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1. 发明申请

US20050283231A1 Everting heart valve 有权
标题翻译：永恒心脏瓣膜
公开(公告)号：US20050283231A1
公开(公告)日：2005-12-22
申请号：US10870340
申请日：2004-06-16
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn , Kenneth Michlitsch
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn , Kenneth Michlitsch
IPC分类号： A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion. The invention also includes methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve, wrapping at least a portion of the replacement valve about the anchor, and expanding the anchor to a deployed configuration.
摘要翻译：本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。该装置包括置换瓣膜和可扩张锚固件，其可构造成用于血管内递送至患者心脏瓣膜附近。在一些实施例中，替换瓣膜适于例如在血管内部署过程中绕过锚固件。在一些实施例中，替换阀不连接到锚的可膨胀部分。在一些实施例中，锚定构件用于在血管内部署过程中进行主动缩短。在一些实施例中，锚固件包括用于在展开期间与患者的心脏瓣膜接合的可扩张唇缘和裙部区域。在一些实施例中，锚固件包括由单股线制成的编织物。在一些实施例中，该装置包括被配置成保持锚固扩展的锁。本发明还包括用于血管内替代患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和可膨胀锚固件血管内输送到心脏瓣膜附近，将替代瓣膜的至少一部分围绕锚定件包裹，并将锚固件扩展至展开构造。

2. 发明申请

US20050137694A1 Methods and apparatus for endovascularly replacing a patient's heart valve 审中-公开
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20050137694A1
公开(公告)日：2005-06-23
申请号：US10893151
申请日：2004-07-15
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
IPC分类号： A61F2/00 , A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2415 , A61F2/2436 , A61F2/2439 , A61F2220/0075 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.
摘要翻译：本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。该装置包括更换阀和具有可膨胀编织物的锚固件。在一些实施例中，可膨胀编织物由单根线材制成。在一些实施例中，可膨胀编织物包括至少一个匝特征。锚和阀优选地构造成用于血管内递送和展开。

3. 发明申请

US20070162107A1 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20070162107A1
公开(公告)日：2007-07-12
申请号：US11716123
申请日：2007-03-09
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2409 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0067 , A61F2230/0078 , A61F2250/006
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.
摘要翻译：本发明提供了用于血管内替代患者心脏瓣膜的方法和装置。该装置包括更换阀和具有可膨胀编织物的锚固件。在一些实施例中，可膨胀编织物由单根线材制成。在一些实施例中，可膨胀编织物包括至少一个匝特征。锚和阀优选地构造成用于血管内递送和展开。

4. 发明申请

US20050137702A1 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20050137702A1
公开(公告)日：2005-06-23
申请号：US10893142
申请日：2004-07-15
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
IPC分类号： A61F2/00 , A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2409 , A61F2/013 , A61F2/2415 , A61F2/2418 , A61F2/2427 , A61F2/2436 , A61F2220/0075 , A61F2230/0054 , A61F2230/0078 , A61F2250/0036 , A61F2250/0039
摘要： The present invention relates to an apparatus for replacing a native aortic valve, the apparatus includes an expandable anchor adapted to be endovascularly delivered and secured at a site within the native aortic valve. The expandable anchor has a delivery length in a delivery configuration substantially greater than a deployed length in a deployed configuration. The apparatus may also include and a replacement valve configured to be secured within the anchor.
摘要翻译：本发明涉及一种用于替换天然主动脉瓣的装置，该装置包括适于在血管内递送并固定在天然主动脉瓣内的部位的可扩张锚。可扩展锚具在传送配置中的传送长度实质上大于部署配置中展开的长度。该装置还可以包括配置成固定在锚中的替换阀。

5. 发明申请

US20050137693A1 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
标题翻译：血管内置换患者心脏瓣膜的方法和装置
公开(公告)号：US20050137693A1
公开(公告)日：2005-06-23
申请号：US10893143
申请日：2004-07-15
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
IPC分类号： A61F2/00 , A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2/2439 , A61F2230/0054 , A61F2250/0039
摘要： The present invention relates to methods for endovascularly replacing a patient's heart valve. In some embodiments, the method includes the steps of endovascularly delivering a replacement valve and an anchor to a vicinity of the heart valve, the anchor having a braid, and expanding the braid to a deployed configuration against the patient's tissue. The braid may be fabricated from a single strand of wire and/or may comprise at least one turn feature.
摘要翻译：本发明涉及血管内置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和锚固件血管内输送到心脏瓣膜附近，锚具具有编织物，并且将编织物扩展到针对患者组织的展开构型。编织物可以由单股线制成和/或可以包括至少一个匝特征。

6. 发明申请

US20050137692A1 Methods and apparatus for endovascularly replacing a patient's heart valve 有权
公开(公告)号：US20050137692A1
公开(公告)日：2005-06-23
申请号：US10893131
申请日：2004-07-15
申请人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
发明人： Ulrich Haug , Hans Valencia , Robert Geshlider , Tom Saul , Amr Salahieh , Dwight Morejohn
IPC分类号： A61F2/00 , A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2418 , A61F2/24 , A61F2/2415 , A61F2/2427 , A61F2/2436 , A61F2210/0014 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： The present invention provides methods and apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an anchor having an expandable braid. In some embodiments, the expandable braid is fabricated from a single strand of wire. In some embodiments, the expandable braid comprises at least one turn feature. The anchor and the valve preferably are configured for endovascular delivery and deployment.

7. 发明申请

US20050137701A1 Locking heart valve anchor 有权
标题翻译：锁心阀锚
公开(公告)号：US20050137701A1
公开(公告)日：2005-06-23
申请号：US10746872
申请日：2003-12-23
申请人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider
发明人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/0069
摘要： Apparatus for endovascularly replacing a patient's heart valve, including: a replacement valve adapted to be delivered endovascularly to a vicinity of the heart valve; an expandable anchor adapted to be delivered endovascularly to the vicinity of the heart valve; and a lock mechanism configured to maintain a minimum amount of anchor expansion. The invention also includes a method for endovascularly replacing a patient's heart valve. In some embodiments the method includes the steps of: endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve; expanding the anchor to a deployed configuration; and locking the anchor in the deployed configuration.
摘要翻译：用于血管内替换患者心脏瓣膜的装置，包括：适于被血管内递送至心脏瓣膜附近的置换瓣膜; 可膨胀的锚固件适于被血管内递送到心脏瓣膜附近; 以及锁定机构，其构造成保持最小量的锚固膨胀。本发明还包括一种用于血管内替换患者心脏瓣膜的方法。在一些实施例中，该方法包括以下步骤：将置换瓣膜和可扩张锚固件血管内输送到心脏瓣膜附近; 将锚扩展到部署配置; 并将锚定器锁定在部署的配置中。

8. 发明申请

US20050137686A1 Externally expandable heart valve anchor and method 审中-公开
标题翻译：外部可扩张心脏瓣膜锚和方法
公开(公告)号：US20050137686A1
公开(公告)日：2005-06-23
申请号：US10746120
申请日：2003-12-23
申请人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
发明人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
IPC分类号： A61F2/06 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2439 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulic or non-pneumatic actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚固件上施加外部非液压或非气动致动力以改变所述锚的形状，诸如通过使用可释放的展开工具向锚固件施加近端和/或远端定向的力以使所述锚或锚的部分。

9. 发明申请

US20070010876A1 Externally Expandable Heart Valve Anchor and Method 审中-公开
标题翻译：外部可扩张心脏瓣膜锚和方法
公开(公告)号：US20070010876A1
公开(公告)日：2007-01-11
申请号：US11531980
申请日：2006-09-14
申请人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
发明人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
IPC分类号： A61F2/24
CPC分类号： A61F2/2439 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2002/9528 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/005 , A61F2230/0054 , A61F2230/0065 , A61F2230/0078 , A61F2250/006
摘要： The invention includes methods of and apparatus for endovascularly replacing a heart valve of a patient. One aspect of the invention provides a method including the steps of endovascularly delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; and applying an external non-hydraulic or non-pneumatic actuation force on the anchor to change the shape of the anchor, such as by applying proximally and/or distally directed force on the anchor using a releasable deployment tool to expand and contract the anchor or parts of the anchor.
摘要翻译：本发明包括用于血管内置换患者心脏瓣膜的方法和装置。本发明的一个方面提供了一种方法，包括以未膨胀的构造将置换瓣膜和可扩张锚固体血管内输送到心脏瓣膜附近的步骤; 以及在所述锚固件上施加外部非液压或非气动致动力以改变所述锚的形状，诸如通过使用可释放的展开工具向锚固件施加近端和/或远端定向的力以使所述锚或锚的部分。

10. 发明申请

US20050137688A1 Repositionable heart valve and method 有权
标题翻译：可重新定位心脏瓣膜及方法
公开(公告)号：US20050137688A1
公开(公告)日：2005-06-23
申请号：US10746280
申请日：2003-12-23
申请人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
发明人： Amr Salahieh , Brian Brandt , Dwight Morejohn , Ulrich Haug , Jean-Pierre Dueri , Hans Valencia , Robert Geshlider , Jeff Krolik
IPC分类号： A61F2/00 , A61F2/01 , A61F2/24 , A61F2/90
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2/2436 , A61F2210/0014 , A61F2220/0016 , A61F2220/0083 , A61F2230/005 , A61F2230/0054 , A61F2230/0078 , A61F2250/0039
摘要： A method for percutaneously replacing a heart valve of a patient. In some embodiments the method includes the steps of percutaneously delivering a replacement valve and an expandable anchor to a vicinity of the heart valve in an unexpanded configuration; expanding the anchor to a deployed configuration in which the anchor contacts tissue at a first anchor site; repositioning the anchor to a second anchor site; and deploying the anchor at the second anchor site.
摘要翻译：一种用于经皮置换患者心脏瓣膜的方法。在一些实施例中，该方法包括以未膨胀构型经皮递送置换瓣膜和可扩张锚定至心脏瓣膜附近的步骤; 将锚扩展到展开构型，其中锚固件在第一锚固部位接触组织; 将锚重新定位到第二锚点; 并在第二锚点部署锚。

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