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1. 发明申请

WO2007084429A2 BIOLOGICAL SAMPLE PROCESSING COMPOSITION AND METHOD 审中-公开
标题翻译：生物样品加工组合物和方法
公开(公告)号：WO2007084429A2
公开(公告)日：2007-07-26
申请号：PCT/US2007000980
申请日：2007-01-12
申请人： VENTANA MED SYST INC , FARRELL MICHAEL , BIENIARZ CHRISTOPHER , REINHARDT KURT , WARD GLEN , KOSMEDER JEROME W , GHUSSON ANDREW , WALK ERIC ENG , MANRIQUEZ GUADALUPE H , GROGAN THOMAS M
发明人： FARRELL MICHAEL , BIENIARZ CHRISTOPHER , REINHARDT KURT , WARD GLEN , KOSMEDER JEROME W , GHUSSON ANDREW , WALK ERIC ENG , MANRIQUEZ GUADALUPE H , GROGAN THOMAS M
IPC分类号： G01N1/31 , G01N1/28
CPC分类号： G01N1/30
摘要： A method and composition are disclosed that are useful for processing biological samples. In one aspect, a biological sample such as a tissue section is treated using a histochemical technique and is contacted with a lipid compound during the process to enhance the definition of cellular and sub-cellular features that are observable in the sample when it is viewed microscopically. In other aspects, a coverslipping composition that includes a lipid compound and a method of coverslipping a sample using the coverslipping composition are disclosed.
摘要翻译：公开了可用于处理生物样品的方法和组合物。在一个方面，使用组织化学技术处理诸如组织切片的生物样品，并且在该过程期间与脂质化合物接触以增强在微观观察时在样品中可观察到的细胞和亚细胞特征的定义。在其它方面，公开了一种包括脂质化合物的覆盖组合物和使用盖玻片组合物覆盖样品的方法。

2. 发明申请

WO2009009419A2 APPARATUS AND METHOD FOR BIOLOGICAL SAMPLE PROCESSING 审中-公开
标题翻译：用于生物样品处理的装置和方法
公开(公告)号：WO2009009419A2
公开(公告)日：2009-01-15
申请号：PCT/US2008069151
申请日：2008-07-03
申请人： VENTANA MED SYST INC , LEMME CHARLES D , RICHARDS WILLIAM , WARD GLEN , ASHBY AUSTIN , GHUSSON ANDREW , JENSEN-LONG LISA , KNAPP KEVIN , KUGIZAKI RODNEY , LARSON ALAIN , RICHARDS PAUL , SHOWALTER WAYNE , WILKINSON CHAD
发明人： LEMME CHARLES D , RICHARDS WILLIAM , WARD GLEN , ASHBY AUSTIN , GHUSSON ANDREW , JENSEN-LONG LISA , KNAPP KEVIN , KUGIZAKI RODNEY , LARSON ALAIN , RICHARDS PAUL , SHOWALTER WAYNE , WILKINSON CHAD
IPC分类号： B01J19/00 , G01N1/28 , G01N1/30 , G01N25/00 , G05B11/00
CPC分类号： G01N1/312 , G01N1/06 , G01N35/00029 , G01N35/0092 , G01N35/1002 , G01N35/1011 , G01N35/1081 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00346 , G01N2035/00376 , G01N2035/0453 , Y10T436/112499 , Y10T436/25 , Y10T436/2575
摘要： An apparatus and method are described that achieve independent and simultaneous processing of a plurality of substrate- supported biological samples. In one embodiment, substrate holders arranged in a minor arc are independently moveable between a processing position and an access position, and reagents are delivered to substrates held in the substrate holders through a nozzle plate that moves along the arc of substrate holders. The disclosed apparatus and method are particularly suited for implementation of lean processing of biological samples.
摘要翻译：描述了实现多个基板支撑的生物样品的独立且同时处理的设备和方法。在一个实施例中，布置成较小弧度的衬底保持器可在处理位置和访问位置之间独立移动，并且试剂通过沿着衬底保持器的弧移动的喷嘴板递送至保持在衬底保持器中的衬底。所公开的设备和方法特别适用于实施生物样品的稀处理。

3. 发明申请

WO2011008415A3 COVER TILE FOR TREATING A SUBSTRATE WITH A FLUID 审中-公开
标题翻译：用流体处理基板的盖板
公开(公告)号：WO2011008415A3
公开(公告)日：2011-04-14
申请号：PCT/US2010039229
申请日：2010-06-18
申请人： VENTANA MED SYST INC , LEMME CHARLES D , WARD GLEN , KRAM BRIAN H , RICHARDS WILLIAM L
发明人： LEMME CHARLES D , WARD GLEN , KRAM BRIAN H , RICHARDS WILLIAM L
IPC分类号： G01N35/00 , G01N1/28
CPC分类号： G01N1/312 , G02B21/34
摘要： A cover tile/substrate construct that includes a cover tile having an upper surface, an opposing lower surface, a proximal edge, a distal edge, and a longitudinal direction extending from the proximal edge to the distal edge, wherein the lower surface defines a three-dimensional surface that includes a protrusion that extends in the longitudinal direction; a substantially planar substrate having an upper surface and an opposing lower surface; and wherein the cover tile is juxtaposed over the substrate so that the lower surface of the cover tile and the upper surface of the substrate together define a wedge-shaped capillary fluid flow gap and the longitudinally extended protrusion of the lower surface of the cover tile protrudes towards the upper surface of the substrate.
摘要翻译：包括具有上表面，相对的下表面，近侧边缘，远侧边缘和从近侧边缘延伸到远侧边缘的纵向方向的覆盖瓦片的覆盖瓦片/基底构造，其中下表面限定三个所述三维表面包括在所述纵向方向上延伸的突起; 基本上平面的基底，其具有上表面和相对的下表面; 并且其中所述盖瓦并置在所述基板上，使得所述盖瓦的下表面和所述基板的上表面一起限定楔形毛细流体流动间隙，并且所述盖瓦的下表面的纵向延伸突出部突出朝向衬底的上表面。

4. 发明申请

WO2004008106A3 TRAY FOR AUTOMATED HISTOCHEMICAL PROCESSING 审中-公开
标题翻译：托盘自动化组织处理
公开(公告)号：WO2004008106A3
公开(公告)日：2004-06-10
申请号：PCT/US0322199
申请日：2003-07-16
申请人： VENTANA MED SYST INC
发明人： WARD GLEN , HENDRICK KENDALL B , RIZZO VINCE
IPC分类号： G01N1/30 , B01L9/00 , G01N1/31 , G01N35/00 , G02B21/34
CPC分类号： B01L9/52 , B01L2200/025 , B01L2300/0609 , B01L2300/0822 , B01L2400/0457 , G01N1/312 , G01N2035/00138 , G02B21/34
摘要： The invention is the combination of a rectangular-shaped tray adapted to hold one or more removable slide frames which orient the slides horizontally, the combination also functioning to accurately and reproducibly align the slides for automated processing. The slide tray has molded features that positively hold the slide frames in place. The slide frames are removable so that the histotechnician may load the five or so slides that each frame holds in groups of five. The frames are removable to facilitate loading of slides and cleaning of the tray. A related invention is a slide tray for holding microscope slides substantially horizontally for automated chemical processing, comprising a tray having a floor and integral means for holding slides securely and fixedly positioned on said floor.
摘要翻译：本发明是一种矩形托盘的组合，该托盘适于保持一个或多个可移动的滑动框架，该滑动框架将滑动件水平定向，该组合也起到准确且可重复地对准滑动件以进行自动化处理的作用。滑动托盘具有模制功能，可将滑动框架牢固地固定到位。幻灯片框架是可拆卸的，以便组织技术人员可以装载五个左右的幻灯片，每个框架以五个为一组。这些框架可拆卸以便于装载幻灯片和清洁托盘。一种相关发明是一种用于保持显微镜载玻片基本水平以进行自动化学处理的滑动托盘，包括具有地板和用于将滑动件牢固地固定并固定在所述地板上的整体装置的托盘。

5. 发明公开

EP1494808A4 AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 有权转让
标题翻译： AUTOMATISIOSESOBJEKTTRÄGERANFÄRBESYSTEMMIT HOHEM DURCHSATZ
公开(公告)号：EP1494808A4
公开(公告)日：2005-05-18
申请号：EP03721687
申请日：2003-04-15
申请人： VENTANA MED SYST INC
发明人： REINHARDT KURT , LEMME CHARLES D , WARD GLEN , RICHARDS WILLIAM , SHOWALTER WAYNE
IPC分类号： G01N1/30 , B01L9/00 , G01N1/00 , G01N1/28 , G01N1/31 , G01N1/36
CPC分类号： B01L9/52 , B01L2300/0822 , G01N1/312 , G01N1/36 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide processing apparatus (20) includes a plurality of work stations (120, 140, 160, 180) arranged in a stack, and a transport/elevator (52) for transporting slides between the various work stations. In particular the device is for deparaffinizing, staining and coverslipping a plurality of biological specimen bearing slides (56), in a fully automated and integrated system.
摘要翻译：一种自动化的载玻片处理设备（20）包括多个布置成堆叠的工作站（120,140,160,180）以及用于在各个工作站之间传送载玻片的运输/升降机（52）。具体来说，该装置用于在全自动化和集成系统中对多个生物样本承载载玻片（56）进行脱蜡，染色和盖玻片。

6. 发明专利

CA2932803C THERMAL MANAGEMENT IN THE CONTEXT OF AUTOMATED HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY 未知
公开(公告)号：CA2932803C
公开(公告)日：2020-09-08
申请号：CA2932803
申请日：2014-12-08
申请人： VENTANA MED SYST INC
发明人： KELLER TIMOTHY , METTE MATTHEW , TSE CHRISTINE , WARD GLEN , WILKINSON CHAD
IPC分类号： G01N1/31
摘要： Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens.

7. 发明专利

AU2018204789B2 Automated histological processing of biological specimens and associated technology 未知
公开(公告)号：AU2018204789B2
公开(公告)日：2019-11-28
申请号：AU2018204789
申请日：2018-06-29
申请人： VENTANA MED SYST INC
发明人： CAPPS KAYLA , GROLL HENNING , KRAM BRIAN HOWARD , METTE MATTHEW , MOUSAVI ALI , O'CONNOR DANIEL , PALUSZCYK TROY , RANDALL BENJAMIN , STUMPE KEN , TSE CHRISTINE , WARD GLEN
IPC分类号： G01N1/31 , G01N35/00
摘要： AUTOMATED HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY A method for processing specimens (3034) carried by slides (3020) within an automated histological system (2), the method comprising: automatically dispensing a liquid (3030) so as to form a freestanding first puddle on a first slide, the liquid (3030) being one of a staining reagent and a counterstaining reagent; automatically dispensing the liquid (3030) so as to form a freestanding second puddle on a second slide (3020); non-immunohistochemically staining the first and second specimens (3020) while the first and second specimens (3020) are in contact with the first and second puddles, respectively; removing at least a portion of the first puddle from the first specimen (3020) so as to at least partially uncover the first specimen (3020) without contacting the first puddle with a solid structure or displacing the first puddle with a liquid (3030); and removing at least a portion of the second puddle from the second specimen (3020) so as to at least partially uncover the second specimen (3020) without contacting the second puddle with a solid structure or displacing the second puddle with a liquid (3030).

8. 发明专利

CA2695837C AUTOMATED HIGH VOLUME SLIDE STAINING SYSTEM 未知
公开(公告)号：CA2695837C
公开(公告)日：2015-12-29
申请号：CA2695837
申请日：2003-04-15
申请人： VENTANA MED SYST INC
发明人： REINHARDT KURT , LEMME CHARLES D , WARD GLEN , RICHARDS WILLIAM , SHOWALTER WAYNE
IPC分类号： G01N1/30 , G01N35/00 , B01L9/00 , G01N1/00 , G01N1/28 , G01N1/31 , G01N1/36
摘要： An automated slide processing apparatus includes a plurality of work stations arranged in a stack, and a transport/elevator for transporting slides between the various work stations. In particular the device is for deparaffinizing, staining and coverslipping a plurality of biological specimen bearing slides, in a fully automated and integrated system.

9. 发明专利

CA2928900A1 AUTOMATED HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY 未知
公开(公告)号：CA2928900A1
公开(公告)日：2015-06-18
申请号：CA2928900
申请日：2014-12-08
申请人： VENTANA MED SYST INC
发明人： CAPPS KAYLA , GROLL HENNING , KRAM BRIAN HOWARD , METTE MATTHEW D , MOUSAVI ALI , O`CONNOR DANIEL , PALUSZCYK TROY , RANDALL BENJAMIN , STUMPE KEN , TSE CHRISTINE , WARD GLEN
IPC分类号： G01N1/31 , G01N35/00
摘要： Automated system configured to perform and methods for performing one or more slide processing operations on slides bearing biological samples. The system and methods enable high sample throughput while also minimizing or limiting the potential for cross-contamination of slides. The automated systems can include features that facilitate consistency, controllability of processing time, and/or processing temperature.

10. 发明专利

ES2435666T3 Aparato y método para el tratamiento de muestras biológicas 未知
公开(公告)号：ES2435666T3
公开(公告)日：2013-12-20
申请号：ES11004066
申请日：2008-07-03
申请人： VENTANA MED SYST INC
发明人： LEMME CHARLES D , RICHARDS WILLIAM , WARD GLEN , ASHBY AUSTIN , GHUSSON ANDREW , JENSEN-LONG LISA , KNAPP KEVIN , KUGIZAKI RODNEY , LARSON ALAIN , RICHARDS PAUL , SHOWALTER WAYNE , WILKINSON CHAD
IPC分类号： G01N35/00
摘要： Un método para controlar el funcionamiento de un sistema (10) de tratamiento de muestras biológicas paraproporcionar las oportunidades de rellenar o cambiar los reactivos en el sistema, en el que cada una de unapluralidad de muestras está siendo procesada o tratada de manera independiente por el sistema (10), quecomprende: determinar puntos de pausa para cada muestra de la pluralidad de muestras, en donde los puntos de pausason lugares en un protocolo de tratamiento de sustratos en donde ningún tratamiento/reacción está activo,de manera que los puntos de pausa son puntos potenciales en los procedimientos de tratamiento oprocesamiento de muestras en donde una muestra puede ser pausada de manera segura, durante una cortacantidad de tiempo, sin efectos adversos para el tratamiento o procesamiento de las muestras: calcular una zona de aterrizaje, que es un punto en el tiempo calculado para proporcionar una pausacoordinada de todas las muestras que actualmente están siendo procesadas o tratadas en un estado dondeellas pueden permanecer de forma segura, alineando los puntos de pausa para todas las de la pluralidad demuestras; y parar automáticamente el procesamiento o tratamiento de muestras en la zona de aterrizaje yautomáticamente proporcionar el acceso a una pluralidad de recipientes (102, 104, 106) de reactivosguardados en el sistema (10) de manera que los recipientes (102, 104, 106) de reactivos puedan sercambiados, en el que dicha etapa de parar automáticamente el tratamiento o procesamiento de muestras enla zona de aterrizaje comprende cambiar sucesivamente el estado de cada muestra que está siendoprocesada a un estado de pausa hasta que todas las muestras en el sistema estén pausadas.

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