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1. 发明授权

US09545247B2 Catching mechanisms for tubular septal occluder 有权
标题翻译：管状隔膜闭塞器的捕获机制
公开(公告)号：US09545247B2
公开(公告)日：2017-01-17
申请号：US13930498
申请日：2013-06-28
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David R. Widomski , Carol A. Devellian
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867
摘要： A septal occluder, such as one made from a polymer tube, can have portions on either side of a patent foramen ovale (PFO) or other septal defect. The portions on either side can be held in place with a catching mechanism that can take one of many forms. The tube can be made of bioresorbable materials.
摘要翻译：隔膜闭塞器，例如由聚合物管制成的隔膜器，可以在卵孔卵泡（PFO）或其他间隔缺损的任一侧具有部分。任何一侧的部分可以用可以采取许多形式之一的捕捉机构保持就位。管可以由生物可吸收材料制成。

2. 发明授权

US09326759B2 Tubular patent foramen ovale (PFO) closure device with catch system 有权
标题翻译：管状卵圆孔（PFO）闭合装置带捕获系统
公开(公告)号：US09326759B2
公开(公告)日：2016-05-03
申请号：US13934031
申请日：2013-07-02
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David J. Callaghan
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： Occluder devices for occluding an anatomical aperture, such as an atrial septal defect (ASD) or a patent foramen ovale (PFO) comprise two sides connected by a central tube. The occluder devices are formed from a tube, which is cut to produce struts in each side. Upon the application of force, the struts deform into loops. The loops may be of various shapes, sizes, and configurations, and, in at least some embodiments, the loops have rounded peripheries. In some embodiments, at least one of the sides includes a tissue scaffold. The occluder devices include a catch system that maintains its deployed state in vivo. When an occluder device is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture and the catch system is deployed so that the occluder device exerts a compressive force on the septal tissue and closes the aperture.
摘要翻译：用于闭塞解剖孔的封堵器装置，例如房间隔缺损（ASD）或卵圆孔卵孔（PFO），包括通过中心管连接的两侧。封堵器装置由管子形成，管子被切割以在每一侧产生支柱。施加力时，支柱变形成环。环可以是各种形状，尺寸和构造，并且在至少一些实施例中，环具有圆形的周边。在一些实施例中，至少一个侧面包括组织支架。闭塞器装置包括在体内保持其部署状态的捕获系统。当在体内部署闭塞器装置时，两侧设置在围绕孔的隔膜组织的相对侧上，并且止动系统被展开，使得封堵器装置对隔膜组织施加压缩力并闭合孔。

3. 发明申请

US20150148841A1 DELIVERY/RECOVERY SYSTEM FOR SEPTAL OCCLUDER 审中-公开
标题翻译： SEPTAL OCCLUDER的交付/恢复系统
公开(公告)号：US20150148841A1
公开(公告)日：2015-05-28
申请号：US14613303
申请日：2015-02-03
申请人： W.L. Gore & Associates, Inc.
发明人： Carol A. Devellian , David R. Widomski , Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.
摘要翻译：一种运输/恢复系统，允许操作者部署和恢复医疗植入物，例如用于闭合卵孔专利（PFO）的封堵器。在一个实施例中，系统包括用于防止封堵器沿近端方向移动的输送心轴，用于将封堵器固定到输送心轴并防止在远端方向上的不期望的运动的输送线，以及用于包封输送线的护套，心轴和闭塞器。通过以一系列步骤相对于闭塞器移动护套，封堵器首先在远端侧开放，然后在近侧开口，以将封堵器保持在适当位置的方式。

4. 发明申请

US20140088640A1 Delivery/Recovery System for Septal Occluder 有权
标题翻译：隔膜闭塞器的交付/恢复系统
公开(公告)号：US20140088640A1
公开(公告)日：2014-03-27
申请号：US14042134
申请日：2013-09-30
申请人： W.L. Gore & Associates, Inc.
发明人： Carol A. Devellian , David R. Widomski , Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.
摘要翻译：一种运输/恢复系统，允许操作者部署和恢复医疗植入物，例如用于闭合卵孔专利（PFO）的封堵器。在一个实施例中，系统包括用于防止封堵器沿近端方向移动的输送心轴，用于将封堵器固定到输送心轴并防止在远端方向上的不期望的运动的输送线，以及用于包封输送线的护套，心轴和闭塞器。通过以一系列步骤相对于闭塞器移动护套，封堵器首先在远端侧开放，然后在近侧开口，以将封堵器保持在适当位置的方式。

5. 发明申请

US20130123808A1 Heart-Shaped PFO Closure Device 审中-公开
标题翻译：心形PFO闭合装置
公开(公告)号：US20130123808A1
公开(公告)日：2013-05-16
申请号：US13734516
申请日：2013-01-04
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/00 , A61B17/08
CPC分类号： A61B17/0057 , A61B17/083 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867
摘要： Patent foramen ovale (PFO) closure clip include two closure members, which may be heart shaped, joined by at least two spaced central connecting members. Each of the at least two spaced central connecting members is attached to each closure member at a location on the periphery of the closure member. The connecting member may be generally square shaped or include other shapes. The clips of the present invention may be formed of various materials, including metals, nonmetallic materials, bioresorbable polymers, spring steel, shape memory materials, bioresorbable shape memory polymers, or combinations thereof. The clips can take various forms depending, in part, upon the distribution of force required to close a given PFO. At least one of the closure members can include a tissue scaffold.
摘要翻译：卵圆孔（PFO）闭合夹包括两个封闭构件，其可以是心形，由至少两个间隔开的中心连接构件连接。所述至少两个间隔开的中心连接构件中的每一个在关闭构件的周边上的位置附接到每个闭合构件。连接构件可以是大致正方形或包括其它形状。本发明的夹子可以由各种材料形成，包括金属，非金属材料，生物可再吸收聚合物，弹簧钢，形状记忆材料，生物可吸收形状记忆聚合物或其组合。剪辑可以采取各种形式，这部分取决于关闭给定PFO所需的力的分布。关闭构件中的至少一个可以包括组织支架。

6. 发明申请

US20130289618A1 Catching Mechanisms for Tubular Septal Occluder 审中-公开
标题翻译：管状间隔封堵器的捕获机制
公开(公告)号：US20130289618A1
公开(公告)日：2013-10-31
申请号：US13930498
申请日：2013-06-28
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko , David R. Widomski , Carol A. Devellian
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00867
摘要： A septal occluder, such as one made from a polymer tube, can have portions on either side of a patent foramen ovale (PFO) or other septal defect. The portions on either side can be held in place with a catching mechanism that can take one of many forms. The tube can be made of bioresorbable materials.
摘要翻译：隔膜闭塞器，例如由聚合物管制成的隔膜器，可以在卵孔卵泡（PFO）或其他间隔缺损的任一侧具有部分。任何一侧的部分可以用可以采取许多形式之一的捕捉机构保持就位。管可以由生物可吸收材料制成。

7. 发明申请

US20130165966A1 Devices, Systems and Methods for Closure of Cardiac Openings 审中-公开
标题翻译：用于闭合心脏开口的装置，系统和方法
公开(公告)号：US20130165966A1
公开(公告)日：2013-06-27
申请号：US13743997
申请日：2013-01-17
申请人： W.L. Gore & Associates, Inc.
发明人： David R. Widomski , Carol A. Devellian , Eileen M. Heneberry , Andrzej J. Chanduszko , Robert M. Carr
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00632
摘要： The invention generally relates to devices, systems, and methods for percutaneous closure of cardiac openings and obliteration of the cardiac cul-de-sacs. In one embodiment, a closure device includes a patch with an adhesive and/or a removable frame. The patch may be placed across a cardiac opening, such as a patent foramen ovale, or across a cardiac cul-de-sac, such as a left atrial appendage. In another embodiment, a closure device includes a balloon together with adhesives and/or substances for stimulating tissue growth coated on, or contained within, the balloon. The balloon may be inserted into a cardiac opening, such as the patent foramen ovale, or into a cardiac cul-de-sac, such as a left atrial appendage.
摘要翻译：本发明一般涉及用于经皮闭塞心脏开口和闭塞心脏死亡囊的装置，系统和方法。在一个实施例中，闭合装置包括具有粘合剂和/或可移除框架的贴片。补片可以放置在心脏开口处，例如卵孔卵泡专利，或穿过心脏死亡细胞，例如左心耳。在另一个实施方案中，闭合装置包括气囊以及粘合剂和/或用于刺激涂覆在气囊上或包含在气囊内的组织生长的物质。气球可以插入心脏开口，例如卵孔卵孔，或插入心脏死亡细胞，例如左心耳。

8. 发明授权

US09028527B2 Patent foramen ovale (PFO) closure device with radial and circumferential support 有权
标题翻译：具有径向和周向支撑的卵圆孔（PFO）闭合装置
公开(公告)号：US09028527B2
公开(公告)日：2015-05-12
申请号：US14334387
申请日：2014-07-17
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/08 , A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00004 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00867
摘要： The present invention provides a device for occluding an anatomical aperture, such as a septal defect or patent foramen ovale (PFO). The occluder includes two sides connected by an intermediate joint. Each of the sides includes at least one elongate element, which is arranged to form non-overlapping loops. Each loop has at least one radially-extending segment that is adjacent to a radially-extending segment of another loop. In at least some embodiments, at least one pair of adjacent radially-extending segments is connected. In some embodiments, at least one of the sides includes a tissue scaffold. When the occluder is deployed in vivo, the two sides are disposed on opposite sides of the septal tissue surrounding the aperture, thereby exerting a compressive force on the septal tissue that is distributed along both the outer periphery of the occluder and the radially-extending segments.
摘要翻译：本发明提供一种用于闭塞解剖孔的装置，例如间隔缺损或卵圆孔卵孔（PFO）。闭塞器包括通过中间接头连接的两侧。每个侧面包括至少一个细长元件，其被布置成形成非重叠的环。每个环具有至少一个径向延伸的段，其邻近另一环的径向延伸的段。在至少一些实施例中，连接至少一对相邻的径向延伸段。在一些实施例中，至少一个侧面包括组织支架。当闭塞器部署在体内时，两侧设置在围绕孔的间隔组织的相对侧上，从而对隔壁组织施加压缩力，该间隔组织沿封堵器的外周分布并且径向延伸段。

9. 发明授权

US08945158B2 Delivery/recovery system for septal occluder 有权
标题翻译：隔膜闭塞器的交付/恢复系统
公开(公告)号：US08945158B2
公开(公告)日：2015-02-03
申请号：US14042134
申请日：2013-09-30
申请人： W.L. Gore & Associates, Inc.
发明人： Carol A. Devellian , David R. Widomski , Andrzej J. Chanduszko
IPC分类号： A61B17/06 , A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623
摘要： A delivery/recovery system to allow an operator to deploy and recover a medical implant, such as an occluder for closing a patent foramen ovale (PFO). In one embodiment, the system includes a delivery mandrel for preventing the occluder from moving in the proximal direction, a delivery wire for securing the occluder to the delivery mandrel and preventing unwanted movement in the distal direction, and a sheath for enveloping the delivery wire, mandrel and occluder. By moving the sheath relative to the occluder in a series of steps, the occluder opens first on a distal side and then on a proximal side, in a manner that holds the occluder in place.
摘要翻译：一种运输/恢复系统，允许操作者部署和恢复医疗植入物，例如用于闭合卵孔专利（PFO）的封堵器。在一个实施例中，系统包括用于防止封堵器沿近端方向移动的输送心轴，用于将封堵器固定到输送心轴并防止在远端方向上的不期望的运动的输送线，以及用于包封输送线的护套，心轴和闭塞器。通过以一系列步骤相对于闭塞器移动护套，封堵器首先在远端侧开放，然后在近侧开口，以将封堵器保持在适当位置的方式。

10. 发明申请

US20130072965A1 Delivery Systems and Methods for PFO Closure Device with Two Anchors 失效
标题翻译：具有两个锚点的PFO封闭装置的输送系统和方法
公开(公告)号：US20130072965A1
公开(公告)日：2013-03-21
申请号：US13651643
申请日：2012-10-15
申请人： W.L. Gore & Associates, Inc.
发明人： Andrzej J. Chanduszko
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00243 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623 , A61B2017/00862 , A61B2017/00867
摘要： A device closes septal openings, such as a patent foramen ovale (PFO). The device includes two anchors and a flexible connector. Tension applied to one or more strings attached to the device causes the device to collapse into a reduced profile form for withdrawal into a delivery catheter, thereby facilitating retrieval of the device after insertion into a septal opening.
摘要翻译：器械关闭隔膜开口，例如卵圆孔卵孔（PFO）。该装置包括两个锚和一个柔性连接器。施加到附接到装置的一个或多个弦的张力导致装置折叠成缩小的轮廓形式以便退回到输送导管中，从而便于在插入间隔开口之后使装置回收。

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