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1. 发明申请

WO1996001276A1 EXPRESSION OF A FUNCTIONAL HUMAN TYPE I INTERFERON RECEPTOR 审中-公开
标题翻译：功能性人类干扰素受体的表达
公开(公告)号：WO1996001276A1
公开(公告)日：1996-01-18
申请号：PCT/US1995008456
申请日：1995-07-06
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , MARIANO, Thomas, M. , SOH, Jaemog
IPC分类号： C07K14/705
CPC分类号： C12N15/81 , A61K38/00 , C07K14/715
摘要： This invention relates to a yeast artificial chromosome, YAC F136C5, containing a segment of human Chromosome 21 which when introduced into Chinese hamster ovary (CHO) cells confers upon these cells a greatly enhanced response to Hu-IFN- alpha A and Hu-IFN- alpha B2 as well as increased response to Hu-IFN-omega, Hu-IFN- alpha A/D (Bgl), and Hu-IFN- beta . This invention also relates to a functional human type I interferon receptor expressed from the yeast artificial chromosome, YAC F136C5.
摘要翻译：本发明涉及酵母人造染色体YAC F136C5，其含有人染色体21的片段，当引入中国仓鼠卵巢（CHO）细胞赋予这些细胞时，对Hu-IFN-αA和Hu-IFN- α-B2，以及Hu-IFN-ω，Hu-IFN-αA/ D（Bgl）和Hu-IFN-β的增加的反应。本发明还涉及从酵母人造染色体YAC F136C5表达的功能性人I型干扰素受体。

2. 发明申请

WO2006099451A2 NOVEL HUMAN, FELINE, CHICKEN AND OTHER ANIMAL INTERFERONS AND USES THEREOF 审中-公开
标题翻译：新人，鱼，鸡和其他动物干扰物及其用途
公开(公告)号：WO2006099451A2
公开(公告)日：2006-09-21
申请号：PCT/US2006/009229
申请日：2006-03-14
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , KRAUSE, Christopher, D.
发明人： PESTKA, Sidney , KRAUSE, Christopher, D.
CPC分类号： C07K14/555 , C07K14/54
摘要： The invention relates to novel interferon polypeptides and nucleic from humans, felines, chicken and other species and to related compositions and uses. The invention also provides novel interleukin polypeptides and nucleic acids, as well as nucleic acids and polypeptides for interferons and interleukin receptors. The invention also provides antibodies specific for the novel polypeptides, assays for identifying modulators of interferon activity, and methods of treating animals, including humans, afflicted with various disorders and conditions by administering interferon polypeptides, including IFN-P polypeptides and fragments.
摘要翻译：本发明涉及新型干扰素多肽和来自人，猫科动物，鸡和其他物种以及相关组合物和用途的核酸。本发明还提供了新型白介素多肽和核酸，以及用于干扰素和白细胞介素受体的核酸和多肽。本发明还提供了针对新型多肽的特异性抗体，用于鉴定干扰素活性调节剂的测定法，以及通过施用包括IFN-P多肽和片段的干扰素多肽来治疗各种疾病和病症的动物（包括人）的方法。

3. 发明申请

WO1997000085A1 GENE THERAPY OF SOLID TUMORS WITH INTERFERONS ALONE OR WITH OTHER IMMUNO-EFFECTOR PROTEINS 审中-公开
标题翻译：具有干扰物的固体肿瘤的基因治疗单独或与其他免疫效应蛋白
公开(公告)号：WO1997000085A1
公开(公告)日：1997-01-03
申请号：PCT/US1996010502
申请日：1996-06-18
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , SARKAR, Srijata , FLORES, Idhaliz , RON, Yacov
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The present invention relates to vectors and compositions for gene therapy strategies against solid tumors, particularly malignant tumors. In one aspect, the invention is directed to a solid tumor vaccine comprising tumor cells transfected to express interferon- alpha in a pharmaceutically acceptable excipient, and to a method for treating a solid tumor by administering such a vaccine. Preferably, the tumor cells are also transfected to express an immunomodulatory molecule, such as interferon- gamma , interferon- beta , interferon- omega , interferon- tau , tumor necrosis factor- alpha , tumor necrosis factor- beta , interleukin-2, interleukin-7, interleukin-12, interleukin-15, B7-1 T cell costimulatory molecule, B7-2 T cell costimulatory molecule, immune cell adhesion molecule (ICAM)-1 T cell costimulatory molecule, granulocyte colony stimulatory factor, granulocyte-macrophage colony stimulatory factor, and combinations thereof, with the proviso that the immunomodulatory molecule is not interferon- alpha . In yet a further embodiment, a soluble immunomodulatory molecule can be included in a vaccine of the invention. The method comprises introducing into a subject suffering a solid tumor a therapeutically effective number of tumor cells from a solid tumor, which tumor cells are transfected to express interferon- alpha . Preferably, the tumor cells are also transfected to express an immunomodulatory molecule, with the proviso that the immunomodulatory molecule is not interferon- alpha . Alternatively, a therapeutically effective number of additional tumor cells transfected to express an immunomodulatory molecule ca be introduced into the subject.
摘要翻译：本发明涉及针对实体瘤，特别是恶性肿瘤的基因治疗策略的载体和组合物。一方面，本发明涉及包含在药学上可接受的赋形剂中转染以表达干扰素-α的肿瘤细胞的实体肿瘤疫苗，以及通过施用这样的疫苗来治疗实体瘤的方法。优选地，肿瘤细胞也被转染以表达免疫调节分子，例如干扰素-γ，干扰素-β，干扰素-ω，干扰素τ，肿瘤坏死因子-α，肿瘤坏死因子-β，白细胞介素-2，白细胞介素-2 7，白细胞介素-12，白细胞介素-15，B7-1T细胞共刺激分子，B7-2T细胞共刺激分子，免疫细胞粘附分子（ICAM）-1T细胞共刺激分子，粒细胞集落刺激因子，粒细胞巨噬细胞集落刺激因子及其组合，条件是免疫调节分子不是干扰素-α。在又一个实施方案中，可溶性免疫调节分子可以包括在本发明的疫苗中。该方法包括向患有实体瘤的受试者中引入治疗有效数量的来自实体瘤的肿瘤细胞，该肿瘤细胞被转染以表达干扰素-α。优选地，肿瘤细胞也被转染以表达免疫调节分子，条件是免疫调节分子不是干扰素-α。或者，可将待转染以表达免疫调节分子的另外的肿瘤细胞的治疗有效数量引入受试者。

4. 发明申请

WO1995005847A1 ACCESSORY FACTOR FUNCTION FOR INTERFERON GAMMA AND ITS RECEPTOR 审中-公开
标题翻译：干扰素及其受体的辅助因子功能
公开(公告)号：WO1995005847A1
公开(公告)日：1995-03-02
申请号：PCT/US1994009438
申请日：1994-08-22
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY , PESTKA, Sidney , KOTENKO, Serguei , SOH, Jaemog , DONNELY, Robert, J. , MARIANO, Thomas, M. , COOK, Jeffrey, R. , EMANUEL, Stuart , SCHWARTZ, Barbara
IPC分类号： A61K38/18
CPC分类号： C07K14/705 , C07K14/7156
摘要： This invention relates (a) to a 540 kb YAC which encodes the necessary species-specific factor(s) and is able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens; (b) to the construction of a plasmid to integrate the selective marker for antibiotic G418 resistance into YACs and to delete some of the human DNA fragments from YACs in order to facilitate the manipulation of human genomic DNA in yeast artificial chromosome (YAC) clones; (c) to two fragmentation vectors, pSE1 and pSE2, which contain a neomycin resistance and URA3 gene, developed for targeting yeast artificial chromosomes (YACs) containing human genomic DNA; (d) to a chromosomal fragmentation procedure employed to produce a deletion set of yeast artificial chromosomes (YACs) from a parental YAC (GART D142H8) known to map to Chromosome 21q and to encode the human interferon-gamma receptor (Hu-IFN-gamma R) accessory factor gene as well as the phosphoribosylglycinamide formyltransferase (GART) gene; and (e) to the isolation of cDNA clones that encode the necessary species-specific factor and that are able to substitute for human Chromosome 21 to reconstitute the Hu-IFN-gamma receptor-mediated induction of class I HLA antigens.
摘要翻译：本发明涉及（a）编码所需物种特异性因子的540kb YAC，并且能够代替人染色体21重建Hu-IFN-γ受体介导的I类HLA抗原的诱导; （b）构建质粒，将抗生素G418抗性的选择性标记整合到YAC中，并从YAC中删除一些人DNA片段，以便于酵母人造染色体（YAC）克隆中人基因组DNA的操作; （c）包含含有新霉素抗性和URA3基因的两个片段化载体pSE1和pSE2，用于靶向含有人基因组DNA的酵母人造染色体（YAC）; （d）涉及从已知映射到染色体21q并编码人干扰素-γ受体（Hu-IFN-γ）的亲本YAC（GART D142H8）产生一组缺失的酵母人造染色体（YAC）的染色体片段化方法 R）辅因子基因以及磷酸核糖基甘氨酰甲酰转移酶（GART）基因; 和（e）分离编码必需物种特异性因子的cDNA克隆，并能够代替人染色体21重建Hu-IFN-γ受体介导的I类HLA抗原的诱导。

5. 发明公开

EP0835130A1 GENE THERAPY OF SOLID TUMORS WITH INTERFERONS ALONE OR WITH OTHER IMMUNO-EFFECTOR PROTEINS 失效
标题翻译：与干扰素一起单独或与其它蛋白质实体肿瘤的基因治疗IMMUNOEFFEKTOREN
公开(公告)号：EP0835130A1
公开(公告)日：1998-04-15
申请号：EP96921666.0
申请日：1996-06-18
申请人： UNIVERSITY OF MEDICINE & DENTISTRY OF NEW JERSEY
发明人： PESTKA, Sidney , SARKAR, Srijata , FLORES, Idhaliz , RON, Yacov
IPC分类号： A61K39
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/5156 , A61K2039/55522
摘要： The present invention relates to vectors and compositions for gene therapy strategies against solid tumors, particularly malignant tumors. In one aspect, the invention is directed to a solid tumor vaccine comprising tumor cells transfected to express interferon-α in a pharmaceutically acceptable excipient, and to a method for treating a solid tumor by administering such a vaccine. Preferably, the tumor cells are also transfected to express an immunomodulatory molecule, such as interferon-η, interferon-β, interferon-φ, interferon-τ, tumor necrosis factor-α, tumor necrosis factor-β, interleukin-2, interleukin-7, interleukin-12, interleukin-15, B7-1 T cell costimulatory molecule, B7-2 T cell costimulatory molecule, immune cell adhesion molecule (ICAM)-1 T cell costimulatory molecule, granulocyte colony stimulatory factor, granulocyte-macrophage colony stimulatory factor, and combinations thereof, with the proviso that the immunomodulatory molecule is not interferon-α. In yet a further embodiment, a soluble immunomodulatory molecule can be included in a vaccine of the invention. The method comprises introducing into a subject suffering a solid tumor a therapeutically effective number of tumor cells from a solid tumor, which tumor cells are transfected to express interferon-α. Preferably, the tumor cells are also transfected to express an immunomodulatory molecule, with the proviso that the immunomodulatory molecule is not interferon-α. Alternatively, a therapeutically effective number of additional tumor cells transfected to express an immunomodulatory molecule ca be introduced into the subject.

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