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1. 发明授权

US5083134A Antenna device for an automobile 失效
标题翻译：天线装置用于汽车
公开(公告)号：US5083134A
公开(公告)日：1992-01-21
申请号：US379345
申请日：1989-07-13
申请人： Toshihiko Saitou , Takashi Yamashita , Kenichi Ishii , Masanobu Ogawa , Shinya Shibata , Kenji Oda , Masaharu Kume
发明人： Toshihiko Saitou , Takashi Yamashita , Kenichi Ishii , Masanobu Ogawa , Shinya Shibata , Kenji Oda , Masaharu Kume
IPC分类号： H01Q1/12
CPC分类号： H01Q1/1271
摘要： An antenna device for an automobile comprises an electric heating type defogger having heating strips and a bus bar for feeding a current to the heating strips and an antenna conductor having antenna strips arranged to form a pattern, which are fitted on the rear window glass fitted to a rear window opening formed in an automobile, wherein the defogger and the antenna conductor are spaced apart from each other with a predetermined small space in a capacitive coupling relation so a reactance circuit is connected to the defogger to effect anti-resonance between the defogger and the rear window opening of the body of the automobile at the central frequency in terms of logarithmic scale of a broadcast frequency band region; a quality factor value is determined by the inductance of a choke coil in the reactance circuit and the stray capacitance between the defogger and the rear window opening of the body of the automobile so that the ratio of an input impedance to a receiver to the impedance of the antenna conductor viewed from the side of a power feeding terminal becomes 1; and a matching circuit is inserted between the power feeding terminal of the antenna conductor and the receiver so that the sum of the impedance of the antenna conductor viewed from the side of the input terminal of the receiver and the functional part as an antenna in the rear window glass exhibits a little capacitive reactance in a broadcast frequency band region.

2. 发明授权

US4439771A Glass antenna system for an automobile 失效
标题翻译：汽车玻璃天线系统
公开(公告)号：US4439771A
公开(公告)日：1984-03-27
申请号：US378329
申请日：1982-05-14
申请人： Masaharu Kume , Kenichi Ishii , Takayasu Hokusho
发明人： Masaharu Kume , Kenichi Ishii , Takayasu Hokusho
IPC分类号： H01Q1/32 , B60J1/00 , H01Q1/12 , H01Q1/02
CPC分类号： H01Q1/1278
摘要： A glass antenna system for an automobile comprises a main antenna disposed at an upper part of a glass plate for a rear window of the automobile and a defogging electric heating element disposed below and separate from the main antenna and comprising a plurality of heating strips and a pair of bus bars for supplying electricity to the heating strips. The glass antenna system is characterized in that a lead wire is connected to a predetermined portion of the lower most heating strip among said heating strips and a feeding point for connection to an antenna feeder line is provided on the lead wire, whereby the defogging electric heating element constitutes a subsidiary antenna having a directivity different from the directivity of the main antenna.
摘要翻译：一种用于汽车的玻璃天线系统包括设置在汽车后窗玻璃板的上部的主天线和设置在主天线下方并与主天线分离的除雾电加热元件，并且包括多个加热带和一对用于向加热带供电的母线。玻璃天线系统的特征在于，引线与所述加热带中的最下部加热条的预定部分连接，并且在引线上设置用于连接到天线馈线的馈电点，由此除雾电加热元件构成具有与主天线的方向性不同的方向性的辅助天线。

3. 发明授权

US5464693A Structure for installing mirror base on glass plate and method for installing mirror base on glass plate 失效
标题翻译：在玻璃板上安装镜座的结构和在玻璃板上安装镜座的方法
公开(公告)号：US5464693A
公开(公告)日：1995-11-07
申请号：US889417
申请日：1992-05-28
申请人： Michio Ono , Masaharu Kume , Takayuki Matsuo
发明人： Michio Ono , Masaharu Kume , Takayuki Matsuo
IPC分类号： B32B17/10 , B60R1/04 , C03C27/04 , C09J183/04 , C08G77/06 , G02B7/18
CPC分类号： C03C27/048 , B32B17/10036 , B60R1/04 , C09J183/04 , Y10T428/2804 , Y10T428/31612 , Y10T428/3163 , Y10T428/31663
摘要： This invention relates to a mirror base-installing structure for installing a mirror base on the surface of a glass plate, characterized in that said mirror base is bonded to the surface of said glass plate with a film-like or sheet-like heat-curable adhesive interposed between the mirror base and the glass plate, said adhesive having elasticity or plasticity after heat-cured, and a method for installing the same. The mirror base can be bonded simultaneously with the preparation of a bilayer glass, thereby simplifying the working process.
摘要翻译：本发明涉及一种用于在玻璃板的表面上安装镜座的镜基座安装结构，其特征在于，所述镜座与膜状或片状可热固化插入在镜底座和玻璃板之间的粘合剂，所述粘合剂在热固化后具有弹性或可塑性，以及其安装方法。镜底可以同时制备双层玻璃，从而简化了工作过程。

4. 发明授权

US08202879B2 Quinazoline derivatives having tyrosine kinase inhibitory activity 有权
标题翻译：具有酪氨酸激酶抑制活性的喹唑啉衍生物
公开(公告)号：US08202879B2
公开(公告)日：2012-06-19
申请号：US11884819
申请日：2006-02-22
申请人： Masaharu Kume , Kenji Matsuo , Naoki Omori , Masami Takayama
发明人： Masaharu Kume , Kenji Matsuo , Naoki Omori , Masami Takayama
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/12
摘要： A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I): wherein RX is a group represented by the formula: wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R10)—, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R12)—, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：提供抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶两者的化合物。由通式（I）表示的化合物：其中RX是由下式表示的基团：其中R1是氢原子，任选取代的烷基等; Z是-O - ， - N（R 10） - 等; R10是氢原子，烷基等; R2是氢原子，任选取代的烷基等; R18是氢原子，任意取代的烷基等; R19是任选取代的烷基等; W1是任选取代的非芳族含氮基团; R 17是氢原子，任选取代的烷基等; R3和R4独立地是氢原子，任选取代的烷基等; X是-O-，-S-或-N（R 12） - 等; R12是氢原子，烷基等; 和A是任选具有取代基的苯基等，其药学上可接受的盐或其溶剂合物。

5. 发明授权

US5580976A Preparation of .beta.-lactam compounds, and intermediates therefor 失效
标题翻译： β-内酰胺化合物及其中间体的制备
公开(公告)号：US5580976A
公开(公告)日：1996-12-03
申请号：US425225
申请日：1995-04-18
申请人： Masaharu Kume , Tadatoshi Kubota
发明人： Masaharu Kume , Tadatoshi Kubota
IPC分类号： C07D205/08 , C07D477/04 , C07D501/04 , C07F9/6561 , C07D205/09 , C07D205/085 , C07D205/095
CPC分类号： C07F9/65611 , C07D205/08 , C07D477/04 , Y02P20/55
摘要： A process for preparing a .beta.-lactam compound of the formula (I): ##STR1## which comprises cyclization of an azetidinone derivative of the formula: ##STR2## is provided in which R.sup.1 is hydrogen, alkyl which is optionally substituted, or amino which is optionally substituted; R.sup.2 is a carboxy-protecting group; and X is alkylene which is optionally intervened by --O-- or --S--, and/or which is optionally substituted; and R.sup.3 is aryl which is optionally substituted.
摘要翻译：提供了式（I）的β-内酰胺化合物的制备方法：其中包括下式所示的氮杂环丁酮衍生物（II）的环化：其中R 1是氢，烷基是任选取代的，或任选取代的氨基; R2是羧基保护基; 并且X是任选被-O-或-S-所介导的亚烷基，和/或任选被取代的; 并且R 3是任选被取代的芳基。

6. 发明申请

US20080227803A1 Indolomorphinan Derivative Having Carboxy in 6'-Position 审中-公开
标题翻译：吲哚并吗啡衍生物具有6'位的羧基
公开(公告)号：US20080227803A1
公开(公告)日：2008-09-18
申请号：US11792876
申请日：2005-12-13
申请人： Masanao Inagaki , Masaharu Kume
发明人： Masanao Inagaki , Masaharu Kume
IPC分类号： A61K31/485 , C07D491/22 , A61K31/34 , A61P25/02 , A61P1/08 , A61K31/439
CPC分类号： C07D491/20
摘要： A compound represented by the formula (I): (wherein R1 denotes hydrogen or —CHRARB (wherein RA denotes a lower alkoxycarbonyloxy, cycloalkoxycarbonyloxy, acyloxy or a group represented by (where R2 denotes hydrogen or a lower alkyl with or without a substituent), and RB denotes hydrogen or methyl, or any of pharmaceutically acceptable salts thereof or any of solvates thereof.
摘要翻译：由式（I）表示的化合物：（其中R 1表示氢或-CHR B）其中R A 表示低级烷氧基羰基氧基，环烷氧基羰基氧基，酰氧基或由（其中R 2表示氢或具有或不具有取代基的低级烷基）表示的基团，和R B >表示氢或甲基，或其任何药学上可接受的盐或其任何溶剂合物。

7. 发明授权

US5362724A Thioalkylthio carbacephalosporin derivatives 失效
标题翻译：硫代烷硫基碳孢霉素衍生物
公开(公告)号：US5362724A
公开(公告)日：1994-11-08
申请号：US128770
申请日：1993-09-17
申请人： Tadatoshi Kubota , Masaharu Kume
发明人： Tadatoshi Kubota , Masaharu Kume
IPC分类号： A61K31/435 , A61K31/4353 , A61P31/04 , C07D463/00 , C07D471/04
CPC分类号： C07D463/18 , C07D463/22 , Y02P20/55
摘要： A compound of the formula I: ##STR1## wherein Acyl is C.sub.1 -C.sub.12 acyl; Het is an optionally substituted monocyclic heteroaromatic group containing one or more hetero atoms; R.sup.1 is a single bond or C.sub.1 -C.sub.4 alkylene; R.sup.2 is a straight or branched C.sub.1 -C.sub.4 alkylene; and Y is a hydrogen atom or methoxy group, or a pharmaceutically acceptable salt or an amino-, carboxy- and/or hydroxy-protected derivative thereof, which have a potent antibiotic activity.
摘要翻译：式I的化合物：其中酰基是C 1 -C 12酰基; Het是含有一个或多个杂原子的任选取代的单环杂芳基; R1是单键或C1-C4亚烷基; R2是直链或支链C1-C4亚烷基; 并且Y是具有有效抗生素活性的氢原子或甲氧基，或其药学上可接受的盐或氨基，羧基和/或羟基保护的衍生物。

8. 发明授权

US08349857B2 Quinazoline derivatives having tyrosine kinase inhibitory activity 有权
标题翻译：具有酪氨酸激酶抑制活性的喹唑啉衍生物
公开(公告)号：US08349857B2
公开(公告)日：2013-01-08
申请号：US13359326
申请日：2012-01-26
申请人： Masaharu Kume , Kenji Matsuo , Naoki Omori , Masami Takayama , Aiko Omori , Takeshi Endo
发明人： Masaharu Kume , Kenji Matsuo , Naoki Omori , Masami Takayama , Aiko Omori , Takeshi Endo
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/12
摘要： A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I): wherein RX is a group represented by the formula: wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R10)—, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R12)—, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：提供抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶两者的化合物。由通式（I）表示的化合物：其中RX是由下式表示的基团：其中R1是氢原子，任选取代的烷基等; Z是-O - ， - N（R 10） - 等; R10是氢原子，烷基等; R2是氢原子，任选取代的烷基等; R18是氢原子，任意取代的烷基等; R19是任选取代的烷基等; W1是任选取代的非芳族含氮基团; R 17是氢原子，任选取代的烷基等; R3和R4独立地是氢原子，任选取代的烷基等; X是-O-，-S-或-N（R 12） - 等; R12是氢原子，烷基等; 和A是任选具有取代基的苯基等，其药学上可接受的盐或其溶剂合物。

9. 发明申请

US20090143414A1 Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity 有权
标题翻译：具有酪氨酸激酶抑制活性的喹唑啉衍生物
公开(公告)号：US20090143414A1
公开(公告)日：2009-06-04
申请号：US11884819
申请日：2006-02-22
申请人： Masaharu Kume
发明人： Masaharu Kume
IPC分类号： A61K31/517 , C07D413/02 , C07D403/02 , C07D239/72
CPC分类号： C07D239/94 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D407/12 , C07D417/12
摘要： A compound which inhibits both of EGF receptor tyrosine kinase and HER2 tyrosine kinase is provided.A compound represented by the general formula (I): wherein RX is a group represented by the formula: wherein R1 is a hydrogen atom, optionally substituted alkyl, etc.; Z is —O—, —N(R10)—, etc.; R10 is a hydrogen atom, alkyl, etc.; R2 is a hydrogen atom, optionally substituted alkyl, etc.; R18 is a hydrogen atom, optionally substituted alkyl, etc.; R19 is optionally substituted alkyl, etc.; W1 is an optionally substituted non-aromatic nitrogen-containing group; R17 is a hydrogen atom, optionally substituted alkyl, etc.; R3 and R4 are independently a hydrogen atom, optionally substituted alkyl, etc.; X is —O—, —S—, or —N(R12)—, etc.; R12 is a hydrogen atom, alkyl, etc.; and A is phenyl optionally having a substituent, etc., its pharmaceutically acceptable salt, or a solvate thereof.
摘要翻译：提供抑制EGF受体酪氨酸激酶和HER2酪氨酸激酶两者的化合物。由通式（I）表示的化合物：其中RX是由下式表示的基团：其中R1是氢原子，任选取代的烷基等; Z是-O - ， - N（R 10） - 等; R10是氢原子，烷基等; R2是氢原子，任选取代的烷基等; R18是氢原子，任意取代的烷基等; R19是任选取代的烷基等; W1是任选取代的非芳族含氮基团; R 17是氢原子，任选取代的烷基等; R3和R4独立地是氢原子，任选取代的烷基等; X是-O-，-S-或-N（R 12） - 等; R12是氢原子，烷基等; 和A是任选具有取代基的苯基等，其药学上可接受的盐或其溶剂合物。

10. 发明授权

US5214037A Thioalkylthio cephalosporin derivatives 失效
标题翻译：噻吗啉胆碱衍生物
公开(公告)号：US5214037A
公开(公告)日：1993-05-25
申请号：US729413
申请日：1991-07-12
申请人： Tadatoshi Kubota , Masaharu Kume
发明人： Tadatoshi Kubota , Masaharu Kume
IPC分类号： A61K31/545 , A61K31/546 , A61P31/00 , A61P31/04 , C07D249/04 , C07D249/08 , C07D401/06 , C07D501/00 , C07D501/04 , C07D501/06 , C07D501/59
CPC分类号： C07D249/04 , C07D501/00 , Y02P20/55
摘要： A novel thioalkylthio cephalosporin antibiotic compound of formula I: ##STR1## wherein Acyl is C.sub.1 -C.sub.12 acyl; Het is optionally substituted monocyclic heteroaromatic group containing one or more hetero atoms; R.sup.1 is a single bond or C.sub.1 -C.sub.4 alkylene; R.sub.2 is a straight or branched C.sub.1 -C.sub.4 alkylene; X is a sulfur atom or sulioxide group; and Y is a hydrogen atom or methoxy group, or a pharmaceutically acceptable salt or an amino-, carboxy- and/or hydroxy-protected derivative thereof, a formulation containing the same and a method for treating bacterial infections.

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