61K38/13 , C07K16/44 , G01N33/5308 , G01N33/57488 , A61K31/16 , A61K31/34 , A61K2300/00
摘要： A method of assaying D-vanillylmandelic acid (D-VMA) contained in a specimen of a living organism through the following steps (A) to (D), and a reagent and a kit used for the assay, wherein a racemic mixture of VMA is used as the standard substance for preparing a calibration curve and a labeled anti-D-VMA antibody is used as the labeled anti-VMA antibody to specifically assay only D-VMA in the specimen: (A) the step of conducting a competitive reaction of VMA in the specimen and VMA in solid phase against the labeled anti-VMA antibody; (B) the step of separating the liquid phase from the solid phase; (C) the step of determining the quantity of labeling of the labeled anti-VMA antibody combined with the solid-phase VMA and that of other substances; and (D) the step of preparing a calibration curve or obtaining a relation by using a standard substance of a known concentration, calculating the concentration of VMA corresponding to the quantity of labeling determined in the step (C) by using the calibration curve or relation thus obtained, and defining the concentration thus calculated as the concentration of VMA contained in the specimen.
摘要翻译：一种通过以下步骤（A）至（D）测定生物体样品中所含的D-香草基扁桃酸（D-VMA）的方法，以及用于该测定的试剂和试剂盒，其中VMA的外消旋混合物用作制备校正曲线的标准物质，并使用标记的抗-D-VMA抗体作为标记的抗VMA抗体，以特异性仅测定样品中的D-VMA：（A）进行竞争反应的步骤的样品中的VMA和针对标记的抗VMA抗体的固相的VMA; （B）将液相与固相分离的步骤; （C）确定与固相VMA和其他物质结合的标记抗VMA抗体的标记量的步骤; 和（D）通过使用已知浓度的标准物质制备校准曲线或获得关系的步骤，通过使用校准曲线或关系计算与步骤（C）中确定的标记量相对应的VMA浓度由此获得，并且将由此计算的浓度定义为样品中所含的VMA的浓度。

9. 发明申请

WO1992019755A1 MONOCLONAL ANTIBODY AGAINST HUMAN 'beta'2-GLYCOPROTEIN I AND USE THEREOF 审中-公开
标题翻译：人类β2糖蛋白I的单克隆抗体及其用途
公开(公告)号：WO1992019755A1
公开(公告)日：1992-11-12
申请号：PCT/JP1992000528
申请日：1992-04-23
申请人： YAMASA SHOYU KABUSHIKI KAISHA , KOIKE, Takao , MATSUURA, Eiji , NAGAE, Hisato
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： C12P21/08
CPC分类号： C07K16/18
摘要： The invention makes it possible to obtain a monoclonal antibody which specifically reacts with human beta 2-glycoprotein I and to determine specifically human beta 2-glycoprotein I in a specimen by using the antibody.
摘要翻译：本发明使得可以获得与人β2-糖蛋白I特异性反应的单克隆抗体，并通过使用抗体确定样品中的特异性人β2-糖蛋白I.

10. 发明申请

WO1992009599A1 PROCESS FOR PRODUCING 1-(2,3-DIDEOXY-'beta'-D-glycero-PENT-2-ENOFURANOSYL)THYMINE 审中-公开
标题翻译：生产1-（2,3-二去氧-β-D-甘油 - 蓬烯-2-烯呋喃）的方法
公开(公告)号：WO1992009599A1
公开(公告)日：1992-06-11
申请号：PCT/JP1991001660
申请日：1991-11-29
申请人： YAMASA SHOYU KABUSHIKI KAISHA , IKEDA, Takao
发明人： YAMASA SHOYU KABUSHIKI KAISHA
IPC分类号： C07D405/04
CPC分类号： C07D405/04
摘要： 1-(2,3-Dideoxy- beta -D-glycero-pent-2-enofuranosyl)thymine, which is known to have an antiretroviral activity, can be produced in one-pot reaction very efficiently by protecting 3'- and 5'-hydroxyl groups of readily available 2,2'-anhydro-1-( beta -D-arabino-furanosyl)thymine with acetic anhydride, etc., halogenating the protected thymine with an acid and an alkali halide into 1-(2'-halogeno-3',5'-diprotected- beta -D-arabino-furanosyl)thymine, and reducing the halogenated thymine with zinc. The objective compound can be efficiently isolated and purified by using a synthetic adsorbent comprising polystyrene and an eluent comprising an aqueous alkali solution with a specified pH value.
摘要翻译：已知具有抗逆转录病毒活性的1-（2,3-二脱氧-β-D-甘油基 - 戊-2-烯呋喃糖基）胸腺嘧啶可以通过保护3'-和5' （β-D-阿拉伯 - 呋喃糖基）胸腺嘧啶与乙酸酐等的 - 羟基，用酸和碱金属卤化物将保护的胸腺嘧啶卤化成1-（2'- 卤素-3'，5'-二保护-β-D-阿拉伯呋喃糖基）胸腺嘧啶，并用锌还原卤代胸腺嘧啶。可以通过使用包含聚苯乙烯的合成吸附剂和包含具有特定pH值的碱性水溶液的洗脱液来有效地分离和纯化目标化合物。

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