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1. 发明申请

WO2019180309A1 HETEROLOGOUS PRODUCTION OF PSILOCYBIN 审中-公开
公开(公告)号：WO2019180309A1
公开(公告)日：2019-09-26
申请号：PCT/FI2019/050199
申请日：2019-03-11
申请人： TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
发明人： MOJZITA, Dominik , RISCHER, Heiko , RANTASALO, Anssi , OKSMAN-CALDENTEY, Kirsi-Marja , KUIVANEN, Joosu
IPC分类号： C12N15/63 , C12N9/10 , C12N15/82
摘要： The invention discloses a recombinant host cell for producing psilocybin and related compounds, such as metabolic intermediates of the psilocybin biosynthesis. Also provided is a method of producing psilocybin and its synthesis intermediates and related compounds, such as metabolic intermediates of the psilocybin biosynthesis, in the host cell, as well as a production system for producing them.

2. 发明申请

WO2017144777A1 EXPRESSION SYSTEM FOR EUKARYOTIC ORGANISMS 审中-公开
标题翻译：真核生物的表达系统
公开(公告)号：WO2017144777A1
公开(公告)日：2017-08-31
申请号：PCT/FI2017/050114
申请日：2017-02-21
申请人： TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
发明人： MOJZITA, Dominik , RANTASALO, Anssi , JÄNTTI, Jussi , LANDOWSKI, Christopher , KUIVANEN, Joosu
IPC分类号： C12N15/79
CPC分类号： C12N15/79
摘要： The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, said core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, said synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising said systems, and methods for producing protein products in eukaryotic hosts.
摘要翻译：本发明提供了用于真核宿主的表达系统，其包含1）包含核心启动子的表达盒，所述核心启动子控制编码合成转录因子（sTF）的DNA序列的表达，和2）一个或多个表达盒，每个表达盒包含编码与合成启动子可操作连接的所需产物的DNA序列，所述合成启动子包含核心启动子和核心启动子上游的sTF特异性结合位点。本发明还提供了用于鉴定真核宿主的通用核心启动子的方法，使用通用核心启动子的表达系统，包含所述系统的宿主以及用于在真核宿主中产生蛋白质产物的方法。

3. 发明公开

EP3768843A1 HETEROLOGOUS PRODUCTION OF PSILOCYBIN 审中-公开
公开(公告)号：EP3768843A1
公开(公告)日：2021-01-27
申请号：EP19713528.8
申请日：2019-03-11
申请人： Teknologian tutkimuskeskus VTT Oy
发明人： MOJZITA, Dominik , RISCHER, Heiko , RANTASALO, Anssi , OKSMAN-CALDENTEY, Kirsi-Marja , KUIVANEN, Joosu
IPC分类号： C12N15/63 , C12N9/10 , C12N15/82

4. 发明公开

EP3405580A1 EXPRESSION SYSTEM FOR EUKARYOTIC ORGANISMS 有权转让
公开(公告)号：EP3405580A1
公开(公告)日：2018-11-28
申请号：EP17712530.9
申请日：2017-02-21
申请人： Teknologian Tutkimuskeskus VTT Oy
发明人： MOJZITA, Dominik , RANTASALO, Anssi , JÄNTTI, Jussi , LANDOWSKI, Christopher , KUIVANEN, Joosu
IPC分类号： C12N15/79
CPC分类号： C12N15/79
摘要： The present invention provides an expression system for a eukaryotic host, which comprises 1) an expression cassette comprising a core promoter, said core promoter controlling the expression of a DNA sequence encoding a synthetic transcription factor (sTF), and 2) one or more expression cassettes each comprising a DNA sequence encoding a desired product operably linked to a synthetic promoter, said synthetic promoter comprising a core promoter, and sTF-specific binding sites upstream of the core promoter. The present invention also provides a method for identifying universal core promoters for eukaryotic hosts, expression systems using universal core promoters, hosts comprising said systems, and methods for producing protein products in eukaryotic hosts.

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