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1. 发明申请

US20070185016A1 Novel Staphylococcus peptides for bacterial interference 有权
标题翻译：新型葡萄球菌肽用于细菌干扰
公开(公告)号：US20070185016A1
公开(公告)日：2007-08-09
申请号：US11212020
申请日：2005-08-25
申请人： Tom Muir , Patricia Mayville , Richard Novick , Ronald Beavis , Guangyong Ji
发明人： Tom Muir , Patricia Mayville , Richard Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/12 , A61K31/43 , A61K31/545
CPC分类号： C07K7/06 , A61K38/00 , C07K14/31
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10 和y为1至10.包括环化方案的制备方法和使用环状肽的方法还公开了本发明。

2. 发明授权

US07419954B2 Staphylococcus peptides for bacterial interference 有权
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US07419954B2
公开(公告)日：2008-09-02
申请号：US11212020
申请日：2005-08-25
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/00 , A61K38/12
CPC分类号： C07K7/06 , A61K38/00 , C07K14/31
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of to an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10 和y为1至10.包括环化方案的制备方法和使用环状肽的方法还公开了本发明。

3. 发明授权

US06953833B2 Staphylococcus peptides for bacterial interference 失效
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US06953833B2
公开(公告)日：2005-10-11
申请号：US10032950
申请日：2001-12-27
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K38/16 , A61K38/12 , A61K38/00 , C07K16/00
CPC分类号： A61K38/164
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)-Z-X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH 4的环肽，（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中 X选自氨基酸，氨基酸类似物，拟肽和非酰胺异构体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，以及 y为1至10.制备方法包括环化方案，以及使用环状肽的方法还公开了本发明。

4. 发明授权

US06337385B1 Staphylococcus peptides for bacterial interference 有权
标题翻译：葡萄球菌肽用于细菌干扰
公开(公告)号：US06337385B1
公开(公告)日：2002-01-08
申请号：US09339511
申请日：1999-06-24
申请人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
发明人： Tom W. Muir , Patricia Mayville , Richard P. Novick , Ronald Beavis , Guangyong Ji
IPC分类号： A61K3812
CPC分类号： A61K38/164
摘要： The present invention provides a cyclic peptide comprising the structure: wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, R is selected from the group consisting of oxygen, nitrogen, sulfur and carbon, n is 0 to 10 and y is 1 to 10. The present invention also provides a cyclic peptide comprising the amino acid sequence of NH2—X(n)—Z—X(y)—COOH and a cyclic bond between the Z residue and COOH other than a thioester bond, wherein X is selected from the group consisting of an amino acid, an amino acid analog, a peptidomimetic and a non-amide isostere, Z is selected from the group consisting of a synthetic amino acid and a biosynthetic amino acid, n is 0 to 10 and y is 1 to 10. Methods of preparation including a cyclization protocol, and methods of use of the cyclic peptides of the invention are also disclosed.
摘要翻译：本发明提供了包含以下结构的环肽：其中X选自氨基酸，氨基酸类似物，拟肽和非酰胺异基因，Z选自合成氨基酸和生物合成氨基酸，R选自氧，氮，硫和碳，n为0至10，y为1至10.本发明还提供了包含氨基酸序列NH2- X（n）-ZX（y）-COOH和除了硫酯键之外的Z残基和COOH之间的环键，其中X选自氨基酸，氨基酸类似物，肽模拟物和非 - 酰胺等离子体，Z选自合成氨基酸和生物合成氨基酸，n为0至10，y为1至10.包括环化方案的制备方法和环肽的使用方法也公开了本发明。

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