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1. 发明授权

US08306618B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08306618B2
公开(公告)日：2012-11-06
申请号：US12763499
申请日：2010-04-20
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/37
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event that includes sensing cardiac signals from a plurality of electrodes, determining rates of change of the sensed cardiac signals, and determining a range of the sensed cardiac signals. The sensed cardiac signals are detected as being associated with the cardiac event in response to the determined rates of change and the determined range.
摘要翻译：一种检测心脏事件的方法，其包括感测来自多个电极的心脏信号，确定所感测的心脏信号的变化速率，以及确定感测的心脏信号的范围。根据所确定的变化速率和所确定的范围，将所感测到的心脏信号检测为与心脏事件相关联。

2. 发明申请

US20120053477A1 METHOD AND APPARATUS FOR ENHANCING TREATABLE ARRHYTHMIA DETECTION SPECIFICITY BY USING ACCUMULATED PATIENT ACTIVITY 有权
标题翻译：通过使用累积患者活动来增强可治疗性脑膜炎检测特异性的方法和装置
公开(公告)号：US20120053477A1
公开(公告)日：2012-03-01
申请号：US12869180
申请日：2010-08-26
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler , Paul G. Krause , Karen J. Kleckner
IPC分类号： A61B5/04
CPC分类号： A61B5/1118 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61N1/36542 , A61N1/3962
摘要： A method and apparatus for detecting a cardiac event in a medical device determine an activity level count from an activity sensor signal for each of a number of time segments, store an activity level count for each of the time segments in a histogram, and accumulate the stored activity level counts to determine a percentage of time segments having an activity level count above a given activity level count.
摘要翻译：用于检测医疗装置中的心脏事件的方法和装置根据多个时间段中的每一个的活动传感器信号确定活动水平计数，将每个时间段的活动水平计数存储在直方图中，并且累积存储的活动级别计数以确定具有高于给定活动级别计数的活动级别计数的时间段的百分比。

3. 发明授权

US08095206B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US08095206B2
公开(公告)日：2012-01-10
申请号：US11742618
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61B5/0402
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for adjusting a sensing parameter in a medical device that includes a sensing electrode sensing cardiac signals, a processor to determine an adjusting characteristic associated with the cardiac signals sensed over a predetermined sensing window, and a control unit to update the sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于调整包括感测心脏信号的感测电极的医疗装置中的感测参数的方法和装置，用于确定与在预定感测窗口上感测到的心脏信号相关联的调整特性的处理器以及用于更新感测参数的控制单元响应于确定的调整特性。

4. 发明授权

US08050751B2 Periodic beat detection to detect artifacts in a cardiac electrogram 有权
标题翻译：定期拍摄检测心脏电图中的伪影
公开(公告)号：US08050751B2
公开(公告)日：2011-11-01
申请号：US12183950
申请日：2008-07-31
申请人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
发明人： Xusheng Zhang , Raja N. Ghanem , Robert W. Stadler
IPC分类号： A61B5/0464
CPC分类号： A61N1/3621 , A61B5/0464 , A61B5/7221 , A61B5/7239 , A61N1/36507 , A61N1/3925 , A61N1/3962
摘要： Techniques for determining whether artifacts are present in a cardiac electrogram are described. According to one example, a medical device senses a cardiac electrogram via electrodes. The medical device determines a derivative, e.g., a second order derivative, the electrogram. The medical device detects beats within the derivative, e.g., by comparing a rectified version of the derivative to one or more thresholds determined based on a maximum of the rectified derivative. The medical device determines whether the beats are periodic, and determines whether artifacts are present in the cardiac electrogram based on the determination of whether the beats are periodic. The medical device may further determine whether tachyarrhythmia is present and/or whether the cardiac rhythm of the patient is treatable based on the determination of whether the beats are periodic. For example, the medical device may determine that an electrogram is not treatable when the beats are periodic.
摘要翻译：描述了用于确定伪像是否存在于心电图中的技术。根据一个示例，医疗装置通过电极感测心电图。医疗设备确定导数，例如二阶导数，电描记图。医疗设备检测导数内的跳动，例如通过将导数的整流版本与基于校正导数的最大值确定的一个或多个阈值进行比较。医疗器械确定节拍是否是周期性的，并且基于确定节拍是否是周期性的确定来确定心脏电图中是否存在假象。医疗装置可以基于是否是周期性的确定来进一步确定是否存在快速性心律失常和/或患者的心律是否可治疗。例如，当节拍是周期性的时，医疗装置可以确定电描记图是不可治疗的。

5. 发明授权

US07991471B2 Method and apparatus for detecting arrhythmias in a subcutaneous medical device 有权
标题翻译：用于检测皮下医疗装置中的心律失常的方法和装置
公开(公告)号：US07991471B2
公开(公告)日：2011-08-02
申请号：US11461269
申请日：2006-07-31
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/368
CPC分类号： A61N1/3956 , A61B5/046 , A61B5/0464 , A61B5/7239 , A61N1/3621
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes forming a first sensing vector and a second sensing vector, advancing from a first state to a second state in response to processing of an interval associated with a cardiac cycle of the sensed cardiac signals, and advancing from the second state in response to processing of a cardiac signal sensed during a predetermined sensing window.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括：感测来自形成第一感测向量的多个电极的心脏信号和响应于间隔的处理从第一状态进入第二状态的第二感测向量与感测的心脏信号的心动周期相关联，并且响应于在预定感测窗口期间感测的心脏信号的处理而从第二状态前进。

6. 发明授权

US07734333B2 Method and apparatus for detecting arrhythmias in a medical device 有权
标题翻译：用于检测医疗装置中的心律失常的方法和装置
公开(公告)号：US07734333B2
公开(公告)日：2010-06-08
申请号：US11380815
申请日：2006-04-28
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method of detecting a cardiac event in a medical device that includes sensing a cardiac signal from a plurality of electrodes, determining amplitudes of the sensed cardiac signal during a predetermined sensing window, determining a noise to signal ratio corresponding to the determined amplitudes, and determining the sensed cardiac signal during the predetermined sensing window is corrupted by noise in response to the determined noise to signal ratio being greater than a noise to signal ratio threshold.
摘要翻译：一种检测医疗装置中的心脏事件的方法，包括感测来自多个电极的心脏信号，确定在预定感测窗口期间检测到的心脏信号的幅度，确定对应于所确定的幅度的噪声信号比，以及确定响应于所确定的噪声信号比大于噪声信号比阈值，在预定感测窗口期间感测到的心脏信号被噪声破坏。

7. 发明申请

US20080275518A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：US20080275518A1
公开(公告)日：2008-11-06
申请号：US11742616
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61N1/00
CPC分类号： A61N1/3704 , A61N1/3925
摘要： A method and apparatus for determining oversensing of cardiac signals that includes a housing containing electronic circuitry, an electrode coupled to the electronic circuitry to sense cardiac signals, and a processor, positioned within the housing, to determine an oversensing characteristic associated with the cardiac signals sensed over a predetermined sensing window, and to identify oversensing in response to the determined oversensing characteristic.
摘要翻译：一种用于确定心脏信号过度感测的方法和装置，其包括包含电子电路的壳体，耦合到电子电路以感测心脏信号的电极以及位于壳体内的处理器，以确定与感测到的心脏信号相关联的过度感应特性在预定的感测窗口上，并且响应于所确定的过敏特性来识别过敏。

8. 发明申请

US20080275517A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A MEDICAL DEVICE 有权
标题翻译：用于检测医疗器械中的ARRHYTHMIAS的方法和装置
公开(公告)号：US20080275517A1
公开(公告)日：2008-11-06
申请号：US11742628
申请日：2007-05-01
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang , Karen J. Kleckner , Paul G. Krause
IPC分类号： A61N1/00
CPC分类号： A61N1/3925 , A61N1/3704
摘要： A method and apparatus for determining oversensing in a medical device that includes sensing cardiac signals, determining an oversensing characteristic associated with cardiac signals sensed during a predetermined sensing window, identifying oversensing in response to the oversensing characteristic, determining, in response to oversensing being identified, an adjusting characteristic associated with cardiac signals sensed during the predetermined sensing window, and updating a sensing parameter in response to the determined adjusting characteristic.
摘要翻译：一种用于确定医疗装置中的过度感测的方法和装置，包括感测心脏信号，确定与在预定感测窗口期间感测到的心脏信号相关联的过度感应特征，响应于过敏特性识别过敏，响应于被识别的过冷而确定，与在预定感测窗口期间感测到的心脏信号相关联的调整特性，以及响应于确定的调整特性来更新感测参数。

9. 发明申请

US20070233198A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A SUBCUTANEOUS MEDICAL DEVICE 审中-公开
标题翻译：用于检测肾上腺髓质瘤的方法和装置
公开(公告)号：US20070233198A1
公开(公告)日：2007-10-04
申请号：US11554346
申请日：2006-10-30
申请人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
发明人： Raja N. Ghanem , Robert W. Stadler , Xusheng Zhang
IPC分类号： A61N1/00
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, the plurality of electrodes forming a first sensing vector and a second sensing vector, initiating charging of an energy storage device in response to the sensed cardiac signals, and determining whether a predetermined number of morphologies associated with cardiac signals sensed along the first sensing vector and the second sensing vector during corresponding sensing windows are indicative of the cardiac event.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，所述多个电极形成第一感测向量和第二感测向量，响应于所述第一感测向量和第二感测向量开始对能量存储装置的充电感测的心脏信号，以及确定在对应的感测窗口期间沿着第一感测向量和第二感测向量感测的与心脏信号相关联的预定数量的形态是否指示心脏事件。

10. 发明申请

US20070232948A1 METHOD AND APPARATUS FOR DETECTING ARRHYTHMIAS IN A SUBCUTANEOUS MEDICAL DEVICE 有权
标题翻译：用于检测肾上腺髓质瘤的方法和装置
公开(公告)号：US20070232948A1
公开(公告)日：2007-10-04
申请号：US11687094
申请日：2007-03-16
申请人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
发明人： Robert W. Stadler , Raja N. Ghanem , Xusheng Zhang
IPC分类号： A61B5/04
CPC分类号： A61N1/3987 , A61B5/04011 , A61B5/0422 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/0468 , A61B5/4836 , A61B5/686 , A61B5/7203 , A61B5/7221 , A61B5/7239 , A61N1/05 , A61N1/3621 , A61N1/3925 , A61N1/3956 , Y10S128/901 , Y10S128/902
摘要： A method and apparatus for detecting a cardiac event in a medical device that includes sensing cardiac signals from a plurality of electrodes, determining a relationship between a plurality of characteristics associated with a morphology of the cardiac signals sensed during a predetermined sensing window, generating a threshold in response to the determined relationship, comparing a first characteristic of the plurality of characteristics with the threshold, and determining whether the sensed cardiac signals are associated with the cardiac event in response to the comparing of the first characteristic.
摘要翻译：一种用于检测医疗设备中的心脏事件的方法和装置，包括感测来自多个电极的心脏信号，确定与在预定感测窗口期间感测到的心脏信号的形态有关的多个特征之间的关系，产生阈值响应于所确定的关系，将所述多个特征的第一特征与所述阈值进行比较，并且响应于所述第一特征的比较，确定所感测的心脏信号是否与心脏事件相关联。

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