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1. 发明申请

WO2010085539A1 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN 审中-公开
标题翻译：基于SHIGA毒素2型蛋白的方法和组合
公开(公告)号：WO2010085539A1
公开(公告)日：2010-07-29
申请号：PCT/US2010/021610
申请日：2010-01-21
申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. , O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
发明人： O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
摘要翻译：本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。本发明还具有产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法表位或使用本发明的方法开发的抗Stx2抗体。此外，本发明的特征在于使用使用本发明的方法开发的抗体检测样品中的Stx2。

2. 发明授权

EP2381954B1 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN 有权转让
标题翻译：基于SHIGA TYPE-2蛋白的方法和组合物
公开(公告)号：EP2381954B1
公开(公告)日：2016-11-02
申请号：EP10733840.2
申请日：2010-01-21
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.

3. 发明公开

EP2381954A1 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN 有权转让
标题翻译：基于SHIGA TYPE-2蛋白的方法和组合物
公开(公告)号：EP2381954A1
公开(公告)日：2011-11-02
申请号：EP10733840.2
申请日：2010-01-21
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.

4. 发明授权

EP2381954B8 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 2 PROTEIN 有权转让
标题翻译： VERFAHREN UND ZUSAMMENSETZUNGEN AUF DER BASIS VON SHIGATOXIN-TYP-2-PROTEIN
公开(公告)号：EP2381954B8
公开(公告)日：2017-01-25
申请号：EP10733840.2
申请日：2010-01-21
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
发明人： O'BRIEN, Alison , MELTON-CELSA, Angela , SMITH, Michael , SINCLAIR, James
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： A61K39/0283 , A61K38/00 , A61K39/0258 , A61K2039/505 , C07K7/06 , C07K7/08 , C07K14/25 , C07K16/1232 , C07K2317/34 , Y02A50/473
摘要： The invention is based on the discovery of the epitope in the Stx2 protein for the 11 E1O antibody. The invention features compositions containing non-full length Stx2 polypeptides that include the 11 E1O monoclonal antibody epitope. The invention also features methods of producing anti-Stx2 antibodies specific for the 11 E1O epitope of the Stx2 protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 11 E1O epitope or with an anti-Stx2 antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stx2 in a sample using the antibodies developed using the methods of the invention.
摘要翻译：本发明基于11 E1O抗体的Stx2蛋白中的表位的发现。本发明的特征在于包含非全长Stx2多肽的组合物，其包括11E1O单克隆抗体表位。本发明还涉及产生对Stx2蛋白的11E1O表位特异的抗Stx2抗体的方法。另外，本发明的特征在于用包含11个E1O的多肽治疗具有或有发展志贺毒素相关疾病（例如，溶血性尿毒症综合征和与大肠杆菌和痢疾杆菌感染相关的疾病）的受试者的方法表位或使用本发明的方法开发的抗Stx2抗体。此外，本发明的特征在于使用使用本发明的方法开发的抗体在样品中检测Stx2。

5. 发明公开

EP2019684A2 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 1 PROTEIN 审中-公开
标题翻译：基于SHIGA-TYPE 1蛋白的方法和组合物
公开(公告)号：EP2019684A2
公开(公告)日：2009-02-04
申请号：EP07775978.5
申请日：2007-04-20
申请人： The Henry M. Jackson Foundation for the advancement of Military Medicine, Inc.
发明人： MELTON-CELSA, Angela , SMITH, Michael , O'BRIEN, Alison
IPC分类号： A61K39/00 , A61K39/108 , A61K39/395
CPC分类号： A61K39/3955 , A61K2039/505 , C07K14/245 , C07K16/1228 , C07K16/1232 , C07K16/18 , C07K2317/76 , G01N33/53
摘要： The invention is based on the discovery of the epitope in the StxI protein for the 13C4 antibody. The invention features non-full length Stxl polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-StxI antibodies specific for the 13C4 epitope of the Stxl protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection) with a polypeptide that includes the 13C4 epitope or with an anti-StxI antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stxl in a sample using the antibodies developed using the methods of the invention.

6. 发明申请

WO2007124133A3 METHODS AND COMPOSITIONS BASED ON SHIGA TOXIN TYPE 1 PROTEIN 审中-公开
公开(公告)号：WO2007124133A3
公开(公告)日：2007-11-01
申请号：PCT/US2007/009799
申请日：2007-04-20
申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE INCORPORATED , MELTON-CELSA, Angela , SMITH, Michael , O'BRIEN, Alison
发明人： MELTON-CELSA, Angela , SMITH, Michael , O'BRIEN, Alison
IPC分类号： A61K39/00 , A61K39/108 , A61K39/395
摘要： The invention is based on the discovery of the epitope in the Stxl protein for the 13C4 antibody. The invention features non-full length Stxl polypeptides that include the epitope for the 13C4 monoclonal antibody epitope. The invention also features methods of producing anti-Stxl antibodies specific for the 13C4 epitope of the Stxl protein. Additionally, the invention features methods for treating a subject having, or at risk of developing, a Shiga toxin associated disease (e.g., hemolytic uremia syndrome and diseases associated with E. coli and S. dysenteriae infection ) with a polypeptide that includes the 13C4 epitope or with an anti-Stxl antibody developed using the methods of the invention. Furthermore, the invention features the detection of Stxl in a sample using the antibodies developed using the methods of the invention.

7. 发明申请

WO2020236187A1 WASTEWATER TREATEMENT SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2020236187A1
公开(公告)日：2020-11-26
申请号：PCT/US2019/033859
申请日：2019-05-23
申请人： SMITH, Michael
发明人： SMITH, Michael
IPC分类号： B01D19/00 , B01D61/02 , B01F3/04 , C02F1/44 , C02F1/74 , C02F11/08 , G01N33/18
摘要： A multi-stage remediation system that treats water is disclosed. The system has sensor arrays positioned along the channel to measure characteristics of the water a first injector in fluid communication with the channel configured to inject a liquid gas and a second injector configured to inject air into the fluid from an air source, a hydrodynamic cavitation reactor in communication with the channel to degrade pollutants, a pre-filter in fluid communication with the channel configured to remove particulates remain within the fluid, and an a reverse osmosis system configured to receive the fluid from the pre-filter output

8. 发明申请

WO2014074710A1 APPARATUS COMPRISING RAKE WITH INTEGRATED TAMPER 审中-公开
标题翻译：包含RAKE与集成夯锤的装置
公开(公告)号：WO2014074710A1
公开(公告)日：2014-05-15
申请号：PCT/US2013/068936
申请日：2013-11-07
申请人： SAXTON, Aaron , SMITH, Michael , GILLIS, Gary , TURK, Dan
发明人： SAXTON, Aaron , SMITH, Michael , GILLIS, Gary , TURK, Dan
IPC分类号： A01B1/04
CPC分类号： A01D7/00 , A01D7/06 , A01D7/10 , E02D3/046
摘要： An exemplary aspect comprises an apparatus, comprising: a handle component comprising a first end and a second end; a collar slidably attached to the handle component; a tamper component affixed to the first end of the handle component; and a tines component affixed to the collar comprising individual tines extending through tine guides of the tamper component.
摘要翻译：示例性方面包括一种装置，包括：手柄部件，包括第一端和第二端; 可滑动地附接到手柄部件的轴环; 捣固部件固定到手柄部件的第一端; 以及固定到所述套环上的尖齿部件，包括通过所述篡改部件的齿导向件延伸的单独齿。

9. 发明申请

WO2010136795A2 HEAT RECOVERY MODULE 审中-公开
标题翻译：热回收模块
公开(公告)号：WO2010136795A2
公开(公告)日：2010-12-02
申请号：PCT/GB2010/050863
申请日：2010-05-26
申请人： DOOSAN POWER SYSTEMS LIMITED , CHEN, Chao Hui , MENG, Li , SMITH, Michael
发明人： CHEN, Chao Hui , MENG, Li , SMITH, Michael
CPC分类号： F22D1/36 , F22D1/02
摘要： A module for heat recovery from exhausted flue gas in a steam generator is described comprising a flue gas outlet conduit defining a flow path for flue gas from a flue gas outlet of a steam generator to a flue gas conduit junction; a first flue gas conduit defining a flow path for flue gas from the junction to a first air heater; a second flue gas conduit defining a flow path for flue gas from the junction to at least one high pressure and at least one low pressure process liquid economiser. A steam generator using the module, a method implementing the flow principles embodied in such a module, and a method of incorporation of such a module into a steam generator, especially by retrofit,are also described.
摘要翻译：描述了一种用于在蒸汽发生器中从排出的废气中回收热量的模块，其包括：烟道气出口导管，其限定用于从蒸汽发生器的烟道气出口到烟道气管道连接处的烟道气的流动路径; 第一烟气管道，其限定用于从所述连接点到第一空气加热器的烟道气的流动路径; 第二烟气管道，其限定用于从所述连接点到至少一个高压和至少一个低压过程液体节能器的烟道气的流动路径。还描述了使用该模块的蒸汽发生器，实现这种模块中实施的流程原理的方法，以及将这种模块并入蒸汽发生器，特别是通过改造的方法。

10. 发明申请

WO2010082980A1 AUTHORIZATION REFRESH SYSTEM AND METHOD 审中-公开
标题翻译：授权刷新系统和方法
公开(公告)号：WO2010082980A1
公开(公告)日：2010-07-22
申请号：PCT/US2009/066311
申请日：2009-12-02
申请人： AMERICAN EXPRESS TRAVEL RELATED SERVICES COMPANY, INC. , BERNSTEIN, Kathi , BUEHLER, Hans , CLARK, William , CURRY, Jeremiah , LUEDERS, Ryan , NELSON, David , SMITH, Michael
发明人： BERNSTEIN, Kathi , BUEHLER, Hans , CLARK, William , CURRY, Jeremiah , LUEDERS, Ryan , NELSON, David , SMITH, Michael
IPC分类号： G06Q40/00
CPC分类号： G06Q20/12 , G06Q20/04 , G06Q20/20 , G06Q20/385 , G06Q20/40 , G06Q30/06 , G06Q40/00 , G06Q40/02 , G06Q40/12
摘要： Limited use account identifiers or secondary account identifiers are enabled with refresh capability. The refreshable account identifiers are used in financial transactions and, specifically, in transaction situations where multiple and/or duplicate authorization requests occur for the same or related transactions. The limited use account identifiers may be used by intermediaries that coordinate the purchase of an item for a buyer. The intermediary also coordinates with the merchant to verify availability of the item, provides the merchant with the refreshable limited use account identifier and provides the purchaser with a confirmation number.
摘要翻译：有限的使用帐户标识符或辅助帐户标识符启用了刷新功能。可刷新的帐户标识符用于金融交易，特别是在相同或相关交易发生多重和/或重复授权请求的交易情况下。有限的使用账户标识符可以由协调为买方购买商品的中间商使用。中介还与商家协调以验证物品的可用性，向商家提供可刷新的有限使用账户标识符并向买方提供确认号码。

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