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1. 发明公开

EP0852502A1 LANTIBIOTIC MUTANTS AND CHIMERAS OF ENHANCED STABILITY AND ACTIVITY 失效
标题翻译： LANTIBIOTIKMUTANTEN和增加稳定性和活性的嵌合
公开(公告)号：EP0852502A1
公开(公告)日：1998-07-15
申请号：EP96933084.0
申请日：1996-09-30
申请人： THE UNIVERSITY OF MARYLAND COLLEGE PARK
发明人： HANSEN, J., Norman
IPC分类号： C12N15 , A21D2 , A23L3 , A61K35 , A61K38 , A61P31 , C07K14 , C07K19 , C12P21
CPC分类号： A21D2/267 , A23L3/3571 , A61K38/00 , C07K14/315 , C07K14/32 , C07K2319/00
摘要： Lantibiotics, such as nisin and subtilin, are peptides that are substantially modified post-translationally, such as by dehydration of serines and threonines and by formation of thioether crosslinkages. Lantibiotics are synthesized with a leader region that directs proper processing; this leader is specific both for the synthesizing organism and for the mature sequence. Chimeric lantibiotics were synthesized that contained the subtilin leader region and either a subtilin-nisin fusion or a nisin-subtilin fusion for the mature region. The nisin-subtilin chimera was efficiently processed into a functional lantibiotic, but the subtilin-nisin fusion produced a heterogeneous mixture of products, none of which had the expected properties of a correctly process polypeptide. This mixture contained a minor component with a specific activity exceeding that of nisin itself.

2. 发明授权

EP0852502B1 LANTIBIOTIC MUTANTS AND CHIMERAS OF ENHANCED STABILITY AND ACTIVITY 失效
标题翻译： LANTIBIOTIKMUTANTEN和增加稳定性和活性的嵌合
公开(公告)号：EP0852502B1
公开(公告)日：2004-11-17
申请号：EP96933084.4
申请日：1996-09-30
申请人： THE UNIVERSITY OF MARYLAND COLLEGE PARK
发明人： HANSEN, J., Norman
IPC分类号： A61K35/74 , A61K38/12 , A21D2/00 , C12P21/04 , C07K14/315 , C07K19/00 , C12N15/31 , C12N15/74 , A23L3/3463
CPC分类号： A21D2/267 , A23L3/3571 , A61K38/00 , C07K14/315 , C07K14/32 , C07K2319/00

3. 发明申请

WO1997011713A1 LANTIBIOTIC MUTANTS AND CHIMERAS OF ENHANCED STABILITY AND ACTIVITY 审中-公开
标题翻译：生态脆弱性和增强稳定性和活性的CHIMERAS
公开(公告)号：WO1997011713A1
公开(公告)日：1997-04-03
申请号：PCT/US1996015160
申请日：1996-09-30
申请人： THE UNIVERSITY OF MARYLAND COLLEGE PARK
发明人： THE UNIVERSITY OF MARYLAND COLLEGE PARK , HANSEN, J., Norman
IPC分类号： A61K35/74
CPC分类号： A21D2/267 , A23L3/3571 , A61K38/00 , C07K14/315 , C07K14/32 , C07K2319/00
摘要： Lantibiotics, such as nisin and subtilin, are peptides that are substantially modified post-translationally, such as by dehydration of serines and threonines and by formation of thioether crosslinkages. Lantibiotics are synthesized with a leader region that directs proper processing; this leader is specific both for the synthesizing organism and for the mature sequence. Chimeric lantibiotics were synthesized that contained the subtilin leader region and either a subtilin-nisin fusion or a nisin-subtilin fusion for the mature region. The nisin-subtilin chimera was efficiently processed into a functional lantibiotic, but the subtilin-nisin fusion produced a heterogeneous mixture of products, none of which had the expected properties of a correctly process polypeptide. This mixture contained a minor component with a specific activity exceeding that of nisin itself.
摘要翻译：羊抗生素如乳链菌肽和子链霉素是在翻译后基本上修饰的肽，例如通过丝氨酸和苏氨酸的脱水以及硫醚交联的形成。羊抗生素与引导适当处理的引导区合成; 这个领导者对于合成生物体和成熟序列都是特异的。合成嵌合羊毛硫抗生素，其含有子带蛋白前导区和成熟区的子生物肽 - 乳链菌肽融合或乳链菌肽 - 子素融合。乳链菌肽 - 子胶质嵌合体被有效地加工成功能性的羊毛硫抗生素，但是子链 - 乳链菌肽融合产生了产物的不均匀混合物，其中没有一个具有正确过程多肽的预期性质。该混合物含有特定活性超过乳链菌肽本身的次要成分。

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