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1. 发明申请

WO2007030611A2 A CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER RELATED GENES 审中-公开
标题翻译：雌激素受体（ER）和ER相关基因的基因表达的计算指标
公开(公告)号：WO2007030611A2
公开(公告)日：2007-03-15
申请号：PCT/US2006/034846
申请日：2006-09-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , SYMMANS, W., Fraser , HATZIS, Christos , ANDERSON, Keith , PUSZTAI, Lajos
发明人： SYMMANS, W., Fraser , HATZIS, Christos , ANDERSON, Keith , PUSZTAI, Lajos
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G06F19/18 , G06F19/20
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.
摘要翻译：本发明提供了在对给定治疗剂有反应的肿瘤中表达的基因的鉴定和组合，并且其组合表达可用作与对该治疗剂的反应性相关的指标。本发明的一个或多个基因可用作标志物（或替代标记物），以鉴定可能被该试剂或一类试剂例如激素或内分泌治疗成功治疗的肿瘤。

2. 发明公开

EP1931802A2 A CALCULATED INDEX OF GENOMIC EXPRESSION OF ESTROGEN RECEPTOR (ER) AND ER RELATED GENES 审中-公开
标题翻译：雌激素受体（ER）和基因的基因组表达与ER计算INDEX
公开(公告)号：EP1931802A2
公开(公告)日：2008-06-18
申请号：EP06814273.6
申请日：2006-09-11
申请人： The Board of Regents of The University of Texas System , Nuvera Biosciences
发明人： SYMMANS, W., Fraser , HATZIS, Christos , ANDERSON, Keith , PUSZTAI, Lajos
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/6842 , G01N33/743 , G01N2333/723 , G01N2800/52 , G06F19/18 , G06F19/20
摘要： The present invention provides the identification and combination of genes that are expressed in tumors that are responsive to a given therapeutic agent and whose combined expression can be used as an index that correlates with responsiveness to that therapeutic agent. One or more of the genes of the present invention may be used as markers (or surrogate markers) to identify tumors that are likely to be successfully treated by that agent or class of agents such as hormonal or endocrine treatment.

3. 发明申请

WO2010115055A1 L-ORNITHINE PHENYL ACETATE AND METHODS OF MAKING THEREOF 审中-公开
标题翻译： L-乙酸乙酯及其制备方法
公开(公告)号：WO2010115055A1
公开(公告)日：2010-10-07
申请号：PCT/US2010/029708
申请日：2010-04-01
申请人： OCERA THERAPEUTICS, INC. , ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
发明人： ANDERSON, Keith , BEHLING, Jim , DOUGAN, Christine, Henderson , WATT, Stephen, William , MANINI, Peter , FIGINI, Attilia
IPC分类号： A61K31/198 , A61P1/16 , C07C229/26 , A61K31/192 , C07C57/46
CPC分类号： C07C227/40 , A61K31/192 , A61K31/198 , A61K31/205 , C07C51/42 , C07C57/32 , C07C227/42 , C07C229/26
摘要： Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.
摘要翻译：本文公开了L-鸟氨酸苯乙酸酯的结晶形式及其制备方法。在一些实施方案中，结晶形式可以是I，II，III和V型，或其混合物。结晶形式可以配制用于治疗具有肝病的受试者，例如肝性脑病。因此，一些实施方案包括施用L-鸟氨酸苯基乙酸酯的制剂和方法。

4. 发明申请

WO2016099709A1 POWERED LAVAGE HANDLE AND ASSOCIATED USE THEREFORE 审中-公开
标题翻译：动力拖车手柄及相关用途
公开(公告)号：WO2016099709A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/059780
申请日：2015-11-09
申请人： DOERR, Daniel Glenn , STRELITZKI, Roland , BARAKAT, Mohammed Ali , ANDERSON, Keith , HABERLAND, Gary Wayne , FARNELLA, John A. , ROGER, Kenneth M.
发明人： DOERR, Daniel Glenn , STRELITZKI, Roland , BARAKAT, Mohammed Ali , ANDERSON, Keith , HABERLAND, Gary Wayne , FARNELLA, John A. , ROGER, Kenneth M.
IPC分类号： A61M1/00 , A61M3/02
CPC分类号： A61M1/0064 , A61M1/0035 , A61M3/0283
摘要： A lavage handle for facilitating at least one of an irrigation function and a suctioning function at a target zone preferably includes a portable body, a power-operated fluid-displacing mechanism in communication with said body wherein said fluid-displacing mechanism has one of a first operating mode for inducing outward irrigation of fluid towards the target zone and a second operating mode for inducing inward suction of fluid from the target zone. An actuation mechanism is located at said body and operable communicated with said fluid-displacing mechanism such that said fluid-displacing mechanism is selectively operated in at least one of said first operating mode and said second operating mode. The actuation mechanism may include an irrigation-inducing mechanism and/or a suction-inducing mechanism.
摘要翻译：用于促进目标区域的冲洗功能和抽吸功能中的至少一个的冲洗手柄优选地包括便携式主体，与所述主体连通的动力操作的流体移动机构，其中所述流体移位机构具有第一用于诱导流体朝向目标区域的向外冲洗的操作模式和用于引导来自目标区域的流体的向内抽吸的第二操作模式。致动机构位于所述主体处，并与所述流体移动机构可操作地连通，使得所述流体移动机构选择性地以所述第一操作模式和所述第二操作模式中的至少一个操作。致动机构可以包括冲洗诱导机构和/或吸引诱导机构。

5. 发明申请

WO2010144498A9 TREATMENT OF PORTAL HYPERTENSION AND RESTORATION OF LIVER FUNCTION USING L-ORNITHINE PHENYLACETATE 审中-公开
公开(公告)号：WO2010144498A9
公开(公告)日：2010-12-16
申请号：PCT/US2010/037838
申请日：2010-06-08
申请人： UCL BUSINESS PLC , OCERA THERAPEUTICS, INC. , JALAN, Rajiv , ANDERSON, Keith
发明人： JALAN, Rajiv , ANDERSON, Keith
IPC分类号： A61K31/195 , A61K31/19 , A61K31/192 , A61P9/12 , A61P1/16

6. 发明申请

WO2009050418A1 IMPROVEMENTS IN OR RELATING TO LIGHTING CONTROL SYSTEMS 审中-公开
标题翻译：照明控制系统的改进或相关
公开(公告)号：WO2009050418A1
公开(公告)日：2009-04-23
申请号：PCT/GB2008/001411
申请日：2008-04-22
申请人： RADIANT RESEARCH LIMITED , ARCHENHOLD, Geoffrey, Howard, Gillet , ANDERSON, Keith
发明人： ARCHENHOLD, Geoffrey, Howard, Gillet , ANDERSON, Keith
IPC分类号： H05B33/08
CPC分类号： H05B33/0866
摘要： A system for controlling solid state lighting comprises a source (1) to supply any one of a range of AC or DC voltages to a plurality of light strings (3, 4, 5). The source (1) includes a power factor correction circuit 14 for controlling the power factor to the system and a separate transformer (15, 16, 17) for each light string (3, 4, 5). The current that can pass through each LED string (3, 4 and 5) is independently limited by each corresponding LED driver circuit (6, 19 and 20). The current through each LED string (3, 4 and 5) can be modified according to a feedback monitor system (18, 21 and 22) that measures parameters such as LED characteristics, forward current, temperature, and LED output intensity / colour. Each LED string (3, 4 and 5) has an independent sensor (7, 23 and 24) that monitors the voltage across each switching device in the corresponding LED driver circuits (6, 19 and 20) and utilises a control unit (8, 25 and 26) to control the voltages supplied by each corresponding transformer (15, 16 and 17) through control signals (2, 27 and 28) in response to the monitored switching device voltages.
摘要翻译：一种用于控制固态照明的系统，包括：向多个灯串（3,4,5）提供AC或DC电压范围中的任何一个的源（1）。源（1）包括用于控制系统的功率因数的功率因数校正电路14和用于每个灯串（3,4,5）的单独的变压器（15,16,17）。可以通过每个LED串（3,4和5）的电流由每个相应的LED驱动电路（6,19和20）独立地限制。可以根据测量诸如LED特性，正向电流，温度和LED输出强度/颜色等参数的反馈监视系统（18,21和22）来修改通过每个LED串（3,4和5）的电流。每个LED串（3,4和5）具有独立的传感器（7,23和24），用于监控相应的LED驱动电路（6,19和20）中每个开关装置的电压，并利用控制单元（8， 25和26），以响应于所监视的开关器件电压来控制由每个相应的变压器（15,16和17）提供的电压通过控制信号（2,27和28）。

7. 发明申请

WO2003022009A1 ILLUMINATION SYSTEM 审中-公开
标题翻译：照明系统
公开(公告)号：WO2003022009A1
公开(公告)日：2003-03-13
申请号：PCT/GB2002/004007
申请日：2002-08-30
申请人： RADIANT RESEARCH LIMITED , ARCHENHOLD, Geoffrey, Howard, Gillett , ANDERSON, Keith
发明人： ARCHENHOLD, Geoffrey, Howard, Gillett , ANDERSON, Keith
IPC分类号： H05B33/08
CPC分类号： H05B33/0818 , H05B33/0842 , H05B33/0866 , H05B33/0872 , Y02B20/347
摘要： A light emitting diode illumination system is disclosed for driving a current circuit for energising one or more LED light sources. The system comprises a control system including a microprocessor arranged to control a pulse amplitude modulated (PAM) voltage controlled current circuit, and may employ a monitor for monitoring at least one ambient condition and a microprocessor operable to control the current circuit in response to the monitored condition.
摘要翻译：公开了一种用于驱动用于激励一个或多个LED光源的电流电路的发光二极管照明系统。该系统包括一个控制系统，该控制系统包括微处理器，该微处理器被布置成控制脉冲幅度调制（PAM）电压控制电流电路，并且可以采用用于监视至少一个环境条件的监视器和可操作以响应于所监视的控制器控制当前电路的微处理器条件。

8. 发明申请

WO2012067714A1 STENT DELIVERY SYSTEM 审中-公开
标题翻译： STENT交付系统
公开(公告)号：WO2012067714A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/052800
申请日：2011-09-22
申请人： BOSTON SCIENTIFIC SCIMED, INC. , RAMOS, Tim , GRABOWSKI, Gerald , ANDERSON, Keith
发明人： RAMOS, Tim , GRABOWSKI, Gerald , ANDERSON, Keith
IPC分类号： A61F2/84
CPC分类号： A61F2/966 , A61F2002/9517
摘要： Stent delivery systems and methods for making and using the same are disclosed. An example stent delivery system may include an inner member having a proximal end. A sleeve may be coupled to the inner member adjacent to the proximal end. A deployment sheath may be disposed about the inner member. A gear rack assembly may be coupled to the deployment sheath. A stent may be disposed between the inner member and the deployment sheath. A handle may be coupled to the inner member and to the deployment sheath. The handle may include an actuation member. The actuation member may be coupled to the gear rack assembly so that actuation of the actuation member shifts the longitudinal position of the gear rack assembly and the deployment sheath. An engagement mechanism may be coupled to the gear rack assembly. The engagement mechanism may be configured to engage the sleeve of the inner member so that proximal retraction of the gear rack assembly results in proximal retraction of the inner shaft.
摘要翻译：公开了支架输送系统及其制造和使用方法。示例性支架输送系统可以包括具有近端的内部构件。套筒可以与邻近近端的内部构件联接。部署护套可以围绕内部构件设置。齿条组件可以联接到展开护套。支架可以设置在内部构件和展开护套之间。手柄可以联接到内部构件和部署护套。手柄可以包括致动构件。致动构件可以联接到齿条组件，使得致动构件的致动使齿条组件和展开护套的纵向位置移动。接合机构可以联接到齿条组件。接合机构可以被配置为接合内部构件的套筒，使得齿条组件的近侧收缩导致内部轴的近端缩回。

9. 发明申请

WO2012052752A2 FLUID DISCRIMINATION APPARATUS AND METHOD 审中-公开
标题翻译：流体识别装置和方法
公开(公告)号：WO2012052752A2
公开(公告)日：2012-04-26
申请号：PCT/GB2011/052014
申请日：2011-10-18
申请人： D. BERRY & CO. (PIPE FITTING SUPPLIES) LIMITED , WILLIAMS, Jacque , ANDERSON, Keith
发明人： WILLIAMS, Jacque , ANDERSON, Keith
IPC分类号： G01N21/41
CPC分类号： G01N21/4133 , G01N21/85 , G01N33/2829 , G01N2021/1774
摘要： In an aspect of the invention there is provided fluid discrimination apparatus comprising fluid inspection means, the fluid inspection means comprising a light source, a detector and an optical element, the inspection means being operable to direct a beam of light from the source through the optical element to an inspection surface of the optical element and to detect by means of the detector light scattered back through the optical element, the apparatus being operable to determine whether a fluid in contact with the inspection surface corresponds to a fluid having a prescribed refractive index characteristic responsive to light detected by the detector.
摘要翻译：在本发明的一个方面，提供了包括流体检查装置的流体鉴别装置，流体检查装置包括光源，检测器和光学元件，检查装置可操作以将来自源的光束引导通过光学元件连接到光学元件的检查表面，并且借助于通过光学元件散射的检测器光来检测该装置，该装置可操作以确定与检查表面接触的流体是否对应于具有规定折射率特性的流体响应于由检测器检测到的光。

10. 发明申请

WO2008021378A1 USE OF ADSBORBENT CARBON MICROSPHERES TO TREAT INTESTINAL BACTERIAL INFECTIONS 审中-公开
标题翻译： ADSBORBENT碳微球用于治疗肠内细菌感染
公开(公告)号：WO2008021378A1
公开(公告)日：2008-02-21
申请号：PCT/US2007/018032
申请日：2007-08-16
申请人： OCERA THERAPEUTICS, INC. , FRAPAISE, Xavier , ANDERSON, Keith
发明人： FRAPAISE, Xavier , ANDERSON, Keith
IPC分类号： A61K33/44 , A61P31/00
CPC分类号： A61K33/44 , B60L8/006 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02E10/725 , Y02T10/7083
摘要： Disclosed herein is the use of adsorbent carbon microspheres for the treatment of intestinal bacterial infections. The infections include infection with Escherichia coli , Shigella dysenteriae , Vibrio cholerae , and Clostridium difficile . The adsorbent carbon microspheres serve to adsorb or bind toxins produced by the bacteria.
摘要翻译：本文公开了使用吸附剂碳微球来治疗肠道细菌感染。感染包括感染大肠杆菌，痢疾志贺氏菌，霍乱弧菌和艰难梭菌。吸附剂碳微球用于吸附或结合由细菌产生的毒素。

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