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1. 发明授权

US09139862B2 Fluorescent cyclic peptides, preparation method thereof and use of these peptides for measuring the enzymatic activity of a protease enzyme 有权
标题翻译：荧光环肽，其制备方法和这些肽用于测量蛋白酶的酶活性的用途
公开(公告)号：US09139862B2
公开(公告)日：2015-09-22
申请号：US12737082
申请日：2009-06-10
申请人： Thomas Berthelot , Gérard Deleris
发明人： Thomas Berthelot , Gérard Deleris
IPC分类号： C07K7/50 , C12Q1/37 , C07K7/64
CPC分类号： C12Q1/37 , C07K7/64 , G01N2333/95 , G01N2333/96494
摘要： The invention pertains to a cyclic peptide comprising the following sequence: -S1-X1-S2-X2- wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 possibly being the same or different, said first peptide sequence S1 and said second peptide sequence S2 comprising 4 to 14 amino acids, E1 and E2 possibly corresponding to the same protease enzyme or to two different protease enzymes, X1 is a probe carrying a fluorescent donor group and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Application of these peptides to determination of the activity of protease enzymes.
摘要翻译：本发明涉及包含以下序列的环肽：-S1-X1-S2-X2-，其中S1是蛋白酶E1的第一个靶肽序列，S2是蛋白酶E2的第二个靶肽序列，S1和 S2可能相同或不同，所述第一肽序列S1和包含4至14个氨基酸的第二肽序列S2，E1和E2可能对应于相同的蛋白酶或两种不同的蛋白酶，X1是携带荧光供体组，X2是携带荧光或非荧光受体组的探针。应用这些肽来测定蛋白酶的活性。

2. 发明申请

US20110256567A1 FLUORESCENT CYCLIC PEPTIDES, PREPARATION METHOD THEREOF AND USE OF THESE PEPTIDES FOR MEASURING THE ENZYMATIC ACTIVITY OF A PROTEASE ENZYME 有权
标题翻译：荧光素环肽，其制备方法及其用途，用于测定蛋白酶的酶活性
公开(公告)号：US20110256567A1
公开(公告)日：2011-10-20
申请号：US12737082
申请日：2009-06-10
申请人： Thomas Berthelot , Gérard Deleris
发明人： Thomas Berthelot , Gérard Deleris
IPC分类号： C12Q1/37 , C07K1/107 , C07K7/64
CPC分类号： C12Q1/37 , C07K7/64 , G01N2333/95 , G01N2333/96494
摘要： The invention pertains to a cyclic peptide comprising the following sequence: -S1-X1-S2-X2- wherein S1 is a first target peptide sequence of a protease enzyme E1, S2 is a second target peptide sequence of a protease enzyme E2, S1 and S2 possibly being the same or different, said first peptide sequence S1 and said second peptide sequence S2 comprising 4 to 14 amino acids, E1 and E2 possibly corresponding to the same protease enzyme or to two different protease enzymes, X1 is a probe carrying a fluorescent donor group and X2 is a probe carrying a fluorescent or non-fluorescent acceptor group. Application of these peptides to determination of the activity of protease enzymes.
摘要翻译：本发明涉及包含以下序列的环肽：-S1-X1-S2-X2-，其中S1是蛋白酶E1的第一个靶肽序列，S2是蛋白酶E2的第二个靶肽序列，S1和 S2可能相同或不同，所述第一肽序列S1和包含4至14个氨基酸的第二肽序列S2，E1和E2可能对应于相同的蛋白酶或两种不同的蛋白酶，X1是携带荧光供体组，X2是携带荧光或非荧光受体组的探针。应用这些肽来测定蛋白酶的活性。

3. 发明授权

US09725602B2 Method for preparing an organic film at the surface of a solid support under non-electrochemical conditions, solid support thus obtained and preparation kit 有权
公开(公告)号：US09725602B2
公开(公告)日：2017-08-08
申请号：US11960109
申请日：2007-12-19
申请人： Vincent Mevellec , Sebastien Roussel , Serge Palacin , Guy Deniau , Thomas Berthelot , Cecile Baudin , Adhitya Trenggono
发明人： Vincent Mevellec , Sebastien Roussel , Serge Palacin , Guy Deniau , Thomas Berthelot , Cecile Baudin , Adhitya Trenggono
IPC分类号： B05D3/10 , C09D4/00 , H01L51/00
CPC分类号： C09D4/00 , H01L51/0006 , H01L51/0075 , Y10T428/25 , Y10T428/26 , Y10T428/31504 , Y10T428/31678 , Y10T428/31989 , Y10T428/31993
摘要： This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.

4. 发明申请

US20130327649A1 Biosensor and Method of Manufacturing Such a Biosensor 有权
标题翻译：生物传感器和制造这种生物传感器的方法
公开(公告)号：US20130327649A1
公开(公告)日：2013-12-12
申请号：US14000957
申请日：2012-02-14
申请人： Jérôme Polesel Maris , Thomas Berthelot
发明人： Jérôme Polesel Maris , Thomas Berthelot
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , B82Y15/00 , B82Y40/00 , G01N29/022 , G01N29/036 , G01N2291/0255 , G01N2291/0257 , G01N2291/0427
摘要： A method of manufacturing a biosensor having a microbeam linked to a support, at least one electrode a biological molecule A grafted onto the microbeam in a different zone from the zone where the electrode is embedded, and a mechanoelectrical transducer for converting variations of the mechanical properties of the microbeam into an electrical signal, when the biological molecule A is placed in contact with a biological molecule B to be detected and/or quantified. The method includes: formation of an electrode on fluoropolymer material sheet, passivation of the electrode(s), creation of the form of the biosensor in the sheet of polymer material and separation of this form from the sheet, functionalization either of a prefunctionalized zone or of a zone of the microbeam, this zone being different from the zone wherein the electrode is embedded, and grafting of a biological molecule A onto the functionalized zone.
摘要翻译：一种制造具有与载体连接的微束的生物传感器的方法，至少一个电极，在与嵌入电极的区域不同的区域中接枝到微束上的生物分子A和用于转换机械性能变化的机械电传感器当将生物分子A与待检测和/或定量的生物分子B接触时，将微束束转化为电信号。该方法包括：在含氟聚合物材料片上形成电极，使电极钝化，在聚合物材料片中形成生物传感器的形式并将该形式与片材分离，将功能化前的功能化区域的微波束的区域，该区域不同于电极被嵌入的区域，并且将生物分子A接枝到官能化区域上。

5. 发明申请

US20080193668A1 METHOD FOR PREPARING AN ORGANIC FILM AT THE SURFACE OF A SOLID SUPPORT UNDER NON-ELECTROCHEMICAL CONDITIONS, SOLID SUPPORT THUS OBTAINED AND PREPARATION KIT 有权
标题翻译：在非电化学条件下在固体支持表面制备有机膜的方法，获得和制备试剂盒的固体支持
公开(公告)号：US20080193668A1
公开(公告)日：2008-08-14
申请号：US11960109
申请日：2007-12-19
申请人： Vincent Mevellec , Sebastien Roussel , Serge Palacin , Guy Deniau , Thomas Berthelot , Cecile Baudin , Adhitya Trenggono
发明人： Vincent Mevellec , Sebastien Roussel , Serge Palacin , Guy Deniau , Thomas Berthelot , Cecile Baudin , Adhitya Trenggono
IPC分类号： B05D3/06 , B32B33/00 , B32B15/00 , B32B21/00 , B32B29/00 , B32B5/16 , B05D3/10 , B32B9/00 , B05D1/32 , B05D3/00
CPC分类号： C09D4/00 , H01L51/0006 , H01L51/0075 , Y10T428/25 , Y10T428/26 , Y10T428/31504 , Y10T428/31678 , Y10T428/31989 , Y10T428/31993
摘要： This invention relates to a method for preparing an organic film at the surface of a solid support, with a step of contacting said surface with a liquid solution including (i) at least one solvent, (ii) at least one adhesion primer, under non-electrochemical conditions, and allowing the formation of radical entities based on the adhesion primer. The liquid solution can also include (iii) at least one monomer different from the adhesion primer and radically polymerizable. This invention also relates to a non-electrically-conductive solid support on which an organic film according to said method is grafted, and a kit for preparing an essentially polymeric organic film at the surface of a solid support.
摘要翻译：本发明涉及一种在固体支持物表面制备有机膜的方法，其中使所述表面与液体溶液接触的步骤包括：（i）至少一种溶剂，（ii）至少一种粘附底漆， - 电化学条件，并且允许基于粘合引物形成基团实体。液体溶液还可以包括（iii）至少一种不同于粘合底漆的单体和可自由基聚合的单体。本发明还涉及一种非导电固体载体，其上接枝有根据所述方法的有机膜，以及用于在固体载体表面制备基本上聚合的有机膜的试剂盒。

6. 发明授权

US09453284B2 Chemical modification process for a deep polymeric matrix 有权
标题翻译：深层聚合物基体的化学修饰方法
公开(公告)号：US09453284B2
公开(公告)日：2016-09-27
申请号：US12772122
申请日：2010-04-30
申请人： Thomas Berthelot , Cécile Baudin
发明人： Thomas Berthelot , Cécile Baudin
IPC分类号： B05D3/06 , C23C18/16 , C08J3/28 , C08J7/12 , C08J7/16 , C23C18/18 , C23C18/20
CPC分类号： C23C18/1601 , C08J3/28 , C08J7/123 , C08J7/16 , C08J2323/26 , C08J2327/18 , C23C18/18 , C23C18/1844 , C23C18/1893 , C23C18/2086 , Y10T428/1352
摘要： The present invention relates to a process for chemically modifying, within its thickness, a polymer matrix chosen from matrices made of fluoropolymers and matrices made of aliphatic polymers, said process comprising at least one step consisting in irradiating said matrix with UV light having a wavelength of less than 300 nm in order to generate, within the thickness of said matrix, zones that have short polymer chains, formed by scission of the existing chains during the passage of the UV radiation and that have free radicals denoted hereinbelow as “activated zones”. The present invention also relates to the polymer matrix capable of being chemically modified by such a process.
摘要翻译：本发明涉及一种在其厚度内化学改性选自由含氟聚合物和由脂族聚合物制成的基质的基体的聚合物基体的方法，所述方法包括至少一个步骤，该步骤包括用波长为小于300nm，以便在所述基质的厚度内产生具有短聚合物链的区域，其通过在UV辐射通过过程中现有链的断裂而形成，并且在下文中具有自由基作为“活化区”。本发明还涉及能够通过这种方法化学改性的聚合物基质。

7. 发明授权

US08959661B2 Atomic force microscope probe, method for preparing same, and uses thereof 有权
标题翻译：原子力显微镜探针，其制备方法及其应用
公开(公告)号：US08959661B2
公开(公告)日：2015-02-17
申请号：US13997139
申请日：2011-12-20
申请人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
发明人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
IPC分类号： G01Q60/24 , G01Q60/38 , G01Q10/04 , G01Q20/04 , G01Q60/42 , B82Y35/00
CPC分类号： G01Q60/38 , B82Y35/00 , G01Q10/045 , G01Q20/04 , G01Q60/42
摘要： An atomic force microscope probe comprising a piezo-electric resonator provided with two electrodes and coated with an insulating layer and a tip attached on the coated resonator and functionalized with at least one group or molecule of interest is disclosed. The disclosed technology also relates to preparation method and to different uses thereof.
摘要翻译：公开了一种原子力显微镜探针，其包括设置有两个电极并涂覆有绝缘层的压电谐振器和附着在涂覆的谐振器上的末端，并且用至少一个感兴趣的组或分子进行官能化。所公开的技术还涉及制备方法及其不同用途。

8. 发明申请

US20130276176A1 ATOMIC FORCE MICROSCOPE PROBE, METHOD FOR PREPARING SAME, AND USES THEREOF 有权
标题翻译：原子力显微镜探针，其制备方法及其用途
公开(公告)号：US20130276176A1
公开(公告)日：2013-10-17
申请号：US13997139
申请日：2011-12-20
申请人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
发明人： Jérôme Polesel-Maris , Thomas Berthelot , Pascal Viel
IPC分类号： G01Q60/38
CPC分类号： G01Q60/38 , B82Y35/00 , G01Q10/045 , G01Q20/04 , G01Q60/42
摘要： An atomic force microscope probe comprising a piezo-electric resonator provided with two electrodes and coated with an insulating layer and a tip attached on the coated resonator and functionalized with at least one group or molecule of interest is disclosed. The disclosed technology also relates to preparation method and to different uses thereof.
摘要翻译：公开了一种原子力显微镜探针，其包括设置有两个电极并涂覆有绝缘层的压电谐振器和附着在涂覆的谐振器上的末端，并且用至少一个感兴趣的组或分子进行官能化。所公开的技术还涉及制备方法及其不同用途。

9. 发明申请

US20120282417A1 METHOD FOR PREPARING A METALLIZED POLYMER SUBSTRATE 审中-公开
标题翻译：制备金属化聚合物基材的方法
公开(公告)号：US20120282417A1
公开(公告)日：2012-11-08
申请号：US13514963
申请日：2010-12-10
申请人： Alexandre Garcia , Thomas Berthelot
发明人： Alexandre Garcia , Thomas Berthelot
IPC分类号： B05D1/18 , B05D3/02 , B05D3/06 , B05D3/12 , B05D3/10
CPC分类号： C23C18/405 , C23C18/1641 , C23C18/2006 , C23C18/2073 , C23C18/24 , C23C18/30
摘要： A method for coating a surface of a substrate in (co)polymer with a metal material is provided. The method may comprise the successive steps of (a) subjecting the surface to an oxidizing treatment by a chemical reaction of the Fenton type in the presence of at least one precursor of the metal material and (b) transforming the precursor into the metal material.
摘要翻译：提供了一种用金属材料涂覆（共）聚合物中的基材表面的方法。该方法可以包括以下连续步骤：（a）在金属材料的至少一种前体存在下，通过芬顿型的化学反应使表面进行氧化处理，和（b）将前体转化成金属材料。

10. 发明授权

US08747954B2 Process for the preparation of an organic film at the surface of a solid support with oxidizing treatment 有权
标题翻译：在固体支持物的表面用氧化处理制备有机膜的方法
公开(公告)号：US08747954B2
公开(公告)日：2014-06-10
申请号：US12772124
申请日：2010-04-30
申请人： Thomas Berthelot , Alexandre Garcia , Sebastien Roussel , Fabien Nekelson
发明人： Thomas Berthelot , Alexandre Garcia , Sebastien Roussel , Fabien Nekelson
IPC分类号： B05D1/36
CPC分类号： C23C18/1601 , C08J3/28 , C08J7/123 , C08J7/16 , C08J2323/26 , C08J2327/18 , C23C18/18 , C23C18/1844 , C23C18/1893 , C23C18/2086 , Y10T428/1352
摘要： The present invention relates to a process for the preparation of an organic film on a portion of the surface of a solid support made of (co)polymer, characterized in that it comprises the successive steps consisting in (i) subjecting said surface portion to an oxidizing treatment and (ii) grafting an organic film to said surface portion by radical chemical grafting.
摘要翻译：本发明涉及在由（共）聚合物制成的固体支持物的表面的一部分上制备有机膜的方法，其特征在于其包括以下步骤：（i）使所述表面部分经受氧化处理和（ii）通过自由基化学接枝将有机膜接枝到所述表面部分。

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