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1. 发明申请

WO2004105862A3 MEASURING HUMAN HEART MUSCLE VIABILITY USING MYOCARDIAL ELECTRICAL IMPEDANCE 审中-公开
标题翻译：使用MYOCARDIAL电气阻抗测量人体心脏肌肉功能
公开(公告)号：WO2004105862A3
公开(公告)日：2005-03-03
申请号：PCT/US2004017224
申请日：2004-05-28
申请人： UNIV OHIO STATE , DZWONCZYK ROGER R , DEL RIO CARLOS L , MCCONNELL PATRICK I , HOWIE MICHAEL B
发明人： DZWONCZYK ROGER R , DEL RIO CARLOS L , MCCONNELL PATRICK I , HOWIE MICHAEL B
IPC分类号： A61B5/05 , A61B5/053 , A61N20060101
CPC分类号： A61B5/053 , A61B5/413
摘要： A method for detecting a quantitative measure of a physiologic state of a myocardium or coronary artery by detecting the extent of change of myocardial electrical impedance from a mean baseline value to provide diagnosis of the extent of ischemia, stenosis, tissue rejection, reperfusion and the effectiveness of cardioplegia . Electrodes (16,18) are attached to the myocardium (14), baseline measurements of the mean myocardial impedance are stored, and the variance of the myocardial electrical impedance and a baseline value of mean myocardial electrical impedance are computed from the baseline measurements using custom circuitry (12) and a computer (10). After a mean myocardial electrical impedance changes from a computed baseline value by at least the measured variance, the extent of change in the myocardial physiologic state is diagnosed as a continuous, smooth, function of the extent or rate of change of a periodically measured myocardial electrical impedance from the baseline value.
摘要翻译：通过从平均基线值检测心肌电阻抗的变化程度来检测心肌或冠状动脉的生理状态的定量测量的方法，以提供缺血，狭窄，组织排斥，再灌注和有效性的程度的诊断的心脏停跳。电极（16,18）连接到心肌（14），存储平均心肌阻抗的基线测量，并且使用定制从基线测量计算心肌电阻抗的方差和平均心肌电阻抗的基线值电路（12）和计算机（10）。在平均心肌电阻抗从计算基线值至少改变测量方差之后，心肌生理状态的变化程度被诊断为周期性测量的心肌电气的变化程度或速率的连续，平滑的功能阻抗从基线值。

2. 发明专利

IL292840A Methods of treatment with myosin modulator 未知
公开(公告)号：IL292840A
公开(公告)日：2022-07-01
申请号：IL29284022
申请日：2022-05-08
申请人： MYOKARDIA INC , CARLSON TIMOTHY , DEL RIO CARLOS L , EDELBERG JAY M , FERNANDES SARAH , HENZE MARCUS PATRICK , MA GRACE YANFEI , MCDOWELL ROBERT , MEALIFFE MATTHEW EDWARDS , SEHNERT AMY , SEMIGRAN MARC J , LAMPL KATHY L , ZHANG DAVID , DESAI MILIND Y , NISSEN STEVE , FANG LIANG , LAMBING JOSEPH , LI WANYING , AUBELE DANIELLE L , KANE BRIAN EDMUND , SEHL LOUIS CHARLES
发明人： CARLSON TIMOTHY , DEL RIO CARLOS L , EDELBERG JAY M , FERNANDES SARAH , HENZE MARCUS PATRICK , MA GRACE YANFEI , MCDOWELL ROBERT , MEALIFFE MATTHEW EDWARDS , SEHNERT AMY , SEMIGRAN MARC J , LAMPL KATHY L , ZHANG DAVID , DESAI MILIND Y , NISSEN STEVE , FANG LIANG , LAMBING JOSEPH , LI WANYING , AUBELE DANIELLE L , KANE BRIAN EDMUND , SEHL LOUIS CHARLES
IPC分类号： A61K31/513
摘要： Disclosed herein are methods of treatment comprising administering a therapeutically effective amount of a myosin modulator or a pharmaceutically acceptable salt thereof to a subject in need thereof and diagnostic methods useful in connection with those treatments. Due to observations unfolding in clinical trials with mavacamten and with mavacamten and other myosin inhibitors in the pre-clinical setting, new insights into how myosin inhibitors can be used beneficially to impact the disease state of HCM and other diseases are provided herein.

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