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1. 发明申请

US20060171964A1 Polypeptides and polynucleotides from coagulase-negative staphylococci 有权
标题翻译：来自凝固酶阴性葡萄球菌的多肽和多核苷酸
公开(公告)号：US20060171964A1
公开(公告)日：2006-08-03
申请号：US11396565
申请日：2006-04-04
申请人： Timothy Foster , Kirk McCrea , Magnus Hook , Stacey Davis , Deirdre Ni Eidhin , Orla Hartford
发明人： Timothy Foster , Kirk McCrea , Magnus Hook , Stacey Davis , Deirdre Ni Eidhin , Orla Hartford
IPC分类号： A61K39/085 , C07H21/04 , C12N15/74 , C07K14/31 , C12N1/21
CPC分类号： C07K16/1271 , A61K39/00 , A61K2039/505 , C07K14/31 , G01N33/56938
摘要： Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided. Methods are also provided wherein antibodies that recognize the SdrG protein or its ligand binding A region are used to treat or prevent staphylococcal infection, and these methods can also be utilized to prevent the formation of infections on indwelling medical devices.
摘要翻译：提供了使用来自凝血酶阴性葡萄球菌细菌如表皮葡萄球菌的蛋白质和多肽（包括称为SdrF，SdrG和SdrH的蛋白质）及其有效片段（例如其各自的A结构域）来治疗或预防来自凝固酶阴性葡萄球菌感染的方法。还提供了方法，其中识别SdrG蛋白或其配体结合A区的抗体用于治疗或预防葡萄球菌感染，并且这些方法也可用于防止在留置医疗器械上形成感染。

2. 发明授权

US07709008B2 Polypeptides and polynucleotides from coagulase-negative staphylococci 有权
标题翻译：来自凝固酶阴性葡萄球菌的多肽和多核苷酸
公开(公告)号：US07709008B2
公开(公告)日：2010-05-04
申请号：US11396565
申请日：2006-04-04
申请人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacey Davis , Deirdre Ni Eidhin , Orla Hartford
发明人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacey Davis , Deirdre Ni Eidhin , Orla Hartford
IPC分类号： A61K39/085 , C07H21/04 , C12N15/74 , C12N1/21 , C07K14/31
CPC分类号： C07K16/1271 , A61K39/00 , A61K2039/505 , C07K14/31 , G01N33/56938
摘要： Methods for treating or preventing infections from coagulase-negative staphylococci using proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided. Methods are also provided wherein antibodies that recognize the SdrG protein or its ligand binding A region are used to treat or prevent staphylococcal infection, and these methods can also be utilized to prevent the formation of infections on indwelling medical devices.
摘要翻译：提供了使用来自凝血酶阴性葡萄球菌细菌如表皮葡萄球菌的蛋白质和多肽（包括称为SdrF，SdrG和SdrH的蛋白质）及其有效片段（例如其各自的A结构域）来治疗或预防来自凝固酶阴性葡萄球菌感染的方法。还提供了方法，其中识别SdrG蛋白或其配体结合A区的抗体用于治疗或预防葡萄球菌感染，并且这些方法也可用于防止在留置医疗器械上形成感染。

3. 发明授权

US06635473B1 Polypeptides and polynucleotides from coagulase-negative staphylococci 有权
标题翻译：来自凝固酶阴性葡萄球菌的多肽和多核苷酸
公开(公告)号：US06635473B1
公开(公告)日：2003-10-21
申请号：US09386962
申请日：1999-08-31
申请人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacy Davis , Deirdre Ni Eidhin , Orla Hartford
发明人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacy Davis , Deirdre Ni Eidhin , Orla Hartford
IPC分类号： C07H2104
CPC分类号： C07K16/1271 , A61K39/00 , A61K2039/505 , C07K14/31 , G01N33/56938
摘要： Isolated proteins, designated SdrF, SdrG and SdrH, and their corresponding amino acid and nucleic acid sequences are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO:16). The proteins, antigenic portions thereof and anti-SdrF, SdrG and SdrH antibodies are also useful for the identification and diagnosis of coagulase-negative staphylococcal infections. In particular, the proteins are advantageous because they may be used as vaccine components or antibodies thereof, and they may be administered to wounds or used to coat biomaterials to act as blocking agents to prevent or inhibit the binding of coagulase-negative staphylococci to wounds or biomaterials.
摘要翻译：提供了称为SdrF，SdrG和SdrH的分离的蛋白质及其相应的氨基酸和核酸序列，其可用于预防和治疗由凝血酶阴性葡萄球菌如表皮葡萄球菌引起的感染。 SdrF，SdrG和SdrH蛋白是特异性结合宿主蛋白的细胞壁相关蛋白，其各自具有高度保守的基序，其共有序列是TYTFTDYVD（SEQ ID NO：16）。蛋白质，其抗原部分和抗SdrF，SdrG和SdrH抗体也可用于鉴定和诊断凝固酶阴性葡萄球菌感染。特别地，蛋白质是有利的，因为它们可以用作疫苗组分或其抗体，并且它们可以施用于伤口或用于涂覆生物材料以用作阻断剂以预防或抑制凝固酶阴性葡萄球菌与伤口的结合或生物材料。

4. 发明授权

US07473762B2 Proteins and polypeptides from coagulaslase-negative staphylococci 有权
标题翻译：来自凝固酶阴性葡萄球菌的蛋白质和多肽
公开(公告)号：US07473762B2
公开(公告)日：2009-01-06
申请号：US10689082
申请日：2003-10-21
申请人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacy Davis , Deirdre Nieidhin , Orla Hartford
发明人： Timothy J. Foster , Kirk McCrea , Magnus A. O. Hook , Stacy Davis , Deirdre Nieidhin , Orla Hartford
IPC分类号： C07K14/00 , C12N15/00
CPC分类号： C07K16/1271 , A61K39/00 , A61K2039/505 , C07K14/31 , G01N33/56938
摘要： Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The proteins and polypetides may be useful in generating antibodies for the diagnosis and treatment of coagulase-negative staphylococcal infections.
摘要翻译：提供来自凝固酶阴性葡萄球菌如表皮葡萄球菌的蛋白质和多肽，包括称为SdrF，SdrG和SdrH的蛋白质及其有效片段，例如其各自的A结构域，其可用于预防和治疗由凝固酶引起的感染 - 阴性葡萄球菌如表皮葡萄球菌。 SdrF，SdrG和SdrH蛋白是特异性结合宿主蛋白的细胞壁相关蛋白，其各自具有高度保守的基序，其共有序列是TYTFTDYVD（SEQ ID NO：16）。蛋白质和多肽可用于产生用于诊断和治疗凝固酶阴性葡萄球菌感染的抗体。

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