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1. 发明授权

US08992553B2 Cutting balloon assembly and method of manufacturing thereof 有权
标题翻译：切割气球组件及其制造方法
公开(公告)号：US08992553B2
公开(公告)日：2015-03-31
申请号：US12571557
申请日：2009-10-01
申请人： Valery Diamant , Haim Danenberg , Chaim Lotan , Nadezda Yasko
发明人： Valery Diamant , Haim Danenberg , Chaim Lotan , Nadezda Yasko
IPC分类号： A61B17/22 , A61B17/3207 , A61B19/00 , A61B17/00 , A61F2/958 , A61M25/00 , A61M25/10
CPC分类号： A61B17/22032 , A61B17/320725 , A61B90/39 , A61B2017/00526 , A61B2017/00539 , A61B2017/00853 , A61B2017/00893 , A61B2017/22061 , A61F2/958 , A61M25/0045 , A61M25/0053 , A61M25/1034 , A61M25/104 , A61M2025/0057 , A61M2025/105 , Y10T29/49826
摘要： A cutting balloon assembly and a method for fabrication of the assembly is described. The cutting balloon assembly comprises a delivery catheter, an expandable balloon mounted on the catheter distal end, and a scoring mesh disposed around the expandable balloon. The scoring mesh comprises interlacing filaments that extend from a mesh proximal end towards a mesh distal end, form distal filament loops at said mesh distal end, and then return to the mesh proximal end. At least a part of the interlacing filaments forms one or more permanent links with neighboring filaments between the mesh proximal end and the mesh distal end.
摘要翻译：描述了一种切割气球组件和该组件的制造方法。切割气囊组件包括输送导管，安装在导管远端上的可膨胀气囊和设置在可膨胀气囊周围的刻痕网。刻痕网包括从网状近端朝向网状远端延伸的交织细丝，在所述网状远端形成远端丝线环，然后返回到网状近端。交织丝的至少一部分在网状物近端和网状物远端之间形成与相邻细丝的一个或多个永久性连接。

2. 发明授权

US08771299B2 Cutting balloon assembly and method of manufacturing thereof 有权
标题翻译：切割气球组件及其制造方法
公开(公告)号：US08771299B2
公开(公告)日：2014-07-08
申请号：US13478242
申请日：2012-05-23
申请人： Valery Diamant , Haim Danenberg , Chaim Lotan , Nadezda Yasko
发明人： Valery Diamant , Haim Danenberg , Chaim Lotan , Nadezda Yasko
IPC分类号： A61B17/22 , A61B17/3207
CPC分类号： A61B17/22032 , A61B17/320725 , A61B90/39 , A61B2017/00526 , A61B2017/00539 , A61B2017/00853 , A61B2017/00893 , A61B2017/22061 , A61F2/958 , A61M25/0045 , A61M25/0053 , A61M25/1034 , A61M25/104 , A61M2025/0057 , A61M2025/105 , Y10T29/49826
摘要： A method for fabrication of a cutting balloon assembly is described. The method includes providing a predetermined number of filaments having predetermined properties, diameter and length and fabricating a scoring mesh on a weaving jig having a plurality of pins disposed circumferentially about the jig's surface. The fabrication of the scoring mesh includes placing the filaments between the pins and interlacing the filaments to form a scoring mesh by interweaving and intertwining at least a part of filament to form one or more permanent links with neighboring filaments. The fabrication of the scoring mesh also includes forming distal and proximal filament loops that protrude from the mesh distal and proximal ends, respectfully. The scoring mesh is mounted on an expandable balloon mounted on a distal end of a delivery catheter.
摘要翻译：描述了一种用于制造切割球囊组件的方法。该方法包括提供具有预定特性，直径和长度的预定数量的长丝，并且在具有围绕夹具表面周向设置的多个销的织造夹具上制造刻痕网。刻痕网的制造包括将细丝放置在销之间并且将细丝交织以通过交织并交织丝线的至少一部分以形成与相邻长丝的一个或多个永久连接而形成刻痕网。刻痕网的制造还包括形成从网孔远端和近端突出的远侧和近端细丝环。评分网安装在安装在输送导管的远端上的可膨胀气囊上。

3. 发明授权

US09526646B2 Stent replacement system 有权
标题翻译：支架置换系统
公开(公告)号：US09526646B2
公开(公告)日：2016-12-27
申请号：US12745617
申请日：2008-12-03
申请人： Valery Diamant , Nadezda Yasko , Boris Varshitsky , Nachum Borivker , Chaim Lotan
发明人： Valery Diamant , Nadezda Yasko , Boris Varshitsky , Nachum Borivker , Chaim Lotan
IPC分类号： A61F2/82 , A61F2/958 , A61F2/954
CPC分类号： A61F2/958 , A61F2/954 , A61F2002/821
摘要： A system for delivering and placement of a medical prosthesis into an ostium of a tract system of an organism is described. The system comprises a stent delivery device that includes a delivery catheter having one or more lumens extending between proximal and distal ends. The stent delivery device also includes an inflatable balloon mounted on the distal end of the delivery catheter for expanding and deploying the medical prosthesis placed on the balloon, and a stent deployment site locator configured for locating an exact place for positioning the medical prosthesis. The deployment site locator comprises an expandable flexible structure including a plurality of filament elements interconnected between a locator proximal end and a locator distal end; thereby forming a unitary structure. The filaments can extend from a locator proximal end towards a locator distal end and then return after winding to the proximal end to form a plurality of filament loops.
摘要翻译：描述了用于将医疗假体递送和放置到生物体的管道系统的口中的系统。该系统包括支架输送装置，其包括具有在近端和远端之间延伸的一个或多个腔的输送导管。支架输送装置还包括安装在输送导管的远端上的可膨胀气囊，用于扩张和展开放置在气囊上的医用假体，以及配置用于定位用于定位医疗假体的确切位置的支架部署位置定位器。部署现场定位器包括可扩展的柔性结构，其包括在定位器近端和定位器远端之间互连的多个细丝元件; 从而形成一体的结构。长丝可以从定位器近端延伸到定位器远端，然后在卷绕到近端之后返回以形成多个细丝环。

4. 发明申请

US20100305679A1 Stent Replacement System 有权
标题翻译：支架置换系统
公开(公告)号：US20100305679A1
公开(公告)日：2010-12-02
申请号：US12745617
申请日：2008-12-03
申请人： Valery Diamant , Nadezda Yasko , Boris Varshitsky , Nachum Borivker , Chaim Lotan
发明人： Valery Diamant , Nadezda Yasko , Boris Varshitsky , Nachum Borivker , Chaim Lotan
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/958 , A61F2/954 , A61F2002/821
摘要： A system for delivering and placement of a medical prosthesis into an ostium of a tract system of an organism is described. The system comprises a stent delivery device that includes a delivery catheter having one or more lumens extending between proximal and distal ends. The stent delivery device also includes an inflatable balloon mounted on the distal end of the delivery catheter for expanding and deploying the medical prosthesis placed on the balloon, and a stent deployment site locator configured for locating an exact place for positioning the medical prosthesis. The deployment site locator comprises an expandable flexible structure including a plurality of filament elements interconnected between a locator proximal end and a locator distal end; thereby forming a unitary structure. The filaments can extend from a locator proximal end towards a locator distal end and then return after winding to the proximal end to form a plurality of filament loops.
摘要翻译：描述了用于将医疗假体递送和放置到生物体的管道系统的口中的系统。该系统包括支架输送装置，其包括具有在近端和远端之间延伸的一个或多个腔的输送导管。支架输送装置还包括安装在输送导管的远端上的可膨胀气囊，用于扩张和展开放置在气囊上的医用假体，以及配置用于定位用于定位医疗假体的确切位置的支架部署位置定位器。部署现场定位器包括可扩展的柔性结构，其包括在定位器近端和定位器远端之间互连的多个细丝元件; 从而形成一体的结构。长丝可以从定位器近端延伸到定位器远端，然后在卷绕到近端之后返回以形成多个细丝环。

5. 发明授权

US08469970B2 Apparatus for entrapping and extracting objects from body cavities 有权
标题翻译：用于从体腔捕获和提取物体的装置
公开(公告)号：US08469970B2
公开(公告)日：2013-06-25
申请号：US13179750
申请日：2011-07-11
申请人： Valery Diamant , Chaim Lotan , Haim Danenberg
发明人： Valery Diamant , Chaim Lotan , Haim Danenberg
IPC分类号： A61B17/22
CPC分类号： A61B17/221 , A61B2017/00862 , A61B2017/00867 , A61B2017/00871 , A61B2017/22039 , A61B2017/2215
摘要： A retrieval apparatus for entrapping and retaining an object located in a body for its extraction therefrom is described. The retrieval apparatus includes a snare and a snare control assembly. The snare has a proximal section and a distal section, and comprises a plurality of filaments extending from a proximal end of the proximal section towards the distal section, and then returning to the proximal end to form a plurality of loops. In the deployed state, the loops are interlaced to each other within the proximal section and are free and not interleaved within the distal section. Segments of the filaments of the distal section are bent with respect to segments of the filaments of the proximal section such that the retrieval snare in the contracted state forms a hollow cavity extending from the distal section towards the proximal section.
摘要翻译：描述了用于捕获和保持位于身体中的物体以从其中提取的取回装置。检索装置包括圈套和圈套控制组件。圈套具有近端部分和远侧部分，并且包括从近端部分的近端向远端部分延伸的多个细丝，然后返回到近端以形成多个环。在展开状态下，环在近端部分内彼此交织，并且在远端部分内是自由的并且不交错的。远端部分的细丝的部分相对于近端部分的细丝的部分弯曲，使得处于收缩状态的取出圈套形成从远侧部分向近侧部分延伸的中空腔。

6. 发明申请

US20100158973A1 THERAPEUTIC USES OF CANNABIDIOL COMPOUNDS 审中-公开
标题翻译： CANNABIDIOL化合物的治疗用途
公开(公告)号：US20100158973A1
公开(公告)日：2010-06-24
申请号：US12282735
申请日：2007-03-13
申请人： Lola Weiss , Vardiella Meiner , Eran Leitersdorf , Shimon Slavin , Raphael Mechoulam , Ruth Gallily , Chaim Lotan , Ronen Durst , Thea Pugatsch
发明人： Lola Weiss , Vardiella Meiner , Eran Leitersdorf , Shimon Slavin , Raphael Mechoulam , Ruth Gallily , Chaim Lotan , Ronen Durst , Thea Pugatsch
IPC分类号： A61K31/05 , A61F2/02 , A61P7/08 , A61P3/06 , A61P9/00
CPC分类号： A61K31/352 , A61K31/35
摘要： The present invention provides the use of a Cannabidiol (CBD) compound for the preparation of a pharmaceutical composition for treatment as well as for the prevention of at least one fundamental parameter affecting a vascular system selected from (a) the cardiovascular system; (b) the peripheral vascular system; or (c) a combination of (a) and (b); as well as pharmaceutical compositions and therapeutic methods for treating the above. A fundamental parameter may include blood/plasma lipid profile; atherosclerosis plaque load; size of heart scar; thickness of heart scar; and cardiac function in general. In accordance with a preferred embodiment the invention concerns treatment of heart scars as well as preventing the formation of heart scars.
摘要翻译：本发明提供大麻二醇（CBD）化合物用于制备用于治疗的药物组合物以及用于预防影响选自（a）心血管系统的血管系统的至少一个基本参数的用途; （b）外周血管系统; 或（c）（a）和（b）的组合; 以及用于治疗上述的药物组合物和治疗方法。基本参数可以包括血液/血浆脂质分布; 动脉粥样硬化斑块负荷; 心脏瘢痕大小; 心脏瘢痕厚度; 和心脏功能一般。根据优选实施方案，本发明涉及心脏瘢痕的治疗以及防止形成心脏瘢痕。

7. 发明申请

US20070043434A1 Biodegradable endovascular stent using stereocomplexation of polymers 审中-公开
标题翻译：使用聚合物立体络合的可生物降解的血管内支架
公开(公告)号：US20070043434A1
公开(公告)日：2007-02-22
申请号：US11206161
申请日：2005-08-18
申请人： David Meerkin , Abraham Domb , Chaim Lotan
发明人： David Meerkin , Abraham Domb , Chaim Lotan
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2210/0004 , A61L31/06 , A61L31/14 , A61L31/148
摘要： A biodegradable stent is comprised of a stereocomplex of polylactide enantiomers. The unique characteristics of stereocomplex polymers allows for the stent to have variable material characteristics along its length, while retaining uniform geometry. Thus, the stent is designed to be flexible upon insertion through the blood vessels while still retaining its rigidity and support upon expansion within the vessel. Furthermore, the material characteristics can be manipulated such that high strengths are possible even with small thicknesses of struts within the stent.
摘要翻译：可生物降解的支架由聚丙交酯对映体的立体络合物组成。立体络合物聚合物的独特特征允许支架沿其长度具有可变的材料特性，同时保持均匀的几何形状。因此，支架被设计成在插入通过血管时是柔性的，同时在容器内膨胀时仍然保持其刚性和支撑。此外，可以操纵材料特性，使得即使在支架内具有小厚度的支柱也可以实现高强度。

8. 发明申请

US20050256441A1 Device for renal protection 审中-公开
标题翻译：肾脏保护装置
公开(公告)号：US20050256441A1
公开(公告)日：2005-11-17
申请号：US10831227
申请日：2004-04-26
申请人： Chaim Lotan , Teddy Weiss , David Meerkin
发明人： Chaim Lotan , Teddy Weiss , David Meerkin
IPC分类号： A61M1/00 , A61M1/36 , A61M25/00 , A61M29/00 , A61M37/00
CPC分类号： A61M1/3621 , A61M1/3613 , A61M1/3679 , A61M25/0017 , A61M25/007 , A61M2025/1052 , A61M2205/32
摘要： A device and method is provided for protecting the renal system from contrast dyes injected into the circulatory system during procedures such as angiograms and angioplasty. The device includes a catheter having a draining portion and an occluding portion. The device is inserted into the coronary sinus at a predetermined time, the occluding portion is inflated, and the contrast-injected blood is diverted. This blood may be reintroduced into the coronary arteries several times.
摘要翻译：提供了一种装置和方法，用于在诸如血管造影和血管成形术的过程期间保护肾系统免于注入循环系统的造影染料。该装置包括具有排液部分和闭塞部分的导管。在预定的时间将装置插入冠状窦中，使闭塞部分膨胀，注入血液的血液被转移。这种血液可能被重新引入冠状动脉几次。

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