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1. 发明申请

WO2003007881A2 ANTIBODIES SPECIFIC FOR NANOTUBES AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译：特定用于纳米管的抗体及相关方法和组合物
公开(公告)号：WO2003007881A2
公开(公告)日：2003-01-30
申请号：PCT/US2002/022620
申请日：2002-07-16
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , ERLANGER, Bernard, F. , BRUS, Louis , SHEETZ, Michael, P.
发明人： ERLANGER, Bernard, F. , BRUS, Louis , SHEETZ, Michael, P.
IPC分类号： A61K
CPC分类号： C07K16/44 , A61K47/6835 , A61K47/6923 , A61K47/6949 , A61K51/0495 , A61K51/1268 , A61K2039/505 , B82Y5/00 , C07K16/18 , C07K16/26 , C07K2317/55 , C07K2317/56
摘要： This invention provides two compositions. The first composition comprises a nanotube and at least one anti-nanotube antibody, wherein the anti-nanotube antibody is bound to the nanotube. The second composition comprises a fullerene and at least one anti-fullerene antibody, wherein the anti-fullerene antibody is bound to the fullerene. Finally, this invention provides methods and kits relating to the antibody and compositions of matter.
摘要翻译：本发明提供了两种组合物。第一组合物包含纳米管和至少一种抗纳米管抗体，其中抗纳米管抗体与纳米管结合。第二组合物包含富勒烯和至少一种抗富勒烯抗体，其中抗富勒烯抗体与富勒烯结合。最后，本发明提供了涉及抗体和物质组合物的方法和试剂盒。

2. 发明申请

WO2003007881A3 ANTIBODIES SPECIFIC FOR NANOTUBES AND RELATED METHODS AND COMPOSITIONS 审中-公开
公开(公告)号：WO2003007881A3
公开(公告)日：2003-01-30
申请号：PCT/US2002/022620
申请日：2002-07-16
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , ERLANGER, Bernard, F. , BRUS, Louis , SHEETZ, Michael, P.
发明人： ERLANGER, Bernard, F. , BRUS, Louis , SHEETZ, Michael, P.
IPC分类号： C12Q1/68
摘要： This invention provides two compositions. The first composition comprises a nanotube and at least one anti-nanotube antibody, wherein the anti-nanotube antibody is bound to the nanotube. The second composition comprises a fullerene and at least one anti-fullerene antibody, wherein the anti-fullerene antibody is bound to the fullerene. Finally, this invention provides methods and kits relating to the antibody and compositions of matter.

3. 发明申请

WO1996025175A1 ADMINISTRATION OF A CYCLOSPORINE-SPECIFIC MONOCLONAL ANTIBODY THAT CROSS-REACTS WITH HIV-1 p24 GAG TO TREAT HIV INFECTION 审中-公开
标题翻译：与HIV-1 p24 GAG交叉反应以治疗HIV感染的环孢菌素特异性单克隆抗体的施用
公开(公告)号：WO1996025175A1
公开(公告)日：1996-08-22
申请号：PCT/US1996002129
申请日：1996-02-16
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , ERLANGER, Bernard, F. , CHEN, Bi-Xing
IPC分类号： A61K39/42
CPC分类号： G01N33/96 , A61K38/00 , A61K47/643 , C07K7/645 , C07K16/1054 , C07K16/14 , C07K16/4208 , C07K16/44 , G01N33/68 , G01N2410/08
摘要： The generation of a monoclonal antibody that specifically recognizes N-methyl leucine residues (9 and 10) of cyclosporine is disclosed. This antibody also displays cross-reactivity towards the HIV-1 p24 Gag protein. Methods for the treatment of HIV infection and acquired immune deficiency syndrome employing this antibody are contemplated.
摘要翻译：公开了特异性识别环孢菌素的N-甲基亮氨酸残基（9和10）的单克隆抗体的产生。该抗体还显示对HIV-1 p24 Gag蛋白的交叉反应性。考虑使用该抗体治疗HIV感染和获得性免疫缺陷综合征的方法。

4. 发明授权

EP1218396B1 ANTIBODIES SPECIFIC FOR FULLERENES 有权
标题翻译：抗体专门为富勒烯
公开(公告)号：EP1218396B1
公开(公告)日：2004-09-22
申请号：EP00957880.8
申请日：2000-08-29
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： ERLANGER, Bernard, F. , CHEN, Bi-Xing
IPC分类号： C07K16/44 , C12N5/16 , G01N33/53 , G01N33/577
CPC分类号： B82Y30/00 , B82Y5/00 , C07K16/44 , G01N33/5308 , G01N2430/00 , Y10S530/807
摘要： This invention provides antibodies specific for a fullerene or derivative thereof, a single-walled fullerene nanotube, and a multi-walled fullerene nanotube, wherein the fullerene is selected from the group consisting of a fullerene carbon compound having from 20 to 540 carbon atoms. The antibodies may be monoclonal or polyclonal antibodies. This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which binds to fullerene C60. This invention provides a mouse monoclonal antibody specific for a fullerene-C60 and produced by the mouse monoclonal antibody-producing hybridoma designated 1-10F-8A. This invention also provides methods of determining a serum concentration of a fullerene in a subject and of purifying a fullerene from a sample. This invention provides methods of preparing nonascale devices which comprise manipulating a single-walled or a multi-walled fullerene nanotube(s) with the above-described antibodies specific for single-walled or multi-walled fullerene nanotubes to assemble electronic or chemical components of the nanoscale device.

5. 发明公开

EP0191846A1 METHOD OF PRODUCING MONOCLONAL ANTI-IDIOTYPIC ANTIBODIES 失效
标题翻译：生产单克隆抗独特型抗体。
公开(公告)号：EP0191846A1
公开(公告)日：1986-08-27
申请号：EP85904390.0
申请日：1985-08-27
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： ERLANGER, Bernard, F. , CLEVELAND, William, L.
IPC分类号： G01N33 , A61K39 , C07K14 , C07K16 , C12N5 , C12N15 , C12P21 , C12R1
CPC分类号： C07K16/4241
摘要： Un procédé auto-anti-idiotypique développé pour produire un anticorps monoclonal anti-idiotypique implique: a) la mise en contact dans des conditions appropriées de cellules lymphoïdes d'un animal avec une quantité efficace génératrice d'anticorps d'un antigène, par exemple d'un liant pour un récepteur; b) la collecte des cellules lymphoïdes de l'animal à un moment approprié après la mise en contact; c) la fusion des cellules lymphoïdes collectées avec des cellules appropriées de myélome afin de produire une série de cellules hybridomes qui produisent chacune un anticorps monoclonal; d) le tamisage dans de conditions appropriées de la série de cellules hybridomes ainsi produites afin d'identifier celles qui sécrètent un anticorps monoclonal susceptible de se lier à un anticorps dirigé contre l'antigène, ou à un récepteur lorsque l'antigène est un liant pour le récepteur; e) la culture séparée d'une cellule hybridome ainsi identifiée dans un milieu approprié et f) la récupération séparée dans des conditions appropriées de l'anticorps monoclonal anti-idiotypique produit par la cellule hybridome. L'antigène peut être associé à une protéine, et peut être un liant pour un récepteur; dans ce cas, l'anticorps monoclonal anti-idiotypique sera capable de se lier au récepteur, et agira de préférence comme un agoniste ou un antagoniste de récepteur. Par ce procédé, il est possible de produire et de récupérer un anticorps monoclonal anti-idiotypique qui, dans un mode préféré de réalisation, est capable de se lier à un récepteur, par exemple à un récepteur de l'acétylcholine ou de l'adénosine.

6. 发明公开

EP1218396A1 ANTIBODIES SPECIFIC FOR FULLERENES 有权
标题翻译：抗体专门为富勒烯
公开(公告)号：EP1218396A1
公开(公告)日：2002-07-03
申请号：EP00957880.8
申请日：2000-08-29
申请人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
发明人： ERLANGER, Bernard, F. , CHEN, Bi-Xing
IPC分类号： C07H21/04 , C07K16/44 , G01N33/53 , G01N33/577
CPC分类号： B82Y30/00 , B82Y5/00 , C07K16/44 , G01N33/5308 , G01N2430/00 , Y10S530/807
摘要： This invention provides antibodies specific for a fullerene or derivative thereof, a single-walled fullerene nanotube, and a multi-walled fullerene nanotube, wherein the fullerene is selected from the group consisting of a fullerene carbon compound having from 20 to 540 carbon atoms. The antibodies may be monoclonal or polyclonal antibodies. This invention provides a hybridoma produced by the fusion of a mouse antibody-producing cell and a mouse myeloma which is designated 1-10F-8A and deposited with the ATCC under Accession Number PTA-279, said hybridoma producing a monoclonal antibody which binds to fullerene C60. This invention provides a mouse monoclonal antibody specific for a fullerene-C60 and produced by the mouse monoclonal antibody-producing hybridoma designated 1-10F-8A. This invention also provides methods of determining a serum concentration of a fullerene in a subject and of purifying a fullerene from a sample. This invention provides methods of preparing nonascale devices which comprise manipulating a single-walled or a multi-walled fullerene nanotube(s) with the above-described antibodies specific for single-walled or multi-walled fullerene nanotubes to assemble electronic or chemical components of the nanoscale device.

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